Publications: Ms Stavroula Kanoni

Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K et al. ( 2024 ) . Genetic architecture of routinely acquired blood tests in a British South Asian cohort . Nature Communications vol. 15 , ( 1 )

Monti R, Eick L, Hudjashov G, Läll K, Kanoni S, Wolford BN, Wingfield B, Pain O et al. ( 2024 ) . Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning . American Journal of Human Genetics vol. 111 , ( 7 ) 1431 - 1447 .

Jermy B, Läll K, Wolford BN, Wang Y, Zguro K, Cheng Y, Kanai M, Kanoni S et al. ( 2024 ) . A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk . Nature Communications vol. 15 , ( 1 )

Smith JL, Tcheandjieu C, Dikilitas O, Iyer K, Miyazawa K, Hilliard A, Lynch J, Rotter JI et al. ( 2024 ) . Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization . Circulation Genomic and Precision Medicine vol. 17 , ( 3 )

( 2024 ) . Genetic drivers of heterogeneity in type 2 diabetes pathophysiology . Nature vol. 627 , ( 8003 ) 347 - 357 .

Williams AT, Chen J, Coley K, Batini C, Izquierdo A, Packer R, Abner E, Kanoni S et al. ( 2023 ) . Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease . Nature Communications vol. 14 , ( 1 )

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

Kanai M, Andrews SJ, Cordioli M, Stevens C, Neale BM, Daly M, Ganna A, Chwialkowska K et al. ( 2023 ) . A second update on mapping the human genetic architecture of COVID-19 . Nature vol. 621 , ( 7977 ) e7 - e26 .

Adlam D, Berrandou T-E, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M et al. ( 2023 ) . Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation . Nature Genetics vol. 55 , ( 6 ) 964 - 972 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Visvikis-Siest S, Stathopoulou MG, Sunder-Plassmann R, Alizadeh BZ, Barouki R, Chatzaki E, Dagher G, Dedoussis G et al. ( 2023 ) . The 10th Santorini conference: Systems medicine, personalised health and therapy. “The odyssey from hope to practice: Patient first. Keep Ithaca always in your mind”, Santorini, Greece, 23–26 May 2022 . Frontiers in Genetics vol. 14 ,

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M et al. ( 2022 ) . Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants . Nature Genetics vol. 54 , ( 12 ) 1803 - 1815 .

Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945 .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Dam V, Onland-Moret NC, Burgess S, Chirlaque M-D, Peters SAE, Schuit E, Tikk K, Weiderpass E et al. ( 2022 ) . Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization . The Journal of Clinical Endocrinology & Metabolism vol. 107 , ( 7 ) e2952 - e2961 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Brown MJ, Alazawi W, Kanoni S ( 2021 ) . Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 . New England Journal of Medicine vol. 385 , ( 12 ) 1147 - 1149 .

Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Davis L, Lee S et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .

Kanoni S, Kumar S, Amerikanou C, Kurth MJ, Stathopoulou MG, Bourgeois S, Masson C, Kannt A et al. ( 2021 ) . Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD . Frontiers in Immunology vol. 12 ,

Amerikanou C, Kanoni S, Kaliora AC, Barone A, Bjelan M, D'Auria G, Gioxari A, Gosalbes MJ et al. ( 2021 ) . Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial . Molecular Nutrition & Food Research vol. 65 , ( 10 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 53 , ( 5 ) 762 - 762 .

Giardoglou P, Bournele D, Park M, Kanoni S, Dedoussis GV, Steinberg SF, Deloukas P, Beis D ( 2021 ) . A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2 . Biology Open vol. 10 , ( 3 )

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J et al. ( 2021 ) . Genome-wide association study of circulating interleukin 6 levels identifies novel loci . Human Molecular Genetics . vol. 30 , 393 - 409 .

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A et al. ( 2020 ) . Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus . Circulation: Genomic and Precision Medicine vol. 13 , ( 6 ) 640 - 648 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .

Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J, Watkins H, Samani NJ, Deloukas P et al. ( 2019 ) . Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases . Journal of the American College of Cardiology vol. 73 , ( 23 ) 2932 - 2942 .

Vackova Z, Niebisch S, Triantafyllou T, Becker J, Hess T, Kreuser N, Kanoni S, Deloukas P et al. ( 2019 ) . First genotype‐phenotype study reveals HLA‐DQβ1 insertion heterogeneity in high‐resolution manometry achalasia subtypes . United European Gastroenterology Journal vol. 7 , ( 1 ) 45 - 51 .

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2019 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S et al. ( 2019 ) . Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection . Journal of the American College of Cardiology vol. 73 , ( 1 ) 58 - 66 .

Aragam KG, Jiang T, Kanoni S, Anuj G, Wolford B, Surakka I, Grace C, Thorleifsson G et al. ( 2019 ) . Genome-Wide Association Study of Over One Million Participants Identifies 49 Novel Loci Associated With Coronary Artery Disease . CIRCULATION . vol. 140 ,

Giannakopoulou O, Kanoni S, Giardoglou P, Kelaidoni K, Dedoussis G, Deloukas P ( 2019 ) . Genome-wide association analysis of recurrent myocardial infarction in UK Biobank identifies suggestive evidence for association to twenty seven loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 159 - 160 .

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry

Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE et al. ( 2018 ) . Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium . Molecular Psychiatry vol. 24 , ( 12 ) 1920 - 1932 .

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EGY et al. ( 2018 ) . GWAS meta-analysis yields novel insights into the biology of male-pattern baldness . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 26 , 761 - 762 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .

Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M et al. ( 2017 ) . Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts . PLoS One vol. 12 , ( 12 ) e0186456 - e0186456 .

Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, Rentari A, Dimitriou M et al. ( 2017 ) . Evaluating the glucose raising effect of established loci via a genetic risk score . PLoS One vol. 12 , ( 11 ) Article 0186669 , e0186669 - e0186669 .

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Wheeler E, Leong A, Liu C-T, Hivert M-F, Strawbridge RJ, Podmore C, Li M, Yao J et al. ( 2017 ) . Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis . PLOS Medicine vol. 14 , ( 9 )

Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ et al. ( 2017 ) . Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk . PLoS One vol. 12 , ( 8 ) e0182999 - e0182999 .

Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I et al. ( 2017 ) . Association analyses based on false discovery rate implicate new loci for coronary artery disease . Nature Genetics vol. 49 , ( 9 ) 1385 - 1391 .

Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K et al. ( 2017 ) . Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions . Circulation vol. 135 , ( 24 ) 2336 - 2353 .

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X et al. ( 2017 ) . Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits . Nat Commun vol. 8 , 14977 - 14977 .

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EGY et al. ( 2017 ) . Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness . Nature Communications vol. 8 , ( 1 )

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NGD, Jansen H, Kanoni S, Nelson CP et al. ( 2017 ) . Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease . J Am Coll Cardiol vol. 69 , ( 7 ) 823 - 836 .

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G et al. ( 2016 ) . A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape . Nature Communications vol. 7 , 13357 - 13357 .

Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF et al. ( 2016 ) . Genome-wide analysis identifies 12 loci influencing human reproductive behavior . Nature Genetics vol. 48 , ( 12 ) 1462 - 1472 .

Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC et al. ( 2016 ) . No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis . Sci Rep vol. 6 , 35278 - 35278 .

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2016 ) . Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLoS Genet vol. 12 , ( 6 ) e1006166 - e1006166 .

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen G-B et al. ( 2016 ) . Genome-wide association study identifies 74 loci associated with educational attainment . Nature vol. 533 , ( 7604 ) 539 - 542 .

Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR et al. ( 2016 ) . Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease . New England Journal of Medicine vol. 374 , ( 12 ) 1134 - 1144 .

Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z et al. ( 2016 ) . New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk . Nature Communications vol. 7 , ( 1 )

Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, Koenig IR, Weeke PE, Webb TR et al. ( 2016 ) . Coding Variation in <i>ANGPTL4</i>, <i>LPL</i>, and <i>SVEP1</i> and the Risk of Coronary Disease (vol 374, pg 1134, 2016) . NEW ENGLAND JOURNAL OF MEDICINE vol. 374 , ( 19 ) 1898 - 1898 .

Marouli E, Kanoni S, Dimitriou M, Kolovou G, Deloukas P, Dedoussis G ( 2015 ) . Lifestyle may modify the glucose-raising effect of genetic loci. A study in the Greek population . Nutrition Metabolism and Cardiovascular Diseases vol. 26 , ( 3 ) 201 - 206 .

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2015 ) . The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLOS Genetics vol. 11 , ( 10 )

Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV et al. ( 2015 ) . Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians 1 , 2 . American Journal of Clinical Nutrition vol. 102 , ( 5 ) 1266 - 1278 .

( 2015 ) . A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease . Nature Genetics vol. 47 , ( 10 ) 1121 - 1130 .

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al. ( 2015 ) . Directional dominance on stature and cognition in diverse human populations . Nature vol. 523 , ( 7561 ) 459 - 462 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry vol. 20 , ( 5 ) 647 - 656 .

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T et al. ( 2015 ) . Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry . Human Molecular Genetics vol. 24 , ( 16 ) 4728 - 4738 .

Coffee and Caffeine Genetics Consortium, Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Mol Psychiatry vol. 20 , ( 5 ) 647 - 656 .

Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, de Geus EJC, Hemani G et al. ( 2015 ) . The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects . Molecular Psychiatry vol. 20 , ( 6 ) 735 - 743 .

Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Assimes TL, Kanoni S, Willenborg C et al. ( 2015 ) . Genetically Determined Height and Coronary Artery Disease . New England Journal of Medicine vol. 372 , ( 17 ) 1608 - 1618 .

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al. ( 2015 ) . New genetic loci link adipose and insulin biology to body fat distribution . Nature vol. 518 , ( 7538 ) 187 - 196 .

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY et al. ( 2014 ) . FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals . Hum Mol Genet vol. 23 , ( 25 ) 6961 - 6972 .

Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF et al. ( 2014 ) . Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants 2–4 . American Journal of Clinical Nutrition vol. 101 , ( 1 ) 135 - 143 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nat Genet vol. 46 , ( 11 ) 1173 - 1186 .

Tsaprouni LG, Yang T-P, Bell J, Dick KJ, Kanoni S, Nisbet J, Viñuela A, Grundberg E et al. ( 2014 ) . Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation . Epigenetics vol. 9 , ( 10 ) 1382 - 1396 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2014 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry

Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes and Nutrition vol. 9 , ( 5 )

Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes Nutr vol. 9 , ( 5 )

de Zeeuw EL, van Beijsterveldt CEM, Glasner TJ, Bartels M, Ehli EA, Davies GE, Hudziak JJ, Rietveld CA et al. ( 2014 ) . Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children . American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics vol. 165 , ( 6 ) 510 - 520 .

TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute, Crosby J, Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y et al. ( 2014 ) . Loss-of-function mutations in APOC3, triglycerides, and coronary disease . N Engl J Med vol. 371 , ( 1 ) 22 - 31 .

Giacconi R, Costarelli L, Malavolta M, Piacenza F, Galeazzi R, Gasparini N, Basso A, Mariani E et al. ( 2014 ) . Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population . Biogerontology vol. 15 , ( 1 ) 65 - 79 .

Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD et al. ( 2014 ) . Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility . NATURE GENETICS vol. 46 , ( 3 ) 234 - + .

Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes and Nutrition vol. 9 , ( 5 )

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al. ( 2014 ) . Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index . PLoS Genetics vol. 10 , ( 7 ) 1 - 12 .

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nature Genetics vol. 45 , ( 11 ) 1345 - 1353 .

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nat Genet vol. 45 , ( 11 ) 1345 - 1352 .

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J et al. ( 2013 ) . Discovery and refinement of loci associated with lipid levels . Nat Genet vol. 45 , ( 11 ) 1274 - 1283 .

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Consortium GIOAT, Berndt SI, Gustafsson S, Mägi R et al. ( 2013 ) . Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics . American Journal of Human Genetics vol. 93 , ( 2 ) 236 - 248 .

Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra H-J, Shakhbazov K et al. ( 2013 ) . GWAS of 126,559 individuals identifies genetic variants associated with educational attainment . Science vol. 340 , ( 6139 ) 1467 - 1471 .

Heilmann S, Kiefer AK, Fricker N, Drichel D, Hillmer AM, Herold C, Tung JY, Eriksson N et al. ( 2013 ) . Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology . J Invest Dermatol vol. 133 , ( 6 ) 1489 - 1496 .

Tanaka T, Ngwa JS, van Rooij FJA, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S et al. ( 2013 ) . Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake . Am J Clin Nutr vol. 97 , ( 6 ) 1395 - 1402 .

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al. ( 2013 ) . Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits . PLoS Genetics vol. 9 , ( 6 )

Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF et al. ( 2013 ) . Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies . J Nutr vol. 143 , ( 3 ) 345 - 353 .

Nettleton JA, Hivert M-F, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A et al. ( 2013 ) . Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts . Am J Epidemiol vol. 177 , ( 2 ) 103 - 115 .

Song C, Pedersen NL, Reynolds CA, Sabater-Lleal M, Kanoni S, Willenborg C, CARDIoGRAMplusC4D Consortium, Syvänen A-C et al. ( 2013 ) . Genetic variants from lipid-related pathways and risk for incident myocardial infarction . PLoS One vol. 8 , ( 3 )

Berndt SI, Gustafsson S, Maegi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al. ( 2013 ) . Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . NATURE GENETICS vol. 45 , ( 5 ) 501 - U69 .

CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E et al. ( 2013 ) . Large-scale association analysis identifies new risk loci for coronary artery disease . Nat Genet vol. 45 , ( 1 ) 25 - 33 .

van der Loos MJHM, Rietveld CA, Eklund N, Koellinger PD, Rivadeneira F, Abecasis GR, Ankra-Badu GA, Baumeister SE et al. ( 2013 ) . The molecular genetic architecture of self-employment . PLoS One vol. 8 , ( 4 )

van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U et al. ( 2012 ) . Seventy-five genetic loci influencing the human red blood cell . Nature vol. 492 , ( 7429 ) 369 - 375 .

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