Publications: Dr Sarah McClelland
Shaikh N, Mazzagatti A, De Angelis S, Johnson SC, Bakker B, Spierings DCJ, Wardenaar R, Maniati E et al.
(
2022
)
.
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
.
Genome Biology
vol.
23
,
(
1
)
Guscott M, Saha A, Maharaj J, McClelland SE
(
2022
)
.
The multifaceted role of micronuclei in tumour progression: A whole organism perspective
.
International Journal of Biochemistry and Cell Biology
vol.
152
,
Barr AR, McClelland SE
(
2022
)
.
Cells on lockdown: long-term consequences of CDK4/6 inhibition
.
EMBO Journal
vol.
41
,
(
6
)
Shaikh N, McClelland SE
(
2021
)
.
Diversity in chromosome numbers promotes resistance to chemotherapeutics
.
Developmental Cell
vol.
56
,
(
17
)
2399
-
2400
.
MacDonald C, McClelland SE
(
2021
)
.
Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution
.
Trends in Genetics
vol.
37
,
(
8
)
691
-
694
.
Moghul M, McClelland S, Rajan P
(
2021
)
.
Cellular and Immunobiology
.
Basic Urological Sciences
,
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al.
(
2020
)
.
Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma
.
Cancer Research
Graham TA, McClelland SE
(
2020
)
.
Strands of evidence about cancer evolution
.
Nature
vol.
583
,
(
7815
)
207
-
209
.
Tovini L, McClelland SE
(
2020
)
.
Towards restoring proper chromosome segregation and preventing ageing
.
EMBO Reports
vol.
21
,
(
5
)
Dumont M, Gamba R, Gestraud P, Klaasen S, Worrall JT, De Vries SG, Boudreau V, Salinas-Luypaert C et al.
(
2020
)
.
Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features
.
EMBO Journal
vol.
39
,
(
2
)
McClelland SE
(
2019
)
.
Single-cell approaches to understand genome organisation throughout the cell cycle
.
Essays in Biochemistry
vol.
63
,
(
2
)
209
-
216
.
Johnson SC, McClelland SE
(
2019
)
.
Watching cancer cells evolve through chromosomal instability
.
Nature
vol.
570
,
(
7760
)
166
-
167
.
Tijhuis AE, Johnson SC, McClelland SE
(
2019
)
.
The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
.
Molecular Cytogenetics
vol.
12
,
(
1
)
Tovini L, McClelland SE
(
2019
)
.
Impaired CENP-E function renders large chromosomes more vulnerable to congression failure
.
Biomolecules
vol.
9
,
(
2
)
Currie CE, Mora-Santos M, Smith CA, McClelland SE, McAinsh AD, Millar JB
(
2018
)
.
Elucidating the role of Bub1 in human checkpoint signalling
.
MOLECULAR BIOLOGY OF THE CELL
.
vol.
29
,
Worrall JT, Tamura N, Mazzagatti A, Shaikh N, van Lingen T, Bakker B, Spierings DCJ, Vladimirou E et al.
(
2018
)
.
Non-random Mis-segregation of Human Chromosomes
.
Cell Reports
vol.
23
,
(
11
)
3366
-
3380
.
McClelland SE
(
2017
)
.
Role of chromosomal instability in cancer progression
.
Endocr Relat Cancer
vol.
24
,
(
9
)
T23
-
T31
.
Worrall JT, McClelland SE
(
2016
)
.
Determining the Missegregation Rates of Individual Human Chromosomes
.
CYTOGENETIC AND GENOME RESEARCH
.
vol.
148
,
131
-
131
.
Worrall JT, McClelland SE
(
2016
)
.
Determining the missegregation rates of individual human chromosomes
.
MOLECULAR BIOLOGY OF THE CELL
.
vol.
27
,
Tamura N, Shaikh N, McGuinness JR, Bowtell D, Balkwill F, Petermann E, McClelland SE
(
2016
)
.
What drives chromosomal instability in high-grade serous ovarian cancer?
.
MOLECULAR BIOLOGY OF THE CELL
.
vol.
27
,
Burrell RA, McClelland SE, Bartek J, Swanton C
(
2014
)
.
Response to Bakhoum et al
.
Curr Biol
vol.
24
,
(
4
)
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N et al.
(
2013
)
.
Erratum: Replication stress links structural and numerical cancer chromosomal instability (Nature (2013) 494 (492-496) DOI: 10.1038/nature11935)
.
Nature
vol.
500
,
(
7463
)
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller M-C, Shaikh N, Domingo E, Kanu N et al.
(
2013
)
.
Replication stress links structural and numerical cancer chromosomal instability
.
Nature
vol.
494
,
(
7438
)
492
-
496
.
Burrell RA, McClelland SE, Endesfelder D, Rowan A, Schenk A, Sheffer M, Shaikh N, Domingo E et al.
(
2012
)
.
Abstract 3105: Chromosome 18q encodes a chromosomal instability suppressor locus in colorectal cancer
.
Cancer Research
.
vol.
72
,
3105
-
3105
.
Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, Tan IB, Richardson AL et al.
(
2011
)
.
Paradoxical relationship between chromosomal instability and survival outcome in cancer
.
Cancer Research
vol.
71
,
(
10
)
3447
-
3452
.
Jaqaman K, King EM, Amaro AC, Winter JR, Dorn JF, Elliott HL, Mchedlishvili N, McClelland SE et al.
(
2010
)
.
Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases
.
Journal of Cell Biology
vol.
188
,
(
5
)
665
-
679
.
Burrell RA, McClelland SE, Juul N, Downward J, Szallasi Z, Swanton C
(
2009
)
.
Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo
.
CANCER RESEARCH
.
vol.
69
,
641S
-
641S
.
Burrell R, McClelland S, Juul N, Downward J, Szallasi Z, Szallasi Z, Swanton C, Swanton C
(
2009
)
.
Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo
.
Cancer Research
.
vol.
69
,
2151
-
2151
.
McClelland SE, McAinsh AD
(
2009
)
.
Hydrodynamic analysis of human kinetochore complexes during mitosis
.
Methods in Molecular Biology
vol.
545
,
81
-
98
.
McClelland SE, Burrell RA, Swanton C
(
2009
)
.
Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy
.
Cell Cycle
vol.
8
,
(
20
)
3262
-
3266
.
McClelland SE, Borusu S, Amaro AC, Winter JR, Belwal M, McAinsh AD, Meraldi P
(
2007
)
.
The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
.
EMBO Journal
vol.
26
,
(
24
)
5033
-
5047
.
Xu C, Losytskyy MY, Kovalska VB, Kryvorotenko DV, Yarmoluk SM, McClelland S, Bianco PR
(
2007
)
.
Novel, monomeric cyanine dyes as reporters for DNA helicase activity
.
Journal of Fluorescence
vol.
17
,
(
6
)
671
-
685
.
Porter IM, McClelland SE, Khoudoli GA, Hunter CJ, Andersen JS, McAinsh AD, Blow JJ, Swedlow JR
(
2007
)
.
Bod1, a novel kinetochore protein required for chromosome biorientation
.
Journal of Cell Biology
vol.
179
,
(
2
)
187
-
197
.
McClelland SE, Dryden DTF, Szczelkun MD
(
2005
)
.
Continuous assays for DNA translocation using fluorescent triplex dissociation: Application to type I restriction endonucleases
.
Journal of Molecular Biology
vol.
348
,
(
4
)
895
-
915
.