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Research

Publications: Dr Jessica Okosun

Pickard L, Palladino G, Okosun J ( 2020 ) . Follicular lymphoma genomics . Leukemia and Lymphoma vol. 61 , ( 10 ) 2313 - 2323 .
Okosun J, Montoto S ( 2020 ) . Cellular Therapy in Follicular Lymphoma: Autologous Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, and Chimeric Antigen Receptor T-cell Therapy . Hematology/Oncology Clinics of North America vol. 34 , ( 4 ) 701 - 714 .
Kumar EA, Okosun J, Fitzgibbon J ( 2020 ) . The Biological Basis of Histologic Transformation . Hematology/Oncology Clinics of North America vol. 34 , ( 4 ) 771 - 784 .
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al. ( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) E318 - E321 .
Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al. ( 2020 ) . Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients . British Journal of Haematology
Krysov S, Odabashian M, Carlotti E, Araf S, Okosun J, Spada F, Gribben J, Forconi F et al. ( 2020 ) . IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution . Blood vol. 135 , ( 11 ) 834 - 844 .
Matasar MJ, Luminari S, Barr PM, Barta SK, Danilov AV, Hill BT, Phillips TJ, Jerkeman M et al. ( 2019 ) . Follicular Lymphoma: Recent and Emerging Therapies, Treatment Strategies, and Remaining Unmet Needs . Oncologist vol. 24 , ( 11 ) e1236 - e1250 .
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B et al. ( 2019 ) . Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR . Nature Metabolism vol. 1 , ( 8 ) 775 - 789 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y) . Leukemia vol. 33 , ( 6 )
Kumar E, Okosun J ( 2019 ) . Follicular lymphoma genomics . HemaSphere vol. 3 , ( S2 ) 79 - 81 .
Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al. ( 2019 ) . Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant . Haematologica vol. 104 , ( 4 ) e174 - e177 .
Okosun J, Kridel R, Fitzgibbon J ( 2018 ) . Rituximab as a first step in tackling transformation . The Lancet Haematology vol. 5 , ( 8 ) e326 - e327 .
Heward JA, Kumar EA, Korfi K, Okosun J, Fitzgibbon J ( 2018 ) . Precision medicine and lymphoma . Curr Opin Hematol vol. 25 , ( 4 ) 329 - 334 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1258 - 1263 .
Araf S, Okosun J, Fitzgibbon J ( 2018 ) . Predicting early relapse in follicular lymphoma: have we turned a corner? . The Lancet Oncology vol. 19 , ( 4 ) 441 - 442 .
Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A et al. ( 2017 ) . Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors . Nature Cell Biology . vol. 19 , 1093 - 1104 .
Larrea E, Fernandez-Mercado M, Ceberio I, Assuncao JAG, Okosun J, Fitzgibbon J, Lawrie C ( 2017 ) . RECURRENT MUTATIONS IN MICRO-RNA BINDING SITES MAY BE POTENTIALLY RELEVANT IN FOLLICULAR LYMPHOMA . HAEMATOLOGICA . vol. 102 , 94 - 95 .
Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V et al. ( 2016 ) . Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma . Blood vol. 128 , ( 23 ) 2666 - 2670 .
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. ( 2016 ) . GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE . HAEMATOLOGICA . vol. 101 , 270 - 270 .
Okosun J, Montoto S, Fitzgibbon J ( 2016 ) . The routes for transformation of follicular lymphoma . Current Opinion in Hematology vol. 23 , ( 4 ) 1 - 1 .
Kotsiou E, Okosun J, Besley C, Iqbal S, Matthews J, Fitzgibbon J, Gribben J, DAVIES JK ( 2016 ) . TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses . Blood vol. 128 , ( 1 ) 72 - 81 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .
Araf S, Okosun J, Koniali L, Fitzgibbon J, Heward J ( 2016 ) . Epigenetic dysregulation in follicular lymphoma . Epigenomics vol. 8 , ( 1 ) 77 - 84 .
Okosun J, Cwynarski K ( 2015 ) . Non-Hodgkin Lymphoma: High Grade . Postgraduate Haematology: Seventh Edition ,
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al. ( 2015 ) . Disease evolution and outcomes in familial AML with germline CEBPA mutations . Blood vol. 126 , ( 10 ) 1214 - 1223 .
Okosun J, Packham G, Fitzgibbon J ( 2014 ) . Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies . Expert Opinion on Investigational Drugs vol. 23 , ( 10 ) 1321 - 1332 .
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .
Popov N, Maniati E, Marzec J, Okosun J, Scott R, Kranz A, Stewart F, Chelala C et al. ( 2013 ) . Investigating The Role Of MLL2 (Mll4) In B Cell Development . Blood . vol. 122 , 343 - 343 .
Okosun J, Clear A, Iqbal S, Matthews J, Gribben J, Fitzgibbon J, Davies J ( 2013 ) . TNFRSF14 aberrations are associated with death from acute GvHD after reduced-intensity conditioned allogeneic haematopoietic stem cell transplantation for follicular lymphoma . BONE MARROW TRANSPLANTATION . vol. 48 , S169 - S169 .
Bödör C, Grossmann V, Popov N, Okosun J, O¿Riain C, Tan K, Marzec J, Araf S et al. ( 2013 ) . EZH2 mutations are frequent and represent an early event in follicular lymphoma . Blood vol. 122 , ( 18 ) 3165 - 3168 .
Montoto S, Shaw K, Okosun J, Gandhi S, Fields P, Wilson A, Shanyinde M, Cwynarski K et al. ( 2012 ) . HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era . Journal of Clinical Oncology vol. 30 , ( 33 ) 4111 - 4116 .
Okosun J, Warbey V, Shaw K, Montoto S, Fields P, Marcus R, Virchis A, McNamara C et al. ( 2012 ) . Interim fluoro-2-deoxy-D-glucose-PET predicts response and progression-free survival in patients with Hodgkin lymphoma and HIV infection . AIDS vol. 26 , ( 7 ) 861 - 865 .
Orkin C, Montoto S, Shaw K, Okosun J, Gandhi S, Fields P, Wilson A, Shanyinde M et al. ( 2012 ) . HIV Status does not Impact on Outcome in Patients with Hodgkin Lymphoma Treated with ABVD Chemotherapy in the HAART Era . HIV MEDICINE vol. 13 , 5 - 5 .
Okosun J, Bödör C, Smith M ( 2011 ) . Myelodysplastic syndrome: 2011 and beyond . British Journal of Nursing vol. 20 , ( 22 )
Montoto S, Shaw K, Okosun J, Gandhi S, Fields P, Wilson A, Shanyinde M, Cwynarski K et al. ( 2011 ) . HIV Status Does Not Impact on Outcome in Patients with Hodgkin Lymphoma Treated with ABVD Chemotherapy in the HAART Era . BLOOD . vol. 118 , 1557 - 1557 .
Okosun J, Fitzgibbon J ( 2011 ) . It's a targeted world in non-Hodgkin's lymphoma . Br J Nurs vol. 20 , ( 17 )
Okosun J, Fitzgibbon J ( 2011 ) . It's a targeted world in non-Hodgkin's lymphoma . British Journal of Nursing vol. 20 , ( 17 SUPPL. )
Okosun J, Mwirigi A, Kyriakou C, Cwynarski K, Hughes D, Fields P, Mcnamara C ( 2011 ) . PROGNOSTIC SIGNIFICANCE OF RESPONSE QUALITY (RQ) IN PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA (FL) PATIENTS TREATED WITH COMBINATION RITUXIMAB, CYCLOPHOSPHAMIDE, VINCRISTINE AND PREDNISOLONE (R-CVP) . ANNALS OF ONCOLOGY . vol. 22 , 218 - 218 .
Okosun J, McNamara C ( 2011 ) . Paraneoplastic peripheral blood eosinophilia in relapsed follicular lymphoma . Leukemia and Lymphoma vol. 52 , ( 2 ) 328 - 330 .
Bower M, Montoto S, Cwynarski K, Lumsden AS, Rajab R, Okosun J, Orkin C, Nelson M et al. ( 2010 ) . Non-germinal centre subtype of AIDS-related diffuse large B-cell lymphomas associated with improved survival . HIV MEDICINE vol. 11 , 13 - 13 .