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Research

Publications: Dr Myles Lewis

Micheroli R, Elhai M, Edalat S, Frank-Bertoncelj M, Bürki K, Ciurea A, MacDonald L, Kurowska-Stolarska M et al. ( 2022 ) . Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: A deconvolution analysis . RMD Open vol. 8 , ( 1 )
Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2021 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution . Scientific Reports vol. 11 , ( 1 )
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,
Boutet MA, Nerviani A, Lliso-Ribera G, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response . Frontiers in Immunology vol. 12 ,
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .
Manou-Stathopoulou S, Hann W, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2021 ) . P162 Incidence of neutropaenia and infections in lupus patients on immunosuppression . Rheumatology vol. 60 , ( Supplement_1 )
Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science and Medicine vol. 8 , ( 1 )
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .
Bellan M, Quaglia M, Nerviani A, Mauro D, Lewis M, Goegan F, Gibbin A, Pagani S et al. ( 2021 ) . Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis . Clinical and Experimental Rheumatology vol. 39 , ( 1 ) 132 - 138 .
Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C, Dalli J ( 2020 ) . Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis . Nature Communications vol. 11 , ( 1 )
Nerviani A, Boutet M-A, Tan WSG, Goldmann K, Purkayastha N, Lajtos T, Hands R, Lewis M et al. ( 2020 ) . IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors . Annals of the Rheumatic Diseases
Sciacca E, Surace A, Lewis M, Alaimo S, Latora V, Rivellese F, Pulvirenti A, Ferro A et al. ( 2020 ) . Novel Network Tool Highlights Key Features Associated with Disease Pathotypes and Response to Treatment in Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . Conference: ACR Convergence 2020 vol. 72 ,
Cherlin S, Lewis MJ, Plant D, Nair N, Goldmann K, Tzanis E, Barnes MR, Mckeigue P et al. ( 2020 ) . Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) 1446 - 1452 .
Humby F, Lewis M, Townsend MJ, Pitzalis C ( 2020 ) . Response to: 'Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients' by Buch et al . Annals of the Rheumatic Diseases vol. 79 , ( 11 )
Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al. ( 2020 ) . Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis . Nature Medicine vol. 26 , ( 8 ) 1295 - 1306 .
Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .
Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,
Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Cove-Smith A ( 2020 ) . EP34 Assessing the ability of anti-C1q antibody measurement to predict a flare of lupus nephritis . Rheumatology . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,
Sciacca E, Alaimo S, Pulvirenti A, Latora V, Humby F, Ferro A, Lewis MJ, Pitzalis C ( 2020 ) . P22 Micro-RNA enriched pathway impact analysis applied to synovial RNA-seq in early rheumatoid arthritis identifies response prediction pathways . Rheumatology . Conference: British Society for Rheumatology Annual Conference 2020 vol. 59 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .
Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Cove-Smith A ( 2020 ) . P13 Assessing the ability of Anti-C1q antibody measurement to predict a flare of lupus nephritis . a35.1 - a3a35 .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology
John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ ( 2020 ) . Spectrum: Fast density-aware spectral clustering for single and multi-omic data . Bioinformatics vol. 36 , ( 4 ) 1159 - 1166 .
John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2020 ) . M3C: Monte Carlo reference-based consensus clustering . Scientific Reports vol. 10 , ( 1 )
Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al. ( 2020 ) . New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis . Disease Markers vol. 2020 , Article 1614627 ,
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of autoimmunity vol. 105 ,
Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al. ( 2019 ) . Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: Results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases vol. 78 , ( 12 ) 1642 - 1652 .
Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al. ( 2019 ) . Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring . Cell Metabolism
Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Antbring R, Cunningham M, Bull R, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2019 ) . Lupus Teledematology: A Pilot Project to Evaluate the Plausibility of a Rapid Access Dermatology Service for Lupus Patients . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . 1548.1 - 151548 .
Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . 130 - 131 .
Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . 134 - 134 .
Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M ( 2019 ) . SAT0025 THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS . 1077.1 - 101077 .
Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S et al. ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the rheumatic diseases vol. 78 , ( 6 ) 761 - 772 .
Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . 394.2 - 39395 .
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . a174.2 - a1a175 .
Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al. ( 2019 ) . Activation of naïve CD4 <sup>+</sup> T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 <sup>+</sup> T cells . Nature Immunology vol. 20 , ( 4 ) 458 - 470 .
Khan A, Pakozdi A, Rajakariar R, Cove-Smith A, Lewis M, Pyne D ( 2019 ) . E090 Sleep disturbances in lupus patients . Rheumatology vol. 58 , ( Supplement_3 )
Almathkouri A, Pyne D, Rajakariar R, Cove-Smith A, Lewis M, Pakozdi A ( 2019 ) . E091 Prevalence of fibromyalgia in a cohort of renal and non-renal systemic lupus erythematosus patients . Rheumatology vol. 58 , ( Supplement_3 )
Almathkouri A, Pyne D, Rajakariar R, Cove-Smith A, Lewis M, Pakozdi A ( 2019 ) . PREVALENCE OF FIBROMYALGIA IN A COHORT OF RENAL AND NON-RENAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS . RHEUMATOLOGY . vol. 58 , 196 - 196 .
Khan A, Pakozdi A, Rajakariar R, Cove-Smith A, Lewis M, Pyne D ( 2019 ) . SLEEP DISTURBANCES IN LUPUS PATIENTS . RHEUMATOLOGY . vol. 58 ,
Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2019 ) . P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . vol. 78 ,
Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH et al. ( 2019 ) . Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology (Oxford)
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al. ( 2019 ) . The autoimmune susceptibility gene C5orf30 regulates macrophage-mediated resolution of inflammation . Journal of Immunology vol. 202 , ( 4 ) 1069 - 1078 .
Nerviani A, Mauro D, Gilio M, Grembiale RD, Lewis MJ ( 2018 ) . To supplement or not to supplement? The rationale of vitamin D supplementation in systemic lupus erythematosus . Open Rheumatology Journal vol. 12 , 226 - 247 .
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 1 ) 53 - 60 .
Khan A, Lewis M, Thomas G ( 2018 ) . 46. Subglottic stenosis in a patient with granulomatosis with polyangiitis recently treated with rituximab . Rheumatology Advances in Practice vol. 2 , ( Suppl 1 )
Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ ( 2018 ) . Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
Bottini A, Wu DJ, Ai R, LeRoux M, Bartok B, Bombardieri M, Zhang V, Doody KM et al. ( 2018 ) . Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
Lewis MJ, McAndrew MB, Wheeler C, Workman N, Agashe P, Koopmann J, Uddin E, Morris DL et al. ( 2018 ) . Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus . Journal of Autoimmunity vol. 91 , 1 - 12 .
Lewis MJ, Barnes MR ( 2018 ) . RNA sequencing and machine learning as molecular scalpels . Nat Rev Rheumatol vol. 14 , ( 7 ) 388 - 390 .
Almathkouri A, Pyne D, Pakozdi A, Rajkariar R, Cove-smith A, Lewis M ( 2018 ) . AB0545 Is lupus more prevalent in world’s most stressed countries? . Annals of the Rheumatic Diseases vol. 77 , ( Suppl 2 )
Mauro D, Tsang V, Lucey-Clayton I, Rivellese F, Pagani S, Alam F, Pontarini E, Nerviani A et al. ( 2018 ) . FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle . Annals of the Rheumatic Diseases . vol. 77 ,
Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 77 ,
Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2018 ) . SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . vol. 77 ,
Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 77 ,
Rivellese F, Congia M, Mauro D, Bombardieri M, Lewis M, Pitzalis C ( 2018 ) . THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates . Annals of the Rheumatic Diseases . vol. 77 ,
Purkayastha N, Tan WS, Mahto A, Lewis M, Lliso G, Nerviani A, Rocher V, Humby F et al. ( 2018 ) . THU0122 Imaging characterisation of remission in rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 77 ,
Waller A, Goulden B, Pakozdi A, Lewis M, Rajakariar R, Cove-Smith A, Pyne D ( 2018 ) . 125 Self reported alopecia in an ethnically diverse lupus cohort . Rheumatology vol. 57 , ( suppl_3 )
Wheeler LM, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2018 ) . 139 Moving with the times: social media use amongst lupus patients . Rheumatology vol. 57 , ( suppl_3 )
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,
Wheeler LM, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2018 ) . MOVING WITH THE TIMES: SOCIAL MEDIA USE AMONGST LUPUS PATIENTS . RHEUMATOLOGY . vol. 57 ,
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )
Hensor EMA, McKeigue P, Buch MH, Barrett JH, Nam JL, Freeston J, Colombo M, Spiliopoulou A et al. ( 2018 ) . O12 Validity of a2-component imaging-derived disease activity score (2C-DAS28) for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )
Waller A, Goulden B, Pakozdi A, Lewis M, Rajakariar R, Cove-Smith A, Pyne D ( 2018 ) . SELF REPORTED ALOPECIA IN AN ETHNICALLY DIVERSE LUPUS COHORT . RHEUMATOLOGY . vol. 57 ,
Ribera GL, Humby F, Kelly S, Lewis M, Bornbardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . THE CLINICAL PHENOTYPE OF INFLAMMATORY ARTHRITIS CORRELATES WITH SYNOVIAL IMMUNE CELL INFILTRATION: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,
Almathkouri A, Pyne D, Pakozdi A, Lewis M, Cove-Smith A, Rajakariar R ( 2018 ) . PS2:43 Is lupus more prevalent in world’s most stressed countries? . a53.2 - a5a54 .
Wheeler L, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2018 ) . PS8:159 Moving with the times: social media use amongst lupus patients . a116.1 - a1a116 .
Pullabhatla V, Roberts AL, Lewis MJ, Mauro D, Morris DL, Odhams CA, Tombleson P, Liljedahl U et al. ( 2018 ) . De novo mutations implicate novel genes in systemic lupus erythematosus . Human Molecular Genetics vol. 27 , ( 3 ) 421 - 429 .
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 2 )
RA-MAP Consortium ( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 )
Ursini F, Leporini C, Bene F, D'Angelo S, Mauro D, Russo E, De Sarro G, Olivieri I et al. ( 2017 ) . Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: A systematic review and meta-analysis . Scientific Reports vol. 7 , ( 1 )
Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Grigoriadou S, Cove-Smith A ( 2017 ) . Anti-C1q Antibodies and Disease Activity in a Multi-Ethnic Lupus Cohort . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Mauro D, Tsang V, Clayton-Lucey IA, Pagani S, Alam F, Pontarini E, Nerviani A, Pakozdi A et al. ( 2017 ) . Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Etomi O, Cove-Smith A, Rajakariar R, Lewis MJ, Pakozdi A, Pyne D ( 2017 ) . The Prevalence of Autoimmune Disease in Families of Patients with Systemic Lupus Erythematosus (SLE). a Single Centre Study . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Nerviani A, Pagani S, Mauro D, Humby F, Kelly S, Rivellese F, Ribera GL, Lewis MJ et al. ( 2017 ) . Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 76 ,
Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 76 ,
Bombardieri M, Lewis M, Pitzalis C ( 2017 ) . Ectopic lymphoid neogenesis in rheumatic autoimmune diseases . Nature Reviews Rheumatology
Lewis MJ, Jawad AS ( 2016 ) . The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus . Rheumatologykew399 - kew399 .
Hensor EMA, McKeigue P, Conaghan PG, Buch MH, Barrett JH, Nam JL, Colombo M, Spiliopoulou A et al. ( 2016 ) . Validity of a 2-Component Disease Activity Score for Accurate Assessment of Synovitis in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,
Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. ( 2016 ) . C1QTNF4 MUTATION IDENTIFIED BY EXOME SEQUENCING IS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND DYSREGULATION OF TNF-INDUCED APOPTOSIS . ANNALS OF THE RHEUMATIC DISEASES . Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75 , 145 - 154 .
Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. ( 2016 ) . FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology . Annals of the Rheumatic Diseases . vol. 75 ,
Lewis MJ, McAndrew MB, Wheeler C, Workman N, Agashe P, Koopmann J, Uddin E, Zou L et al. ( 2016 ) . FUNCTIONAL CLUSTERS OF AUTOANTIBODIES TARGETING TLR AND SMAD PATHWAYS DEFINE NEW SUBGROUPS IN SYSTEMIC LUPUS ERYTHEMATOSUS . ANNALS OF THE RHEUMATIC DISEASES . Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75 , 278 - 278 .
Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. ( 2016 ) . OP0232 C1qtnf4 Mutation Identified by Exome Sequencing Is Associated with Systemic Lupus Erythematosus and Dysregulation of Tnf-Induced Apoptosis . Annals of the Rheumatic Diseases vol. 75 , ( Suppl 2 )
Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. ( 2016 ) . OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy . Annals of the Rheumatic Diseases . vol. 75 ,
Nerviani A, DiCicco M, Kelly S, Humby F, Hands R, Zou L, Lewis M, Rocher V et al. ( 2016 ) . FIBROID SYNOVIAL PATHOTYPE AND TYROSINE KINASE AXL CORRELATE WITH POOR CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS PATIENTS . Rheumatology . Conference: Rheumatology 2016 from: 26/09/2016 to: 28/04/2016 , vol. 55 , 61 - 61 .
Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS . RHEUMATOLOGY . Conference: British Society for Rheumatology annual conference 2016 vol. 55 , 145 - 146 .
Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1 . Arthritis Research and Therapy vol. 18 , ( 1 )
Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . O37. The Autoimmune Risk Gene UBE2L3 is Highly Expressed During B Cell Proliferation and is Correlated with Plasmablast and Plasma Cell Expansion in SLE . Rheumatology vol. 54 , ( suppl_1 ) i41 - i41 .
Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE . RHEUMATOLOGY . vol. 54 , 41 - 41 .
Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, Lehner P, Walczak H et al. ( 2015 ) . Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus . Lancet . vol. 385 Suppl 1 ,
Vyse S, Shields A, Boeltz S, Leirer D, Gordon P, Spector T, Lehner P, Walczak H et al. ( 2015 ) . A2.10 SLE associated UBE2L3 haplotype modulates plasma cell differentiation via genotypic regulation of NF-κB . Annals of the Rheumatic Diseases . vol. 74 ,
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H et al. ( 2015 ) . UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases . American Journal of Human Genetics vol. 96 , ( 2 ) 221 - 234 .
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon P, Spector TD, Lehner PJ, Walczak H et al. ( 2014 ) . UBE2L3 genotype Influences Plasma Cell Proliferation in Systemic Lupus Erythematosus By Regulation of NF-kappa B By the Linear Ubiquitination Assembly Complex . ARTHRITIS & RHEUMATOLOGY vol. 66 , S384 - S384 .
Lewis MJ, Vyse S, Boeltz S, Walczak H, Spector TD, Lehner PJ, Vyse TJ ( 2014 ) . O47. SLE Susceptibility Gene UBE2L3 Polymorphism Controls Sensitivity of NF-KB to TNF and CD40 In Vivo . Rheumatology vol. 53 , ( suppl_1 ) i49 - i49 .
Lewis MJ, Vyse S, Boeltz S, Walczak H, Spector TD, Lehner PJ, Vyse TJ ( 2014 ) . SLE SUSCEPTIBILITY GENE UBE2L3 POLYMORPHISM CONTROLS SENSITIVITY OF NF-KB TO TNF AND CD40 IN VIVO . RHEUMATOLOGY . vol. 53 , 49 - 49 .
McAndrew M, Wheeler C, Koopmann J, Uddin E, Lewis M, Vyse T ( 2013 ) . SAT0528 Novel Autoantibody Biomarkers for the Improved Diagnosis of Systemic Lupus Erythematosus . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Davies RJ, Sangle SR, Jordan NP, Aslam L, Lewis MJ, Wedgwood R, D'Cruz DP ( 2013 ) . Rituximab in the treatment of resistant lupus nephritis: Therapy failure in rapidly progressive crescentic lupus nephritis . Lupus vol. 22 , ( 6 ) 574 - 582 .
Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M ( 2012 ) . Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia . Arthritis and Rheumatism vol. 64 , ( 8 ) 2707 - 2718 .
Haskard D, Talat M, Lewis M, Leung V, Yun S, Boyle JJ, Botto M ( 2011 ) . Bifunctional roles of complement and antibodies in atherosclerosis . IMMUNOLOGY . vol. 135 , 16 - 16 .
Malik TH, Cortini A, Carassiti D, Leung VWY, Lewis MJ, Haskard DO, Botto M ( 2010 ) . FC4 The alternative pathway is critical for pathogenic complement activation in diet -induced and endotoxin-induced atherosclerosis in low-density lipoprotein receptor-deficient mice . Heart vol. 96 , ( 17 )
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2009 ) . Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice . Circulation vol. 120 , ( 5 ) 417 - 426 .
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2009 ) . COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND GLOMERULONEPHRITIS IN SLE . RHEUMATOLOGY . vol. 48 , I15 - I16 .
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . IgM deficiency accelerates atherosclerosis: A potential adverse consequence of B cell depletion therapy? . ARTHRITIS AND RHEUMATISM . vol. 58 , S934 - S934 .
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . Atheroprotective functions of IgM and complement C1q: do low IgM levels and impaired complement activity provide a new link between atherosclerosis and SLE? . RHEUMATOLOGY . vol. 47 , II7 - II8 .
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2008 ) . Lupus phenotype accelerates atherosclerosis in a novel mouse model of SLE . RHEUMATOLOGY . vol. 47 , II97 - II98 .
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . Hierarchical contributions of IgM and complement C1q in protection against murine atherosclerosis . The FASEB Journal vol. 22 , ( S1 ) 463.2 - 463.2 .
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2007 ) . Serum IgM plays an important protective role in murine atherosclerosis . Atherosclerosis . vol. 193 , s3 - s4 .
Lewis MJ, Botto M ( 2006 ) . Complement deficiencies in humans and animals: Links to autoimmunity . Autoimmunity vol. 39 , ( 5 ) 367 - 378 .
Lewis MJ, D'Cruz D ( 2005 ) . Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus . Lupus vol. 14 , ( SUPPL. 1 )
Kenwright S, Maughan TS, Lewis M ( 2005 ) . The assisted dying for the terminally III Bill 2004 [3] (multiple letters) . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 5 , ( 2 ) 185 - 186 .
Descamps MJL, Lewis MJ, Hart PE, Brew S, Jäger HR, Greenwood R ( 2004 ) . Brainstem infarction during long-haul air travel . Eur Neurol vol. 52 , ( 3 ) 181 - 184 .
Lewis M, Gibson T ( 2003 ) . Systemic lupus erythematous with recurrent Guillain-Barré-like syndrome treated with intravenous immunoglobulins . Lupus vol. 12 , ( 11 ) 857 - 859 .
Lewis MJ, Greenwood RJ, Brew S, Jäger HR ( 2003 ) . Economy class stroke syndromes: vertebral artery dissection revisited . J Neurol Neurosurg Psychiatry vol. 74 , ( 11 ) 1594 - 1595 .
Lewis MJ, Chan YP, Lewis RR ( 2002 ) . Ring lesions in the brain and a mass in the kidney . Journal of the Royal Society of Medicine vol. 95 , ( 1 ) 34 - 35 .
Lewis MJ, Chan YP, Lewis RR ( 2002 ) . Ring Lesions in the Brain and A Mass in the Kidney . Journal of the Royal Society of Medicine vol. 95 , ( 1 ) 34 - 35 .