Publications: Dr Helen Warren

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB ( 2024 ) . Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease . European Heart Journal vol. 45 , ( Supplement_1 )

Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Caulfield MJ et al. ( 2024 ) . Pharmacogenomics of CRP response to statins: a GIST consortium study . European Heart Journal vol. 45 , ( Supplement_1 )

Rathod KS, Mathur A, Shabbir A, Khambata RS, Lau C, Beirne A-M, Chhetri I, Ono M et al. ( 2024 ) . The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial . EClinicalMedicine vol. 77 ,

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 )

Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE et al. ( 2024 ) . SMIM1 absence is associated with reduced energy expenditure and excess weight . Med vol. 5 , ( 9 ) 1083 - 1095.e6 .

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al. ( 2024 ) . Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits . Nature Genetics vol. 56 , ( 5 ) 778 - 791 .

Breeyear JH, Mautz BS, Keaton JM, Hellwege JN, Torstenson ES, Liang J, Bray MJ, Giri A et al. ( 2024 ) . A new test for trait mean and variance detects unreported loci for blood-pressure variation . American Journal of Human Genetics vol. 111 , ( 5 ) 954 - 965 .

Xu J, Choi R, Gupta K, Warren HR, Santhanam L, Pluznick JL ( 2024 ) . An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure . Science Advances vol. 10 , ( 12 )

Ganji-Arjenaki M, Kamali Z, Pressure ICOB, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N et al. ( 2024 ) . Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure . Kidney International Reports vol. 9 , ( 6 ) 1849 - 1859 .

Souza-Teodoro LH, Davies NM, Warren HR, Andrade LHSG, Carvalho LA ( 2024 ) . DHEA and response to antidepressant treatment: A Mendelian Randomization analysis . Journal of Psychiatric Research vol. 173 , 151 - 156 .

Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM et al. ( 2024 ) . Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . Hypertension vol. 81 , ( 3 ) 552 - 560 .

Guirette M, Lan J, Mckeown N, Brown MR, Chen H, De Vries PS, Kim H, Rebholz CM et al. ( 2023 ) . Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure . vol. 4 , ( 11-20 )

Magavern EF, Jacobs B, Warren H, Finocchiaro G, Finer S, Van Heel DA, Smedley D, Caulfield MJ ( 2023 ) . CYP2C19 genotype prevalence and association with recurrent myocardial infarction in British-South Asians treated with clopidogrel . European Heart Journal vol. 44 , ( Supplement_2 )

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

Magavern EF, Jacobs B, Warren H, Finocchiaro G, Finer S, van Heel DA, Team GHR, Smedley D et al. ( 2023 ) . CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel . JACC Advances vol. 2 , ( 7 )

Rathod K, Warren H, Tufaro V, Jain A, Ono M, Chhetri I, Garcia-Garcia H, Bourantas C et al. ( 2023 ) . 34 Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (nitrate-oct study) . Conference: Acute coronary syndromes & Interventional Cardiologya37 - a38 .

Rathod KS, Shabbir A, Jones DA, Khambata RS, Lau C, Beirne A-M, Ono M, Chhetri I et al. ( 2023 ) . D Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (NITRATE-OCT study) . Conference: Young investigators awarda314 - a315 .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A et al. ( 2023 ) . Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH . Diabetologia vol. 66 , ( 7 ) 1260 - 1272 .

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart J-A, Bourcier R, Sawada T et al. ( 2023 ) . Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity . Stroke vol. 54 , ( 3 ) 810 - 818 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Xu J, Choi R, Warren HR, Gupta K, Santhanam L, Pluznick JL ( 2022 ) . Olfactory Receptor 558 (Olfr558) Is Required for Sex Differences in Blood Pressure . Journal of the American Society of Nephrology vol. 33 , ( 11S ) 816 - 816 .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X et al. ( 2022 ) . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension . Hypertension vol. 79 , ( 8 ) 1656 - 1667 .

Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLOS Genetics vol. 18 , ( 4 )

Jepson RE, Warren H, Wallace MD, Syme HM, Elliott J, Munroe PB ( 2022 ) . First genome-wide association study investigating blood pressure and renal traits in domestic cats . Scientific Reports vol. 12 , ( 1 )

Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

McDonough CW, Warren HR, Jack JR, Motsinger‐Reif AA, Armstrong ND, Bis JC, House JS, Singh S et al. ( 2021 ) . Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies . Clinical Pharmacology & Therapeutics vol. 110 , ( 3 ) 723 - 732 .

Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Godolphin J, Warren HR ( 2021 ) . Investigation into The Robustness of Balanced Incomplete Block Designs . Statistics and Applications vol. 19 , ( 1 ) 467 - 481 .

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization . Circulation Genomic and Precision Medicine vol. 14 , ( 3 )

Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .

Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 53 , ( 5 ) 762 - 762 .

Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician’s Road Map to Hypertension Genomics . Hypertension vol. 77 , ( 2 ) 284 - 295 .

Boguslavskyi A, Tokar S, Prysyazhna O, Rudyk O, Sanchez-Tatay D, Lemmey HAL, Dora KA, Garland CJ et al. ( 2020 ) . Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans . Circulation vol. 143 , ( 11 ) 1123 - 1138 .

Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S et al. ( 2020 ) . Cerebral small vessel disease genomics and its implications across the lifespan . Nature Communications vol. 11 , ( 1 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Gallo JE, Ochoa JE, Warren HR, Misas E, Correa MM, Gallo-Villegas JA, Bedoya G, Aristizábal D et al. ( 2020 ) . Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data . International Journal of Cardiology Cardiovascular Risk and Prevention vol. 7 ,

Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H et al. ( 2020 ) . Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation . Circulation: Genomic and Precision Medicine389 - 395 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )

de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry

Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .

Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR et al. ( 2019 ) . Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study . Pharmacogenomics Journal

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al. ( 2019 ) . Associations of autozygosity with a broad range of human phenotypes . Nature Communications vol. 10 , ( 1 ) 4957 - 4957 .

Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, Nelson CP, Bastiaenen R et al. ( 2019 ) . KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern . JCI insight

Petersen S, Munroe P, Aung N, Fung K, Vargas J, Yang C, Cabrera CP, Warren H et al. ( 2019 ) . Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development . Circulation

Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T et al. ( 2019 ) . Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group . American Journal of Hypertension vol. 32 , ( 12 ) 1146 - 1153 .

Iniesta R, Campbell D, Venturini C, Faconti L, Singh S, Irvin MR, Cooper-DeHoff RM, Johnson JA et al. ( 2019 ) . Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals . Hypertension vol. 74 , ( 3 ) 614 - 622 .

Singh S, Warren HR, Hiltunen TP, McDonough CW, El Rouby N, Salvi E, Wang Z, Garofalidou T et al. ( 2019 ) . Genome-Wide Meta-Analysis of Blood Pressure Response to β<inf>1</inf>-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies) . Journal of the American Heart Association vol. 8 , ( 16 )

Fung K, Ramírez J, Warren HR, Aung N, Lee AM, Tzanis E, Petersen SE, Munroe PB ( 2019 ) . Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants . Scientific Reports vol. 9 , ( 1 )

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . 199Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . P463Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .

Sung YJ, de las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al. ( 2019 ) . A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure . Human Molecular Genetics vol. 28 , ( 15 ) 2615 - 2633 .

Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Communications Biology vol. 2 , ( 1 )

Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al. ( 2019 ) . Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease . Commun Biol vol. 2 , ( 1 )

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I et al. ( 2019 ) . Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits . European Journal of Human Genetics vol. 27 , ( 6 ) 952 - 962 .

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2019 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .

McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, El Rouby NM, Gong Y, Mychaleckyj JC, Benavente OR et al. ( 2019 ) . DRUG-SNP INTERACTIONS AND CARDIOVASCULAR OUTCOMES: A GENOME-WIDE META-ANALYSIS IN THE INTERNATIONAL CONSORTIUM FOR ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S105 - S106 .

Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUM OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S16 - S16 .

Singh S, Warren HR, Hiltunen TP, Salvi E, El Rouby N, Garofalidou T, Fyhrquist F, Kontula KK et al. ( 2019 ) . GENOME WIDE META-ANALYSIS OF BLOOD PRESSURE RESPONSE TO B-BLOCKERS: RESULTS FROM INTERNATIONAL CONSORTIUNI OF ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES . CLINICAL PHARMACOLOGY & THERAPEUTICS . vol. 105 , S27 - S27 .

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 155 - 156 .

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 377 - 378 .

Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .

Ntalla I, Weng L, Warren HR, Jamshidi Y, Munroe PB, Lubitz SA ( 2019 ) . Multi-ancestry genome-wide association meta-analysis of 293,000 individuals identifies 217 regions for the electrocardiographic PR interval . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 158 - 159 .

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al. ( 2018 ) . Trans-ethnic association study of blood pressure determinants in over 750,000 individuals . Nature Genetics vol. 51 , ( 1 ) 51 - 62 .

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .

Bastiaenen R, Nolte IM, Munroe PB, Riese H, Nelson C, O'Connor H, Gang Y, Warren HR et al. ( 2018 ) . The narrow-sense and common single nucleotide polymorphism heritability of early repolarization . International Journal of Cardiology vol. 279 , 135 - 140 .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nature Genetics vol. 50 , ( 10 ) 1412 - 1425 .

Ng FL, Warren HR, Caulfield MJ ( 2018 ) . Hypertension genomics and cardiovascular prevention . Ann Transl Med vol. 6 , ( 15 ) 291 - 291 .

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 )

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .

Warren HR, Evangelou E, Mosen D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . GENETIC ANALYSIS OF OVER ONE MILLION PEOPLE IDENTIFIES 535 NOVEL LOCI ASSOCIATED WITH BLOOD PRESSURE AND RISK OF CARDIOVASCULAR DISEASE . Journal of Hypertension . vol. 36 ,

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 )

Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L et al. ( 2018 ) . Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval . Circulation Genomic and Precision Medicine vol. 11 , ( 5 )

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al. ( 2018 ) . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes . Nature Genetics vol. 50 , ( 4 ) 559 - 571 .

Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al. ( 2018 ) . A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure . American Journal of Human Genetics vol. 102 , ( 3 ) 375 - 400 .

Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, Liu C-T, Marten J et al. ( 2018 ) . ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals . Circulation Genomic and Precision Medicine vol. 11 , ( 1 ) e001758 - e001758 .

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation Genomic and Precision Medicine vol. 11 , ( 1 )

Munroe PB, Warren HR ( 2018 ) . Chapter 5 Hypertension . Genomic and Precision Medicine , Elsevier

Munroe PB, Warren HR ( 2018 ) . Hypertension . Genomic and Precision Medicine: Cardiovascular Disease: Third Edition ,

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nat Genet vol. 50 , ( 5 ) 765 - 766 .

Pazoki R, Dehghan A, Evangelou E, Warren H, Gao H, Caulfield M, Elliott P, Tzoulaki I ( 2017 ) . Genetic Predisposition to High Blood Pressure and Lifestyle Factors . Circulation vol. 137 , ( 7 ) 653 - 661 .

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2017 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation Genomic and Precision Medicine vol. 10 , ( 5 )

Little L, Kraja AT, Cook JP, Warren HR, Newton-Cheh C, Munroe PB, Howson JMM, BP CE et al. ( 2017 ) . New blood pressure associated loci identified in meta-analyses of 475,000 individuals using the Exome Chip . vol. 31 , is. 10 , pp. 665 - 666 .

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 10 ) 1558 - 1558 .

Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D et al. ( 2017 ) . Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos . Sci Rep vol. 7 , ( 1 ) 10348 - 10348 .

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T et al. ( 2017 ) . Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus . Circulation vol. 135 , ( 24 ) 2373 - 2388 .

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics

Munroe PB, Warren HR ( 2017 ) . Hypertension . Genomic and Precision Medicine: Primary Care: Third Edition ,

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .

Munroe PB, Warren HR ( 2017 ) . Chapter 7 Hypertension . Genomic and Precision Medicine , Elsevier

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR et al. ( 2016 ) . A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium . J Med Genet

Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK et al. ( 2016 ) . Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study . BMJ Open vol. 6 , ( 12 )

Warren HR, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BH, Munroe PB, Grp CHARGECEKGW ( 2016 ) . Discovery of Novel Loci Associated with Heart Rate from Exome Chip Analysis . GENETIC EPIDEMIOLOGY . Conference: International Genetic Epidemiology Society vol. 40 , 670 - 670 .

Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB ( 2016 ) . Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study . J Small Anim Pract vol. 57 , ( 11 ) 580 - 588 .

Warren HR, Surendran P, Manning AK, van den Berg ME, van der Harst P, Verweij N, Eijgelsheim M, Stricker BHC et al. ( 2016 ) . Novel loci discovery for blood pressure and heart rate using the Exome chip . JOURNAL OF HUMAN HYPERTENSION vol. 30 , ( 10 ) 653 - 653 .

Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA et al. ( 2016 ) . Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment . Pharmacogenomics vol. 17 , ( 15 ) 1621 - 1628 .

MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al. ( 2016 ) . Meta-analysis of genome-wide association studies of HDL cholesterol response to statins . Journal of Medical Genetics

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .

HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE et al. ( 2016 ) . IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty . EMBO Molecular Medicine vol. 8 , ( 6 ) 626 - 42 .

Leusink M, der Zee AHM-V, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA et al. ( 2016 ) . A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics vol. 17 , ( 6 ) 583 - 591 .

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2016 ) . Role of IGSF10 mutations in self-limited delayed puberty . The Lancet . vol. 387 ,

White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA et al. ( 2016 ) . Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis . The Lancet Diabetes & Endocrinology vol. 4 , ( 4 ) 327 - 336 .

Howard S, Poliandre A, Storr HL, Metherell LA, Cabrera C, Warren H, Barnes M, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH) . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Cabrera C et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty . Endocrine Abstracts

Howard S, Poliandri A, Storr H, Metherell L, Cabrera C, Barnes M, Warren H, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration . Endocrine Abstracts

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C et al. ( 2015 ) . Directional dominance on stature and cognition in diverse human populations . Nature vol. 523 , ( 7561 ) 459 - 462 .

Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, Goel A, Padmanabhan S et al. ( 2015 ) . Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis . International Journal of Epidemiology vol. 45 , ( 6 ) 1927 - 1937 .

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB, Caulfield MJ ( 2015 ) . Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics . WIREs Mechanisms of Disease vol. 7 , ( 2 ) 73 - 90 .

Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E, Johnson N, Ghoussaini M et al. ( 2015 ) . Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 . Human Molecular Genetics vol. 24 , ( 10 ) 2966 - 2984 .

Warren HR, Surendran P, Drenos F, Young R, Cook JP, Manning AK, Grarup N, Sim X et al. ( 2015 ) . Investigating the Association of Rare Genetic Variants with Blood Pressure traits . GENETIC EPIDEMIOLOGY . vol. 39 , 591 - 591 .

Godolphin JD, Warren HR ( 2014 ) . An efficient procedure for the avoidance of disconnected incomplete block designs . COMPUTATIONAL STATISTICS & DATA ANALYSIS vol. 71 , 1134 - 1146 .

Postmus I, Trompet S, Warren HR, Jukema JW, Caulfield MJ ( 2014 ) . Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins . JOURNAL OF HUMAN HYPERTENSION . vol. 28 , 624 - 624 .

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D et al. ( 2013 ) . Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium . PLoS ONE vol. 8 , ( 8 )

Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK et al. ( 2013 ) . Genome-wide association studies identify four ER negative-specific breast cancer risk loci . Nat Genet vol. 45 , ( 4 ) 392 - 398 .

Warren H, Casas J, Hingorani A, Dudbridge F, Whittaker J ( 2013 ) . Genetic Prediction of Quantitative Lipid Traits: Comparing Shrinkage Models to Gene Scores . Genet. Epidemiol. vol. 38 , ( 1 ) 72 - 83 .

Warren H, Dudbridge F, Fletcher O, Orr N, Johnson N, Hopper JL, Apicella C, Southey MC et al. ( 2012 ) . 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium . Cancer Epidemiology Biomarkers & Prevention vol. 21 , ( 10 ) 1783 - 1791 .

Godolphin JD, Warren HR ( 2011 ) . Improved conditions for the robustness of binary block designs against the loss of whole blocks . Journal of Statistical Planning and Inference vol. 141 , ( 11 ) 3498 - 3505 .