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Research

Publications: Dr Nuria Gavara

Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )
Júnior C, Narciso M, Marhuenda E, Almendros I, Farré R, Navajas D, Otero J, Gavara N ( 2021 ) . Baseline stiffness modulates the non-linear response to stretch of the extracellular matrix in pulmonary fibrosis . International Journal of Molecular Sciences vol. 22 , ( 23 )
Narciso M, Otero J, Navajas D, Farré R, Almendros I, Gavara N ( 2021 ) . Image-based method to quantify decellularization of tissue sections . International Journal of Molecular Sciences vol. 22 , ( 16 )
Connelly JT, Gavara N, Sliogeryte K, Blowes LM ( 2021 ) . Research Techniques Made Simple: Analysis of Skin Cell and Tissue Mechanics Using Atomic Force Microscopy . Journal of Investigative Dermatology vol. 141 , ( 8 ) 1867 - 1871.e1 .
Gavara N ( 2021 ) . The cytoskeleton, by the numbers . EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS . vol. 50 , 63 - 63 .
Meng H, Chowdhury TT, Gavara N ( 2021 ) . The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force Microscopy . Frontiers in Cell and Developmental Biology vol. 9 ,
Ho-Pl Garo T, Huertas RL, Tamayo-Navarrete MAI, Blancaflor E, Gavara N, Garc A-Garrido JM ( 2021 ) . A Novel Putative Microtubule-Associated Protein Is Involved in Arbuscule Development during Arbuscular Mycorrhiza Formation . Plant & cell physiology vol. 62 , ( 2 ) 306 - 320 .
Narciso ML, Júnior C, Navajas D, Farre R, Otero J, Gavara N, Almendros I ( 2021 ) . Comparison Between Different Strategies for the Decellularization of Lung Slices . Conference: TP107. TP107 PULMONARY FIBROSIS: MOLECULAR AND CELLULAR MECHANISMSa4251 - a4251 .
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N et al. ( 2021 ) . The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction . Science Advances vol. 7 , ( 5 )
Keeling MC, Gavara N ( 2020 ) . Withaferin-a can be used to modulate the keratin network of intermediate filaments in human epidermal keratinocytes . International Journal of Molecular Sciences vol. 21 , ( 12 ) 1 - 11 .
Zhang, Flores, Keeling, Sliogeryte, Gavara ( 2020 ) . Ezrin Phosphorylation at T567 Modulates Cell Migration, Mechanical Properties, and Cytoskeletal Organization . International Journal of Molecular Sciences vol. 21 , ( 2 ) 435 - 435 .
Flores LR, Keeling MC, Zhang X, Sliogeryte K, Gavara N ( 2019 ) . Author Correction: Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour (Scientific Reports, (2019), 9, 1, (3241), 10.1038/s41598-019-40092-w) . Scientific Reports vol. 9 , ( 1 )
Gavara N, Sliogeryte K ( 2019 ) . Vimentin plays a crucial role in fibroblast ageing by regulating biophysical properties and cell migration . Cells
Blowes LM, Sliogeryte K, Gavara N, Connelly J ( 2019 ) . 268 Geometry-dependent chromatin remodelling in keratinocytes is altered by cell-cell adhesions . Journal of Investigative Dermatology . vol. 139 ,
GAVARA N, Flores L, KEELING M, ZHANG X, SLIOGERYTE K ( 2019 ) . Lifeact-GFP alters F-actin organization, cellular morphology and biophysical behaviour . Scientific Reports
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC ( 2018 ) . Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages . European Cells and Materials vol. 36 , 142 - 155 .
Gonzalez-Molina J, Zhang X, Borghesan M, Mendonça da Silva J, Awan M, Fuller B, Gavara N, Selden C ( 2018 ) . Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration . Biomaterials vol. 177 , 113 - 124 .
Keeling MC, Flores LR, Dodhy AH, Murray ER, Gavara N ( 2017 ) . Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization . Scientific Reports vol. 7 , ( 1 )
MATA A, Azevedo HS, Botto L, Gavara N, Su L ( 2017 ) . New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine . Current Stem Cell Reports
Gavara N ( 2017 ) . A beginner's guide to atomic force microscopy probing for cell mechanics . Microscopy Research and Technique vol. 80 , ( 1 ) 75 - 84 .
Akhtar R, Graham HK, Derby B, Sherratt MJ, Trafford AW, Chadwick RS, Gavara N ( 2016 ) . Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta . Journal of the Mechanical Behavior of Biomedical Materials vol. 64 , 10 - 17 .
Gavara N ( 2016 ) . Combined strategies for optimal detection of the contact point in AFM force-indentation curves obtained on thin samples and adherent cells . Scientific Reports vol. 6 ,
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM ( 2016 ) . Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration . Journal of Biomechanics vol. 49 , ( 2 ) 310 - 317 .
Mao X, Gavara N, Song G ( 2015 ) . Nuclear Mechanics and Stem Cell Differentiation . Stem Cell Reviews and Reports vol. 11 , ( 6 ) 804 - 812 .
Gavara N, Chadwick RS ( 2015 ) . Relationship between cell stiffness and stress fiber amount, assessed by simultaneous atomic force microscopy and live-cell fluorescence imaging . Biomech Model Mechanobiol vol. 15 , ( 3 ) 511 - 523 .
Szarama KB, Gavara N, Petralia RS, Chadwick RS, Kelley MW ( 2013 ) . Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti . BMC Dev Biol vol. 13 ,
Szarama KB, Stepanyan R, Petralia RS, Gavara N, Frolenkov GI, Kelley MW, Chadwick RS ( 2012 ) . Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti . Bioarchitecture vol. 2 , ( 6 )
Szarama KB, Gavara N, Petralia RS, Kelley MW, Chadwick RS ( 2012 ) . Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea . Journal of Cell Science vol. 125 , ( 13 ) e1 - e1 .
Szarama KB, Gavara N, Petralia RS, Kelley MW, Chadwick RS ( 2012 ) . Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea . Development (Cambridge) vol. 139 , ( 12 ) 2187 - 2197 .
Petrie RJ, Gavara N, Chadwick RS, Yamada KM ( 2012 ) . Nonpolarized signaling reveals two distinct modes of 3D cell migration . Journal of Cell Biology vol. 197 , ( 3 ) 439 - 455 .
Manoussaki D, Shin W, Gavara NC, Chadwick RS, Waterman C ( 2012 ) . A hybrid confocal & atomic force microscope for probing biophysical properties of migrating cells . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,
Petrie R, Gavara N, Chadwick RS, Yamada KM ( 2012 ) . Actomyosin cytoskeletal organization distinguishes lobopodia from lamellipodia . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,
Gavara N, Chadwick RS ( 2012 ) . Determination of the elastic moduli of thin samples and adherent cells using conical atomic force microscope tips . Nature Nanotechnology vol. 7 , ( 11 ) 733 - 736 .
Gavara N, Manoussaki D, Chadwick RS ( 2011 ) . Auditory mechanics of the tectorial membrane and the cochlear spiral . Curr Opin Otolaryngol Head Neck Surg vol. 19 , ( 5 ) 382 - 387 .
Gavara N, Chadwick RS ( 2010 ) . Noncontact microrheology at acoustic frequencies using frequency-modulated atomic force microscopy . Nature Methods vol. 7 , ( 8 ) 650 - 654 .
Cortijo J, Milara J, Mata M, Donet E, Gavara N, Peel SE, Hall IP, Morcillo EJ ( 2010 ) . Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells . Chem Biol Interact vol. 183 , ( 1 ) 25 - 33 .
Puig F, Gavara N, Sunyer R, Carreras A, Farré R, Navajas D ( 2009 ) . Stiffening and contraction induced by dexamethasone in alveolar epithelial cells . Experimental Mechanics vol. 49 , ( 1 ) 47 - 55 .
Gavara N, Chadwick RS ( 2009 ) . Collagen-based mechanical anisotropy of the tectorial membrane: implications for inter-row coupling of outer hair cell bundles . PLoS One vol. 4 , ( 3 )
Gavara N, Roca-Cusachs P, Sunyer R, Farré R, Navajas D ( 2008 ) . Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton . Biophys J vol. 95 , ( 1 ) 464 - 471 .
Abad E, Lorente G, Gavara N, Morales M, Gual A, Gasull X ( 2008 ) . Activation of store-operated Ca(2+) channels in trabecular meshwork cells . Invest Ophthalmol Vis Sci vol. 49 , ( 2 ) 677 - 686 .
Gavara N, Chadwick RS ( 2008 ) . Measurement of anisotropic mechanical properties of the tectorial membrane . Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 . 276 - 282 .
Roca-Cusachs P, Almendros I, Sunyer R, Gavara N, Farré R, Navajas D ( 2006 ) . Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy . Biophys J vol. 91 , ( 9 ) 3508 - 3518 .
Gavara N, Sunyer R, Roca-Cusachs P, Farré R, Rotger M, Navajas D ( 2006 ) . Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy . J Appl Physiol (1985) vol. 101 , ( 2 ) 512 - 520 .
Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D ( 2006 ) . Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin . Am J Physiol Lung Cell Mol Physiol vol. 290 , ( 6 ) L1104 - L1110 .
Puig F, Gavara N, Sunyer R, Navajas D, Farré R ( 2006 ) . Dexamethasone induces stiffening of alveolar epithelial cells . Journal of Biomechanics vol. 39 , s593 - s594 .
Gavara N, Puig F, Sunyer R, Farré R, Navajas D ( 2006 ) . Effects of dexamethasone in contraction of alveolar epithelial cells . Journal of Biomechanics vol. 39 ,
Rico F, Roca-Cusachs P, Gavara N, Farré R, Rotger M, Navajas D ( 2005 ) . Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips . Physical Review E - Statistical, Nonlinear, and Soft Matter Physics vol. 72 , ( 2 )
Rico F, Roca-Cusachs P, Gavara N, Farré R, Rotger M, Navajas D ( 2005 ) . Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips . Phys Rev E Stat Nonlin Soft Matter Phys vol. 72 , ( 2 Pt 1 )