Publications: Prof Adrian Hobbs

Perez-Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W, Hobbs AJ ( 2024 ) . Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis and portal hypertension . PNAS Nexus

de Jesus DS, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al. ( 2024 ) . Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension . Free Radical Biology and Medicine vol. 224 ,

Lowe VJ, Aubdool AA, Moyes AJ, Dignam JP, Perez-Ternero C, Baliga RS, Smart N, Hobbs AJ ( 2024 ) . Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden . Pharmacological Research vol. 209 ,

Dickinson YA, Moyes AJ, Hobbs AJ ( 2024 ) . C-type natriuretic peptide (CNP): The cardiovascular system and beyond . Pharmacology & Therapeutics vol. 262 ,

Barsha G, Hong Q, Nelson J, Walton S, Hetherington K, Thomas J, Nicholls S, Hobbs A et al. ( 2024 ) . Activation of the C-Type Natriuretic Peptide Pathway Offers a Novel Therapeutic Target for Gestational Hypertension . Heart Lung and Circulation . vol. 33 ,

de Alwis N, Hannan NJ, Fato B, Beard S, Hobbs A, Lino TK, Binder N, Bubb K ( 2024 ) . Targeting the natriuretic peptide system to treat preeclampsia . Pregnancy Hypertension vol. 36 ,

Papaioannou I, Dritsoula A, Kang P, Baliga RS, Trinder SL, Cook E, Xu S, Hobbs A et al. ( 2024 ) . NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension . JCI Insight vol. 9 , ( 10 )

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E et al. ( 2023 ) . The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors . British Journal of Pharmacology vol. 180 , ( S2 ) s241 - s288 .

Christie IN, Theparambil SM, Braga A, Doronin M, Hosford PS, Brazhe A, Mascarenhas A, Nizari S et al. ( 2023 ) . Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia . Cell Reports vol. 42 , ( 12 )

Aubdool AA, Moyes AJ, Perez-Ternero C, Tsui JC, Lu HS, Daugherty A, Hobbs AJ ( 2023 ) . Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm . Circulation vol. 148 , ( Suppl_1 ) a15171 - a15171 .

Fato BR, de Alwis N, Hobbs AJ, Kaitu'u-Lino TJ, Bubb KJ, Hannan NJ ( 2023 ) . PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia . Pregnancy Hypertension vol. 33 ,

Andresen H, Pérez‐Ternero C, Robinson J, Dickey DM, Hobbs AJ, Potter LR, Levy FO, Cataliotti A et al. ( 2023 ) . Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation . British Journal of Pharmacology vol. 180 , ( 24 ) 3254 - 3270 .

Dignam JP, Perez-Ternero C, Aubdool AA, Hobbs AJ ( 2023 ) . C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling . Presented at: A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION ,

Moyes A, Sand C, Aubdool A, Perez-Ternero C, Mohammad S, Thiemermann C, Hobbs A ( 2023 ) . C-type Natriuretic Peptide Attenuates Endothelial and Cardiac Dysfunction During Endotoxemia and Polymicrobial Sepsis . Conference: B45. NEW STUDIES IN SEPSIS AND INFECTIOUS DISEASESa3433 - a3433 .

Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al. ( 2023 ) . Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1 . IUPHAR/BPS Guide to Pharmacology CITE vol. 2023 , ( 1 )

Dignam JP, Perez-Ternero C, Aubdool A, Hobbs AJ ( 2023 ) . C-type natriuretic peptide offsets the development of pulmonary hypertension . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A ( 2023 ) . C-type natriuretic peptide regulates metabolic homeostasis . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Andresen H, Perez-Ternero C, Robinson J, Dickey D, Hobbs A, Potter LR, Levy FO, Cataliotti A et al. ( 2023 ) . Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Dignam JP, Perez-Ternero C, Aubdool A, Hobbs AJ ( 2023 ) . C-type natriuretic peptide offsets the development of pulmonary hypertension . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Perez-Ternero C, Li W, Aubdool A, Goldin R, Alazawi W, Hobbs A ( 2023 ) . C-type natriuretic peptide protects against the development of non-alcoholic steatohepatitis and portal hypertension . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 6 - 7 .

Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A ( 2023 ) . C-type natriuretic peptide regulates metabolic homeostasis . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Andresen H, Perez-Ternero C, Robinson J, Dickey D, Hobbs A, Potter LR, Levy FO, Cataliotti A et al. ( 2023 ) . Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 21 ,

Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ ( 2022 ) . C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity . Frontiers in Molecular Neuroscience vol. 15 ,

Zarenkiewicz J, Perez-Ternero C, Kojasoy V, McGinity C, Khodade VS, Lin J, Tantillo DJ, Toscano JP et al. ( 2022 ) . The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications . Free Radical Biology and Medicine vol. 188 , 459 - 467 .

Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ ( 2022 ) . C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis . Proc Natl Acad Sci U S A vol. 119 , ( 13 )

Smith RJ, Perez-Ternero C, Conole D, Martin C, Myers SH, Hobbs AJ, Selwood DL ( 2022 ) . A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C . Journal of Medicinal Chemistry vol. 65 , ( 7 ) 5495 - 5513 .

Fukuto JM, Perez-Ternero C, Zarenkiewicz J, Lin J, Hobbs AJ, Toscano JP ( 2022 ) . Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO) . Antioxidants vol. 11 , ( 1 )

Scott TE, Qin CX, Drummond GR, Hobbs AJ, Kemp-Harper BK ( 2021 ) . Innovative Anti-Inflammatory and Pro-resolving Strategies for Pulmonary Hypertension: High Blood Pressure Research Council of Australia Award 2019 . Hypertension vol. 78 , ( 5 ) 1168 - 1184 .

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E et al. ( 2021 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors . British Journal of Pharmacology vol. 178 , ( S1 ) S264 - S312 .

Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al. ( 2021 ) . Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3 . IUPHAR/BPS Guide to Pharmacology CITE vol. 2021 , ( 3 )

Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC et al. ( 2021 ) . Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology . Cardiovascular Research vol. 118 , ( 9 ) 2085 - 2102 .

Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA et al. ( 2021 ) . Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature . British Journal of Pharmacology vol. 179 , ( 11 ) 2443 - 2459 .

Dignam JP, Scott TE, Kemp‐Harper BK, Hobbs AJ ( 2021 ) . Animal models of pulmonary hypertension: Getting to the heart of the problem . British Journal of Pharmacology vol. 179 , ( 5 ) 811 - 837 .

Fukuto JM, Hobbs AJ ( 2020 ) . A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles . Nitric Oxide vol. 107 , 46 - 57 .

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine

Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al. ( 2020 ) . Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2020 , ( 3 )

Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A et al. ( 2020 ) . Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy . Journal of Thrombosis and Haemostasis

Scott TE, Ung V, Baliga RS, Robertson AAB, Nold-Petry CA, Nold MF, Drummond GR, Hobbs AJ et al. ( 2020 ) . Targeting the NLRP3 Inflammasome as a Novel Approach to Treat Pulmonary Hypertension . Conference: American Thoracic Societya3830 - a3830 .

Perez-Ternero C, Aubdool AA, Moyes AJ, Hobbs AJ ( 2019 ) . C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling . CIRCULATION . Conference: American Heart Association vol. 140 ,

Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease . The Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .

Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al. ( 2019 ) . Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2019 , ( 4 )

Hobbs AJ ( 2019 ) . Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman . Nitric Oxide vol. 90 ,

Preedy MEJ, Baliga RS, Hobbs AJ ( 2019 ) . Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure . Journal of Cardiovascular Pharmacology

Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P ( 2019 ) . Correction to: Soluble Guanylate Cyclase Stimulators and Activators . Handbook of Experimental Pharmacology

Moyes AJ, Hobbs AJ ( 2019 ) . C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature . International Journal of Molecular Sciences vol. 20 , ( 9 )

Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al. ( 2019 ) . Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial . British Journal of Pharmacology vol. 176 , ( 9 ) 1251 - 1267 .

Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al. ( 2019 ) . C-type natriuretic peptide co-ordinates cardiac structure and function . European Heart Journal vol. 41 , ( 9 ) 1006 - 1020 .

Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P ( 2019 ) . Soluble Guanylate Cyclase Stimulators and Activators . Handb Exp Pharmacol

Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC et al. ( 2018 ) . Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling . Circulation

Conole D, Myers SH, Mota F, Hobbs AJ, Selwood DL ( 2018 ) . Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands . Chemical Biology & Drug Design vol. 93 , ( 6 ) 1011 - 1020 .

Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2018 ) . Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure . Proc Natl Acad Sci U S A

Scott TE, Kemp‐Harper BK, Hobbs AJ ( 2018 ) . Inflammasomes: a novel therapeutic target in pulmonary hypertension? . British Journal of Pharmacology vol. 176 , ( 12 ) 1880 - 1896 .

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese‐Krott MM, Bianco CL et al. ( 2018 ) . Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology . FEBS Letters vol. 592 , ( 12 ) 2140 - 2152 .

Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ, Greenwood IA ( 2018 ) . Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90) . Hypertension vol. 71 , ( 6 ) 1091 - 1100 .

Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ et al. ( 2018 ) . Potent Anti‐Inflammatory and Pro‐Resolving Effects of Anabasum in a Human Model of Self‐Resolving Acute Inflammation . Clinical Pharmacology & Therapeutics vol. 104 , ( 4 ) 675 - 686 .

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al. ( 2017 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview . British Journal of Pharmacology vol. 174 , S1 - S16 .

Kapil V ( 2017 ) . Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 . BMC Pharmacol Toxicol vol. 18 , ( Suppl 1 ) 64 - 64 .

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2017 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .

Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ ( 2016 ) . Functional pharmacological characterization of SER100 in cardiovascular health and disease . Br J Pharmacol

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2016 ) . [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II . vol. 34 Suppl 2 , Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable , Medium: Print ,

Hobbs AJ ( 2016 ) . A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction? . Circ Res vol. 119 , ( 2 ) 181 - 183 .

Hobbs AJ ( 2016 ) . Guanylyl cyclase can't stand the HETE . Am J Physiol Heart Circ Physiol vol. 310 , ( 11 ) H1608 - H1610 .

Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N et al. ( 2016 ) . IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD . Journal of the American Society of Nephrology

Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ, Ramage AG ( 2016 ) . Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism . Experimental Physiology vol. 101 , ( 5 ) 588 - 598 .

Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI, Hobbs AJ, Schmidt HHHW ( 2016 ) . Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology . CLINICAL PHARMACOLOGY & THERAPEUTICS vol. 99 , ( 4 ) 360 - 362 .

Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ ( 2016 ) . Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 193 ,

Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . Circulation vol. 132 , ( suppl_3 )

Sand CA, Hobbs AJ ( 2015 ) . The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer? . Vascular Pharmacology vol. 77 , 35 - 37 .

Allen RMH, Renukanthan A, Bubb KJ, Villar IC, Moyes AJ, Baliga RS, Hobbs AJ ( 2015 ) . Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )

Hobbs AJ ( 2015 ) . Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP) . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II . Hypertension vol. 66 , ( suppl_1 )

Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT ( 2015 ) . C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes . Biochemical and Biophysical Research Communications vol. 465 , ( 4 ) 784 - 789 .

O'Brien A, China L, Massey KA, Nicolaou A, Winstanley A, Newson J, Hobbs A, Audzevich T et al. ( 2015 ) . Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences . Liver International vol. 36 , ( 6 ) 837 - 846 .

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . PP.LB03.07 . Journal of Hypertension . vol. 33 , e518 - e519 .

Allen R, Renukanthan A, Bubb K, Villar I, Moyes A, Baliga R, Hobbs A ( 2015 ) . Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis . The FASEB Journal vol. 29 , ( S1 )

Peake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G, Hobbs A, Chowdhury T ( 2015 ) . Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage . Osteoarthritis and Cartilage vol. 23 , a141 - a142 .

Papapetropoulos A, Hobbs AJ, Topouzis S ( 2015 ) . Extending the translational potential of targeting NO/cGMP‐regulated pathways in the CVS . British Journal of Pharmacology vol. 172 , ( 6 ) 1397 - 1414 .

Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ, CHOWDHURY TT ( 2015 ) . Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants . Biomacromolecules

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Blood-pressure associated variants in <i>NPR3</i> affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II . vol. 29 , is. 10 , pp. 624 - 624 .

Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . CIRCULATION . vol. 132 ,

Bubb KJ, Hobbs AJ, Klinger JR ( 2015 ) . Modulation of cGMP Synthesis and Metabolism . Diagnosis and Management of Pulmonary Hypertension , vol. 12 , Springer Nature

Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P et al. ( 2014 ) . Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility . Free Radic Biol Med vol. 77 , 82 - 94 .

Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F, Chowdhury TT ( 2014 ) . Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function . Osteoarthritis Cartilage vol. 22 , ( 11 ) 1800 - 1807 .

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin Invest vol. 124 , ( 9 ) 4039 - 4051 .

Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ, Hobbs AJ ( 2014 ) . Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension . Circulation vol. 130 , ( 6 ) 496 - 507 .

Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ ( 2014 ) . Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis . Br J Pharmacol vol. 171 , ( 14 ) 3463 - 3475 .

Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ, Mascharak PK ( 2014 ) . Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex . JOURNAL OF MATERIALS CHEMISTRY B vol. 2 , ( 15 ) 2107 - 2113 .

Hobbs AJ ( 2014 ) . Natriuretic peptide receptors and heart failure: to B or not to B blocked? . Naunyn Schmiedebergs Arch Pharmacol vol. 387 , ( 1 ) 1 - 4 .

Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. ( 2014 ) . Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo model . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A27 - A27 .

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M et al. ( 2013 ) . The Concise Guide to PHARMACOLOGY 2013/14: Overview . British Journal of Pharmacology vol. 170 , ( 8 ) 1449 - 1458 .

Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ et al. ( 2013 ) . Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension . Arthritis Rheum vol. 65 , ( 11 ) 2928 - 2939 .

Baliga RS, MacAllister RJ, Hobbs AJ ( 2013 ) . Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application . Pharmacotherapy of Pulmonary Hypertension , vol. 218 , Springer Nature

Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al. ( 2013 ) . Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential . Hypertension vol. 61 , ( 5 ) 1091 - 1102 .

Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M et al. ( 2013 ) . C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling . CIRCULATION RESEARCH vol. 112 , ( 10 ) 1355 - + .

Ahluwalia A, Hobbs AJ ( 2013 ) . Letter by Ahluwalia and Hobbs Regarding Article, "Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics" . CIRCULATION vol. 127 , ( 2 ) E275 - E275 .

Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. ( 2013 ) . Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model . Arthritis Research and Therapy vol. 15 , ( 4 )

Bubb KJ, Trinder S, Baliga R, MacAllister RJ, Hobbs AJ ( 2013 ) . Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 187 ,

Baliga RS, Macallister RJ, Hobbs AJ ( 2013 ) . Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application . Handb Exp Pharmacol vol. 218 , 477 - 511 .

Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS, Ahluwalia A ( 2012 ) . Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation . Br J Pharmacol vol. 167 , ( 4 ) 805 - 817 .

Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ ( 2012 ) . Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase . Circulation vol. 125 , ( 23 ) 2922 - 2932 .

Baliga RS, Milsom AB, Trinder SL, Ghosh S, MacAllister RJ, Ahluwalia A, Hobbs AJ ( 2012 ) . Dietary Nitrate: A Novel Therapy For Pulmonary Hypertension . Conference: B63. EXPERIMENTAL MODELS IN PULMONARY HYPERTENSION Ia3413 - a3413 .

Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ ( 2012 ) . Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide . CIRCULATION vol. 126 , ( 21 )

Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ, Mascharak PK ( 2012 ) . Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules . INORGANIC CHEMISTRY vol. 51 , ( 1 ) 601 - 608 .

Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham D, Denton C ( 2012 ) . SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA . RHEUMATOLOGY . vol. 51 , 41 - 41 .

Hobbs AJ, Ignarro LJ ( 2011 ) . Chemistry and Molecular Biology of Nitric Oxide Synthesis . The Haemodynamic Effects of Nitric Oxide , World Scientific Publishing

Khambata RS, Panayiotou CM, Hobbs AJ ( 2011 ) . Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide . Br J Pharmacol vol. 164 , ( 2b ) 584 - 597 .

Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA et al. ( 2011 ) . LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8 . Circ Res vol. 109 , ( 5 ) 492 - 501 .

Quinteiro FM, Gane P, Rebstock A-S, Worthington R, Simone M, Djordevic S, Hobbs A, Selwood D ( 2011 ) . Design and development of novel non-peptide agonists at NPR-C . BMC Pharmacology vol. 11 , ( Suppl 1 )

Baliga RS, Trinder SL, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ ( 2011 ) . Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis . BMC Pharmacology vol. 11 , ( Suppl 1 )

Velmurugan S, Kapil V, McKnight AHO, Aboud Z, Davies S, Milsom AB, Pearl V, Liverani E et al. ( 2011 ) . Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 24 , S35 - S36 .

Baliga RS, MacAllister RJ, Hobbs AJ ( 2011 ) . New perspectives for the treatment of pulmonary hypertension . Br J Pharmacol vol. 163 , ( 1 ) 125 - 140 .

Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ ( 2011 ) . Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target? . Conference: C61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS IIa6409 - a6409 .

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al. ( 2011 ) . Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin . Arterioscler Thromb Vasc Biol vol. 31 , ( 5 ) 1075 - 1083 .

Gonzalez MA, Fry NL, Burt R, Davda R, Hobbs A, Mascharak PK ( 2011 ) . Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta . INORG CHEM vol. 50 , ( 7 ) 3127 - 3134 .

Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton C ( 2011 ) . AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGF beta-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS . RHEUMATOLOGY . vol. 50 , 134 - 135 .

Kapil V, Benjamin N, Hobbs A, Ahluwalia A ( 2011 ) . Response to Inorganic Nitrate for Blood Pressure Lowering? . HYPERTENSION vol. 57 , ( 2 ) E3 - E3 .

Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP ( 2011 ) . Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma . ARTHRITIS AND RHEUMATISM . vol. 63 , S1022 - S1023 .

Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP ( 2010 ) . Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis . CLIN EXP RHEUMATOL vol. 28 , ( 5 ) S63 - S63 .

Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al. ( 2010 ) . Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury . AM J PHYSIOL-HEART C vol. 299 , ( 3 ) H827 - H836 .

Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V et al. ( 2010 ) . Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO . Hypertension vol. 56 , ( 2 ) 274 - 281 .

Kapil V, Maleki-Toyserkani S, Rehman F, Arghandawi S, Pearl V, Milsom A, Benjamin N, Hobbs A et al. ( 2010 ) . Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 70 , 285 - 285 .

Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ ( 2010 ) . Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A . Br J Pharmacol vol. 160 , ( 8 ) 2045 - 2054 .

Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al. ( 2010 ) . Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice . NITRIC OXIDE-BIOL CH vol. 22 , ( 2 ) 141 - 148 .

Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target . CURR PHARM DESIGN vol. 16 , ( 37 ) 4080 - 4088 .

Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target . Curr Pharm Des vol. 16 , ( 37 ) 4080 - 4088 .

Hobbs AJ, Stasch J-P ( 2010 ) . Chapter 9 Soluble Guanylate Cyclase Allosteric Activation and Redox Regulation . Nitric Oxide , Elsevier

Hobbs AJ, Stasch JP ( 2010 ) . Soluble Guanylate Cyclase. Allosteric Activation and Redox Regulation . Nitric Oxide ,

Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ ( 2010 ) . The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C . FASEB JOURNAL vol. 24 ,

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al. ( 2009 ) . Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis . Arterioscler Thromb Vasc Biol vol. 29 , ( 11 ) 1757 - 1763 .

Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM et al. ( 2009 ) . The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS . J BIOL CHEM vol. 284 , ( 33 ) 21788 - 21796 .

Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ ( 2009 ) . Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension . BMC Pharmacology vol. 9 , ( Suppl 1 )

Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A et al. ( 2009 ) . BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE . BASIC CLIN PHARMACOL vol. 105 , 31 - 31 .

Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G et al. ( 2009 ) . Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans . J IMMUNOL vol. 183 , ( 3 ) 2089 - 2096 .

Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R et al. ( 2009 ) . ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS . BASIC CLIN PHARMACOL vol. 105 , 26 - 26 .

Kapil V, Okorie M, Akram F, Rehman F, Milsom A, Arghandawi S, Pearl V, Deanfield J et al. ( 2009 ) . Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 20 , S37 - S37 .

Milsom A, Patel N, Storey A, Cuzzocrea S, Mazzon E, Webb A, Hobbs A, Thiemermann C et al. ( 2009 ) . Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 20 , S39 - S40 .

Diller GP, Bedard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J et al. ( 2009 ) . Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension" . CIRCULATION vol. 119 , ( 9 ) E231 - E231 .

Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R et al. ( 2009 ) . Design and development of novel non-peptide agonists at natriuretic peptide receptor-C . FASEB JOURNAL vol. 23 ,

Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J et al. ( 2009 ) . Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs . FASEB JOURNAL vol. 23 ,

Stasch J-P, Hobbs AJ ( 2009 ) . NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators . cGMP: Generators, Effectors and Therapeutic Implications , vol. 191 , Springer Nature

Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D et al. ( 2008 ) . Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase . Circ Res vol. 103 , ( 9 ) 957 - 964 .

Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ et al. ( 2008 ) . Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension . Am J Respir Crit Care Med vol. 178 , ( 8 ) 861 - 869 .

Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW, Hobbs AJ ( 2008 ) . Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor . J BIOL CHEM vol. 283 , ( 29 ) 20027 - 20036 .

Diller GP, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E et al. ( 2008 ) . Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension . CIRCULATION vol. 117 , ( 23 ) 3020 - 3030 .

Chan MV, Hobbs AJ, Scotland RS, Ahluwalia A ( 2008 ) . Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent . BASIC CLIN PHARMACOL . vol. 102 , 38 - 38 .

Villar IC, Hobbs AJ, Ahluwalia A ( 2008 ) . Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor . J ENDOCRINOL vol. 197 , ( 3 ) 447 - 462 .

Aboud Z, Misra S, Warner T, Miall P, Benjamin N, Hobbs A, Webb A, Ahluwalia A ( 2008 ) . The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 65 , 999 - 999 .

Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP et al. ( 2008 ) . Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice . BLOOD vol. 111 , ( 10 ) 5187 - 5194 .

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al. ( 2008 ) . Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite . HYPERTENSION vol. 51 , ( 3 ) 784 - 790 .

Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al. ( 2008 ) . Acute blood pressure lowering and vasoprotective effects of dietary nitrate . FASEB JOURNAL vol. 22 ,

Milsom AB, Hobbs AJ, Ahluwalia A ( 2008 ) . Endothelial nitric oxide synthase acts as a nitrite reductase in human endotheliall cells . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 19 , S51 - S52 .

Panayiotou CM, Stidwill R, Taylor V, Singer M, Hobbs AJ ( 2008 ) . Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A . FASEB JOURNAL vol. 22 ,

Baliga R, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ ( 2007 ) . Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension? . CIRCULATION . vol. 116 , 456 - 456 .

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, MacAllister R et al. ( 2007 ) . Acute blood pressure (BP) lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate . J HUM HYPERTENS . vol. 21 , 834 - 835 .

Hobbs AJ ( 2007 ) . Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension . BMC Pharmacology vol. 7 , ( Suppl 1 )

Panayiotou CM, Hobbs AJ ( 2007 ) . NPR-A gene deletion reverses vascular dysfunction associated with sepsis . BMC Pharmacology vol. 7 , ( Suppl 1 )

Baliga RS, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ ( 2007 ) . Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension? . BMC Pharmacology vol. 7 , ( Suppl 1 )

Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A et al. ( 2007 ) . Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor . CARDIOVASC RES vol. 74 , ( 3 ) 515 - 525 .

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, Macallister R et al. ( 2007 ) . Acute blood pressure lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate . EUROPEAN HEART JOURNAL . vol. 28 , 865 - 866 .

Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM ( 2007 ) . The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO . PHARMACOLOGY & THERAPEUTICS vol. 113 , ( 2 ) 442 - 458 .

Madhani M, Patra AK, Miller TW, Eroy-Reveles AA, Hobbs AJ, Fukuto JM, Mascharak PK ( 2006 ) . Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta . J Med Chem vol. 49 , ( 25 ) 7325 - 7330 .

Madhani M, Okorie M, Hobbs AJ, MacAllister RJ ( 2006 ) . Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo . Br J Pharmacol vol. 149 , ( 6 ) 797 - 801 .

Villar IC, Ahluwalia A, Hobbs AJ ( 2006 ) . Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries . ACTA PHARMACOL SIN vol. 27 , ( 9 ) 1276 - 1276 .

Villar IC, Francis S, Webb A, Hobbs AJ, Ahluwalia A ( 2006 ) . Novel aspects of endothelium-dependent regulation of vascular tone . KIDNEY INT vol. 70 , ( 5 ) 840 - 853 .

Panayiotou CM, Hobbs AJ ( 2006 ) . C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells . ACTA PHARMACOL SIN vol. 27 , 170 - 170 .

Marro M, Panayiotou C, Hobbs A ( 2006 ) . Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs) . ACTA PHARMACOL SIN vol. 27 , 172 - 172 .

Miller TW, Franco NE, Hobbs AJ, Ignarro LJ, Fukuto JM ( 2006 ) . Effect of changing redox status on the activation of soluble guanylate cyclase by nitrogen oxides . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 14 , A38 - A38 .

Scotland RS, Duchene J, Hobbs A, Ahluwalia A ( 2006 ) . Gender-differences in leukocyte activation in vivo: role of endothelium-derived mediators . FASEB JOURNAL . vol. 20 , A1193 - A1193 .

Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A, Hobbs AJ ( 2005 ) . C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression . P NATL ACAD SCI USA vol. 102 , ( 40 ) 14452 - 14457 .

Marro ML, Hobbs AJ ( 2005 ) . Characterisation of human a1 and b1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells . BMC Pharmacology vol. 5 , ( Suppl 1 )

Connelly L, Madhani M, Hobbs AJ ( 2005 ) . Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo . J Biol Chem vol. 280 , ( 11 ) 10040 - 10046 .

Ahluwalia A, Villar I, Scotland RS, Hobbs A ( 2005 ) . The natriuretic peptide receptor-C antagonist, M372049, blocks C-type natriuretic peptide and endothelium-derived hyperpolarizing factor-induced relaxation of resistance arteries . FASEB JOURNAL . vol. 19 , A1556 - A1556 .

Ahluwalia A, Hobbs AJ ( 2005 ) . Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor . TRENDS PHARMACOL SCI vol. 26 , ( 3 ) 162 - 167 .

Hobbs AJ ( 2005 ) . Soluble guanylate cyclase . Expert Opinion on Therapeutic Targets vol. 4 , ( 6 ) 735 - 749 .

Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A ( 2005 ) . Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo . CIRCULATION vol. 111 , ( 6 ) 796 - 803 .

Scotland RS, Ahluwalia A, Hobbs AJ ( 2005 ) . C-type natniuretic peptide in vascular physiology and disease . PHARMACOL THERAPEUT vol. 105 , ( 2 ) 85 - 93 .

Scotland R, Foster P, Ahluwalia A, Hobbs AJ ( 2004 ) . C-type natriuretic peptide inhibits leukocyte recruitment in vivo via natriuretic peptide receptor-C activation . CIRCULATION . vol. 110 , 240 - 240 .

Ahluwalia A, Foster P, Prescott C, Hobbs AJ ( 2004 ) . Endothelial C-type natriuretic peptide regulates coronary blood flow and prevents ischemia-reperfusion injury . CIRCULATION . vol. 110 , 77 - 77 .

Chauhan SD, Hobbs AJ, Ahluwalia A ( 2004 ) . C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor . Int J Biochem Cell Biol vol. 36 , ( 10 ) 1878 - 1881 .

Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A ( 2004 ) . Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide . CIRCULATION vol. 110 , ( 10 ) 1231 - 1235 .

Connelly L, Hobbs AJ ( 2004 ) . Endothelial nitric oxide synthase promotes inducible NOS expression in LPS-challenged mice in vivo . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 11 , 122 - 122 .

Madhani M, MacAllister RJ, Hobbs AJ ( 2004 ) . Reciprocal interaction between soluble and particulate guanylate cyclases in vivo . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 11 , 120 - 120 .

Ahluwalia A, MacAllister RJ, Hobbs AJ ( 2004 ) . Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms . Basic Res Cardiol vol. 99 , ( 2 ) 83 - 89 .

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ ( 2004 ) . Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment . P NATL ACAD SCI USA vol. 101 , ( 5 ) 1386 - 1391 .

AHLUWALIA A, Hobbs A, Prescott C, Scotland R, Foster P ( 2004 ) . Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide . Circulation vol. 110 , ( 10 ) 1231 - 1235 .

Hobbs AJ, Moncada S ( 2003 ) . Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272 . Vascul Pharmacol vol. 40 , ( 3 ) 149 - 154 .

Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ ( 2003 ) . Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling . Br J Pharmacol vol. 139 , ( 7 ) 1289 - 1296 .

Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ ( 2003 ) . Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression . J Biol Chem vol. 278 , ( 29 ) 26480 - 26487 .

Madhani M, MacAllister R, Hobbs A ( 2003 ) . Interactions between soluble guanylate cyclase and natriuretic peptide receptor-linked particulate guanylate cyclases in the mammalian vasculature . BMC News and views vol. 3 , ( S2 )

Madhani M, MacAllister R, Hobbs A ( 2003 ) . Vascular natriuretic peptide receptors modulated by NO-cyclic GMP signalling . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U17 - U17 .

Foster P, Mathur A, McLean P, Perretti M, Moncada S, Ahluwalia A, Hobbs A ( 2003 ) . Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272 . FASEB JOURNAL . vol. 17 , A1052 - A1052 .

Scotland RS, Chauhan SD, Hobbs AJ, Ahluwalia A ( 2003 ) . Characterisation of eNOS/COX-1 double knockout mice: a novel model for the study of endothelium-derived hyperpolarising factor . FASEB JOURNAL . vol. 17 , A225 - A225 .

Hobbs AJ, Chauhan SD, Nilsson H, Ahluwalia A ( 2003 ) . Endothelium-derived hyperpolarising factor (EDHF) is C-type natriuretic peptide (CNP) in mesenteric resistance arteries . FASEB JOURNAL . vol. 17 , A226 - A226 .

Chauhan SD, Nilsson H, Ahluwalia A, Hobbs AJ ( 2003 ) . Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor . P NATL ACAD SCI USA vol. 100 , ( 3 ) 1426 - 1431 .

KALSI JS, REES RW, HOBBS AJ, ROYLE M, KELL PD, RALPH DJ, MONCADA S, CELLEK S ( 2003 ) . BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro . Journal of Urology vol. 169 , ( 2 ) 761 - 766 .

Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S ( 2003 ) . BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro . J Urol vol. 169 , ( 2 ) 761 - 766 .

AHLUWALIA A, Hobbs AJ, Seggara G, Chauhan SD, Vo PA, MacAllister RJ ( 2003 ) . Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice . Faseb J vol. 17 , ( 6 ) 773 - 775 .

Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR ( 2002 ) . Haemoglobin: NO transporter, NO inactivator or NOne of the above? . Trends Pharmacol Sci vol. 23 , ( 9 ) 406 - 411 .

Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR ( 2002 ) . Haernoglobin: NO transporter, NO inactivator or NOne of the above? . TRENDS PHARMACOL SCI vol. 23 , ( 9 ) 406 - 411 .

Hobbs AJ ( 2002 ) . Soluble guanylate cyclase: an old therapeutic target re-visited . Br J Pharmacol vol. 136 , ( 5 ) 637 - 640 .

Chauhan SD, MacAllister RJ, Hobbs AJ, Ahluwalia A ( 2002 ) . Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries . FASEB J vol. 16 , ( 4 ) A572 - A572 .

Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ ( 2001 ) . Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide . J Immunol vol. 166 , ( 6 ) 3873 - 3881 .

Hussain MB, MacAllister RJ, Hobbs AJ ( 2001 ) . Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases . Am J Physiol Heart Circ Physiol vol. 280 , ( 3 ) H1151 - H1159 .

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA et al. ( 2001 ) . Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase . J MED CHEM vol. 44 , ( 1 ) 78 - 93 .

Cavero M, Hobbs A, Madge D, Motherwell WB, Selwood D, Potier P ( 2000 ) . Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe . Bioorg Med Chem Lett vol. 10 , ( 7 ) 641 - 644 .

Shah S, Hobbs A, Singh R, Cuevas J, Ignarro LJ, Chaudhuri G ( 2000 ) . Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves . AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY vol. 279 , ( 4 ) R1478 - R1485 .

Hussain MB, MacAllister RJ, Hobbs AJ ( 2000 ) . Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases . BRIT J PHARMACOL vol. 129 ,

Hussain MB, Hobbs AJ, MacAllister RJ ( 1999 ) . Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta . Br J Pharmacol vol. 128 , ( 5 ) 1082 - 1088 .

Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P, Hobbs AJ ( 1999 ) . Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity . J Biol Chem vol. 274 , ( 41 ) 28983 - 28990 .

Hussain MB, Hobbs AJ, MacAllister RJ ( 1999 ) . Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse . BRIT J PHARMACOL vol. 126 , U41 - U41 .

Hobbs AJ, Moncada S ( 1999 ) . Inducible nitric oxide synthase and inflammation . Inducible Enzymes in the Inflammatory Response , Springer Nature

Hobbs AJ, Higgs A, Moncada S ( 1999 ) . Inhibition of nitric oxide synthase as a potential therapeutic target . Annu Rev Pharmacol Toxicol vol. 39 , 191 - 220 .

Hobbs AJ ( 1997 ) . Soluble guanylate cyclase: the forgotten sibling . Trends Pharmacol Sci vol. 18 , ( 12 ) 484 - 491 .

Hobbs AJ ( 1997 ) . Soluble guanylate cyclase: the forgotten sibling . Trends in Pharmacological Sciences vol. 18 , ( 4 ) 484 - 491 .

Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G, Ignarro LJ ( 1996 ) . Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo . Am J Physiol vol. 271 , ( 1 Pt 2 ) H133 - H139 .

Hobbs AJ, Ignarro LJ ( 1996 ) . Nitric oxide cyclic GMP signal transduction system . NITRIC OXIDE, PT B vol. 269 , 134 - 148 .

SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, IGNARRO LJ, ASHLEY SW, CHAUDHURI G ( 1995 ) . ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY . GASTROENTEROLOGY vol. 108 , ( 4 ) A1246 - A1246 .

SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G ( 1995 ) . CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE . GASTROENTEROLOGY vol. 108 , ( 4 ) A688 - A688 .

HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G, IGNARRO LJ ( 1995 ) . DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO . FASEB JOURNAL vol. 9 , ( 3 ) A328 - A328 .

Griscavage JM, Hobbs AJ, Ignarro LJ ( 1995 ) . Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds . Adv Pharmacol vol. 34 , 215 - 234 .

COHEN GA, HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G, IGNARRO LJ ( 1995 ) . STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO . FASEB JOURNAL vol. 9 , ( 3 ) A328 - A328 .

SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G ( 1995 ) . THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY . FASEB JOURNAL vol. 9 , ( 3 ) A86 - A86 .

HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ ( 1994 ) . FORMATION OF FREE NITRIC OXIDE FROM L-ARGININE BY NITRIC OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE DISMUTASE . BIOLOGY OF NITRIC OXIDE, PT 4 . vol. 8 , 36 - 42 .

HOBBS AJ, FUKUTO JM, IGNARRO LJ ( 1994 ) . FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 91 , ( 23 ) 10992 - 10996 .

HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ ( 1994 ) . FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE . FASEB JOURNAL vol. 8 , ( 4 ) A360 - A360 .

Fukuto JM, Hobbs AJ, Ignarro LJ ( 1993 ) . Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO . Biochem Biophys Res Commun vol. 196 , ( 2 ) 707 - 713 .

Brave SR, Bhat S, Hobbs AJ, Tucker JF, Gibson A ( 1993 ) . The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle . J Auton Pharmacol vol. 13 , ( 3 ) 219 - 225 .

Gibson A, Babbedge R, Brave SR, Hart SL, Hobbs AJ, Tucker JF, Wallace P, Moore PK ( 1992 ) . An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus . Br J Pharmacol vol. 107 , ( 3 ) 715 - 721 .

Hobbs AJ, Tucker JF, Gibson A ( 1991 ) . Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions . Br J Pharmacol vol. 104 , ( 3 ) 645 - 650 .

Brave SR, Hobbs AJ, Gibson A, Tucker JF ( 1991 ) . The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle . Biochem Biophys Res Commun vol. 179 , ( 2 ) 1017 - 1022 .

Mirzazadeh S, Hobbs AJ, Tucker JF, Gibson A ( 1991 ) . Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation . J Pharm Pharmacol vol. 43 , ( 4 ) 247 - 251 .

Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gibson A ( 1990 ) . L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle . Br J Pharmacol vol. 100 , ( 4 ) 663 - 664 .

Hobbs AJ, Gibson A ( 1990 ) . L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus . Br J Pharmacol vol. 100 , ( 4 ) 749 - 752 .

Gibson A, Hobbs AJ, Mirzazadeh S ( 1990 ) . L-NG-nitroarginine is a potent inhibitor of non-adrenergic, non-cholinergic relaxations in the rat anococcygeus muscle . European Journal of Pharmacology vol. 183 , ( 5 )

Gibson A, Mirzazadeh S, Hobbs AJ, Moore PK ( 1990 ) . L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle . Br J Pharmacol vol. 99 , ( 3 ) 602 - 606 .