Publications: Dr Nuria Gavara

Peracaula M, Martinez-Blanco A, Gavara N, Gratacos M, Peinado VI, Blanco I, Barbera JA, Tura-Ceide O ( 2024 ) . Endothelial cells in chronic thromboembolic pulmonary hypertension exhibit cytoskeletal alteration . Cardiovascular Research vol. 120 , ( Supplement_1 )

Almendros I, Rodriguez-Lazaro MA, Otero J, Gavara N, Sunyer R, Farre N, Gozal D, Farre R ( 2024 ) . Experimental Setting for Simultaneously Subjecting Rodents to Different Circadian Cycles of Light, Food, and Temperature in Sleep Apnea Models . Conference: A77. DECODING THE MOLECULAR MAZE OF SLEEP APNEAa2666 - a2666 .

Almendros I, Herranz-Díez C, Ulldemolins A, Sunyer R, Gavara N, Farre R, Otero J ( 2024 ) . Lung Derived-Extracellular Matrix Hydrogels Promote Inflammation and Migration in Alveolar Epithelial Type 2 Cells . Conference: A69. PATHOGENESIS OF INTERSTITIAL AND PLEURAL DISEASESa2497 - a2497 .

Ulldemolins A, Narciso M, Sanz-Fraile H, Otero J, Farré R, Gavara N, Almendros I ( 2024 ) . Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch . Frontiers in Cell and Developmental Biology vol. 12 ,

Farré R, Rodríguez-Lázaro MA, Otero J, Gavara N, Sunyer R, Farré N, Gozal D, Almendros I ( 2024 ) . Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature . Frontiers in Physiology vol. 15 ,

Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R et al. ( 2024 ) . Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy . Journal of The Royal Society Interface vol. 21 , ( 211 )

Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ et al. ( 2023 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function . The Journal of Pathology vol. 262 , ( 1 ) 90 - 104 .

Narciso M, Ulldemolins A, Jurado A, Navajas D, Farré R, Gavara N, Almendros I ( 2023 ) . Age related changes of the lung extracellular matrix stiffness and stem cell viability . Conference: Mechanisms of lung injury and repair

Jurado A, Ulldemolins A, Lluis H, Gasull X, Gavara N, Sunyer R, Otero J, Gozal D et al. ( 2023 ) . Application of intermittent hypoxia to precisely-cut tissue slices: a novel ex vivo model for studying the parenchymal effects of obstructive sleep apnea (OSA) . Conference: Sleep science

Ulldemolins A, Jurado A, Herranz-Diez C, Gavara N, Otero J, Farré R, Almendros I ( 2023 ) . Lung Extracellular Matrix Hydrogels-Derived Vesicles Contribute to Epithelial Lung Repair . Conference: Mechanisms of lung injury and repair

Martínez-Blanco Á, Noé S, Carreras-Vidal L, Otero J, Gavara N ( 2023 ) . Cryosectioning of Hydrogels as a Reliable Approach to Increase Yield and Further Tune Mechanical Properties . Gels vol. 9 , ( 10 )

Sanz-Fraile H, Herranz-Diez C, Ulldemolins A, Falcones B, Almendros I, Gavara N, Sunyer R, Farré R et al. ( 2023 ) . Characterization of Bioinks Prepared via Gelifying Extracellular Matrix from Decellularized Porcine Myocardia . Gels vol. 9 , ( 9 )

Almendros I, Jurado A, Ulldemolins A, Lluis H, Gasull X, Gavara N, Sunyer R, Otero J et al. ( 2023 ) . Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea . Conference: Sleep & Breathing disorders

Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A et al. ( 2023 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function . Pancreatology vol. 23 , ( 4 ) e13 - e14 .

Ulldemolins A, Jurado A, Herranz-Diez C, Gavara N, Otero J, Farre R, Almendros I ( 2023 ) . Lung Extracellular Matrix Hydrogels - Derived Nanoparticles Contribute to Epithelial Lung Repair . Conference: C68. TOPICS IN AIRWAY AND ALVEOLAR EPITHELIAL CELL BIOLOGYa5694 - a5694 .

Narciso M, Martínez Á, Júnior C, Díaz-Valdivia N, Ulldemolins A, Berardi M, Neal K, Navajas D et al. ( 2023 ) . Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin . Cancers vol. 15 , ( 8 )

Júnior C, Ulldemolins A, Narciso M, Almendros I, Farré R, Navajas D, López J, Eroles M et al. ( 2023 ) . Multi-Step Extracellular Matrix Remodelling and Stiffening in the Development of Idiopathic Pulmonary Fibrosis . International Journal of Molecular Sciences vol. 24 , ( 2 )

Jurado A, Ulldemolins A, Lluís H, Gasull X, Gavara N, Sunyer R, Otero J, Gozal D et al. ( 2023 ) . Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea . Frontiers in Pharmacology vol. 13 ,

Narciso M, Ulldemolins A, Navajas D, Farre R, Gavara N, Almendros Lopez I ( 2022 ) . Aging Induces Stiffening of the Lung Extracellular Matrix . Conference: 03.02 - Airway cell biology and immunopathology

Narciso M, Díaz-Valdivia N, Junior C, Otero J, Alcaraz J, Navajas D, Farre R, Almendros Lopez I et al. ( 2022 ) . Changes in Structure and Stiffness of the Lung Extracellular Matrix in Lung Cancer . Conference: 11.01 - Lung cancer

Marhuenda E, Villarino A, Narciso ML, Gavara N, Farré R, Almendros I, Otero J ( 2022 ) . Culturing primary alveolar epithelial cells on lung hydrogels preserves the type II phenotype . Conference: 03.03 - Mechanisms of lung injury and repair

Marhuenda E, Villarino A, Narciso M, Gavara N, Farre R, Almendros I, Otero J ( 2022 ) . New physiomimetic model for ARDS in vitro studies . Conference: 03.03 - Mechanisms of lung injury and repair

Narciso M, Ulldemolins A, Júnior C, Otero J, Navajas D, Farré R, Gavara N, Almendros I ( 2022 ) . A Fast and Efficient Decellularization Method for Tissue Slices . Bio-protocol vol. 12 , ( 22 )

Ulldemolins A, Jurado A, Herranz-Diez C, Gavara N, Otero J, Farré R, Almendros I ( 2022 ) . Lung Extracellular Matrix Hydrogels-Derived Vesicles Contribute to Epithelial Lung Repair . Polymers vol. 14 , ( 22 )

Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM ( 2022 ) . YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression . Osteoarthritis and Cartilage vol. 31 , ( 5 ) 600 - 612 .

Marhuenda E, Villarino A, Narciso M, Elowsson L, Almendros I, Westergren-Thorsson G, Farré R, Gavara N et al. ( 2022 ) . Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices . Frontiers in Pharmacology vol. 13 ,

Almendros I, Júnior C, Narciso ML, Marhuenda E, Farre R, Navajas D, Otero J, Gavara N ( 2022 ) . Baseline Stiffness Modulates the Non-Linear Response to Stretch of the Extracellular Matrix in Pulmonary Fibrosis . Conference: A60. PULMONARY FIBROSIS: ANIMAL AND CELL CULTURE MODELSa1966 - a1966 .

Marhuenda E, Villarino A, Narciso ML, Gavara N, Farre R, Almendros I, Otero J ( 2022 ) . Lung Derived Hydrogels as Substrate for Subculturing Primary Alveolar Type II Epithelial Cells . Conference: B61. MOLECULAR AND CELLULAR MECHANISMS IN LUNG EPITHELIAL CELLSa3256 - a3256 .

Almendros I, Narciso ML, Ulldemolins A, Júnior C, Otero J, Navajas D, Farre R, Gavara N ( 2022 ) . Novel Method for Fast Decellularization of Lung Slices . Conference: B59. ACUTE LUNG INJURY AND ARDS: CELLS, TISSUES, AND ANIMAL MODELSa3221 - a3221 .

Marhuenda E, Villarino A, Narciso ML, Camprubí-Rimblas M, Farré R, Gavara N, Artigas A, Almendros I et al. ( 2022 ) . Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells . International Journal of Molecular Sciences vol. 23 , ( 9 )

Narciso M, Ulldemolins A, Júnior C, Otero J, Navajas D, Farré R, Gavara N, Almendros I ( 2022 ) . Novel Decellularization Method for Tissue Slices . Frontiers in Bioengineering and Biotechnology vol. 10 ,

Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )

Júnior C, Narciso M, Marhuenda E, Almendros I, Farré R, Navajas D, Otero J, Gavara N ( 2021 ) . Baseline Stiffness Modulates the Non-Linear Response to Stretch of the Extracellular Matrix in Pulmonary Fibrosis . International Journal of Molecular Sciences vol. 22 , ( 23 )

Narciso M, Otero J, Navajas D, Farré R, Almendros I, Gavara N ( 2021 ) . Image-Based Method to Quantify Decellularization of Tissue Sections . International Journal of Molecular Sciences vol. 22 , ( 16 )

Connelly JT, Gavara N, Sliogeryte K, Blowes LM ( 2021 ) . Research Techniques Made Simple: Analysis of Skin Cell and Tissue Mechanics Using Atomic Force Microscopy . Journal of Investigative Dermatology vol. 141 , ( 8 ) 1867 - 1871.e1 .

Meng H, Chowdhury TT, Gavara N ( 2021 ) . The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force Microscopy . Frontiers in Cell and Developmental Biology vol. 9 ,

Narciso ML, Júnior C, Navajas D, Farre R, Otero J, Gavara N, Almendros I ( 2021 ) . Comparison Between Different Strategies for the Decellularization of Lung Slices . Conference: TP107. TP107 PULMONARY FIBROSIS: MOLECULAR AND CELLULAR MECHANISMSa4251 - a4251 .

Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N et al. ( 2021 ) . The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction . Science Advances vol. 7 , ( 5 )

Ho-Plágaro T, Huertas R, Tamayo-Navarrete MI, Blancaflor E, Gavara N, García-Garrido JM ( 2021 ) . A Novel Putative Microtubule-Associated Protein Is Involved in Arbuscule Development during Arbuscular Mycorrhiza Formation . Plant and Cell Physiology vol. 62 , ( 2 ) 306 - 320 .

Gavara N ( 2021 ) . The cytoskeleton, by the numbers . EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS . vol. 50 , 63 - 63 .

Keeling MC, Gavara N ( 2020 ) . Withaferin-A Can Be Used to Modulate the Keratin Network of Intermediate Filaments in Human Epidermal Keratinocytes . International Journal of Molecular Sciences vol. 21 , ( 12 )

Zhang, Flores, Keeling, Sliogeryte, Gavara ( 2020 ) . Ezrin Phosphorylation at T567 Modulates Cell Migration, Mechanical Properties, and Cytoskeletal Organization . International Journal of Molecular Sciences vol. 21 , ( 2 ) 435 - 435 .

Gavara N, Sliogeryte K ( 2019 ) . Vimentin plays a crucial role in fibroblast ageing by regulating biophysical properties and cell migration . Cells

Blowes LM, Sliogeryte K, Gavara N, Connelly J ( 2019 ) . 268 Geometry-dependent chromatin remodelling in keratinocytes is altered by cell-cell adhesions . Journal of Investigative Dermatology . vol. 139 ,

Flores LR, Keeling MC, Zhang X, Sliogeryte K, Gavara N ( 2019 ) . Author Correction: Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour . Scientific Reports vol. 9 , ( 1 )

GAVARA N, Flores L, KEELING M, ZHANG X, SLIOGERYTE K ( 2019 ) . Lifeact-GFP alters F-actin organization, cellular morphology and biophysical behaviour . Scientific Reports

Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC ( 2018 ) . Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages . European Cells and Materials vol. 36 , 142 - 155 .

Gonzalez-Molina J, Zhang X, Borghesan M, Mendonça da Silva J, Awan M, Fuller B, Gavara N, Selden C ( 2018 ) . Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration . Biomaterials vol. 177 , 113 - 124 .

Keeling MC, Flores LR, Dodhy AH, Murray ER, Gavara N ( 2017 ) . Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization . Scientific Reports vol. 7 , ( 1 )

MATA A, Azevedo HS, Botto L, Gavara N, Su L ( 2017 ) . New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine . Current Stem Cell Reports

Akhtar R, Graham HK, Derby B, Sherratt MJ, Trafford AW, Chadwick RS, Gavara N ( 2016 ) . Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta . Journal of the Mechanical Behavior of Biomedical Materials vol. 64 , 10 - 17 .

Gavara N ( 2016 ) . A beginner's guide to atomic force microscopy probing for cell mechanics . Microscopy Research and Technique vol. 80 , ( 1 ) 75 - 84 .

Gavara N ( 2016 ) . Combined strategies for optimal detection of the contact point in AFM force-indentation curves obtained on thin samples and adherent cells . Scientific Reports vol. 6 , ( 1 )

Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM ( 2016 ) . Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration . Journal of Biomechanics vol. 49 , ( 2 ) 310 - 317 .

Mao X, Gavara N, Song G ( 2015 ) . Nuclear Mechanics and Stem Cell Differentiation . Stem Cell Reviews and Reports vol. 11 , ( 6 ) 804 - 812 .

Gavara N, Chadwick RS ( 2015 ) . Relationship between cell stiffness and stress fiber amount, assessed by simultaneous atomic force microscopy and live-cell fluorescence imaging . Biomech Model Mechanobiol vol. 15 , ( 3 ) 511 - 523 .

Szarama KB, Gavara N, Petralia RS, Chadwick RS, Kelley MW ( 2013 ) . Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti . BMC Dev Biol vol. 13 ,

Szarama KB, Stepanyan R, Petralia RS, Gavara N, Frolenkov GI, Kelley MW, Chadwick RS ( 2012 ) . Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti . Bioarchitecture vol. 2 , ( 6 )

Szarama KB, Gavara N, Petralia RS, Kelley MW, Chadwick RS ( 2012 ) . Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea . Journal of Cell Science vol. 125 , ( 13 ) e1 - e1 .

Szarama KB, Gavara N, Petralia RS, Kelley MW, Chadwick RS ( 2012 ) . Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea . Development (Cambridge) vol. 139 , ( 12 ) 2187 - 2197 .

Petrie RJ, Gavara N, Chadwick RS, Yamada KM ( 2012 ) . Nonpolarized signaling reveals two distinct modes of 3D cell migration . Journal of Cell Biology vol. 197 , ( 3 ) 439 - 455 .

GAVARA N, CHADWICK RS ( 2009 ) . MEASUREMENT OF ANISOTROPIC MECHANICAL PROPERTIES OF THE TECTORIAL MEMBRANE . Conference: Concepts and Challenges in the Biophysics of Hearing276 - 282 .

Manoussaki D, Shin W, Gavara NC, Chadwick RS, Waterman C ( 2012 ) . A hybrid confocal & atomic force microscope for probing biophysical properties of migrating cells . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,

Petrie R, Gavara N, Chadwick RS, Yamada KM ( 2012 ) . Actomyosin cytoskeletal organization distinguishes lobopodia from lamellipodia . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,

Gavara N, Chadwick RS ( 2012 ) . Determination of the elastic moduli of thin samples and adherent cells using conical atomic force microscope tips . Nature Nanotechnology vol. 7 , ( 11 ) 733 - 736 .

Szarama KB, Stepanyan R, Petralia RS, Gavara N, Frolenkov GI, Kelley MW, Chadwick RS ( 2012 ) . Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti . Bioarchitecture vol. 2 , ( 6 ) 214 - 219 .

Gavara N, Manoussaki D, Chadwick RS ( 2011 ) . Auditory mechanics of the tectorial membrane and the cochlear spiral . Curr Opin Otolaryngol Head Neck Surg vol. 19 , ( 5 ) 382 - 387 .

Cortijo J, Milara J, Mata M, Donet E, Gavara N, Peel SE, Hall IP, Morcillo EJ ( 2010 ) . Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells . Chem Biol Interact vol. 183 , ( 1 ) 25 - 33 .

Gavara N, Chadwick RS ( 2010 ) . Noncontact microrheology at acoustic frequencies using frequency-modulated atomic force microscopy . Nature Methods vol. 7 , ( 8 ) 650 - 654 .

Puig F, Gavara N, Sunyer R, Carreras A, Farré R, Navajas D ( 2009 ) . Stiffening and contraction induced by dexamethasone in alveolar epithelial cells . Experimental Mechanics vol. 49 , ( 1 ) 47 - 55 .

Gavara N, Chadwick RS ( 2009 ) . Collagen-based mechanical anisotropy of the tectorial membrane: implications for inter-row coupling of outer hair cell bundles . PLoS One vol. 4 , ( 3 )

Gavara N, Roca-Cusachs P, Sunyer R, Farré R, Navajas D ( 2008 ) . Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton . Biophys J vol. 95 , ( 1 ) 464 - 471 .

Abad E, Lorente G, Gavara N, Morales M, Gual A, Gasull X ( 2008 ) . Activation of store-operated Ca(2+) channels in trabecular meshwork cells . Invest Ophthalmol Vis Sci vol. 49 , ( 2 ) 677 - 686 .

Roca-Cusachs P, Almendros I, Sunyer R, Gavara N, Farré R, Navajas D ( 2006 ) . Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy . Biophys J vol. 91 , ( 9 ) 3508 - 3518 .

Gavara N, Sunyer R, Roca-Cusachs P, Farré R, Rotger M, Navajas D ( 2006 ) . Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy . J Appl Physiol (1985) vol. 101 , ( 2 ) 512 - 520 .

Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D ( 2006 ) . Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin . Am J Physiol Lung Cell Mol Physiol vol. 290 , ( 6 ) L1104 - L1110 .

Puig F, Gavara N, Sunyer R, Navajas D, Farré R ( 2006 ) . Dexamethasone induces stiffening of alveolar epithelial cells . Journal of Biomechanics vol. 39 , s593 - s594 .

Gavara N, Puig F, Sunyer R, Farré R, Navajas D ( 2006 ) . Effects of dexamethasone in contraction of alveolar epithelial cells . Journal of Biomechanics vol. 39 ,

Rico F, Roca-Cusachs P, Gavara N, Farré R, Rotger M, Navajas D ( 2005 ) . Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips . Physical Review E - Statistical, Nonlinear, and Soft Matter Physics vol. 72 , ( 2 )

Rico F, Roca-Cusachs P, Gavara N, Farré R, Rotger M, Navajas D ( 2005 ) . Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips . Phys Rev E Stat Nonlin Soft Matter Phys vol. 72 , ( 2 Pt 1 )