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Research

Publications: Dr Andrejs Brauns

Edelmann J, Dokal AD, Vilventhraraja E, Holzmann K, Britton D, Klymenko T, Döhner H, Cragg M et al. ( 2021 ) . Rituximab and obinutuzumab differentially hijack the B-cell receptor and NOTCH1 signaling pathways . iScience102089 - 102089 .
Bloehdorn J, Braun A, Jebaraj BMC, Taylor-Weiner A, Robrecht S, Krzykalla J, Holzmann K, Johnston H et al. ( 2020 ) . Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia . Blood . Conference: American Society of Hematology Annual Meeting vol. 136 , 12 - 13 .
Edelmann J, Britton DJ, Vilventhraraja E, Dokal A, Holzmann K, Cragg MC, Braun A, Cutillas P et al. ( 2018 ) . Anti-CD20 Monoclonal Antibodies Hijack the B-Cell Receptor Signaling Cascade Thereby Activating the NOTCH1 Signaling Pathway . Blood . Conference: American Society of Hematology Annual Congress vol. 132 , 588 - 588 .
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al. ( 2017 ) . Lamin B1 regulates somatic mutations and progression of B-cell malignancies . Leukemia vol. 32 , ( 2 ) 364 - 375 .
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Wang J, Fischer K, Akylzhanova G, Edelmann J et al. ( 2017 ) . NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES . HAEMATOLOGICA . vol. 102 , 228 - 228 .
BRAUNS A ( 2017 ) . ONCOGENE-EXPRESSING SENESCENT MELANOCYTES UPREGULATE MHC CLASS II, A CANDIDATE MELANOMA SUPPRESSOR FUNCTION . Journal of Investigative Dermatology
Edelmann J, Klymenko T, Lu C, Vilventhraraja E, Estenfelder S, Tausch E, Beers SA, Stilgenbauer S et al. ( 2016 ) . In Chronic Lymphocytic Leukemia ΔCT7544-7545 Mutant NOTCH1 Maintains Transcription Factor Activity with Longer Lasting Effects Due to Slower Degradation . Blood . vol. 128 , 971 - 971 .
Dou Z, Ivanov A, Adams PD, Berger SL ( 2016 ) . Mammalian autophagy degrades nuclear constituents in response to tumorigenic stress . Autophagy vol. 12 , ( 8 ) 1416 - 1417 .
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC et al. ( 2015 ) . Autophagy mediates degradation of nuclear lamina . Nature vol. 527 , ( 7576 ) 105 - 109 .
Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O et al. ( 2014 ) . HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of Neoplasia . Genes and Development vol. 28 , ( 24 ) 2712 - 2725 .
Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G et al. ( 2013 ) . Lysosome-mediated processing of chromatin in senescence . J Cell Biol vol. 202 , ( 1 ) 129 - 143 .
Jackson TR, Salmina K, Huna A, Inashkina I, Jankevics E, Riekstina U, Kalnina Z, Ivanov A et al. ( 2013 ) . DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells . CELL CYCLE vol. 12 , ( 3 ) 430 - 441 .
Honeychurch J, Alduaij W, Azizyan M, Cheadle EJ, Pelicano H, Ivanov A, Huang P, Cragg MS et al. ( 2012 ) . Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway . Blood vol. 119 , ( 15 ) 3523 - 3533 .
Honeychurch J, Alduaij W, Cheadle E, Azizyan M, Pelicano H, Huang P, Ivanov A, Cragg MS et al. ( 2011 ) . Antibody-Induced Non-Apoptotic Cell Death in Human Lymphoma and Leukemia Cells Is Mediated Through NADPH Oxidase-Derived Reactive Oxygen Species . Blood vol. 118 , ( 21 ) 1651 - 1651 .
Alduaij W, Ivanov A, Honeychurch J, Cheadle EJ, Potluri S, Lim SH, Shimada K, Chan CHT et al. ( 2011 ) . Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies . Blood vol. 117 , ( 17 ) 4519 - 4529 .
Ivanov A, Adams PD ( 2011 ) . A damage limitation exercise . Nature Cell Biology vol. 13 , ( 3 ) 193 - 195 .
Salmina K, Jankevics E, Huna A, Perminov D, Radovica I, Klymenko T, Ivanov A, Jascenko E et al. ( 2010 ) . Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells . Experimental Cell Research vol. 316 , ( 13 ) 2099 - 2112 .
Alduau W, Potluri S, Ivanov A, Honeychurch J, Beers SA, Chan C, Shimada K, Glennie MJ et al. ( 2009 ) . New-Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma . BLOOD . vol. 114 , 302 - 303 .
Alduaij W, Potluri S, Ivanov A, Honeychurch J, Beers SA, Chan C, Shimada K, Glennie MJ et al. ( 2009 ) . New-Generation Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-Cell Lymphoma . Blood vol. 114 , ( 22 ) 725 - 725 .
Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S et al. ( 2009 ) . Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells . J Clin Invest vol. 119 , ( 8 ) 2143 - 2159 .
Illidge T, Ivanov A, Beers SA, Walshe C, Chan C, Alduaij W, Glennie MJ, Cragg MS ( 2008 ) . Novel Mechanisms of Non-Apoptotic Cell Death Evoked by Type II Anti-CD20 (Tositumomab) and HLA-DR Monoclonal Antibodies . Blood vol. 112 , ( 11 ) 883 - 883 .
Erenpreisa J, Ivanov A, Wheatley SP, Kosmacek EA, Ianzini F, Anisimov AP, Mackey M, Davis PJ et al. ( 2008 ) . Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase . CELL BIOLOGY INTERNATIONAL vol. 32 , ( 9 ) 1044 - 1056 .
Ivanov A, Swann R, Illidge T ( 2008 ) . New insights into the mechanisms of action of radioimmunotherapy in lymphoma . J Pharm Pharmacol vol. 60 , ( 8 ) 987 - 998 .
Ivanov A, Krysov S, Cragg MS, Illidge T ( 2008 ) . Radiation therapy with tositumomab (B1) anti-CD20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-activated protein kinase-dependent cell death that overcomes resistance to apoptosis . Clin Cancer Res vol. 14 , ( 15 ) 4925 - 4934 .
Ivanov A, Cragg MS, Illidge TM ( 2006 ) . Treatment with the anti-CD20 antibody (B1) and irradiation result in synergistic cytotoxicity that is dependent on MAPK activation . BLOOD . vol. 108 , 710A - 710A .
Kalejs M, Ivanov A, Plakhins G, Cragg MS, Emzinsh D, Lllidge TM, Erenpreisa J ( 2006 ) . Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe . BMC Cancer vol. 6 ,
Erenpreisa J, Kalejs M, Ianzini F, Kosmacek EA, Mackey MA, Emzinsh D, Cragg MS, Ivanov A et al. ( 2005 ) . Segregation of genomes in polyploid tumour cells following mitotic catastrophe . CELL BIOLOGY INTERNATIONAL vol. 29 , ( 12 ) 1005 - 1011 .
Cragg MS, Walshe CA, Ivanov AO, Glennie MJ ( 2005 ) . The biology of CD20 and its potential as a target for mAb therapy . Curr Dir Autoimmun vol. 8 , 140 - 174 .
Ivanov A, Cragg MS, Erenpreisa J, Emzinsh D, Lukman H, Illidge TM ( 2003 ) . Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks . J Cell Sci vol. 116 , ( Pt 20 ) 4095 - 4106 .
Ivanov A, Cragg MS, Erenpreisa J, Emzinsh D, Lukman H, Illidge TM ( 2003 ) . Endopolyploid cells produced aftere severe genotoxic damage have the potential to repair DNA double strand breaks . Journal of Cell Science vol. 116 , ( 20 ) 4095 - 4106 .
Ivanov A, Cragg M, Erenpreisa J, Illidge T ( 2003 ) . Radiation-induced MAPK activation produces polyploid tumour cells that undergo DNA double strand break repair . BRITISH JOURNAL OF CANCER . vol. 88 , S26 - S26 .
Erenpreisa J, Erenpreiss J, Freivalds T, Slaidina M, Krampe R, Butikova J, Ivanov A, Pjanova D ( 2003 ) . Toluidine blue test for sperm DNA integrity and elaboration of image cytometry algorithm . Cytometry A vol. 52 , ( 1 ) 19 - 27 .
Erenpreisa J, Ivanov A, Cragg M, Selivanova G, Illidge T ( 2002 ) . Nuclear envelope-limited chromatin sheets are part of mitotic death . Histochem Cell Biol vol. 117 , ( 3 ) 243 - 255 .
Ivanov A, Cragg MS, Illidge TM, Erenpreisa J ( 2000 ) . The delayed action of the spindle checkpoint in p53 mutated lymphoid tumour cells . BRITISH JOURNAL OF CANCER vol. 83 , 58 - 58 .
Erenpreisa JE, Ivanov A, Dekena G, Vitina A, Krampe R, Freivalds T, Selivanova G, Roach HI ( 2000 ) . Arrest in metaphase and anatomy of mitotic catastrophe: mild heat shock in two human osteosarcoma cell lines . Cell Biol Int vol. 24 , ( 2 ) 61 - 70 .