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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Thomas Nightingale

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El-Mansi S, Mitchell TP, Mobayen G, McKinnon TAJ, Miklavc P, Frick M, Nightingale TD ( 2024 ) . Myosin-1C augments endothelial secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane . Blood Advances vol. 8 , ( 17 ) 4714 - 4726 .
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .
Bosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale TD et al. ( 2023 ) . Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow . Science Signaling vol. 16 , ( 786 )
El-Mansi S, Robinson CL, Kostelnik KB, McCormack JJ, Mitchell TP, Lobato-Márquez D, Rajeeve V, Cutillas P et al. ( 2022 ) . Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor . Blood vol. 141 , ( 8 ) 930 - 944 .
Carpintero-Fernández P, Borghesan M, Eleftheriadou O, Pan-Castillo B, Fafián-Labora JA, Mitchell TP, Yuste A, Ogrunc M et al. ( 2022 ) . Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence . Cell Death & Disease vol. 13 , ( 2 )
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al. ( 2021 ) . Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation . Immunity vol. 54 , ( 9 ) 1989 - 2004.e9 .
El-Mansi S, Nightingale TD ( 2020 ) . Emerging mechanisms to modulate VWF release from endothelial cells . The International Journal of Biochemistry & Cell Biology vol. 131 ,
Mitchell TP, Kostelnik KB, Barker A, Schultz C, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al. ( 2020 ) . Trafficking of JAM-C is regulated by cytoplasmic tail motifs and is essential to endothelial cell migration . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 101 , A4 - A4 .
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al. ( 2019 ) . Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration . PLOS Biology vol. 17 , ( 12 )
del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S et al. ( 2019 ) . NMDA receptor modulation of glutamate release in activated neutrophils . EBioMedicine
Tarvala U, Matary RE, Nightingale T, Poston R ( 2018 ) . Decrease in Von-Willebrand factor protein in the endothelium of human coronary atherosclerotic plaques: Possible mechanisms and role in thrombosis . Atherosclerosis . vol. 275 ,
NIGHTINGALE TD, McCormack JJ, Grimes W, ROBINSON C, Lopes da Silva M, White IJ, Vaughan A, Cramer LP et al. ( 2018 ) . Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies . Journal of Thrombosis and Haemostasis
Robinson CL, McCormack JJ, White IJ, Cutler DF, Nightingale TD ( 2018 ) . F-actin and septin coordinate to drive the exocytosis of a pro-haemostatic molecule from endothelial cells . MOLECULAR BIOLOGY OF THE CELL . vol. 29 ,
NIGHTINGALE TD, CUTLER DF, Robinson C, McCormack JJ, White IJ, Stevenson NL ( 2017 ) . Clathrin-mediated post-fusion membrane retrieval influences the exocytic mode of endothelial Weibel-Palade bodies . Journal of Cell Science
Reglero N, Beal R, Cabrera C, Pickworth C, Golding M, Whiteford J, Nightingale T, Imhof B et al. ( 2016 ) . JAM‐C deficiency primes endothelial cells for a pro‐inflammatory state . The FASEB Journal . vol. 30 ,
Nightingale T, Cutler D ( 2013 ) . The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story . Journal of Thrombosis and Haemostasis vol. 11 , ( Suppl 1 ) 192 - 201 .
Nightingale TD, Cutler DF, Cramer LP ( 2012 ) . Actin coats and rings promote regulated exocytosis . Trends in Cell Biology vol. 22 , ( 6 ) 329 - 337 .
Pulido IR, Nightingale TD, Darchen F, Seabra MC, Cutler DF, Gerke V ( 2011 ) . Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von‐Willebrand Factor Release from Endothelial Cells . Traffic vol. 12 , ( 10 ) 1371 - 1382 .
Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF ( 2011 ) . Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood. 2009;113(20):5010–5018 . Blood vol. 117 , ( 12 )
MICHAUX G, DYER CEF, NIGHTINGALE TD, GALLAUD E, NURRISH S, CUTLER DF ( 2011 ) . A role for Rab10 in von Willebrand factor release discovered by an AP‐1 interactor screen in C. elegans . Journal of Thrombosis and Haemostasis vol. 9 , ( 2 ) 392 - 401 .
NIGHTINGALE TD, White IJ, Doyle EL, Turmaine M, Harrison-Lavoie KJ, Webb KF, Cramer LP, Cutler DF ( 2011 ) . Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis . J Cell Biol. vol. 194 , ( 4 ) 613 - 629 .
NIGHTINGALE TD, Pattni K, Hume AN, Seabra MC, Cutler DF ( 2009 ) . Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells . Blood vol. 113 , ( 20 ) 5010 - 5018 .
Nightingale TD, Frayne MEF, Clasper S, Banerji S, Jackson DG ( 2008 ) . A Mechanism of Sialylation Functionally Silences the Hyaluronan Receptor LYVE-1 in Lymphatic Endothelium* . Journal of Biological Chemistry vol. 284 , ( 6 ) 3935 - 3945 .
Lui-Roberts WWY, Ferraro F, Nightingale TD, Cutler DF ( 2008 ) . Aftiphilin and γ-Synergin Are Required for Secretagogue Sensitivity of Weibel-Palade Bodies in Endothelial Cells . Molecular Biology of the Cell vol. 19 , ( 12 ) 5072 - 5081 .
Metcalf DJ, Nightingale TD, Zenner HL, Lui-Roberts WW, Cutler DF ( 2008 ) . Formation and function of Weibel-Palade bodies . Journal of Cell Science vol. 121 , ( 1 ) 19 - 27 .
Nightingale TD, Banerji S, Jackson DG ( 2005 ) . Functional regulation of the lymphatic hyaluronan receptor (LYVE-1) by terminal sialic acid . JOURNAL OF LEUKOCYTE BIOLOGY . 54 - 54 .
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