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Research

Publications: Ms Stavroula Kanoni

Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Paula Longhi M, Vyas VS et al. ( 2022 ) . Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .
Dam V, Onland-Moret NC, Burgess S, Chirlaque MD, Peters SAE, Schuit E, Tikk K, Weiderpass E et al. ( 2022 ) . Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization . Journal of Clinical Endocrinology and Metabolism vol. 107 , ( 7 ) E2952 - E2961 .
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen A et al. ( 2022 ) . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke S, Bhatti KF et al. ( 2021 ) . Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis .
Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Pathak GA, Andrews SJ et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke S et al. ( 2021 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids .
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9) . Nature Communications vol. 12 , ( 1 )
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )
Brown MJ, Alazawi W, Kanoni S ( 2021 ) . Interleukin-6 receptor antagonists in critically ill patients with covid-19 . New England Journal of Medicine vol. 385 , ( 12 )
Aragam K, Jiang T, Goel A, Kanoni S, Wolford B, Weeks E, Wang M, Hindy G et al. ( 2021 ) . Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants .
Kanoni S, Kumar S, Amerikanou C, Kurth MJ, Stathopoulou MG, Bourgeois S, Masson C, Kannt A et al. ( 2021 ) . Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD . Frontiers in Immunology vol. 12 ,
Amerikanou C, Kanoni S, Kaliora AC, Barone A, Bjelan M, D'Auria G, Gioxari A, Gosalbes MJ et al. ( 2021 ) . Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial . Molecular Nutrition and Food Research vol. 65 , ( 10 )
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x) . Nature Genetics vol. 53 , ( 5 )
Giardoglou P, Bournele D, Park M, Kanoni S, Dedoussis GV, Steinberg SF, Deloukas P, Beis D ( 2021 ) . A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2 . Biology Open vol. 10 , ( 3 )
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J et al. ( 2021 ) . Genome-wide association study of circulating interleukin 6 levels identifies novel loci . Human Molecular Genetics . vol. 30 , 393 - 409 .
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2020 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .
Van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A et al. ( 2020 ) . Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus . Circulation: Genomic and Precision Medicine vol. 13 , ( 6 ) 640 - 648 .
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE et al. ( 2019 ) . Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium . Molecular Psychiatry vol. 24 , ( 12 ) 1920 - 1932 .
Ng N, Willems S, Fernandez J, Fine R, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2019 ) . Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x) . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .
Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J, Watkins H, Samani NJ, Deloukas P et al. ( 2019 ) . Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases . Journal of the American College of Cardiology vol. 73 , ( 23 ) 2932 - 2942 .
Vackova Z, Niebisch S, Triantafyllou T, Becker J, Hess T, Kreuser N, Kanoni S, Deloukas P et al. ( 2019 ) . First genotype-phenotype study reveals HLA-DQβ1 insertion heterogeneity in high-resolution manometry achalasia subtypes . United European Gastroenterology Journal vol. 7 , ( 1 ) 45 - 51 .
Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S et al. ( 2019 ) . Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection . Journal of the American College of Cardiology vol. 73 , ( 1 ) 58 - 66 .
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry
Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M et al. ( 2017 ) . Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts . PLoS One vol. 12 , ( 12 ) e0186456 - e0186456 .
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .
Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, Rentari A, Dimitriou M et al. ( 2017 ) . Evaluating the glucose raising effect of established loci via a genetic risk score . PLoS One vol. 12 , ( 11 ) Article 0186669 , e0186669 - e0186669 .
Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I et al. ( 2017 ) . Association analyses based on false discovery rate implicate new loci for coronary artery disease . Nature Genetics vol. 49 , ( 9 ) 1385 - 1391 .
Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J et al. ( 2017 ) . Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis . PLoS Medicine vol. 14 , ( 9 )
Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ et al. ( 2017 ) . Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk . PLoS One vol. 12 , ( 8 ) e0182999 - e0182999 .
Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K et al. ( 2017 ) . Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions . Circulation vol. 135 , ( 24 ) 2336 - 2353 .
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X et al. ( 2017 ) . Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits . Nat Commun vol. 8 , 14977 - 14977 .
Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EGY et al. ( 2017 ) . Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness . Nature Communications vol. 8 ,
Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NGD, Jansen H, Kanoni S, Nelson CP et al. ( 2017 ) . Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease . J Am Coll Cardiol vol. 69 , ( 7 ) 823 - 836 .
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .
Barban N, Jansen R, De Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF et al. ( 2016 ) . Genome-wide analysis identifies 12 loci influencing human reproductive behavior . Nature Genetics vol. 48 , ( 12 ) 1462 - 1472 .
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G et al. ( 2016 ) . A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape . Nature Communications vol. 7 , 13357 - 13357 .
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC et al. ( 2016 ) . No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis . Sci Rep vol. 6 , 35278 - 35278 .
MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics
Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2016 ) . Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLoS Genet vol. 12 , ( 6 ) e1006166 - e1006166 .
Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen G-B et al. ( 2016 ) . Genome-wide association study identifies 74 loci associated with educational attainment . Nature vol. 533 , ( 7604 ) 539 - 542 .
Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR et al. ( 2016 ) . Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease . New England Journal of Medicine vol. 374 , ( 12 ) 1134 - 1144 .
Marouli E, Kanoni S, Dimitriou M, Kolovou G, Deloukas P, Dedoussis G ( 2016 ) . Lifestyle may modify the glucose-raising effect of genetic loci. A study in the Greek population . Nutrition, Metabolism and Cardiovascular Diseases vol. 26 , ( 3 ) 201 - 206 .
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z et al. ( 2016 ) . New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk . Nature Communications vol. 7 ,
Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV et al. ( 2015 ) . Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: A meta-analysis of 50,345 Caucasians . American Journal of Clinical Nutrition vol. 102 , ( 5 ) 1266 - 1278 .
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2015 ) . The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLoS genetics vol. 11 , ( 10 )
Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T et al. ( 2015 ) . A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease . Nature Genetics vol. 47 , ( 10 ) 1121 - 1130 .
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al. ( 2015 ) . Directional dominance on stature and cognition in diverse human populations . Nature vol. 523 , ( 7561 ) 459 - 462 .
Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, De Geus EJC, Hemani G et al. ( 2015 ) . The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects . Molecular Psychiatry vol. 20 , ( 6 ) 735 - 743 .
Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry vol. 20 , ( 5 ) 647 - 656 .
Coffee and Caffeine Genetics Consortium, Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Mol Psychiatry vol. 20 , ( 5 ) 647 - 656 .
Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T et al. ( 2015 ) . Gene × dietary pattern interactions in obesity: Analysis of up to 68 317 adults of European ancestry . Human Molecular Genetics vol. 24 , ( 16 ) 4728 - 4738 .
Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Assimes TL, Kanoni S, Willenborg C et al. ( 2015 ) . Genetically determined height and coronary artery disease . New England Journal of Medicine vol. 372 , ( 17 ) 1608 - 1618 .
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al. ( 2015 ) . New genetic loci link adipose and insulin biology to body fat distribution . Nature vol. 518 , ( 7538 ) 187 - 196 .
Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF et al. ( 2015 ) . Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants . American Journal of Clinical Nutrition vol. 101 , ( 1 ) 135 - 143 .
Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY et al. ( 2014 ) . FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals . Hum Mol Genet vol. 23 , ( 25 ) 6961 - 6972 .
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nat Genet vol. 46 , ( 11 ) 1173 - 1186 .
Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2014 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry
Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes and Nutrition vol. 9 , ( 5 )
Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes Nutr vol. 9 , ( 5 )
de Zeeuw EL, van Beijsterveldt CEM, Glasner TJ, Bartels M, Ehli EA, Davies GE, Hudziak JJ, Rietveld CA et al. ( 2014 ) . Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children . American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics vol. 165 , ( 6 ) 510 - 520 .
TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute, Crosby J, Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y et al. ( 2014 ) . Loss-of-function mutations in APOC3, triglycerides, and coronary disease . N Engl J Med vol. 371 , ( 1 ) 22 - 31 .
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD et al. ( 2014 ) . Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility . NATURE GENETICS vol. 46 , ( 3 ) 234 - + .
Giacconi R, Costarelli L, Malavolta M, Piacenza F, Galeazzi R, Gasparini N, Basso A, Mariani E et al. ( 2014 ) . Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population . Biogerontology vol. 15 , ( 1 ) 65 - 79 .
Tsaprouni LG, Yang TP, Bell J, Dick KJ, Kanoni S, Nisbet J, Viñuela A, Grundberg E et al. ( 2014 ) . Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation . Epigenetics vol. 9 , ( 10 ) 1382 - 1396 .
Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A et al. ( 2014 ) . Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation . Genes and Nutrition vol. 9 , ( 5 )
Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al. ( 2014 ) . Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index . PLoS Genetics vol. 10 , ( 7 ) 1 - 12 .
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nature Genetics vol. 45 , ( 11 ) 1345 - 1353 .
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nat Genet vol. 45 , ( 11 ) 1345 - 1352 .
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J et al. ( 2013 ) . Discovery and refinement of loci associated with lipid levels . Nat Genet vol. 45 , ( 11 ) 1274 - 1283 .
Hu YJ, Berndt SI, Gustafsson S, Ganna A, Ingelsson E, Hirschhorn J, North KE, Lin DY et al. ( 2013 ) . Meta-analysis of gene-level associations for rare variants based on single-variant statistics . American Journal of Human Genetics vol. 93 , ( 2 ) 236 - 248 .
Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra H-J, Shakhbazov K et al. ( 2013 ) . GWAS of 126,559 individuals identifies genetic variants associated with educational attainment . Science vol. 340 , ( 6139 ) 1467 - 1471 .
Heilmann S, Kiefer AK, Fricker N, Drichel D, Hillmer AM, Herold C, Tung JY, Eriksson N et al. ( 2013 ) . Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology . J Invest Dermatol vol. 133 , ( 6 ) 1489 - 1496 .
Tanaka T, Ngwa JS, van Rooij FJA, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S et al. ( 2013 ) . Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake . Am J Clin Nutr vol. 97 , ( 6 ) 1395 - 1402 .
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al. ( 2013 ) . Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits . PLoS Genetics vol. 9 , ( 6 )
Berndt SI, Gustafsson S, Maegi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al. ( 2013 ) . Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . NATURE GENETICS vol. 45 , ( 5 ) 501 - U69 .
Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF et al. ( 2013 ) . Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies . J Nutr vol. 143 , ( 3 ) 345 - 353 .
Nettleton JA, Hivert M-F, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A et al. ( 2013 ) . Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts . Am J Epidemiol vol. 177 , ( 2 ) 103 - 115 .
Song C, Pedersen NL, Reynolds CA, Sabater-Lleal M, Kanoni S, Willenborg C, CARDIoGRAMplusC4D Consortium, Syvänen A-C et al. ( 2013 ) . Genetic variants from lipid-related pathways and risk for incident myocardial infarction . PLoS One vol. 8 , ( 3 )
CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E et al. ( 2013 ) . Large-scale association analysis identifies new risk loci for coronary artery disease . Nat Genet vol. 45 , ( 1 ) 25 - 33 .
van der Loos MJHM, Rietveld CA, Eklund N, Koellinger PD, Rivadeneira F, Abecasis GR, Ankra-Badu GA, Baumeister SE et al. ( 2013 ) . The molecular genetic architecture of self-employment . PLoS One vol. 8 , ( 4 )
van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U et al. ( 2012 ) . Seventy-five genetic loci influencing the human red blood cell . Nature vol. 492 , ( 7429 ) 369 - 375 .
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics vol. 44 , ( 9 ) 991 - 1005 .
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H et al. ( 2012 ) . Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes . Nat Genet vol. 44 , ( 9 ) 981 - 990 .
Manning AK, Hivert M-F, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu C-T et al. ( 2012 ) . A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance . NATURE GENETICS vol. 44 , ( 6 ) 659 - U81 .
Li R, Brockschmidt FF, Kiefer AK, Stefansson H, Nyholt DR, Song K, Vermeulen SH, Kanoni S et al. ( 2012 ) . Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases . PLoS Genet vol. 8 , ( 5 )
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN et al. ( 2012 ) . A genome-wide association search for type 2 diabetes genes in African Americans . PLoS One vol. 7 , ( 1 )
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics
Stathopoulou MG, Kanoni S, Papanikolaou G, Antonopoulou S, Nomikos T, Dedoussis G ( 2012 ) . Mineral intake . Prog Mol Biol Transl Sci vol. 108 , 201 - 236 .
Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM et al. ( 2012 ) . Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals . PLoS Genet vol. 8 , ( 3 )
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U et al. ( 2011 ) . New gene functions in megakaryopoiesis and platelet formation . NATURE vol. 480 , ( 7376 ) 201 - 208 .
Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S et al. ( 2011 ) . Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children . PLoS Med vol. 8 , ( 11 )
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME et al. ( 2011 ) . Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes . Diabetes vol. 60 , ( 10 ) 2624 - 2634 .
Kanoni S, Nettleton JA, Hivert M-F, Ye Z, van Rooij FJA, Shungin D, Sonestedt E, Ngwa JS et al. ( 2011 ) . Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis . Diabetes vol. 60 , ( 9 ) 2407 - 2416 .
Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S et al. ( 2011 ) . Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children . Diabetes vol. 60 , ( 6 ) 1805 - 1812 .
Dedoussis GVZ, Yannakoulia M, Timpson NJ, Manios Y, Kanoni S, Scott RA, Papoutsakis C, Deloukas P et al. ( 2011 ) . Does a short breastfeeding period protect from FTO-induced adiposity in children? . Int J Pediatr Obes vol. 6 , ( 2-2 ) e326 - e335 .
Dedoussis GV, Manios Y, Kourlaba G, Kanoni S, Lagou V, Butler J, Papoutsakis C, Scott RA et al. ( 2011 ) . An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children . Metabolism vol. 60 , ( 4 ) 467 - 473 .
Kilpeläinen TO, Den Hoed M, Ong KK, Grøntved A, Brage S, Jameson K, Cooper C, Khaw KT et al. ( 2011 ) . Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals . American Journal of Clinical Nutrition vol. 93 , ( 4 ) 851 - 860 .
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, Van Rooij FJA, Sonestedt E et al. ( 2011 ) . Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies (Diabetes Care (2010) 33 (2684-2691)) . Diabetes Care vol. 34 , ( 3 ) 785 - 786 .
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E et al. ( 2010 ) . Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies . Diabetes Care vol. 33 , ( 12 ) 2684 - 2691 .
Giacconi R, Kanoni S, Mecocci P, Malavolta M, Richter D, Pierpaoli S, Costarelli L, Cipriano C et al. ( 2010 ) . Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort . J Nutr Biochem vol. 21 , ( 10 ) 1008 - 1014 .
Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis GV, Bougioukas G, Manolopoulos VG ( 2010 ) . Endothelial nitric oxide synthase gene polymorphisms - 786T > C and 894G > T in coronary artery bypass graft surgery patients . Human Genomics vol. 4 , ( 6 ) 375 - 383 .
Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis GV, Bougioukas G, Manolopoulos VG ( 2010 ) . Endothelial nitric oxide synthase gene polymorphisms -786T >C and 894G >Tin coronary artery bypass graft surgery patients . Human Genomics
Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis GV, Bougioukas G, Manolopoulos VG ( 2010 ) . Endothelial nitric oxide synthase gene polymorphisms -786T > C and 894G > T in coronary artery bypass graft surgery patients . Hum Genomics vol. 4 , ( 6 ) 375 - 383 .
Kanoni S, Dedoussis GV, Herbein G, Fulop T, Varin A, Jajte J, Rink L, Monti D et al. ( 2010 ) . Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score--ZINCAGE study . J Nutr Biochem vol. 21 , ( 6 ) 526 - 531 .
Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis GV, Bougioukas G, Manolopoulos VG ( 2010 ) . Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients . J Renin Angiotensin Aldosterone Syst vol. 11 , ( 2 ) 136 - 145 .
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) . Nature Genetics vol. 42 , ( 5 )
Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, Warrington NM, Widen E et al. ( 2010 ) . Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight . Nat Genet vol. 42 , ( 5 ) 430 - 435 .
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . NAT GENET vol. 42 , ( 2 ) 105 - U32 .
Mariani E, Neri S, Cattini L, Mocchegiani E, Malavolta M, Dedoussis GV, Kanoni S, Rink L et al. ( 2008 ) . Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles . Exp Gerontol vol. 43 , ( 5 ) 462 - 471 .
Varin A, Larbi A, Dedoussis GV, Kanoni S, Jajte J, Rink L, Monti D, Malavolta M et al. ( 2008 ) . In vitro and in vivo effects of zinc on cytokine signalling in human T cells . Exp Gerontol vol. 43 , ( 5 ) 472 - 482 .
Mocchegiani E, Giacconi R, Costarelli L, Muti E, Cipriano C, Tesei S, Pierpaoli S, Giuli C et al. ( 2008 ) . Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study . Exp Gerontol vol. 43 , ( 5 ) 433 - 444 .
Kanoni S, Dedoussis GV ( 2008 ) . Design and descriptive characteristics of the GHRAS: the Greek Health Randomized Aging Study . Med Sci Monit vol. 14 , ( 4 ) CR204 - CR212 .
Dedoussis GV, Kanoni S, Panagiotakos DB, Louizou E, Grigoriou E, Chrysohoou C, Pitsavos C, Stefanadis C ( 2008 ) . Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels . Exp Mol Med vol. 40 , ( 1 ) 27 - 34 .
Dedoussis GV, Kanoni S, Mariani E, Cattini L, Herbein G, Fulop T, Varin A, Rink L et al. ( 2008 ) . Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study . Clin Chem Lab Med vol. 46 , ( 7 ) 990 - 996 .
Kanoni S, Dedoussis G, Manios Y, Malavolta M, Mocchegiani E ( 2006 ) . Health status, blood and anthropometrical indices from Greek old and nonagenarian subjects . Biogerontology vol. 7 , ( 5-6 ) 329 - 337 .