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Research

Publications: Dr Simon McArthur

Wickstead ES, Solito E, Mcarthur S ( 2022 ) . Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class . Life vol. 12 , ( 12 ) Article 2009 ,
Stachulski AV, Knausenberger TB-A, Shah SN, Hoyles L, McArthur S ( 2022 ) . A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo . Tissue Barriers
Wickstead ES, Irving MA, Getting SJ, McArthur S ( 2022 ) . Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer’s disease treatment . FEBS Journal vol. 289 , ( 7 ) 1801 - 1822 .
Stachulski A, Knausenberger TB-A, Shah S, Hoyles L, McArthur S ( 2022 ) . A host–gut microbial co-metabolite of aromatic amino acids, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i> .
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al. ( 2022 ) . Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues . FASEB Journal vol. 36 , ( 1 )
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al. ( 2021 ) . Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide . Microbiome
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2021 ) . Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders . Brain Communications vol. 3 , ( 3 )
Pearson JRD, Cuzzubbo S, McArthur S, Durrant LG, Adhikaree J, Tinsley CJ, Pockley AG, McArdle SEB ( 2020 ) . Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment . Frontiers in Immunology vol. 11 ,
Wickstead E, Elliott B, Biggs C, Getting S, McArthur S ( 2020 ) . Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation .
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S et al. ( 2020 ) . Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier . Journal of Neuroinflammation
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2020 ) . Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis .
Wickstead E, Karim H, Manuel R, Biggs C, Getting S, McArthur S ( 2020 ) . Reversal of β-amyloid induced microglial toxicity <i>in vitro</i> by activation of Fpr2/3 .
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al. ( 2020 ) . Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation . Journal of Clinical Investigation
Wickstead ES, Karim HA, Manuel RE, Biggs CS, Getting SJ, McArthur S ( 2020 ) . Reversal of β-Amyloid-Induced Microglial Toxicity in Vitro by Activation of Fpr2/3 . Oxidative Medicine and Cellular Longevity vol. 2020 ,
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K ( 2019 ) . Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity . Frontiers in Immunology vol. 10 ,
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al. ( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development
Loiola RA, Wickstead ES, Solito E, Mcarthur S ( 2019 ) . Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1 . Frontiers in Endocrinology
Loiola RA, Wickstead ES, Solito E, McArthur S ( 2019 ) . Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance through the Actions of Annexin A1 . Frontiers in Endocrinology vol. 10 , ( JUN )
Loiola RA, Wickstead E, Solito E, McArthur S ( 2018 ) . Estrogen promotes pro-resolving microglial behaviour and phagocytic cell clearance through the actions of annexin A1 .
Barrios-Silva LV, Parnell M, Shinwari ZB, Chaudhary GA, Xenofontos T, van Bekhoven A, MCARTHUR S, Elliott BT ( 2018 ) . Activin sub-family peptides predict chronological age in humans . Physiological Reports vol. 6 , ( 17 ) e13823 - e13823 .
MCARTHUR S, GOBBETTI T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C et al. ( 2018 ) . Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation . Biorxiv vol. 375709 , ( 375709 ) Article 375709 , 1 - 1 .
Hoyles L, Snelling T, Umlai U-K, Nicholson JK, Carding SR, Glen RC, MCARTHUR S ( 2018 ) . Microbiome-host systems interactions: Protective effects of propionate upon the bloodbrain barrier . BMC Microbiome vol. 6 , 55 - 55 .
Bruzzi S, Sutti S, Toscani A, Bozzola C, Reutelingsperger C, Kusters D, Mcarthur S, Perretti M et al. ( 2017 ) . Annexin A1 supplementation prevents the progression to fibrosis of nonalcoholic steatoepatitis (NASH) . JOURNAL OF HEPATOLOGY . Conference: The International Liver Congress 2017 vol. 66 , S608 - S608 .
Virdee K, Kentrop J, Jupp B, Venus B, Hensman D, McArthur S, Wilkinson J, Robbins TW et al. ( 2016 ) . Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory . Psychopharmacology vol. 233 , ( 21-22 ) 3751 - 3761 .
McArthur S, Loiola RA, Maggioli, E, Errede M, Virgintino D, SOLITO E ( 2016 ) . The restorative role of annexin A1 at the blood–brain barrier . Fluids and Barriers of the CNS vol. 13 , ( 17 )
McArthur S, Pienaar IS, Siddiqi SM, Gillies GE ( 2016 ) . Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment . Brain Structure and Function vol. 221 , ( 5 ) 2459 - 2475 .
Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M, Solito E ( 2016 ) . Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking . Brain, Behavior, and Immunity vol. 51 , 212 - 222 .
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ, Perretti M ( 2015 ) . Definition of a novel pathway centered on lysophosphatidic acid to recruit monocytes during the resolution phase of tissue inflammation . Journal of Immunology vol. 195 , ( 3 ) 1139 - 1151 .
Shende VH, McArthur S, Gillies GE, Opacka-Juffry J ( 2015 ) . Astroglial plasticity is implicated in hippocampal remodelling in adult rats exposed to antenatal dexamethasone . Neural Plasticity vol. 2015 ,
Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C et al. ( 2014 ) . Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 52 ) 18685 - 18690 .
Gillies GE, Virdee K, McArthur S, Dalley JW ( 2014 ) . Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis . Neuroscience vol. 282 , 69 - 85 .
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al. ( 2014 ) . P261 ROLE OF ANNEXIN A1 IN THE PROGRESSION OF NONALCOHOLIC STEATOHEPATITIS (NASH) . Journal of Hepatology . vol. 60 ,
Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE ( 2014 ) . Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience . Neuropsychopharmacology vol. 39 , ( 2 ) 339 - 350 .
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al. ( 2014 ) . Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice . Hepatology vol. 60 , ( 2 ) 531 - 544 .
Thompson D, McArthur S, Hislop JN, Flower RJ, Perretti M ( 2014 ) . Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: Association with cell protection from apoptosis . Journal of Biological Chemistry vol. 289 , ( 52 ) 36166 - 36178 .
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M ( 2013 ) . Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses . Proc Natl Acad Sci U S A vol. 110 , ( 45 ) 18232 - 18237 .
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V, Perretti M ( 2013 ) . Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23 . EMBO Rep vol. 14 , ( 11 ) 999 - 1007 .
Nadkarni S, McArthur S ( 2013 ) . Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity . Curr Opin Pharmacol vol. 13 , ( 4 ) 576 - 581 .
Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D et al. ( 2013 ) . Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease . Neurobiol Aging vol. 34 , ( 4 ) 1105 - 1115 .
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al. ( 2013 ) . Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications . Proc Natl Acad Sci U S A vol. 110 , ( 3 ) 832 - 841 .
Dalli J, Montero-Melendez T, McArthur S, Perretti M ( 2012 ) . Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils . Front Pharmacol vol. 3 ,
McArthur S, Robinson IC, Gillies GE ( 2011 ) . Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice . Endocrinology vol. 152 , ( 2 ) 607 - 617 .
McArthur S, Gillies GE ( 2011 ) . Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson's Disease . Front Endocrinol (Lausanne) vol. 2 ,
McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E ( 2010 ) . Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia . J Immunol vol. 185 , ( 10 ) 6317 - 6328 .
Gillies GE, McArthur S ( 2010 ) . Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines . Pharmacol Rev vol. 62 , ( 2 ) 155 - 198 .
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ ( 2010 ) . Anti-allergic drugs and the Annexin-A1 system . Pharmacol Rep vol. 62 , ( 3 ) 511 - 517 .
Gillies GE, McArthur S ( 2010 ) . Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens . Horm Behav vol. 57 , ( 1 ) 23 - 34 .
McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, Solito E ( 2009 ) . Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization . FASEB J vol. 23 , ( 11 ) 4000 - 4010 .
Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R ( 2009 ) . Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1 . Biochem Pharmacol vol. 77 , ( 12 ) 1814 - 1826 .
McArthur S, Prasongchean W, Gillies G, Solito E ( 2008 ) . A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 22 , 23 - 23 .
Solito E, McArthur S, Christian H, Gavins F, Buckingham JC, Gillies GE ( 2008 ) . Annexin A1 in the brain--undiscovered roles? . Trends Pharmacol Sci vol. 29 , ( 3 ) 135 - 142 .
McArthur S, McHale E, Gillies GE ( 2007 ) . The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner . Neuropsychopharmacology vol. 32 , ( 7 ) 1462 - 1476 .
McArthur S, Murray HE, Dhankot A, Dexter DT, Gillies GE ( 2007 ) . Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition . J Neurochem vol. 100 , ( 3 ) 678 - 692 .
Gillies G, McArthur S, McHale E ( 2006 ) . Sex dimorphisms in the 3D cytoarchitecture of the adult VTA and permanent alterations by glucocorticoid exposure in late gestation . Frontiers in Neuroendocrinology vol. 27 , ( 1 ) 95 - 96 .
McArthur S, Siddique Z-L, Christian HC, Capone G, Theogaraj E, John CD, Smith SF, Morris JF et al. ( 2006 ) . Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats . Endocrinology vol. 147 , ( 4 ) 1904 - 1915 .
McArthur S, McHale E, Dalley JW, Buckingham JC, Gillies GE ( 2005 ) . Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure . J Neuroendocrinol vol. 17 , ( 8 ) 475 - 482 .
Gillies GE, Murray HE, Dexter D, McArthur S ( 2004 ) . Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease . Pharmacol Biochem Behav vol. 78 , ( 3 ) 513 - 522 .
Murray HE, Pillai AV, Mcarthur SR, Razvi N, Datla KP, Dexter DT, Gillies GE ( 2003 ) . Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: Differential actions of estrogen in males and females . Neuroscience vol. 116 , ( 1 ) 213 - 222 .