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Research

Publications: Prof Anthony Michael

Michael AE ( 2023 ) . Steroid Hormones and Prostaglandins . Part 1 MRCOG Synoptic Revision Guide , Cambridge University Press (CUP)
Michael AE, Thurston LM, Fowkes RC ( 2019 ) . Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells . Biology vol. 8 , ( 4 )
Hannen R, Udeh-Momoh C, Upton J, Wright M, Michael A, Gulati A, Rajpopat S, Clayton N et al. ( 2017 ) . Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis . Journal of Investigative Dermatology vol. 137 , ( 8 ) 1630 - 1637 .
Michael AE, Glenn C, Wood PJ, Webb RJ, Pellatt L, Mason HD ( 2013 ) . Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Is Suppressed in Women With Anovulatory Polycystic Ovary Syndrome (PCOS): Apparent Role for Ovarian Androgens . The Journal of Clinical Endocrinology & Metabolism vol. 98 , ( 8 ) 3375 - 3383 .
Cabrera-Sharp V, Mirczuk SM, Shervill E, Michael AE, Fowkes RC ( 2013 ) . Regulation of glucocorticoid metabolism in the boar testis and caput epididymidis by the gonadotrophin-cAMP signalling pathway . Cell and Tissue Research vol. 352 , ( 3 ) 751 - 760 .
Mukherjee S, James JL, Thilaganathan B, Whitley, Michael AE, Cartwright JE ( 2011 ) . Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia . Placenta vol. 32 , ( 9 ) 687 - 693 .
Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP ( 2010 ) . Steroid synthesis by primary human keratinocytes; implications for skin disease . Biochemical and Biophysical Research Communications vol. 404 , ( 1 ) 62 - 67 .
Sharp V, Thurston LM, Fowkes RC, Michael AE ( 2009 ) . Expression and activities of 11βHSD enzymes in the testes and reproductive tracts of sexually immature male pigs . The Journal of Steroid Biochemistry and Molecular Biology vol. 115 , ( 3-5 ) 98 - 106 .
Webb RJ, Sunak N, Wren L, Michael AE ( 2008 ) . Inactivation of glucocorticoids by 11β-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes . Reproduction vol. 136 , ( 6 ) 725 - 732 .
Michael AE, Papageorghiou AT ( 2008 ) . Potential significance of physiological and pharmacological glucocorticoids in early pregnancy . Human Reproduction Update vol. 14 , ( 5 ) 497 - 517 .
Hannen RF, Michael AE, Burrin J, Philpott MP ( 2008 ) . StAR role for glucocorticoid synthesis in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 881 - 881 .
Hannen RF, Michael AE, Burrin JM, Philpott M ( 2007 ) . Human skin and keratinocytes express cholesterol transporters and primary keratinocytes are capable of metabolising progesterone into cortisol . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S60 - S60 .
Sharp V, Thurston LM, Fowkes RC, Michael AE ( 2007 ) . 11β-Hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology . Reproduction vol. 134 , ( 3 ) 473 - 482 .
Chandras C, Harris TE, Bernal AL, Abayasekara DRE, Michael AE ( 2007 ) . PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells . Journal of Endocrinology vol. 194 , ( 3 ) 595 - 602 .
Sunak N, Green DF, Abeydeera LR, Thurston LM, Michael AE ( 2007 ) . Implication of cortisol and 11β-hydroxysteroid dehydrogenase enzymes in the development of porcine (Sus scrofa domestica) ovarian follicles and cysts . Reproduction vol. 133 , ( 6 ) 1149 - 1158 .
Thurston LM, Abayasekara DRE, Michael AE ( 2007 ) . 11β-Hydroxysteroid dehydrogenase expression and activities in bovine granulosa cells and corpora lutea implicate corticosteroids in bovine ovarian physiology . Journal of Endocrinology vol. 193 , ( 2 ) 299 - 310 .
Jonas KC, Chandras C, Abayasekara DRE, Michael AE ( 2006 ) . Role for Prostaglandins in the Regulation of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Granulosa-Lutein Cells . Endocrinology vol. 147 , ( 12 ) 5865 - 5872 .
McMullen S, Osgerby JC, Thurston LM, Gadd TS, Wood PJ, Wathes DC, Michael AE ( 2004 ) . Alterations in placental 11β-hydroxysteroid dehydrogenase (11βHSD) activities and fetal cortisol:cortisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes . Reproduction vol. 127 , ( 6 ) 717 - 725 .
Michael AE ( 2003 ) . Life after liquorice: the link between cortisol and conception . Reproductive BioMedicine Online vol. 7 , ( 6 ) 683 - 690 .