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Research

Publications: Prof Panagiotis Deloukas

Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B et al. ( 2022 ) . DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases . Nature Communications vol. 13 , ( 1 )
Kjaergaard AD, Teumer A, Marouli E, Deloukas P, Kuś A, Sterenborg R, Åsvold BO, Medici M et al. ( 2022 ) . Thyroid function, pernicious anemia and erythropoiesis: A two-sample Mendelian randomization study . Human Molecular Genetics vol. 31 , ( 15 ) 2548 - 2559 .
Dam V, Onland-Moret NC, Burgess S, Chirlaque MD, Peters SAE, Schuit E, Tikk K, Weiderpass E et al. ( 2022 ) . Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization . Journal of Clinical Endocrinology and Metabolism vol. 107 , ( 7 ) E2952 - E2961 .
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen A et al. ( 2022 ) . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .
Amanatidou AI, Kaliora AC, Amerikanou C, Stojanoski S, Milosevic N, Vezou C, Beribaka M, Banerjee R et al. ( 2022 ) . Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study . International Journal of Environmental Research and Public Health vol. 19 , ( 2 )
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR et al. ( 2022 ) . Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function . Nature Genetics vol. 54 , ( 1 ) 18 - 29 .
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al. ( 2021 ) . Epigenome-wide association study detects a novel loci associated with central obesity in healthy subjects . BMC Medical Genomics vol. 14 , ( 1 )
Bourgeois S, Carr DF, Musumba CO, Penrose A, Esume C, Morris AP, Jorgensen AL, Zhang JE et al. ( 2021 ) . Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration: GWAS of aspirin-induced peptic ulceration . EBioMedicine vol. 74 ,
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9) . Nature Communications vol. 12 , ( 1 )
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )
Marouli E, Yusuf L, Kjaergaard AD, Omar R, Kuś A, Babajide O, Sterenborg R, Åsvold BO et al. ( 2021 ) . Thyroid Function and the Risk of Alzheimer's Disease: A Mendelian Randomization Study . Thyroid vol. 31 , ( 12 ) 1794 - 1799 .
Papadopoulou A, Musa H, Sivaganesan M, McCoy D, Deloukas P, Marouli E ( 2021 ) . COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases . PLoS ONE vol. 16 , ( 9 September )
Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J et al. ( 2021 ) . Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations . Cell vol. 184 , ( 18 ) 4784 - 4818.e17 .
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A et al. ( 2021 ) . Effects of thyroid function on hemostasis, coagulation, and fibrinolysis: A mendelian randomization study . Thyroid vol. 31 , ( 9 ) 1305 - 1315 .
Kuś A, Kjaergaard AD, Marouli E, Del Greco M. F, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T et al. ( 2021 ) . Thyroid Function and Mood Disorders: A Mendelian Randomization Study . Thyroid vol. 31 , ( 8 ) 1171 - 1181 .
Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM et al. ( 2021 ) . Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes . Nature Genetics vol. 53 , ( 7 ) 962 - 971 .
Kanoni S, Kumar S, Amerikanou C, Kurth MJ, Stathopoulou MG, Bourgeois S, Masson C, Kannt A et al. ( 2021 ) . Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD . Frontiers in Immunology vol. 12 ,
Amerikanou C, Kanoni S, Kaliora AC, Barone A, Bjelan M, D'Auria G, Gioxari A, Gosalbes MJ et al. ( 2021 ) . Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial . Molecular Nutrition and Food Research vol. 65 , ( 10 )
Kuś A, Marouli E, Del Greco M. F, Chaker L, Bednarczuk T, Peeters RP, Teumer A, Medici M et al. ( 2021 ) . Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study . Thyroid vol. 31 , ( 5 ) 721 - 731 .
Giardoglou P, Bournele D, Park M, Kanoni S, Dedoussis GV, Steinberg SF, Deloukas P, Beis D ( 2021 ) . A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2 . Biology Open vol. 10 , ( 3 )
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J et al. ( 2021 ) . Genome-wide association study of circulating interleukin 6 levels identifies novel loci . Human Molecular Genetics . vol. 30 , 393 - 409 .
Kjaergaard AD, Marouli E, Papadopoulou A, Deloukas P, Kuś A, Sterenborg R, Teumer A, Burgess S et al. ( 2021 ) . Thyroid function, sex hormones and sexual function: a Mendelian randomization study . European Journal of Epidemiology vol. 36 , ( 3 ) 335 - 344 .
Cuellar-Partida G, Tung JY, Eriksson N, Albrecht E, Aliev F, Andreassen OA, Barroso I, Beckmann JS et al. ( 2021 ) . Genome-wide association study identifies 48 common genetic variants associated with handedness . Nature Human Behaviour vol. 5 , ( 1 ) 59 - 70 .
Hanna DB, Guo M, Bůžková P, Miller TL, Post WS, Stein JH, Currier JS, Kronmal RA et al. ( 2021 ) . HIV infection and carotid artery intima-media thickness: Pooled analyses across 5 cohorts of the NHLBI HIV-CVD collaborative . Clinical Infectious Diseases vol. 63 , ( 2 ) 249 - 256 .
Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E et al. ( 2020 ) . Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study . Scientific Data vol. 7 , ( 1 )
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2020 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .
Van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A et al. ( 2020 ) . Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus . Circulation: Genomic and Precision Medicine vol. 13 , ( 6 ) 640 - 648 .
Mahmoodi BK, Tragante V, Kleber ME, Holmes MV, Schmidt AF, McCubrey RO, Howe LJ, Direk K et al. ( 2020 ) . Association of factor v leiden with subsequent atherothrombotic events: A GENIUS-CHD study of individual participant data . Circulation vol. 142 , ( 6 ) 546 - 555 .
Marouli E, Kus A, Del Greco M F, Chaker L, Peeters R, Teumer A, Deloukas P, Medici M ( 2020 ) . Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study . Journal of Clinical Endocrinology and Metabolism vol. 105 , ( 8 ) 2634 - 2641 .
Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 ) 200088 - 200088 .
AI-Ghalayini KW, Salama MA, Al Mahdi HB, Al-Harthi S, Alhejily WA, Alasnag MA, Tasbhji NO, Al-Quwaie DAH et al. ( 2020 ) . Identification of genetic variants associated with myocardial infarction in Saudi Arabia . Heart Surgery Forum vol. 23 , ( 4 ) E517 - E523 .
Schunkert H, Erdmann J, Samani NJ, Deloukas P, Zeng L ( 2020 ) . Genetics of educational attainment and coronary risk in Mendelian randomization studies . European Heart Journal vol. 41 , ( 7 ) 894 - 895 .
Fabre MA, McKerrell T, Zwiebel M, Vijayabaskar MS, Park N, Wells PM, Rad R, Deloukas P et al. ( 2020 ) . Concordance for clonal hematopoiesis is limited in elderly twins . Blood vol. 135 , ( 4 ) 269 - 273 .
Allum F, Hedman ÅK, Shao X, Cheung WA, Vijay J, Guénard F, Kwan T, Simon MM et al. ( 2019 ) . Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements . Nature Communications vol. 10 , ( 1 )
Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Höhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P et al. ( 2019 ) . Erratum to: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (Nature Communications, (2018), 9, 1, (1864), 10.1038/s41467-018-03646-6) . Nature Communications vol. 10 , ( 1 )
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE et al. ( 2019 ) . Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium . Molecular Psychiatry vol. 24 , ( 12 ) 1920 - 1932 .
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Communications Biology vol. 2 , ( 1 )
Aragam KG, Jiang T, Kanoni S, Anuj G, Wolford B, Surakka I, Grace C, Thorleifsson G et al. ( 2019 ) . Genome-Wide Association Study of Over One Million Participants Identifies 49 Novel Loci Associated With Coronary Artery Disease . CIRCULATION . vol. 140 ,
Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF et al. ( 2019 ) . Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study . JAMA network open vol. 2 , ( 9 ) e1910915 - e1910915 .
Murphy AM, Smith CE, Murphy LM, Follis JL, Tanaka T, Richardson K, Noordam R, Lemaitre RN et al. ( 2019 ) . Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals . Molecular Nutrition and Food Research vol. 63 , ( 22 )
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al. ( 2019 ) . Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2) . Nature Genetics vol. 51 , ( 9 ) 1423 - 1424 .
Zeng L, Ntalla I, Kessler T, Kastrati A, Erdmann J, Danesh J, Watkins H, Samani NJ et al. ( 2019 ) . Genetically modulated educational attainment and coronary disease risk . European Heart Journal vol. 40 , ( 29 ) 2413 - 2420 .
Giannakopoulou O, Kanoni S, Giardoglou P, Kelaidoni K, Dedoussis G, Deloukas P, CardioMetabolic U ( 2019 ) . Genome-wide association analysis of recurrent myocardial infarction in UK Biobank identifies suggestive evidence for association to twenty seven loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 159 - 160 .
Chen Z, Chen JA, Shatunov A, Jones AR, Kravitz SN, Huang AY, Lawrence L, Lowe JK et al. ( 2019 ) . Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy . Movement Disorders vol. 34 , ( 7 ) 1049 - 1059 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x) . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .
Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J, Watkins H, Samani NJ, Deloukas P et al. ( 2019 ) . Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases . Journal of the American College of Cardiology vol. 73 , ( 23 ) 2932 - 2942 .
Huang T, Sun D, Heianza Y, Bergholdt HKM, Gao M, Fang Z, Ding M, Frazier-Wood AC et al. ( 2019 ) . Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies . Clinical Chemistry vol. 65 , ( 6 ) 751 - 760 .
Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ et al. ( 2019 ) . Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals . Clinical Pharmacology and Therapeutics vol. 105 , ( 6 ) 1477 - 1491 .
Fabre M, McKerrell T, Zwiebel M, Vijayabaskar M, Rad R, Deloukas P, Small K, Steves CJ et al. ( 2019 ) . PF196 IDENTICAL TWINS DO NOT DISPLAY INCREASED CONCORDANCE FOR CLONAL HEMATOPOIESIS . HemaSphere vol. 3 , ( S1 )
Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ et al. ( 2019 ) . Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia . American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics vol. 180 , ( 3 ) 223 - 231 .
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Commun Biol vol. 2 , ( 1 )
Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A et al. ( 2019 ) . Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events . Circ Genom Precis Med vol. 12 , ( 4 ) e002471 - e002471 .
Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A et al. ( 2019 ) . Subsequent Event Risk in Individuals With Established Coronary Heart Disease . Circ Genom Precis Med vol. 12 , ( 4 ) e002470 - e002470 .
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al. ( 2019 ) . Epigenome-wide association study (EWAS) of blood lipids in healthy population from STANISLAS family study (SFS) . International Journal of Molecular Sciences vol. 20 , ( 5 )
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al. ( 2019 ) . Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing . Nature Genetics vol. 51 , ( 3 ) 414 - 430 .
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .
Vackova Z, Niebisch S, Triantafyllou T, Becker J, Hess T, Kreuser N, Kanoni S, Deloukas P et al. ( 2019 ) . First genotype-phenotype study reveals HLA-DQβ1 insertion heterogeneity in high-resolution manometry achalasia subtypes . United European Gastroenterology Journal vol. 7 , ( 1 ) 45 - 51 .
Hess JL, Tylee DS, Mattheisen M, Adolfsson R, Agartz I, Agerbo E, Albus M, Alexander M et al. ( 2019 ) . A polygenic resilience score moderates the genetic risk for schizophrenia . Molecular Psychiatry
Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Höhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P et al. ( 2018 ) . Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases . Nature Communications vol. 9 , ( 1 )
Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV et al. ( 2018 ) . Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function . Nature Communications vol. 9 , ( 1 )
Visvikis-Siest S, Gorenjak V, Stathopoulou MG, Petrelis AM, Weryha G, Masson C, Hiegel B, Kumar S et al. ( 2018 ) . The 9th santorini conference: systems medicine, personalised health and therapy. “The odyssey from hope to practice”, Santorini, Greece, 30 september–3 october 2018 . Journal of Personalized Medicine vol. 8 , ( 4 )
Tsai PC, Glastonbury CA, Eliot MN, Bollepalli S, Yet I, Castillo-Fernandez JE, Carnero-Montoro E, Hardiman T et al. ( 2018 ) . Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics . Clinical Epigenetics vol. 10 , ( 1 )
Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S et al. ( 2018 ) . Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention . Journal of the American College of Cardiology vol. 72 , ( 16 ) 1883 - 1893 .
Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE et al. ( 2018 ) . Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos . BMC Obesity vol. 5 , ( 1 )
Huckins LM, Hatzikotoulas K, Southam L, Thornton LM, Steinberg J, Aguilera-McKay F, Treasure J, Schmidt U et al. ( 2018 ) . Correction to: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa (Molecular Psychiatry, (2018), 23, 5, (1169-1180), 10.1038/mp.2017.88) . Molecular Psychiatry vol. 23 , ( 9 )
Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G et al. ( 2018 ) . Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases . Molecular Neurodegeneration vol. 13 , ( 1 )
Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO et al. ( 2018 ) . Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study . The Lancet Haematology vol. 5 , ( 8 ) e333 - e345 .
Huckins LM, Hatzikotoulas K, Southam L, Thornton LM, Steinberg J, Aguilera-Mckay F, Treasure J, Schmidt U et al. ( 2018 ) . Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa . Molecular Psychiatry vol. 23 , ( 5 ) 1169 - 1180 .
Smith AJP, Deloukas P, Munroe PB ( 2018 ) . Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits . Physiol Genomics
Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F et al. ( 2018 ) . Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: The cohorts for heart and aging research in genomic epidemiology . Pharmacogenomics Journal vol. 18 , ( 2 ) 215 - 226 .
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al. ( 2018 ) . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article . Nature Genetics vol. 50 , ( 4 ) 559 - 571 .
Stathopoulou MG, Xie T, Ruggiero D, Chatelin J, Rancier M, Weryha G, Kurth MJ, Aldasoro Arguinano AA et al. ( 2018 ) . A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: The VEGF Consortium . Clinical Chemistry and Laboratory Medicine vol. 56 , ( 4 ) e83 - e86 .
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al. ( 2018 ) . Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls . Scientific data vol. 5 ,
Peña MSB, Swett K, Kaplan RC, Perreira K, Daviglus M, Kansal MM, Cai J, Giachello AL et al. ( 2018 ) . Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: Results from Echo-SOL . Open Heart vol. 5 , ( 2 )
Floyd JS, Sitlani CM, Avery CL, Noordam R, Li X, Smith AV, Gogarten SM, Li J et al. ( 2018 ) . Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group . Pharmacogenomics Journal vol. 18 , ( 1 ) 127 - 135 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2018 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 35 .
Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C et al. ( 2018 ) . Regulatory CD4<sup>+</sup> T cells recognize major histocompatibility complex class II molecule-restricted peptide epitopes of apolipoprotein B . Circulation vol. 138 , ( 11 ) 1130 - 1143 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nat Genet vol. 50 , ( 5 ) 766 - 767 .
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al. ( 2017 ) . Sequence data and association statistics from 12,940 type 2 diabetes cases and controls . Sci Data vol. 4 , 170179 - 170179 .
Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M et al. ( 2017 ) . Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts . PLoS One vol. 12 , ( 12 ) e0186456 - e0186456 .
Robak LA, Jansen IE, Rooij JV, Uitterlinden AG, Kraaij R, Jankovic J, Heutink P, Shulman JM et al. ( 2017 ) . Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease . Brain vol. 140 , ( 12 ) 3191 - 3203 .
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in &gt;300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .
Márquez-Luna C, Loh PR, Price AL, Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W et al. ( 2017 ) . Multiethnic polygenic risk scores improve risk prediction in diverse populations . Genetic Epidemiology vol. 41 , ( 8 ) 811 - 823 .
Gottlieb A, Daneshjou R, DeGorter M, Bourgeois S, Svensson PJ, Wadelius M, Deloukas P, Montgomery SB et al. ( 2017 ) . Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans . Genome Medicine vol. 9 , ( 1 )
Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, Rentari A, Dimitriou M et al. ( 2017 ) . Evaluating the glucose raising effect of established loci via a genetic risk score . PLoS One vol. 12 , ( 11 ) Article 0186669 , e0186669 - e0186669 .
Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH et al. ( 2017 ) . An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans . Diabetes vol. 66 , ( 11 ) 2888 - 2902 .
Hu YJ, Schmidt AF, Dudbridge F, Holmes MV, Brophy JM, Tragante V, Li Z, Liao P et al. ( 2017 ) . Impact of Selection Bias on Estimation of Subsequent Event Risk . Circulation: Cardiovascular Genetics vol. 10 , ( 5 )
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation: Cardiovascular Genetics vol. 10 , ( 5 )
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U et al. ( 2017 ) . CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits . Nat Commun vol. 8 , ( 1 ) 744 - 744 .
Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I et al. ( 2017 ) . Association analyses based on false discovery rate implicate new loci for coronary artery disease . Nature Genetics vol. 49 , ( 9 ) 1385 - 1391 .
Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J et al. ( 2017 ) . Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis . PLoS Medicine vol. 14 , ( 9 )
Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ et al. ( 2017 ) . Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk . PLoS One vol. 12 , ( 8 ) e0182999 - e0182999 .
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA et al. ( 2017 ) . A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk . Diabetes vol. 66 , ( 7 ) 2019 - 2032 .
Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF et al. ( 2017 ) . Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms . Nature Genetics vol. 49 , ( 7 ) 1113 - 1119 .
Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG et al. ( 2017 ) . Genome-wide pleiotropy between Parkinson disease and autoimmune diseases . JAMA Neurology vol. 74 , ( 7 ) 780 - 792 .
Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K et al. ( 2017 ) . Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions . Circulation vol. 135 , ( 24 ) 2336 - 2353 .
Panoutsopoulou K, Thiagarajah S, Zengini E, Day-Williams AG, Ramos YF, Meessen JM, Huetink K, Nelissen RG et al. ( 2017 ) . Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis . Ann Rheum Dis vol. 76 , ( 7 ) 1199 - 1206 .
Visvikis-Siest S, Aldasoro Arguinano AA, Stathopoulou M, Xie T, Petrelis A, Weryha G, Froguel P, Meier-Abt P et al. ( 2017 ) . 8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3-5 October 2016 . Drug Metabolism and Personalized Therapy vol. 32 , ( 2 ) 119 - 127 .
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Kaplan RC, Psaty BM ( 1999 ) . ACE-inhibitor therapy and nosocomial pneumonia . American Journal of Hypertension vol. 12 , ( 11 I ) 1161 - 1162 .
Kaplan RC, Psaty BM, Heckbert SR, Smith NL, Lemaitre RN ( 1999 ) . Blood pressure level and incidence of myocardial infarction among patients treated for hypertension . American Journal of Public Health vol. 89 , ( 9 ) 1414 - 1417 .
Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH ( 1998 ) . Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique . Genomics vol. 53 , ( 3 ) 296 - 299 .
Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tomé P, Hui L, Matise TC et al. ( 1998 ) . A physical map of 30,000 human genes . Science vol. 282 , ( 5389 ) 744 - 746 .
Bentley DR, Pruitt KD, Deloukas P, Schuler GD, Ostell J ( 1998 ) . Coordination of human genome sequencing via a consensus framework map . Trends Genet vol. 14 , ( 10 ) 381 - 384 .
Kaplan RC, Heckbert SR, Weiss NS, Wahl PW, Smith NL, Newton KM, Psaty BM ( 1998 ) . Postmenopausal estrogens and risk of myocardial infarction in diabetic women . Diabetes Care vol. 21 , ( 7 ) 1117 - 1121 .
Bench AJ, Aldred MA, Holloway TL, Champion KM, Gilbert JGR, Humphray SJ, Gwilliam R, Deloukas P et al. ( 1998 ) . Transcript mapping of the region of chromosome 20q that is deleted in myeloproliferative disorders . BRITISH JOURNAL OF HAEMATOLOGY . vol. 102 , 156 - 156 .
Bench AJ, Aldred MA, Humphray SJ, Champion KM, Gilbert JG, Asimakopoulos FA, Deloukas P, Gwilliam R et al. ( 1998 ) . A detailed physical and transcriptional map of the region of chromosome 20 that is deleted in myeloproliferative disorders and refinement of the common deleted region . Genomics vol. 49 , ( 3 ) 351 - 362 .
Kaplan RC, Psaty BM, Kriesel D, Heckbert SR, Smith NL, Gillett C, Golston AG ( 1998 ) . Replacing short-acting nifedipine with alternative medications at a large health maintenance organization . American Journal of Hypertension vol. 11 , ( 4 I ) 471 - 477 .
Soderlund C, Lau T, Deloukas P ( 1998 ) . Z extensions to the RHMAPPER package . Bioinformatics vol. 14 , ( 6 ) 538 - 539 .
Mungall AJ, Humphray SJ, Ranby SA, Edwards CA, Heathcott RW, Clee CM, Holloway E, Peck AI et al. ( 1997 ) . From long range mapping to sequence-ready contigs on human chromosome 6 . Mitochondrial DNA vol. 8 , ( 3 ) 151 - 154 .
Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tomé P et al. ( 1996 ) . A gene map of the human genome . Science vol. 274 , ( 5287 ) 540 - 546 .
Schuler GD, Boguski MS, Hudson TJ, Hui L, Ma J, Castle AB, Wu X, Silva J et al. ( 1996 ) . Genome maps 7. The human transcript map. Wall chart . Science vol. 274 , ( 5287 ) 547 - 562 .
Mungall AJ, Edwards CA, Ranby SA, Humphray SJ, Heathcott RW, Clee CM, East CL, Holloway E et al. ( 1996 ) . Physical mapping of chromosome 6: a strategy for the rapid generation of sequence-ready contigs . DNA Seq vol. 7 , ( 1 ) 47 - 49 .
Héron E, Deloukas P, van Loon AP ( 1995 ) . The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction . Genomics vol. 30 , ( 3 ) 493 - 505 .
Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP ( 1994 ) . The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12 . Genomics vol. 19 , ( 3 ) 592 - 594 .
Moschonas NK, Goulielmos G, Lubyova B, Manifava M, Deloukas P, Loon AP, Kapsetaki M ( 1993 ) . Dinucleotide repeat polymorphism (D10S608) adjacent to the GLUD1 locus . Hum Mol Genet vol. 2 , ( 11 )
Deloukas P, van Loon AP ( 1993 ) . Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing . Hum Mol Genet vol. 2 , ( 11 ) 1895 - 1900 .
Deloukas P, Dauwerse JG, Moschonas NK, van Ommen GJ, van Loon AP ( 1993 ) . Three human glutamate dehydrogenase genes (GLUD1, GLUDP2, and GLUDP3) are located on chromosome 10q, but are not closely physically linked . Genomics vol. 17 , ( 3 ) 676 - 681 .
Deloukas P, Aigner L, Kania M, van Loon AP ( 1992 ) . Construction of yeast artificial chromosome (YAC) clone banks covering three genome equivalents and isolation of YACs containing the human gene encoding tumor necrosis factor receptor beta . Gene vol. 110 , ( 2 ) 189 - 195 .