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Research

Publications: Dr Jordi Lopez Tremoleda

Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL, Hao Y ( 2022 ) . Deep learning for behaviour classification in a preclinical brain injury model . PLoS ONE vol. 17 , ( 6 June )
Tremoleda JL, Law B ( 2022 ) . Success for our first Virtual LASA Annual Conference . Laboratory animals vol. 56 , ( 2 ) 201 - 203 .
Lang A, Jirkof P, Mocho JP, Sanchez-Morgado J, Tremoleda JL ( 2022 ) . Report from the 11th edition of the World Congress on Alternatives and Animal Use in the Life Sciences (WC11) . Laboratory Animals vol. 56 , ( 1 ) 101 - 102 .
Sánchez-Morgado JM, Whitfield L, Tremoleda JL, Mocho JP, Lang A, Jirkof P ( 2022 ) . How to publish a case report in Laboratory Animals? . Laboratory Animals
Sánchez-Morgado JM, Jirkof P, Lang A, Mocho JP, Tremoleda JL ( 2022 ) . Is it time for a ‘Culture of Carers’? . Laboratory Animals
Osman M, Olkun A, Maldonado AM, Lopez-Tremoleda J, Sanchez-Perea N, Paredes UM ( 2021 ) . Parentally deprived juvenile Owl monkeys suffer from long-term high infection rates but not from altered hair cortisol concentrations nor from stereotypic behaviours . Journal of Medical Primatology vol. 50 , ( 6 ) 306 - 312 .
Jirkof P, Lang A, Mocho JP, Sanchez-Morgado J, Tremoleda JL ( 2021 ) . Do you want to join our Editorial Board? . Laboratory Animals vol. 55 , ( 3 ) 202 - 214 .
Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J, Davenport R ( 2021 ) . O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC) . British Journal of Surgery vol. 108 , ( Supplement_1 )
Jirkof P, Sanchez-Morgado J, Tremoleda JL ( 2021 ) . News from the EIC team . Laboratory animals vol. 55 , ( 2 )
Tremoleda JL, Kerton A ( 2021 ) . Teaching a culture of care: Why it matters . Revista de Bioética y Derecho vol. 0 , ( 51 ) 43 - 60 .
Praditsuktavorn B, Wall J, Thiemermann C, Tremoleda JL, Brohi K ( 2020 ) . Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury . CIRCULATION . vol. 142 , E496 - E497 .
Tremoleda JL, Kerton A ( 2020 ) . Creating space to build emotional resilience in the animal research community . Lab Animal vol. 49 , ( 10 ) 275 - 277 .
Nandi M, Jackson SK, Macrae D, Shankar-Hari M, Tremoleda JL, Lilley E ( 2020 ) . Rethinking animal models of sepsis - Working towards improved clinical translation whilst integrating the 3Rs . Clinical Science vol. 134 , ( 13 ) 1715 - 1734 .
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C et al. ( 2020 ) . Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody . Frontiers in Immunology vol. 11 ,
Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B et al. ( 2020 ) . A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice . Theranostics vol. 11 , ( 1 ) 346 - 360 .
Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al. ( 2020 ) . A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice . Journal of Neurotrauma vol. 37 , ( 1 ) 66 - 79 .
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K ( 2019 ) . Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity . Frontiers in Immunology vol. 10 ,
Zuchman OT, Svendsen L, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2019 ) . A NEW KETOGENIC FORMULATION IMPROVES FUNCTIONAL OUTCOME AND REDUCES TISSUE DAMAGE FOLLOWING TRAUMATIC BRAIN INJURY . JOURNAL OF NEUROTRAUMA . vol. 36 , A131 - A132 .
Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT et al. ( 2019 ) . Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system . Journal of Neuroscience Methods vol. 321 , 49 - 63 .
Thau-Zuchman O, Gomes RN, Dyall SC, Davies M, Priestley JV, Groenendijk M, De Wilde MC, Tremoleda JL et al. ( 2019 ) . Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury . Journal of Neurotrauma vol. 36 , ( 1 ) 25 - 42 .
Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Cole JE, Goddard M, Cheung MSH, Bhakoo KK et al. ( 2018 ) . Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging . Journal of Vascular Surgery vol. 67 , ( 5 ) 1571 - 1583.e3 .
Tremoleda JL, Macholl S, Sosabowski JK ( 2018 ) . Anesthesia and monitoring of animals during MRI studies . Methods in Molecular Biology , vol. 1718 ,
Alvarez K, Lopez-Tremoleda J, Donnan R, Michael-Titus AT, Tomlins PH ( 2018 ) . Heart rate sensitive optical coherence angiography . Progress in Biomedical Optics and Imaging - Proceedings of SPIE . vol. 10493 ,
Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT, TOMLINS PH ( 2017 ) . Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice . Journal of Biomedical Optics vol. 22 , ( 12 ) 121710 - 121710 .
Venero JL, Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Tr AMSEZ-HLAJSJL et al. ( 2017 ) . Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury . GLIA . Conference: XIII European Glial Meeting vol. 65 , E504 - E504 .
Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K ( 2017 ) . Modelling Acute Traumatic Haemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies . Shock
Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J et al. ( 2017 ) . Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate . PLoS One vol. 12 , ( 2 ) e0172776 - e0172776 .
Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H et al. ( 2017 ) . Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration . Scientific Reports vol. 7 , Article 41689 , 41689 - 41689 .
Pedrigi RM, Mehta V, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al. ( 2016 ) . Influence of shear stress magnitude and direction on atherosclerotic plaque composition . Royal Society Open Science vol. 3 , ( 10 )
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al. ( 2016 ) . In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid . Eur J Nucl Med Mol Imaging vol. 43 , ( 9 ) 1710 - 1722 .
Luong L, Duckles H, Schenkel T, Mahmoud MM, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP et al. ( 2016 ) . Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries . Thrombosis and Haemostasis vol. 116 , ( 1 ) 181 - 190 .
LOPEZ TREMOLEDA J ( 2016 ) . In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid . Eur J Nucl Med Mol Imaging
Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2016 ) . A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury . BRAIN INJURY vol. 30 , ( 5-6 ) 679 - 679 .
Wall JM, Tremoleda JL, Thiemermann C, Brohi K ( 2015 ) . HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE . SHOCK . vol. 44 , 21 - 22 .
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . SHOCK . vol. 44 , 24 - 25 .
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . Shock vol. 44 Suppl 2 , 24 - 25 .
Tremoleda JL, Sosabowski J ( 2015 ) . Imaging technologies and basic considerations for welfare of laboratory rodents . LAB ANIMAL vol. 44 , ( 3 ) 101 - 109 .
Tremoleda JL, Sosabowski J ( 2015 ) . Imaging technologies and basic considerations for welfare of laboratory rodents . Lab Animal vol. 44 , ( 3 ) 97 - 105 .
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W, Krams R ( 2014 ) . Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis . Atherosclerosis vol. 237 , ( 2 )
Cuhlmann S, Gsell W, Van Der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In vivo mapping of vascular inflammation using the translocator protein tracer <sup>18</sup>F-FEDAA1106 . Molecular Imaging vol. 13 , ( 6 )
Guerreiro M, Tremoleda JL, Frith D, Thiemermann C, Brohi K ( 2014 ) . Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22 , ( 1 )
Guerreiro ML, Tremoleda JL, Thiemermann C, Brohi K ( 2014 ) . REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 41 , 51 - 51 .
Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RGJ ( 2014 ) . Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis Using Iron Oxide Particles and MRI . Journal of Vascular Surgery vol. 59 , ( 5 )
Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RGJ ( 2014 ) . Imaging of the vulnerable carotid plaque: biological targeting of inflammation in atherosclerosis using iron oxide particles and MRI . Eur J Vasc Endovasc Surg vol. 47 , ( 5 ) 462 - 469 .
Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Gsell W, Reneman L ( 2013 ) . P.1.i.016 Amphetamine pretreatment alters the response to a methylphenidate challenge: a pharmacological magnetic resonance imaging study . European Neuropsychopharmacology . vol. 23 ,
Lopez-Tremoleda J, Gsell W ( 2013 ) . The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodents . Animal Technology and Welfare vol. 12 , ( 1 ) 59 - 62 .
Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Morisson Iveson V, Gavins FNE et al. ( 2013 ) . Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation . Chem Commun (Camb) vol. 49 , ( 6 ) 564 - 566 .
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al. ( 2013 ) . Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications . Proc Natl Acad Sci U S A vol. 110 , ( 3 ) 832 - 841 .
Tremoleda JL, Khan NS, Mann V, Racey SN, Martin AJ, Simpson AHWR, Noble BS ( 2012 ) . Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation . J Musculoskelet Neuronal Interact vol. 12 , ( 4 ) 241 - 253 .
Van Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W et al. ( 2012 ) . Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root . J R Soc Interface vol. 9 , ( 76 ) 2834 - 2844 .
Tremoleda JL, Kerton A, Gsell W ( 2012 ) . Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare . EJNMMI Res vol. 2 , ( 1 )
Seyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer C-T et al. ( 2012 ) . Roux-en-Y gastric bypass in mice--surgical technique and characterisation . Obes Surg vol. 22 , ( 7 ) 1117 - 1125 .
Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J et al. ( 2012 ) . Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment . Psychopharmacology (Berl) vol. 221 , ( 2 ) 329 - 339 .
Stuckey DJ, Tremoleda JL, Mcsweeney S, Fiedler L, Harada M, Carr CA, Tyler DJ, Gsell W et al. ( 2012 ) . Systematic evaluation of 2D versus M-mode echocardiography in mice, compared to ex vivo and in vivo MRI . CARDIOVASCULAR RESEARCH . vol. 93 , S90 - S90 .
Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W, Reneman L ( 2012 ) . Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI . Neuroimage vol. 59 , ( 1 ) 218 - 226 .
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al. ( 2011 ) . (18)FEDAA is a more specific probe than (18)FDG for imaging vascular inflammation . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S210 - S210 .
Tremoleda JL, Khalil M, Gsell W, Vincent T ( 2011 ) . The use of micro-computed tomography to study bone changes in a preclinical model of Osteoarthritis . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S418 - S418 .
Song W, Dyer E, Stuckey DJ, Copeland O, Leung M-C, Bayliss C, Messer A, Wilkinson R et al. ( 2011 ) . Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse . J Biol Chem vol. 286 , ( 31 ) 27582 - 27593 .
Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T, Gsell W ( 2011 ) . Imaging technologies for preclinical models of bone and joint disorders . EJNMMI Res vol. 1 , ( 1 )
Cuhlmann S, Van Der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al. ( 2011 ) . Disturbed blood flow induces rela expression via c-Jun N-terminal kinase 1: A novel mode of NF-κB regulation that promotes arterial inflammation . Circulation Research vol. 108 , ( 8 ) 950 - 959 .
Kazakidi A, Wylezinska M, Bohraus Y, Van Doormaal M, Tremoleda JL, Gsell W, Weinberg PD, Ethier CR et al. ( 2010 ) . NUMERICAL MODELLING OF BLOOD FLOW IN THE MOUSE AORTIC ARCH USING INFLOW VELOCITIES OBTAINED BY PHASE-CONTRAST MRI . PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010 . 555 - 556 .
Khan NS, Tremoleda JL, Riahi S, Lucendo B, Pier D, Hughes O, Mann V, Dauphin DS et al. ( 2009 ) . 488 POTENTIAL OF HUMAN EMBRYONIC STEM CELL-DERIVED CHONDROGENIC CELLS TO REPAIR AN ARTICULAR DEFECT . Osteoarthritis and Cartilage vol. 17 ,