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Research

Publications: Dr Amie Moyes

Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez-Ternero C, Aubdool AA et al. ( 2022 ) . Multidrug resistance proteins preferentially regulate natriuretic peptide-driven cGMP signalling in the heart and vasculature . British Journal of Pharmacology vol. 179 , ( 11 ) 2443 - 2459 .
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ ( 2022 ) . C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 13 )
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al. ( 2020 ) . C-type natriuretic peptide co-ordinates cardiac structure and function . European Heart Journal vol. 41 , ( 9 ) 1006 - 1020 .
Perez-Ternero C, Aubdool AA, Moyes AJ, Hobbs AJ ( 2019 ) . C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling . CIRCULATION . Conference: American Heart Association vol. 140 ,
Preedy MEJ, Baliga R, Dukinfield M, Chu S, Aubdool A, Bubb K, Moyes A, Tones M et al. ( 2019 ) . Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 17 ,
Preedy ME, Baliga RS, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2019 ) . Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3008 - 3009 .
Moyes AJ, Hobbs AJ ( 2019 ) . C-type natriuretic peptide: A multifaceted paracrine regulator in the heart and vasculature . International Journal of Molecular Sciences vol. 20 , ( 9 )
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al. ( 2019 ) . Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial . British Journal of Pharmacology vol. 176 , ( 9 ) 1251 - 1267 .
Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC et al. ( 2018 ) . Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling . Circulation
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2018 ) . Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure . Proc Natl Acad Sci U S A
Aubdool AA, Bubb KJ, Moyes AJ, Drayton JP, Mehta V, Zachary IC, Tsui J, Abraham DJ et al. ( 2017 ) . Endothelium-Derived C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodelling . CIRCULATION . vol. 136 ,
Kapil V ( 2017 ) . Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 . BMC Pharmacol Toxicol vol. 18 , ( Suppl 1 ) 64 - 64 .
Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ ( 2016 ) . Functional pharmacological characterization of SER100 in cardiovascular health and disease . Br J Pharmacol
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N et al. ( 2016 ) . IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD . Journal of the American Society of Nephrology
Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ, Ramage AG ( 2016 ) . Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism . Experimental Physiology vol. 101 , ( 5 ) 588 - 598 .
Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ, Pharmacology C ( 2016 ) . Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 193 ,
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . Circulation vol. 132 , ( suppl_3 )
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . CIRCULATION . vol. 132 ,
Allen R, Renukanthan A, Bubb K, Villar I, Moyes A, Baliga R, Hobbs A ( 2015 ) . Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis . The FASEB Journal vol. 29 , ( S1 )
Allen RMH, Renukanthan A, Bubb KJ, Villar IC, Moyes AJ, Baliga RS, Hobbs AJ ( 2015 ) . Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis . BMC pharmacology & toxicology vol. 16 , ( Suppl 1 ) A33 - A33 .
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin.Invest vol. 124 , ( 9 ) 4039 - 4051 .
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. ( 2014 ) . Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo model . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A27 - A27 .
Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ, Mascharak PK ( 2014 ) . Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex . JOURNAL OF MATERIALS CHEMISTRY B vol. 2 , ( 15 ) 2107 - 2113 .
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M et al. ( 2013 ) . C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling . CIRCULATION RESEARCH vol. 112 , ( 10 ) 1355 - + .
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. ( 2013 ) . Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model . Arthritis Research and Therapy vol. 15 , ( 4 )
Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ ( 2012 ) . Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide . CIRCULATION vol. 126 , ( 21 )
Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ, Mascharak PK ( 2012 ) . Manganese carbonyls bearing tripodal polypyridine ligands as photoactive carbon monoxide-releasing molecules . Inorganic Chemistry vol. 51 , ( 1 ) 601 - 608 .