Publications: Dr Simon McArthur
Shah SN, Knausenberger TB-A, Pontifex MG, Connell E, Le Gall G, Hardy TAJ, Randall DW, McCafferty K et al.
(
2024
)
.
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
.
Gut Microbes
vol.
16
,
(
1
)
Dalile B, Boyle NB, Ruiz FT, Chakrabarti A, Respondek F, Dodd GF, Kadosh KC, Hepsomali P et al.
(
2024
)
.
Targeting cognitive resilience through prebiotics: A focused perspective
.
Advances in Nutrition
Connell E, Le Gall G, McArthur S, Lang L, Breeze B, Pontifex MG, Sami S, Pourtau L et al.
(
2024
)
.
(Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins
.
Neurochemistry International
vol.
180
,
Maitre L, De Leeuw VC, Van Oostrom CT, Anguita A, Chatzi L, Coen M, Gražulevičienė R, Heude B et al.
(
2024
)
.
Integrated Insights into Neurodevelopmental Effects of Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA): A Multi-Cohort Study Combining Epidemiology and Toxicology
.
ISEE Conference Abstracts
vol.
2024
,
(
1
)
Láng L, McArthur S, Lazar AS, Pourtau L, Gaudout D, Pontifex MG, Müller M, Vauzour D
(
2024
)
.
Dietary (Poly)phenols and the Gut–Brain Axis in Ageing
.
Nutrients
vol.
16
,
(
10
)
1500
-
1500
.
Wickstead ES, Elliott BT, Pokorny S, Biggs C, Getting SJ, Mcarthur S
(
2023
)
.
Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
.
International Journal of Molecular Sciences
vol.
24
,
(
21
)
15996
-
15996
.
McArthur S
(
2023
)
.
The gut microbe‐derived methylamine TMAO protects against neuroinflammation through restraint of pro‐inflammatory glial behaviour
.
Alzheimer's & Dementia
vol.
19
,
(
S1
)
Mcarthur S
(
2023
)
.
Regulation of Physiological Barrier Function by the Commensal Microbiota
.
Life
Stachulski AV, Knausenberger TB-A, Shah SN, Hoyles L, McArthur S
(
2023
)
.
A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo
.
Tissue Barriers
vol.
11
,
(
1
)
Wickstead ES, Solito E, Mcarthur S
(
2022
)
.
Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
.
Life
vol.
12
,
(
12
)
Article
2009
,
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al.
(
2021
)
.
Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues
.
The FASEB Journal
vol.
36
,
(
1
)
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al.
(
2021
)
.
Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
.
Microbiome
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al.
(
2021
)
.
Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders
.
Brain Communications
vol.
3
,
(
3
)
Wickstead ES, Irving MA, Getting SJ, McArthur S
(
2021
)
.
Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer’s disease treatment
.
The FEBS Journal
vol.
289
,
(
7
)
1801
-
1822
.
Pearson JRD, Cuzzubbo S, McArthur S, Durrant LG, Adhikaree J, Tinsley CJ, Pockley AG, McArdle SEB
(
2020
)
.
Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment
.
Frontiers in Immunology
vol.
11
,
Wickstead ES, Karim HA, Manuel RE, Biggs CS, Getting SJ, McArthur S
(
2020
)
.
Reversal of β‐Amyloid‐Induced Microglial Toxicity In Vitro by Activation of Fpr2/3
.
Oxidative Medicine and Cellular Longevity
vol.
2020
,
(
1
)
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S et al.
(
2020
)
.
Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier
.
Journal of Neuroinflammation
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al.
(
2020
)
.
Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation
.
Journal of Clinical Investigation
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K
(
2019
)
.
Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity
.
Frontiers in Immunology
vol.
10
,
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al.
(
2019
)
.
Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells
.
Mechanisms of Ageing and Development
Loiola RA, Wickstead ES, Solito E, Mcarthur S
(
2019
)
.
Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1
.
Frontiers in Endocrinology
Barrios-Silva LV, Parnell M, Shinwari ZB, Chaudhary GA, Xenofontos T, van Bekhoven A, MCARTHUR S, Elliott BT
(
2018
)
.
Activin sub-family peptides predict chronological age in humans
.
Physiological Reports
vol.
6
,
(
17
)
e13823
-
e13823
.
MCARTHUR S, GOBBETTI T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C et al.
(
2018
)
.
Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation
.
Biorxiv
vol.
375709
,
(
375709
)
Article
375709
,
1
-
1
.
Hoyles L, Snelling T, Umlai U-K, Nicholson JK, Carding SR, Glen RC, MCARTHUR S
(
2018
)
.
Microbiome-host systems interactions: Protective effects of propionate upon the bloodbrain barrier
.
BMC Microbiome
vol.
6
,
55
-
55
.
Bruzzi S, Sutti S, Toscani A, Bozzola C, Reutelingsperger C, Kusters D, Mcarthur S, Perretti M et al.
(
2017
)
.
Annexin A1 supplementation prevents the progression to fibrosis of nonalcoholic steatoepatitis (NASH)
.
JOURNAL OF HEPATOLOGY
.
Conference:
The International Liver Congress 2017
vol.
66
,
S608
-
S608
.
McArthur S, Loiola RA, Maggioli, E, Errede M, Virgintino D, SOLITO E
(
2016
)
.
The restorative role of annexin A1 at the blood–brain barrier
.
Fluids and Barriers of the CNS
vol.
13
,
(
17
)
Virdee K, Kentrop J, Jupp B, Venus B, Hensman D, McArthur S, Wilkinson J, Robbins TW et al.
(
2016
)
.
Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory
.
Psychopharmacology
vol.
233
,
(
21-22
)
3751
-
3761
.
Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M, Solito E
(
2015
)
.
Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking
.
Brain Behavior and Immunity
vol.
51
,
212
-
222
.
Shende VH, McArthur S, Gillies GE, Opacka-Juffry J
(
2015
)
.
Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone
.
Neural Plasticity
vol.
2015
,
(
1
)
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ, Perretti M
(
2015
)
.
Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation
.
The Journal of Immunology
vol.
195
,
(
3
)
1139
-
1151
.
McArthur S, Pienaar IS, Siddiqi SM, Gillies GE
(
2015
)
.
Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment
.
Brain Structure and Function
vol.
221
,
(
5
)
2459
-
2475
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Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C et al.
(
2014
)
.
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
111
,
(
52
)
18685
-
18690
.
Gillies GE, Virdee K, McArthur S, Dalley JW
(
2014
)
.
Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis
.
Neuroscience
vol.
282
,
69
-
85
.
Thompson D, McArthur S, Hislop JN, Flower RJ, Perretti M
(
2014
)
.
Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS*
.
Journal of Biological Chemistry
vol.
289
,
(
52
)
36166
-
36178
.
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al.
(
2014
)
.
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
.
Hepatology
vol.
60
,
(
2
)
531
-
544
.
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al.
(
2014
)
.
P261 ROLE OF ANNEXIN A1 IN THE PROGRESSION OF NONALCOHOLIC STEATOHEPATITIS (NASH)
.
Journal of Hepatology
.
vol.
60
,
Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE
(
2014
)
.
Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience
.
Neuropsychopharmacology
vol.
39
,
(
2
)
339
-
350
.
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M
(
2013
)
.
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses
.
Proc Natl Acad Sci U S A
vol.
110
,
(
45
)
18232
-
18237
.
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V, Perretti M
(
2013
)
.
Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23
.
EMBO Rep
vol.
14
,
(
11
)
999
-
1007
.
Nadkarni S, McArthur S
(
2013
)
.
Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity
.
Curr Opin Pharmacol
vol.
13
,
(
4
)
576
-
581
.
Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D et al.
(
2013
)
.
Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
.
Neurobiol Aging
vol.
34
,
(
4
)
1105
-
1115
.
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al.
(
2013
)
.
Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications
.
Proc Natl Acad Sci U S A
vol.
110
,
(
3
)
832
-
841
.
Dalli J, Montero-Melendez T, McArthur S, Perretti M
(
2012
)
.
Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils
.
Front Pharmacol
vol.
3
,
McArthur S, Robinson IC, Gillies GE
(
2011
)
.
Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice
.
Endocrinology
vol.
152
,
(
2
)
607
-
617
.
McArthur S, Gillies GE
(
2011
)
.
Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson's Disease
.
Front Endocrinol (Lausanne)
vol.
2
,
McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E
(
2010
)
.
Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia
.
J Immunol
vol.
185
,
(
10
)
6317
-
6328
.
Gillies GE, McArthur S
(
2010
)
.
Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
.
Pharmacol Rev
vol.
62
,
(
2
)
155
-
198
.
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ
(
2010
)
.
Anti-allergic drugs and the Annexin-A1 system
.
Pharmacol Rep
vol.
62
,
(
3
)
511
-
517
.
Gillies GE, McArthur S
(
2010
)
.
Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens
.
Horm Behav
vol.
57
,
(
1
)
23
-
34
.
McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, Solito E
(
2009
)
.
Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization
.
FASEB J
vol.
23
,
(
11
)
4000
-
4010
.
Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R
(
2009
)
.
Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1
.
Biochem Pharmacol
vol.
77
,
(
12
)
1814
-
1826
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Solito E, McArthur S, Christian H, Gavins F, Buckingham JC, Gillies GE
(
2008
)
.
Annexin A1 in the brain--undiscovered roles?
.
Trends Pharmacol Sci
vol.
29
,
(
3
)
135
-
142
.
McArthur S, Prasongchean W, Gillies G, Solito E
(
2008
)
.
A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis
.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
vol.
22
,
23
-
23
.
McArthur S, McHale E, Gillies GE
(
2007
)
.
The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner
.
Neuropsychopharmacology
vol.
32
,
(
7
)
1462
-
1476
.
McArthur S, Murray HE, Dhankot A, Dexter DT, Gillies GE
(
2007
)
.
Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition
.
J Neurochem
vol.
100
,
(
3
)
678
-
692
.
Gillies G, McArthur S, McHale E
(
2006
)
.
Sex dimorphisms in the 3D cytoarchitecture of the adult VTA and permanent alterations by glucocorticoid exposure in late gestation
.
Frontiers in Neuroendocrinology
vol.
27
,
(
1
)
95
-
96
.
McArthur S, Siddique Z-L, Christian HC, Capone G, Theogaraj E, John CD, Smith SF, Morris JF et al.
(
2006
)
.
Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats
.
Endocrinology
vol.
147
,
(
4
)
1904
-
1915
.
McArthur S, McHale E, Dalley JW, Buckingham JC, Gillies GE
(
2005
)
.
Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure
.
J Neuroendocrinol
vol.
17
,
(
8
)
475
-
482
.
Gillies GE, Murray HE, Dexter D, McArthur S
(
2004
)
.
Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease
.
Pharmacol Biochem Behav
vol.
78
,
(
3
)
513
-
522
.
Murray HE, Pillai AV, McArthur SR, Razvi N, Datla KP, Dexter DT, Gillies GE
(
2003
)
.
Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females
.
Neuroscience
vol.
116
,
(
1
)
213
-
222
.