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Research

Publications: Dr Helen Warren

Jepson RE, Warren H, Wallace MD, Syme HM, Elliott J, Munroe PB ( 2022 ) . First genome-wide association study investigating blood pressure and renal traits in domestic cats . Scientific Reports vol. 12 , ( 1 )
Young WJ, Lahrouchi N, Isaacs A, Duong TV, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .
Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X et al. ( 2022 ) . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension . Hypertension vol. 79 , ( 8 ) 1656 - 1667 .
Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLoS Genetics vol. 18 , ( 4 )
Warren H, Edwards T, Vaez A, Keaton J, Kamali Z, Xie T, Ani A, Evangelou E et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure .
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen A et al. ( 2022 ) . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .
Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke S, Bhatti KF et al. ( 2021 ) . Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis .
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke S et al. ( 2021 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids .
Young W, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody J, Salman R et al. ( 2021 ) . Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization .
McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, Armstrong ND, Bis JC, House JS, Singh S et al. ( 2021 ) . Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies . Clinical Pharmacology and Therapeutics vol. 110 , ( 3 ) 723 - 732 .
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, Van Duijvenboden S, Orini M, Tinker A, Van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank . Circulation: Genomic and Precision Medicine vol. 14 , ( 3 )
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x) . Nature Genetics vol. 53 , ( 5 )
Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .
Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )
Boguslavskyi A, Tokar S, Prysyazhna O, Rudyk O, Sanchez-Tatay D, Lemmey HAL, Dora KA, Garland CJ et al. ( 2021 ) . Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans . Circulation vol. 143 , ( 11 ) 1123 - 1138 .
Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX . Hypertension vol. 77 , ( 2 ) 284 - 295 .
Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S et al. ( 2020 ) . Cerebral small vessel disease genomics and its implications across the lifespan . Nature Communications vol. 11 , ( 1 )
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .
Gallo JE, Ochoa JE, Warren HR, Misas E, Correa MM, Gallo-Villegas JA, Bedoya G, Aristizábal D et al. ( 2020 ) . Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data . International Journal of Cardiology: Hypertension vol. 7 ,
Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )
Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2020 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .
Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H et al. ( 2020 ) . Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation . Circulation: Genomic and Precision Medicine389 - 395 .
de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry
Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR et al. ( 2019 ) . Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study . Pharmacogenomics Journal
Fung K, Ramírez J, Warren HR, Aung N, Lee AM, Tzanis E, Petersen SE, Munroe PB ( 2019 ) . Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants . Scientific Reports vol. 9 , ( 1 )
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Communications Biology vol. 2 , ( 1 )
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T et al. ( 2019 ) . Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group . American Journal of Hypertension vol. 32 , ( 12 ) 1146 - 1153 .
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al. ( 2019 ) . Associations of autozygosity with a broad range of human phenotypes . Nature Communications vol. 10 , ( 1 ) 4957 - 4957 .
Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, Nelson CP, Bastiaenen R et al. ( 2019 ) . KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern . JCI insight
Ng N, Willems S, Fernandez J, Fine R, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2019 ) . Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .
Petersen S, Munroe P, Aung N, Fung K, Vargas J, Yang C, Cabrera CP, Warren H et al. ( 2019 ) . Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development . Circulation
Iniesta R, Campbell D, Venturini C, Faconti L, Singh S, Irvin MR, Cooper-DeHoff RM, Johnson JA et al. ( 2019 ) . Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals . Hypertension vol. 74 , ( 3 ) 614 - 622 .
Singh S, Warren HR, Hiltunen TP, McDonough CW, El Rouby N, Salvi E, Wang Z, Garofalidou T et al. ( 2019 ) . Genome-Wide Meta-Analysis of Blood Pressure Response to Ī²<inf>1</inf>-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies) . Journal of the American Heart Association vol. 8 , ( 16 )
Sung YJ, De Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al. ( 2019 ) . A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure . Human Molecular Genetics vol. 28 , ( 15 ) 2615 - 2633 .
Ntalla I, Weng L-C, Cartwright J, Hall AW, Sveinbjornsson G, Tucker N, Choi SH, Chaffin M et al. ( 2019 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction .
Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .
Ntalla I, Weng L, Warren HR, Jamshidi Y, Munroe PB, Lubitz SA, Consortium CHARGEEKG ( 2019 ) . Multi-ancestry genome-wide association meta-analysis of 293,000 individuals identifies 217 regions for the electrocardiographic PR interval . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 158 - 159 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x) . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .
Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg M, Kaess B, Nelson C, Bastiaenen R et al. ( 2019 ) . <i>KCND3</i> is a novel susceptibility locus for early repolarization .
Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . 199Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . European Heart Journal - Cardiovascular Imaging . vol. 20 ,
Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 155 - 156 .
van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I et al. ( 2019 ) . Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits . European Journal of Human Genetics vol. 27 , ( 6 ) 952 - 962 .
Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 377 - 378 .
Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . P463Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . European Heart Journal - Cardiovascular Imaging . vol. 20 ,
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Commun Biol vol. 2 , ( 1 )
Bastiaenen R, Nolte IM, Munroe PB, Riese H, Nelson C, O'Connor H, Gang Y, Warren HR et al. ( 2019 ) . The narrow-sense and common single nucleotide polymorphism heritability of early repolarization . International Journal of Cardiology vol. 279 , 135 - 140 .
McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, El Rouby NM, Gong Y, Mychaleckyj JC, Benavente OR et al. ( 2019 ) . DRUG-SNP INTERACTIONS AND CARDIOVASCULAR OUTCOMES: A GENOME-WIDE META-ANALYSIS IN THE INTERNATIONAL CONSORTIUM FOR ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S105 - S106 .
Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUM OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S16 - S16 .
Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUNI OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S27 - S27 .
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .
Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al. ( 2019 ) . Trans-ethnic association study of blood pressure determinants in over 750,000 individuals . Nature Genetics vol. 51 , ( 1 ) 51 - 62 .
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 )
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nature Genetics vol. 50 , ( 10 ) 1412 - 1425 .
Ng FL, Warren HR, Caulfield MJ ( 2018 ) . Hypertension genomics and cardiovascular prevention . Ann Transl Med vol. 6 , ( 15 ) 291 - 291 .
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 )
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .
Warren HR, Evangelou E, Mosen D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . GENETIC ANALYSIS OF OVER ONE MILLION PEOPLE IDENTIFIES 535 NOVEL LOCI ASSOCIATED WITH BLOOD PRESSURE AND RISK OF CARDIOVASCULAR DISEASE . Journal of Hypertension . vol. 36 ,
Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L et al. ( 2018 ) . Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval . Circulation. Genomic and precision medicine vol. 11 , ( 5 )
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al. ( 2018 ) . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article . Nature Genetics vol. 50 , ( 4 ) 559 - 571 .
Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al. ( 2018 ) . A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure . American Journal of Human Genetics vol. 102 , ( 3 ) 375 - 400 .
Pazoki R, Dehghan A, Evangelou E, Warren H, Gao H, Caulfield M, Elliott P, Tzoulaki I ( 2018 ) . Genetic predisposition to high blood pressure and lifestyle factors: Associations with midlife blood pressure levels and cardiovascular events . Circulation vol. 137 , ( 7 ) 653 - 661 .
Munroe PB, Warren HR ( 2018 ) . Chapter 5 Hypertension . Genomic and Precision Medicine ,
Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, Liu CT, Marten J et al. ( 2018 ) . ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated with QT and JT Intervals . Circulation: Genomic and Precision Medicine vol. 11 , ( 1 )
Munroe PB, Warren HR ( 2018 ) . Hypertension . Genomic and Precision Medicine: Cardiovascular Disease: Third Edition ,
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation: Genomic and Precision Medicine vol. 11 , ( 1 )
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2018 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 35 .
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2018 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nat Genet vol. 50 , ( 5 ) 765 - 766 .
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in &gt;300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation: Cardiovascular Genetics vol. 10 , ( 5 )
Little L, Kraja AT, Cook JP, Warren HR, Newton-Cheh C, Munroe PB, Howson JMM, BP CE et al. ( 2017 ) . New blood pressure associated loci identified in meta-analyses of 475,000 individuals using the Exome Chip . vol. 31 , is. 10 , pp. 665 - 666 .
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 10 ) 1558 - 1558 .
Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D et al. ( 2017 ) . Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos . Sci Rep vol. 7 , ( 1 ) 10348 - 10348 .
Wain LV, Vaez A, Jansen R, Joehanes R, Van Der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .
Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T et al. ( 2017 ) . Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis . Circulation vol. 135 , ( 24 ) 2373 - 2388 .
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics
Munroe PB, Warren HR ( 2017 ) . Hypertension . Genomic and Precision Medicine: Primary Care: Third Edition ,
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .
Munroe PB, Warren HR ( 2017 ) . Chapter 7 Hypertension . Genomic and Precision Medicine ,
Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR et al. ( 2016 ) . A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium . J Med Genet
Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EPA, Goel A, Padmanabhan S et al. ( 2016 ) . Adult height, coronary heart disease and stroke: A multi-locus Mendelian randomization meta-analysis . International Journal of Epidemiology vol. 45 , ( 6 ) 1927 - 1937 .
Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK et al. ( 2016 ) . Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: Protocol of the NITRATE-OCT study . BMJ Open vol. 6 , ( 12 )
Warren HR, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BH, Munroe PB, Grp CHARGECEKGW ( 2016 ) . Discovery of Novel Loci Associated with Heart Rate from Exome Chip Analysis . GENETIC EPIDEMIOLOGY . Conference: International Genetic Epidemiology Society vol. 40 , 670 - 670 .
Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB ( 2016 ) . Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study . J Small Anim Pract vol. 57 , ( 11 ) 580 - 588 .
Warren HR, Surendran P, Manning AK, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BHC et al. ( 2016 ) . Novel loci discovery for blood pressure and heart rate using the Exome chip . JOURNAL OF HUMAN HYPERTENSION vol. 30 , ( 10 ) 653 - 653 .
Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA et al. ( 2016 ) . Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment . Pharmacogenomics vol. 17 , ( 15 ) 1621 - 1628 .
MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics
MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al. ( 2016 ) . Meta-analysis of genome-wide association studies of HDL cholesterol response to statins . Journal of Medical Genetics
Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .
HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE et al. ( 2016 ) . IGSF10 mutations dysregulate gonadotropinā€releasing hormone neuronal migration resulting in delayed puberty . EMBO Molecular Medicine vol. 8 , ( 6 ) 626 - 42 .
Leusink M, Maitland-Van Der Zee AH, Ding B, Drenos F, Van Iperen EPA, Warren HR, Caulfield MJ, Cupples LA et al. ( 2016 ) . A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics vol. 17 , ( 6 ) 583 - 591 .
White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA et al. ( 2016 ) . Plasma urate concentration and risk of coronary heart disease: A Mendelian randomisation analysis . The Lancet Diabetes and Endocrinology vol. 4 , ( 4 ) 327 - 336 .
Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2016 ) . Role of IGSF10 mutations in self-limited delayed puberty . The Lancet . vol. 387 ,
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