Publications: Dr Matthew Caley

Hindle SA, Brook HB, Chrysanthou A, Chambers ES, Caley MP, Connelly JT ( 2025 ) . Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent . Advanced Science vol. 12 , ( 10 )

Garcha P, Petrof G, Martinez A, McGrath JA, O’Toole EA, Rognoni E, Caley M ( 2024 ) . 182 Dissecting Epidermolysis Bullosa Heterogeneity . Journal of Investigative Dermatology vol. 144 , ( 12 )

Giusto E, Jones E, Ahmed A, Cottle D, Smyth I, Caley M, Rognoni E, O’Toole EA ( 2024 ) . 232 JAK Inhibitors to Restore Skin Barrier Function in a Mouse Model of Harlequin Ichthyosis . Journal of Investigative Dermatology vol. 144 , ( 12 )

Jones EM, Garcha P, Aumailley M, O'Toole EA, Rognoni E, Caley M ( 2024 ) . Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes . JID Innovations vol. 5 , ( 2 )

Macken JH, Senusi A, O’Toole EA, Caley M, Rognoni E, Fortune F ( 2024 ) . Erosive lichen planus: an unmet disease burden . Frontiers in Medicine vol. 11 ,

Quílez C, Bebiano LB, Jones E, Maver U, Meesters L, Parzymies P, Petiot E, Rikken G et al. ( 2024 ) . Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments . Journal of Investigative Dermatology vol. 144 , ( 12 ) 2650 - 2670 .

Idrissi M, Caley M, Aviezer D, Brener E, Mashriki T, Barak SL, Michel D, O’Toole EA et al. ( 2024 ) . 771 Novel TRPV3 inhibitors developed for the treatment of Palmoplantar keratodermas, demonstrate safety and efficacy in preclinical models . Journal of Investigative Dermatology vol. 144 , ( 8 )

Tawfik S, Thomas B, Caley M, Jones E, O’Shaughnessy R, O’Toole E ( 2024 ) . P038 Impact of cumulative low-level ozone on keratinocytes and implications for atopic eczema pathogenesis . British Journal of Dermatology vol. 191 , ( Supplement_1 ) i31 - i32 .

Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M, O’Toole E ( 2024 ) . O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics . British Journal of Dermatology vol. 190 , ( 6 ) e71 - e72 .

Jones E, Garcha P, Aumailley M, O’Toole E, Rognoni E, Caley M ( 2024 ) . O19 Improvement of a junctional epidermolysis bullosa mouse model . British Journal of Dermatology vol. 190 , ( 6 ) e77 - e77 .

Garcha P, Jones E, Ahmed AA, Aumailley M, Rognoni E, Caley M ( 2024 ) . O20 Dissecting junctional epidermolysis bullosa heterogeneity . British Journal of Dermatology vol. 190 , ( 6 ) e77 - e78 .

Giusto E, Jones E, Enjalbert F, Ahmed A, Caley M, Rognoni E, O’Toole E ( 2024 ) . P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis . British Journal of Dermatology vol. 190 , ( 6 ) e83 - e84 .

Khan MRA, Kirk T, Caley MP, Rognoni E ( 2024 ) . P16 Fibroblast signalling crosstalk drives junctional epidermolysis bullosa disease progression . British Journal of Dermatology vol. 190 , ( 6 ) e86 - e86 .

Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL et al. ( 2024 ) . Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro . Journal of Investigative Dermatology vol. 144 , ( 10 ) 2314 - 2317.e3 .

Caley M, Idrissi M, Braiman L, Brener E, O'Toole E ( 2023 ) . LB1754 Treatment of human palmoplantar keratoderma skin equivalents with a TRPV3 antagonist, KM-001 . Journal of Investigative Dermatology vol. 143 , ( 9 )

Giusto E, Enjalbert F, Rognoni E, Caley M, O’Toole E ( 2023 ) . O13 JAK inhibitors to restore skin barrier function in ARCI . British Journal of Dermatology vol. 189 , ( 1 ) e9 - e10 .

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E, Caley M ( 2023 ) . O14 Junctional epidermolysis bullosa: repairing the epidermal lipid barrier . British Journal of Dermatology vol. 189 , ( 1 ) e10 - e10 .

Parzymies P, Jones EM, Mayes A, Messenger D, O’Toole E, Caley M ( 2023 ) . O16 The novel roles of laminin α3 in epidermal barrier function and metabolism . British Journal of Dermatology vol. 189 , ( 1 ) e11 - e11 .

Summan SK, Mayes A, Gunn D, Gautrot J, Caley M, O’Toole E ( 2023 ) . P16 How does skin ageing-related basement membrane collagen loss affect the nucleus? . British Journal of Dermatology vol. 189 , ( 1 ) e20 - e20 .

Garcha P, Jones E, Shelley J, Caley M ( 2023 ) . P32 Restoring the ageing skin barrier in vitro . British Journal of Dermatology vol. 189 , ( 1 ) e26 - e27 .

Lohana P, Suryaprawira A, Woods EL, Dally J, Gait-Carr E, Alaidaroos NYA, Heard CM, Lee KY et al. ( 2023 ) . Role of Enzymic Antioxidants in Mediating Oxidative Stress and Contrasting Wound Healing Capabilities in Oral Mucosal/Skin Fibroblasts and Tissues . Antioxidants vol. 12 , ( 7 )

McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP et al. ( 2023 ) . RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis . Frontiers in Molecular Biosciences vol. 10 ,

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J ( 2023 ) . 1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin . Journal of Investigative Dermatology vol. 143 , ( 5 )

Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E ( 2023 ) . 1157 Ozone as an aggravating factor in atopic eczema . Journal of Investigative Dermatology vol. 143 , ( 5 )

Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M, O'Toole E ( 2023 ) . 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus . Journal of Investigative Dermatology vol. 143 , ( 5 ) s127 - s127 .

Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E, Caley M ( 2023 ) . 753 Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa . Journal of Investigative Dermatology vol. 143 , ( 5 )

Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E, Caley M ( 2023 ) . 763 Novel roles of laminin α3 in epidermal homeostasis . Journal of Investigative Dermatology vol. 143 , ( 5 )

Tawfik S, O'Toole E, Thomas B, Caley M, Jones E, O'Shaughnessy R ( 2023 ) . ISID1157 - Ozone as an aggravating factor in atopic eczema .

Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP et al. ( 2023 ) . Regulation of human trophoblast gene expression by endogenous retroviruses . Nature Structural & Molecular Biology vol. 30 , ( 4 ) 527 - 538 .

Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R, Metherell LA ( 2023 ) . Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation . Journal of Lipid Research vol. 64 , ( 4 )

Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E, Caley M ( 2023 ) . Novel roles of laminin α3 in epidermal homeostasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S131 - S131 .

Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E ( 2023 ) . Ozone as an aggravating factor in atopic eczema . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S198 - S198 .

Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E, Caley M ( 2023 ) . Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S129 - S129 .

Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M, O'Toole E ( 2023 ) . The effect of skin ageing-related basement membrane collagen loss on the nucleus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S127 - S127 .

Caley M, Idrissi M, Braiman L, Brener E, O'Toole E ( 2023 ) . Treatment of human palmoplantar keratoderma skin equivalents with a TRPV3 antagonist, KM-001 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , B26 - B26 .

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J ( 2023 ) . Understanding dynamic immune responses within a 3D microfluidic model of human skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S177 - S177 .

Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R, O’Toole EA ( 2022 ) . 144 Carbonylated proteins and Ozone in atopic eczema . Journal of Investigative Dermatology vol. 142 , ( 12 )

Smith CJ, Williams JL, Hall C, Caley MP, O’Toole EA, Prasad R, Metherell LA ( 2022 ) . 181 Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions . Journal of Investigative Dermatology vol. 142 , ( 12 )

Parzymies P, Jones E, Caley MP, O’Toole EA, Messenger D, Mayes A ( 2022 ) . 184 The role of the Laminin 332 in cholesterol transport in dry and Aged skin . Journal of Investigative Dermatology vol. 142 , ( 12 )

Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA, Caley MP ( 2022 ) . 191 Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier . Journal of Investigative Dermatology vol. 142 , ( 12 )

Dina DO, Caley MP, Raj N, O’Toole EA, Connelly J ( 2022 ) . 216 Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models . Journal of Investigative Dermatology vol. 142 , ( 12 )

Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E, Thomas B, Prasad Baruah K ( 2022 ) . ESDR144 - Carbonylated proteins and Ozone in atopic eczema .

Dina D, Caley M, Raj N, O'Toole E, Connelly J ( 2022 ) . ESDR216 - Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models .

Parzymies P, Jones E, Caley M, O'Toole E, Messenger D, Mayes A ( 2022 ) . ESDR184 - The role of the Laminin 332 in cholesterol transport in dry and Aged skin .

Smith C, Williams J, Hall C, Caley M, O'Toole E, Prasad R, Metherell L ( 2022 ) . ESDR181 - Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions .

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E, Caley M ( 2022 ) . ESDR191 - Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier .

Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP, Braun KM ( 2022 ) . Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures . Journal of Dentistry vol. 125 ,

Tawfik SS, Thomas B, Jones E, Caley MP, O'Shaughnessy R, O'Toole EA ( 2022 ) . Carbonylated proteins and Ozone in atopic eczema . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 142 , S204 - S204 .

Huang M, Miettinen S, Caley M, O'Toole E ( 2022 ) . Finding a new treatment for X-linked recessive ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 187 , E12 - E12 .

Jones E, O'Toole E, Caley M ( 2022 ) . Investigating the role of the basement membrane in modulating the inflammasome in ageing skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E235 - E235 .

Jones E, Stewart-McGuiness C, O'Toole E, Caley M ( 2022 ) . Investigating the role of the basement membrane in modulating the skin inflammasome . BRITISH JOURNAL OF DERMATOLOGY . vol. 187 , E17 - E18 .

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath JA, O'Toole EA, Caley MP ( 2022 ) . Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 142 , S213 - S213 .

Smith CJ, Williams JL, Hall C, Caley MP, O'Toole EA, Prasad R, Metherell LA ( 2022 ) . Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 142 , S211 - S211 .

Parzymies P, Jones E, Caley MP, O'Toole EA, Messenger D, Mayes A ( 2022 ) . The role of the Laminin 332 in cholesterol transport in dry and Aged skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 142 , S212 - S212 .

Parzymies P, Jones E, Caley M, O'Toole E, Mayes A, Messenger D ( 2022 ) . The role of the laminin 332-actin-cholesterol axis in skin conditions with altered lipid profiles . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E228 - E228 .

Dina DO, Caley MP, Raj N, O'Toole EA, Connelly J ( 2022 ) . Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 142 , S217 - S217 .

Smith CJ, Williams JL, Caley MP, O’Toole EA, Prasad R, Metherell LA ( 2021 ) . 099 Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation . Journal of Investigative Dermatology vol. 141 , ( 10 ) s165 - s165 .

Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E et al. ( 2021 ) . Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma . Br J Dermatol vol. 184 , ( 5 ) 923 - 934 .

Smith CJ, Williams JL, Caley MP, O'Toole EA, Prasad R, Metherell LA ( 2021 ) . Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 141 , S165 - S165 .

Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch‐Machin MA, O'Toole EA et al. ( 2020 ) . Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing . Journal of the European Academy of Dermatology and Venereology vol. 35 , ( 3 ) 762 - 768 .

Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ, O'Toole EA ( 2020 ) . 3D model of harlequin ichthyosis reveals inflammatory therapeutic targets . Journal of Clinical Investigation

Caley M, Mai Jones E ( 2019 ) . Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier? .

Jones EM, Marsh S, O’Shaughnessy RF, CAMERA E, Picardo M, Aumailley M, O’Toole E, Caley M ( 2019 ) . 274 Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier? . Journal of Investigative Dermatology . vol. 139 ,

Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al. ( 2019 ) . A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing . International Journal of Molecular Sciences vol. 20 , ( 14 )

Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch-Machin MA, O'Toole E et al. ( 2019 ) . Differential ageing responses to chronic ultraviolet irradiation: characterizing the molecular phenotype of atrophic and hypertrophic facial skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E198 - E198 .

Jones EM, Marsh ST, O'Shaughnessy RF, Aumailley M, Camera E, Picardo M, McGrath JA, O'Toole EA et al. ( 2019 ) . Laminin 332: bottom-up control of the skin barrier? . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E185 - E185 .

Thomas BR, Caley MP, O'Toole EA ( 2019 ) . Novel frameshift variant in <i>EBP</i>: late diagnosis of Conradi-Hunermann syndrome in a 41-year-old woman . BRITISH JOURNAL OF DERMATOLOGY . vol. 181 , 79 - 80 .

Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E188 - E189 .

Enjalbert F, Dewan P, Caley M, Morse M, Kelsell D, O'Toole E ( 2019 ) . Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E185 - E185 .

Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA ( 2018 ) . 661 Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis . Journal of Investigative Dermatology . vol. 138 ,

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP ( 2018 ) . 680 A role for the basement membrane in skin lipid trafficking . Journal of Investigative Dermatology . vol. 138 ,

Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA ( 2018 ) . 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage . Journal of Investigative Dermatology . vol. 138 ,

Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW, Stephens P ( 2018 ) . Development and Characterisation of a Human Chronic Skin Wound Cell Line—Towards an Alternative for Animal Experimentation . International Journal of Molecular Sciences vol. 19 , ( 4 )

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP ( 2018 ) . A role for the basement membrane in skin lipid trafficking . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 138 , S116 - S116 .

Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C ( 2018 ) . Development of a three-dimensional living skin equivalent to explore the influence of senescence on the skin ageing phenotype . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E420 - E420 .

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J ( 2018 ) . INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES . WOUND REPAIR AND REGENERATION . vol. 26 , A30 - A31 .

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J, Braun KM ( 2018 ) . Investigating the differences in the wound healing responses of skin and gingival keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E416 - E416 .

Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell D, Enright A, O'Toole E ( 2018 ) . Investigating the role of <i>ABCA12</i> in the pathomechanisms of harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E406 - E406 .

Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E ( 2018 ) . Loss of Lamα3 drives M2 macrophage differentiation in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E399 - E400 .

Huang M, Ruban E, Caley M, O'Toole E ( 2018 ) . Phospholipase C-β4 regulation of chromatin via kindlin-2 in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E409 - E409 .

Jones E, Marsh S, O'Shaugnessy R, Aumailley M, O'Toole E, Caley M ( 2018 ) . The role of laminin 332 in skin lipid biosynthesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E407 - E408 .

Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA ( 2018 ) . Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 138 , S138 - S138 .

Alexander SC, Marsh S, Caley M, O'Toole EA ( 2018 ) . Understanding Angiogenesis in Squamous Cell Carcinoma with Loss of Type VII Collagen . JOURNAL OF PATHOLOGY . vol. 246 , S44 - S44 .

Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA ( 2018 ) . Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 138 , S112 - S112 .

Caley M, Martins V, Moore K, Lashari M, Marshall J, O’Toole EA ( 2017 ) . 336 Tumour associated macrophage recruitment in SCC . Journal of Investigative Dermatology . vol. 137 ,

Shams F, Krupiczojc MA, Alexander S, Rashidghamat E, McGrath J, Caley M, O’Toole EA, Harwood CA ( 2017 ) . 568 Investigation of the role of type VII collagen in the HIF1α induced pro-angiogenic pathway . Journal of Investigative Dermatology . vol. 137 ,

Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C ( 2017 ) . 682 Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotype . Journal of Investigative Dermatology . vol. 137 ,

Marsh S, Caley M, Martins V, Barnes MR, Chen M, O'Toole EA ( 2017 ) . Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: ESDR 2017 vol. 137 , S225 - S225 .

Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell DP, Enright A, O'Toole EA ( 2017 ) . Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: ESDR 2017 vol. 137 , S208 - S208 .

McGeoghan F, Menon M, Dewan P, Caley M, Donaldson M, O’Toole EA ( 2016 ) . 132 Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,

Enjalbert F, Dewan P, Caley M, Fell B, Donaldson M, Kelsell DP, O’Toole EA ( 2016 ) . 133 Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,

Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al. ( 2016 ) . 472 Loss of Laminin α3 drives SCC invasion via ROCK signalling . Journal of Investigative Dermatology . vol. 136 ,

Krupiczojc MA, Caley M, Marsh S, Donaldson M, Martins V, O’Toole E ( 2016 ) . 569 Loss of collagen 7 drives HIF-1 alpha induced pro-angiogenic pathways . Journal of Investigative Dermatology . vol. 136 ,

McGeoghan FT, O’Toole E, Caley M, Menon M, Dewan P, Donaldson M ( 2016 ) . 375 Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro . Journal of Investigative Dermatology . vol. 136 ,

Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ et al. ( 2016 ) . Maternal DNA Methylation Regulates Early Trophoblast Development . Developmental Cell vol. 36 , ( 2 ) 152 - 163 .

O'Toole EA, Ruban EL, Balogun M, Martins VL, Caley MP, Falasca M ( 2016 ) . Phospholipase C beta4 is a therapeutic target in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 56 - 57 .

Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA ( 2016 ) . ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332 . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E51 .

Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J, Sturge J ( 2015 ) . Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces . Clinical & Experimental Metastasis vol. 33 , ( 2 ) 151 - 165 .

Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE ( 2015 ) . A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion . Molecular Cancer Therapeutics vol. 14 , ( 11 ) 2665 - 2673 .

Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA et al. ( 2015 ) . Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression . Oncotarget vol. 6 , ( 34 ) 36426 - 36440 .

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )

Pinato DJ, Trousil S, Caley M, Mauri FA, Aboagye E, Sharma R ( 2015 ) . Pharmacological inhibition of Axl tyrosine kinase as a novel therapeutic strategy in hepatocellular carcinoma . Journal of Clinical Oncology . vol. 33 , e15152 - e15152 .

Caley MP, Martins VLC, O'Toole EA ( 2015 ) . Metalloproteinases and Wound Healing . Advances in Wound Care vol. 4 , ( 4 ) 225 - 234 .

McGeoghan F, Dewan P, Caley M, Donaldson M, O'Toole E ( 2015 ) . Generation of an <i>in vitro</i> three-dimensional model of X-linked recessive ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E40 - E40 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson MJ, O'toole E ( 2015 ) . Loss of keratinocyte type VII collagen induces pro-carcinogenic transcriptomic pathways . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S44 - S44 .

McGeoghan FT, Derwin P, Caley M, Donaldson MJ, O'toole E ( 2015 ) . Modelling X-linked recessive ichthyosis <i>in vitro</i> . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S62 - S62 .

Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. ( 2015 ) . Skin type VII collagen acts as a tumour suppressor by regulating TGFβ and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S28 - S28 .

Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E ( 2015 ) . Squamous Cell Carcinoma progression and Laminin 332 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S23 - S23 .

Rodriguez‐Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR et al. ( 2014 ) . AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival . The Journal of Pathology vol. 235 , ( 4 ) 581 - 592 .

Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA ( 2014 ) . The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma . Oncogene vol. 33 , ( 32 ) 4185 - 4192 .

Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Caley M, Proby C, Pouniotis D et al. ( 2014 ) . Cytoskeletal protein Flii is elevated in human cSCCs and overexpression of Flii in mice leads to higher incidence and severity of tumour formation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S28 - S28 .

Caley M, Martins V, Moore K, Marshall J, O'toole E ( 2014 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S19 - S19 .

Caley M, Martins V, Moore K, Marshall J, O'Toole E ( 2014 ) . Diverse roles for laminin-332 subunits in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E26 - E26 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E ( 2014 ) . Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E37 - E38 .

Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW et al. ( 2014 ) . Identification of a transcriptional signature for the wound healing continuum . Wound Repair Regen vol. 22 , ( 3 ) 399 - 405 .

Ruban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M ( 2014 ) . Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC <i>in vivo</i> . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S22 - S22 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E ( 2014 ) . RNA-Seqing the skin basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S25 - S25 .

Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M et al. ( 2013 ) . miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts . Nucleic Acids Res vol. 41 , ( 10 ) 5400 - 5412 .

Martins VL, Caley M, O'Toole EA ( 2013 ) . Matrix metalloproteinases and epidermal wound repair . Cell Tissue Res vol. 351 , ( 2 ) 255 - 268 .

Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J et al. ( 2013 ) . Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer . Br J Cancer vol. 108 , ( 1 ) 163 - 169 .

Stephens P, Caley M, Peake M ( 2013 ) . Alternatives for animal wound model systems . Methods in Molecular Biology vol. 1037 , 177 - 201 .

Stephens P, Caley M, Peake M ( 2013 ) . Alternatives for animal wound model systems . Methods Mol Biol vol. 1037 , 177 - 201 .

Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA ( 2013 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S64 - S64 .

Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A ( 2013 ) . Formation and inhibition of invadopodia in oral squamous cell carcinoma . MOLECULAR BIOLOGY OF THE CELL . vol. 24 ,

Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. ( 2013 ) . Loss of type VII collagen in cutaneous SCC increases angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S158 - S158 .

Ruban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA ( 2013 ) . Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S73 - S73 .

Marsh ST, Caley MP, Kwan A, O'Toole EA, Donaldson M ( 2013 ) . Transcriptome profiling identifies novel functions of acitretin in human epidermis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S186 - S186 .

Sturge J, Caley M, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Waxman J, Palmieri C ( 2012 ) . Abstract P2-02-03: The Collagen Receptor Endo180: A Metastatic Plasma Marker In Breast Cancer Modulated By Bisphosphonate Treatment . Cancer Research . vol. 72 ,

Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA, Calle Y ( 2012 ) . Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells . Br J Haematol vol. 157 , ( 5 ) 564 - 579 .

Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca A-V, Mauri F, Sandison A et al. ( 2012 ) . TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis . J Pathol vol. 226 , ( 5 ) 775 - 783 .

Singh M, Caley M, Jones M, Breuer J, O'Toole E ( 2012 ) . Keratin 15 and VZV replication in skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S112 - S112 .

Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA ( 2012 ) . Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .

Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E ( 2012 ) . Loss of type VII collagen in squamous cell carcinoma increases angiogenesis <i>in vitro</i> and <i>in vivo</i> . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e25 - e26 .

Szentpetery Z, Cichon M, Caley M, O'Toole E ( 2012 ) . The receptor tyrosine kinase Axl regulates intercellular adhesion, epithelial-mesenchymal transition and stemness in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .

Sturge J, Caley MP, Waxman J ( 2011 ) . Bone metastasis in prostate cancer: emerging therapeutic strategies . Nat Rev Clin Oncol vol. 8 , ( 6 ) 357 - 368 .

Sturge J, Caley MP, Waxmanin J ( 2011 ) . Authors' reply: Expanding horizons in metastatic prostate cancer treatment . NATURE REVIEWS CLINICAL ONCOLOGY vol. 8 , ( 10 )

Sturge J, Caley MP, Waxman J ( 2011 ) . Bone metastasis in prostate cancer: emerging therapeutic strategies (vol 8, pg 357, 2011) . NATURE REVIEWS CLINICAL ONCOLOGY vol. 8 , ( 10 ) 568 - 568 .

Bruche S, Caley MP, Pshezhetskiy D, Sturge J ( 2010 ) . Sphingosine kinase-1 and the collagen-binding receptor Endo180 cooperate to mediate collagen remodelling by stromal fibroblasts . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A9 - A9 .

Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M ( 2008 ) . Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals . Genes Chromosomes Cancer vol. 47 , ( 3 ) 238 - 246 .

Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M ( 2008 ) . Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals . GENES CHROMOSOMES & CANCER vol. 47 , ( 3 ) 238 - 246 .

Caley M, Wall I, Kipling D, Thomas DW, Stephens P ( 2007 ) . Development and characterisation of a human cell-based chronic wound bioassay . WOUND REPAIR AND REGENERATION vol. 15 , ( 6 ) A133 - A133 .