Publications: Dr Jordi Lopez Tremoleda

Tremoleda J, Jirkof P, Lang A, Sanchez-Morgado JM ( 2024 ) . To our esteemed colleague J-P . Laboratory Animals vol. 58 , ( 6 ) 510 - 511 .

Tremoleda JL ( 2024 ) . Our 61st Annual Meeting: An exciting programme is shaping up! . Laboratory Animals vol. 58 , ( 5 ) 499 - 499 .

Al-Khateeb ZF, Boumenar H, Adebimpe J, Shekerzade S, Henson SM, Tremoleda JL, Michael-Titus AT ( 2024 ) . The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury . Experimental Neurology vol. 374 ,

Simpson R, Praditsuktavorn B, Wall J, Morales V, Thiemermann C, Tremoleda JL, Brohi K ( 2023 ) . Myocardial alterations following traumatic hemorrhagic injury . Journal of Trauma and Acute Care Surgery vol. 95 , ( 4 ) 481 - 489 .

Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J, Screen HRC ( 2023 ) . Development and application of a novel in vivo overload model of the Achilles tendon in rat . Journal of Biomechanics vol. 151 ,

Warner A, Law B, Tremoleda JL ( 2023 ) . A successful return to in-person LASA Annual Conference 2022 . Laboratory Animals vol. 57 , ( 1 ) 87 - 88 .

Tremoleda JL, Cederroth C, Jirkof P ( 2023 ) . Engaging on discussions about the use and the replacement of animals in research with young minds . Laboratory Animals vol. 57 , ( 3 ) 221 - 223 .

Kirtland J, Tremoleda JL, Trivedy C ( 2022 ) . Traumatic injury patterns in humans from large feline predators: A systematic review and descriptive analysis . Trauma (London, England) vol. 26 , ( 1 ) 28 - 42 .

Tremoleda JL ( 2022 ) . Reducing the Number of Research Animals: How Imaging Technologies Can Help . Frontiers for Young Minds vol. 10 ,

Tremoleda JL, Kerton A, Mazhary H, Greenhough B ( 2022 ) . New perspectives for teaching Culture of Care and their strengths and challenges . Laboratory Animals vol. 57 , ( 2 ) 170 - 181 .

Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ ( 2022 ) . C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity . Frontiers in Molecular Neuroscience vol. 15 ,

Sánchez-Morgado JM, Whitfield L, Tremoleda JL, Mocho J-P, Lang A, Jirkof P ( 2022 ) . How to publish a case report in Laboratory Animals? . Laboratory Animals vol. 57 , ( 1 ) 2 - 2 .

Sánchez-Morgado JM, Jirkof P, Lang A, Mocho J-P, Tremoleda JL ( 2022 ) . Is it time for a ‘Culture of Carers’? . Laboratory Animals vol. 56 , ( 6 ) 498 - 498 .

Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL, Hao Y ( 2022 ) . Deep learning for behaviour classification in a preclinical brain injury model . PLOS ONE vol. 17 , ( 6 )

Tremoleda JL, Law B ( 2022 ) . Success for our first Virtual LASA Annual Conference . Laboratory Animals vol. 56 , ( 2 ) 201 - 203 .

Lang A, Jirkof P, Mocho J-P, Sanchez-Morgado J, Tremoleda JL ( 2022 ) . Report from the 11th edition of the World Congress on Alternatives and Animal Use in the Life Sciences (WC11) . Laboratory Animals vol. 56 , ( 1 ) 101 - 102 .

Osman M, Olkun A, Maldonado AM, Lopez‐Tremoleda J, Sanchez‐Perea N, Paredes UM ( 2021 ) . Parentally deprived juvenile Owl monkeys suffer from long‐term high infection rates but not from altered hair cortisol concentrations nor from stereotypic behaviours . Journal of Medical Primatology vol. 50 , ( 6 ) 306 - 312 .

Jirkof P, Lang A, Mocho J-P, Sanchez-Morgado J, Tremoleda JL ( 2021 ) . Do you want to join our Editorial Board? . Laboratory Animals vol. 55 , ( 3 ) 202 - 214 .

Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J, Davenport R ( 2021 ) . O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC) . British Journal of Surgery vol. 108 , ( Supplement_1 )

Jirkof P, Sanchez-Morgado J, Tremoleda JL ( 2021 ) . News from the EIC team . Laboratory Animals vol. 55 , ( 2 ) 189 - 189 .

Kerton A, Tremoleda JL ( 2021 ) . Emotional challenges in our work with laboratory animals: tools that support caring for others and yourself . Animal Technology and Welfare vol. 20 , ( 1 ) 35 - 41 .

Jennings M, Berdoy M, Farmer AM, Hawkins P, Lilley E, Kerton A, Law B, Tremoleda JL et al. ( 2021 ) . Guiding principles to help deliver the ethics learning outcomes of module 2 for personal licensees . Animal Technology and Welfare vol. 20 , ( 1 ) 63 - 72 .

Tremoleda JL, Kerton A ( 2021 ) . Teaching a culture of care: Why it matters . Revista de Bioética y Derecho vol. 0 , ( 51 ) 43 - 60 .

Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B et al. ( 2021 ) . A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice . Theranostics vol. 11 , ( 1 ) 346 - 360 .

Tremoleda JL, Kerton A ( 2020 ) . Creating space to build emotional resilience in the animal research community . Lab Animal vol. 49 , ( 10 ) 275 - 277 .

Nandi M, Jackson SK, Macrae D, Shankar-Hari M, Tremoleda JL, Lilley E ( 2020 ) . Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs . Clinical Science vol. 134 , ( 13 ) 1715 - 1734 .

Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C et al. ( 2020 ) . Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody . Frontiers in Immunology vol. 11 ,

Praditsuktavorn B, Wall J, Thiemermann C, Tremoleda JL, Brohi K ( 2020 ) . Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury . CIRCULATION . vol. 142 , E496 - E497 .

Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K ( 2019 ) . Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity . Frontiers in Immunology vol. 10 ,

Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al. ( 2019 ) . A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice . Journal of Neurotrauma vol. 37 , ( 1 ) 66 - 79 .

Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT et al. ( 2019 ) . Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system . Journal of Neuroscience Methods vol. 321 , 49 - 63 .

Zuchman OT, Svendsen L, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2019 ) . A NEW KETOGENIC FORMULATION IMPROVES FUNCTIONAL OUTCOME AND REDUCES TISSUE DAMAGE FOLLOWING TRAUMATIC BRAIN INJURY . JOURNAL OF NEUROTRAUMA . vol. 36 , A131 - A132 .

THAU ZUCHMAN O, Gomes RN, DYALL SC, Davies M, PRIESTLEY JV, Groenendijk M, De Wilde MC, LOPEZ TREMOLEDA J et al. ( 2018 ) . Brain phospholipid precursors administered post-injury reduce tissue damage and improve neurological outcome in experimental traumatic brain injury . Journal of Neurotrauma vol. 36 , ( 1 ) 25 - 42 .

Alvarez K, Lopez-Tremoleda J, Donnan R, Michael-Titus AT, Tomlins PH ( 2018 ) . Heart rate sensitive optical coherence angiography . Conference: Dynamics and Fluctuations in Biomedical Photonics XV vol. 10493 ,

Tremoleda JL, Macholl S, Sosabowski JK ( 2018 ) . Anesthesia and Monitoring of Animals During MRI Studies . Preclinical MRI , vol. 1718 , Springer Nature

Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT, TOMLINS PH ( 2017 ) . Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice . Journal of Biomedical Optics vol. 22 , ( 12 ) 121710 - 121710 .

Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K ( 2017 ) . Modeling Acute Traumatic Hemorrhagic Shock Injury . Shock vol. 48 , ( 6 ) 610 - 623 .

Luong L, Duckles H, Schenkel T, Mahmoud M, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP et al. ( 2017 ) . Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries . Thrombosis and Haemostasis vol. 116 , ( 01 ) 181 - 190 .

Venero JL, Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Tr AMSEZ-HLAJSJL et al. ( 2017 ) . Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury . GLIA . Conference: XIII European Glial Meeting vol. 65 , E504 - E504 .

Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Cole JE, Goddard M, Cheung MSH, Bhakoo KK et al. ( 2017 ) . Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging . Journal of Vascular Surgery vol. 67 , ( 5 ) 1571 - 1583.e3 .

Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J et al. ( 2017 ) . Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate . PLoS One vol. 12 , ( 2 ) e0172776 - e0172776 .

Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H et al. ( 2017 ) . Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration . Scientific Reports vol. 7 , Article 41689 , 41689 - 41689 .

Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al. ( 2016 ) . Influence of shear stress magnitude and direction on atherosclerotic plaque composition . Royal Society Open Science vol. 3 , ( 10 )

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al. ( 2016 ) . In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid . Eur J Nucl Med Mol Imaging vol. 43 , ( 9 ) 1710 - 1722 .

LOPEZ TREMOLEDA J ( 2016 ) . In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid . Eur J Nucl Med Mol Imaging

Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT ( 2016 ) . A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury . BRAIN INJURY vol. 30 , ( 5-6 ) 679 - 679 .

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . Shock vol. 44 Suppl 2 , 24 - 25 .

Tremoleda JL, Sosabowski J ( 2015 ) . Imaging technologies and basic considerations for welfare of laboratory rodents . Lab Animal vol. 44 , ( 3 ) 97 - 105 .

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. ( 2015 ) . <i>IN VIVO</i> IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION . SHOCK . vol. 44 , 24 - 25 .

Wall JM, Tremoleda JL, Thiemermann C, Brohi K ( 2015 ) . HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE . SHOCK . vol. 44 , 21 - 22 .

Tremoleda JL, Sosabowski J ( 2015 ) . Imaging technologies and basic considerations for welfare of laboratory rodents . LAB ANIMAL vol. 44 , ( 3 ) 101 - 109 .

Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W, Krams R ( 2014 ) . Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis . Atherosclerosis vol. 237 , ( 2 )

Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106 . Molecular Imaging vol. 13 , ( 6 )

Guerreiro M, Tremoleda JL, Frith D, Thiemermann C, Brohi K ( 2014 ) . Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22 , ( Suppl 1 )

Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RGJ ( 2014 ) . Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis Using Iron Oxide Particles and MRI . Journal of Vascular Surgery vol. 59 , ( 5 )

Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RGJ ( 2014 ) . Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI . European Journal of Vascular and Endovascular Surgery vol. 47 , ( 5 ) 462 - 469 .

Guerreiro ML, Tremoleda JL, Thiemermann C, Brohi K ( 2014 ) . REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 41 , 51 - 51 .

Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Gsell W, Reneman L ( 2013 ) . P.1.i.016 Amphetamine pretreatment alters the response to a methylphenidate challenge: a pharmacological magnetic resonance imaging study . European Neuropsychopharmacology . vol. 23 ,

Lopez-Tremoleda J, Gsell W ( 2013 ) . The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodents . Animal Technology and Welfare vol. 12 , ( 1 ) 59 - 62 .

Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al. ( 2013 ) . Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications . Proc Natl Acad Sci U S A vol. 110 , ( 3 ) 832 - 841 .

Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Iveson VM, Gavins FNE et al. ( 2013 ) . Gd 3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation . Chemical Communications vol. 49 , ( 6 ) 564 - 566 .

Tremoleda JL, Khan NS, Mann V, Racey SN, Martin AJ, Simpson AHWR, Noble BS ( 2012 ) . Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation . Journal of musculoskeletal & neuronal interactions vol. 12 , ( 4 ) 241 - 253 .

Tremoleda JL, Kerton A, Gsell W ( 2012 ) . Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare . EJNMMI Research vol. 2 , ( 1 )

Van Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W et al. ( 2012 ) . Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root . Journal of The Royal Society Interface vol. 9 , ( 76 ) 2834 - 2844 .

Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J et al. ( 2012 ) . Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment . Psychopharmacology (Berl) vol. 221 , ( 2 ) 329 - 339 .

Seyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer C-T et al. ( 2012 ) . Roux-en-Y Gastric Bypass in Mice—Surgical Technique and Characterisation . Obesity Surgery vol. 22 , ( 7 ) 1117 - 1125 .

Stuckey DJ, Tremoleda JL, Mcsweeney S, Fiedler L, Harada M, Carr CA, Tyler DJ, Gsell W et al. ( 2012 ) . Systematic evaluation of 2D versus M-mode echocardiography in mice, compared to ex vivo and in vivo MRI . CARDIOVASCULAR RESEARCH . vol. 93 , S90 - S90 .

Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W, Reneman L ( 2011 ) . Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI . NeuroImage vol. 59 , ( 1 ) 218 - 226 .

Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T, Gsell W ( 2011 ) . Imaging technologies for preclinical models of bone and joint disorders . EJNMMI Research vol. 1 , ( 1 )

Song W, Dyer E, Stuckey DJ, Copeland O, Leung M-C, Bayliss C, Messer A, Wilkinson R et al. ( 2011 ) . Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse* . Journal of Biological Chemistry vol. 286 , ( 31 ) 27582 - 27593 .

Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al. ( 2011 ) . Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1 . Circulation Research vol. 108 , ( 8 ) 950 - 959 .

Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al. ( 2011 ) . <SUP>18</SUP>FEDAA is a more specific probe than <SUP>18</SUP>FDG for imaging vascular inflammation . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S210 - S210 .

Tremoleda JL, Khalil M, Gsell W, Vincent T ( 2011 ) . The use of micro-computed tomography to study bone changes in a preclinical model of Osteoarthritis . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S418 - S418 .

Kazakidi A, Wylezinska M, Bohraus Y, Van Doormaal M, Tremoleda JL, Gsell W, Weinberg PD, Ethier CR ( 2010 ) . NUMERICAL MODELLING OF BLOOD FLOW IN THE MOUSE AORTIC ARCH USING INFLOW VELOCITIES OBTAINED BY PHASE-CONTRAST MRI . PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010 . 555 - 556 .

Khan NS, Tremoleda JL, Riahi S, Lucendo B, Pier D, Hughes O, Mann V, Dauphin DS et al. ( 2009 ) . 488 POTENTIAL OF HUMAN EMBRYONIC STEM CELL-DERIVED CHONDROGENIC CELLS TO REPAIR AN ARTICULAR DEFECT . Osteoarthritis and Cartilage vol. 17 ,