Publications: Dr Myles Lewis

Iseppon F, Kanellopoulos AH, Tian N, Zhou J, Caan G, Chiozzi R, Thalassinos K, Çubuk C et al. ( 2024 ) . Sodium channels Nav1.7, Nav1.8 and pain; two distinct mechanisms for Nav1.7 null analgesia . Neurobiology of Pain vol. 16 ,

Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O'Rourke AM, Tynan O et al. ( 2024 ) . Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset . Science Advances vol. 10 , ( 39 )

Bangash MA, Cubuk C, Iseppon F, Haroun R, Garcia C, Luiz AP, Arcangeletti M, Gossage SJ et al. ( 2024 ) . Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes . Cell Reports vol. 43 , ( 8 )

Zack SR, Alzoubi O, Satoeya N, Singh KP, Deen S, Nijim W, Lewis MJ, Pitzalis C et al. ( 2024 ) . Another Notch in the Belt of Rheumatoid Arthritis . Arthritis & Rheumatology vol. 76 , ( 10 ) 1475 - 1487 .

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 632 , ( 8025 ) e6 - e6 .

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 631 , ( 8022 ) 857 - 866 .

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .

Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al. ( 2024 ) . Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes . Arthritis Research & Therapy vol. 26 , ( 1 )

Pontarini E, Sciacca E, Cavallaro G, Galbraith D, Pulvirenti A, Hao LY, Sivils K, Lewis M et al. ( 2024 ) . AB0809 USER-FRIENDLY TOOL FOR EXPLORING RNA-SEQUENCE AND BIOMARKER DISCOVERY IN SJOGREN’S DISEASE: ANALYSE THE TWO BIGGEST DATASETS OF BLOOD AND SALIVARY GLAND RNA-SEQUENCING DATA USING R SHINY APPS . Conference: Scientific Abstracts1699.2 - 161699 .

Aldeyarbi H, George S, Marchan G, Rajakariar R, Cove-Smith A, Pakozdi A, Cunningham M, Lewis M et al. ( 2024 ) . AB1122 MALE LUPUS CHARACTERISTICS FROM MULTI ETHNIC COHORT . Conference: Scientific Abstracts1892.1 - 181893 .

Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al. ( 2024 ) . OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Conference: Scientific Abstracts12 - 12 .

Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al. ( 2024 ) . OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS . Conference: Scientific Abstracts13.1 - 1313 .

Surace A, Overend L, Sciacca E, Fossati-Jimack L, Jaworska E, Pontarini E, Bashford-Rogers RJM, Pitzalis C et al. ( 2024 ) . OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA . Conference: Scientific Abstracts13.2 - 1314 .

Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E et al. ( 2024 ) . Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response . Journal of Clinical Investigation vol. 134 , ( 12 )

Aldeyarbi H, George S, Marchan G, Rajakariar R, Cove-Smith A, Pakozdi A, Cunningham M, Lewis M et al. ( 2024 ) . P154 Male lupus characteristics from multi-ethnic cohort . Rheumatology vol. 63 , ( Supplement_1 )

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E et al. ( 2024 ) . Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis . Science Translational Medicine vol. 16 , ( 742 )

Henkin R, Goldmann K, Lewis M, Barnes MR ( 2024 ) . shinyExprPortal: a configurable ‘shiny’ portal for sharing analysis of molecular expression data . Bioinformatics vol. 40 , ( 4 )

Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )

Khan M, Huang S, Marchan G, Rajakariar R, Cove-Smith A, Pakozdi A, Lewis M, Cunningham M et al. ( 2024 ) . O36 HPV vaccination and cervical screening in SLE patients . Conference: Oral Presentationsa34 - a35 .

Aldeyarbi HM, George S, Marchan G, Rajakariar R, Cove-Smith A, Pakozdi A, Cunningham M, Lewis M et al. ( 2024 ) . P33 Male lupus characteristics from multi ethnic cohort . Conference: Poster Presentationsa64.2 - a6a64 .

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis & Rheumatology vol. 76 , ( 5 ) 763 - 776 .

Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D, Network AMPPRS, Rao DA et al. ( 2024 ) . Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States . Arthritis & Rheumatology vol. 76 , ( 3 ) 356 - 362 .

Meyer A, Zack SR, Nijim W, Burgos A, Patel V, Zanotti B, Volin MV, Amin MA et al. ( 2023 ) . Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis . Cellular & Molecular Immunology vol. 21 , ( 1 ) 33 - 46 .

Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA et al. ( 2023 ) . Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution . Nature Genetics vol. 55 , ( 12 ) 2255 - 2268 .

Lewis MJ ( 2023 ) . Predicting best treatment in rheumatoid arthritis . Seminars in Arthritis and Rheumatism vol. 64 ,

Goldmann K, Spiliopoulou A, Iakovliev A, Plant D, Nair N, Cubuk C, Consortium TM, McKeigue P et al. ( 2023 ) . Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome . Annals of the Rheumatic Diseases vol. 83 , ( 3 ) 288 - 299 .

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W et al. ( 2023 ) . Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes . Nature vol. 623 , ( 7987 ) 616 - 624 .

Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F et al. ( 2023 ) . Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials . The Lancet Rheumatology vol. 5 , ( 11 ) e648 - e659 .

Zack SR, Meyer A, Zanotti B, Volin MV, Deen S, Satoeya N, Sweiss N, Lewis MJ et al. ( 2023 ) . Notch ligands are biomarkers of anti-TNF response in RA patients . Angiogenesis vol. 27 , ( 2 ) 273 - 283 .

Wang SS, Lewis MJ, Pitzalis C ( 2023 ) . DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis . Biomedicines vol. 11 , ( 7 )

Sumner EJ, McCluskey D, Mahil SK, Lewis M, Capon F ( 2023 ) . P17 A signature of IL-36 activation in systemic lupus erythematosus skin . British Journal of Dermatology vol. 189 , ( 1 ) e20 - e21 .

Kugler M, Dellinger M, Kartnig F, Müller L, Preglej T, Heinz LX, Simader E, Göschl L et al. ( 2023 ) . Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 82 , ( 9 ) 1142 - 1152 .

Vigorito E, Barton A, Pitzalis C, Lewis MJ, Wallace C ( 2023 ) . BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing . Bioinformatics vol. 39 , ( 7 )

Esposito I, Kontra I, Giacomassi C, Manou-Stathopoulou S, Brown J, Stratton R, Verykokou G, Buccafusca R et al. ( 2023 ) . Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma . Frontiers in Immunology vol. 14 ,

Rivellese F, Currado D, Giorli G, Prediletto E, Nerviani A, Khmelevskaya A, Micheroli R, Ospelt C et al. ( 2023 ) . AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL . 1353 - 1354 .

Pontarini E, Lucchesi D, Goldmann K, Lewis M, Song Q, Thomas E, Hao LY, Sivils K et al. ( 2023 ) . POS0292 TRANSCRIPTOMIC PROFILING OF SJOGREN’S SALIVARY GLANDS IDENTIFIES FOLLICULAR AND EXTRA-FOLLICULAR GENE SIGNATURES ASSOCIATED WITH RHEUMATOID FACTOR SEROPOSITIVITY . 388.2 - 38388 .

Mancuso S, Giacomassi C, Truglia S, Barbati C, Alessandri C, Corsiero E, Caliste M, Lewis M et al. ( 2023 ) . POS1425 ANTIB2GLYCOPROTEIN I ANTIBODIES CAN INDUCE NETOSIS . 1066.2 - 101066 .

Townsend K, Cove-Smith A, Rajakariar R, Pakozdi A, Lewis M, Cunningham M, Pyne D ( 2023 ) . P056 Analysis of antibody response to SARS-CoV-2 vaccination and natural infection in a tertiary centre cohort of lupus nephritis patients . Rheumatology vol. 62 , ( Supplement_2 )

Sciacca E, Alaimo S, Silluzio G, Ferro A, Latora V, Pitzalis C, Pulvirenti A, Lewis MJ ( 2023 ) . DEGGs: an R package with shiny app for the identification of differentially expressed gene–gene interactions in high-throughput sequencing data . Bioinformatics vol. 39 , ( 4 )

Lewis MJ, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes MR ( 2023 ) . nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data . Bioinformatics Advances vol. 3 , ( 1 )

Mauro D, Manou-Stathopoulou S, Rivellese F, Sciacca E, Goldmann K, Tsang V, Lucey-Clayton I, Pagani S et al. ( 2023 ) . UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus . Journal of Autoimmunity vol. 136 ,

Meyer A, Sienes RE, Nijim W, Zanotti B, Umar S, Volin MV, Van Raemdonck K, Lewis M et al. ( 2023 ) . Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells . Annals of the Rheumatic Diseases vol. 82 , ( 4 ) 483 - 495 .

Lewis MJ, Pitzalis C ( 2022 ) . Progress continues in prediction of the response to treatment of RA . Nature Reviews Rheumatology vol. 19 , ( 2 ) 68 - 69 .

Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 ,

Wang J, Conlon D, Rivellese F, Nerviani A, Lewis MJ, Housley W, Levesque MC, Cao X et al. ( 2022 ) . Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients . Arthritis & Rheumatology vol. 74 , ( 12 ) 1916 - 1927 .

Schmidt M, Sondermann JR, Gomez-Varela D, Çubuk C, Millet Q, Lewis MJ, Wood JN, Zhao J ( 2022 ) . Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors . Frontiers in Molecular Neuroscience vol. 15 ,

Manou-Stathopoulou S, Lewis MJ ( 2022 ) . Diversity of NF-κB signalling and inflammatory heterogeneity in Rheumatic Autoimmune Disease . Seminars in Immunology vol. 58 ,

Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al. ( 2022 ) . Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT . Efficacy and Mechanism Evaluation vol. 9 , ( 7 ) 1 - 58 .

Sciacca E, Surace AEA, Alaimo S, Pulvirenti A, Rivellese F, Goldmann K, Ferro A, Latora V et al. ( 2022 ) . Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis . Arthritis Research & Therapy vol. 24 , ( 1 )

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Banda NK, Deane KD, Bemis EA, Strickland C, Seifert J, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features . The Journal of Immunology vol. 208 , ( 11 ) 2482 - 2496 .

Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 52.2 - 5253 .

Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .

Goldmann K, Vigorito E, Wallace C, Barnes M, Barton A, Pitzalis C, Lewis M ( 2022 ) . OP0109 EXPRESSION QUANTITATIVE TRAIT LOCI IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 71 - 72 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299.2 - 29300 .

Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 470.1 - 47470 .

Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 475.2 - 47476 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )

Banda NK, Deane KD, Seifert J, Strickland C, Bemis E, Jordan K, Goldmann K, Morgan BP et al. ( 2022 ) . A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients . The Journal of Immunology vol. 208 , ( 1_Supplement ) 108.03 - 108.03 .

Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2022 ) . High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership . Rheumatology vol. 61 , ( 11 ) 4335 - 4343 .

Kefas J, Harwood C, Lewis MJ, Szlosarek P ( 2022 ) . Small vessel vasculitis and dry gangrene secondary to combined CTLA-4 and PD-1 blockade in malignant mesothelioma . BMC Rheumatology vol. 6 , ( 1 )

Micheroli R, Elhai M, Edalat S, Frank-Bertoncelj M, Bürki K, Ciurea A, MacDonald L, Kurowska-Stolarska M et al. ( 2022 ) . Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis . RMD Open vol. 8 , ( 1 )

Iakovliev A, Ling SF, Colombo M, Plant D, Lewis M, Pitzalis C, Barton A, McKeigue P et al. ( 2022 ) . Association of Genetic Loci for Human Plasma Proteins with Response to Treatment in People with Rheumatoid Arthritis . GENETIC EPIDEMIOLOGY . vol. 46 , 501 - 502 .

Banda N, Deane K, Seifert J, Strickland C, Bemis E, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Complement gene expression and biodistribution of complement proteins in the synovium from early rheumatoid arthritis patients . MOLECULAR IMMUNOLOGY . vol. 141 , 156 - 156 .

Maurits M, Abasolo Alcazar L, van den Akker E, Askling J, Barton A, Bluml S, Bohringer S, Cope A et al. ( 2022 ) . GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 2265 - 2269 .

Rivellese F, Pontarini E, Cubuk C, Nerviani A, Fossati-Jimack L, Surace A, Sciacca E, Goldmann K et al. ( 2022 ) . Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3345 - 3347 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 1242 - 1244 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .

Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,

Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2021 ) . Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network . Lupus Science & Medicine vol. 8 , ( 1 )

Boutet M-A, Nerviani A, Lliso-Ribera G, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response . Frontiers in Immunology vol. 12 ,

Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2021 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution . Scientific Reports vol. 11 , ( 1 )

Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .

Manou-Stathopoulou S, Hann W, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2021 ) . P162 Incidence of neutropaenia and infections in lupus patients on immunosuppression . Rheumatology vol. 60 , ( Supplement_1 )

Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science & Medicine vol. 8 , ( 1 )

Pitzalis C, Humby F, Rivellese F, Nerviani A, Lewis M ( 2021 ) . Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes Article (Randomised Controlled Trial) . The Lancet

Boutet MA, Nerviani A, Ribera GL, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 66 - 66 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou SA, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren's Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 2065 - 2066 .

Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .

Nerviani A, Boutet M-A, Tan WSG, Goldmann K, Purkayastha N, Lajtos T, Hands R, Lewis M et al. ( 2020 ) . IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors . Annals of the Rheumatic Diseases

Sciacca E, Surace A, Lewis M, Alaimo S, Latora V, Rivellese F, Pulvirenti A, Ferro A et al. ( 2020 ) . Novel Network Tool Highlights Key Features Associated with Disease Pathotypes and Response to Treatment in Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . Conference: ACR Convergence 2020 vol. 72 ,

Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C, Dalli J ( 2020 ) . Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis . Nature Communications vol. 11 , ( 1 )

Cherlin S, Lewis MJ, Plant D, Nair N, Goldmann K, Tzanis E, Barnes MR, McKeigue P et al. ( 2020 ) . Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) 1446 - 1452 .

Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al. ( 2020 ) . Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis . Nature Medicine vol. 26 , ( 8 ) 1295 - 1306 .

Bellan M, Quaglia M, Nerviani A, Mauro D, Lewis M, Goegan F, Gibbin A, Pagani S et al. ( 2020 ) . Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis . Clinical and Experimental Rheumatology vol. 39 , ( 1 ) 132 - 138 .

Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .

Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .

Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,

Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Cove-Smith A ( 2020 ) . EP34 Assessing the ability of anti-C1q antibody measurement to predict a flare of lupus nephritis . Rheumatology . vol. 59 ,

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )

Sciacca E, Alaimo S, Pulvirenti A, Latora V, Humby F, Ferro A, Lewis MJ, Pitzalis C ( 2020 ) . P22 Micro-RNA enriched pathway impact analysis applied to synovial RNA-seq in early rheumatoid arthritis identifies response prediction pathways . Rheumatology . Conference: British Society for Rheumatology Annual Conference 2020 vol. 59 ,

Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Cove-Smith A ( 2020 ) . P13 Assessing the ability of Anti-C1q antibody measurement to predict a flare of lupus nephritis . Conference: Poster presentationsa35.1 - a3a35 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2020 ) . M3C: Monte Carlo reference-based consensus clustering . Scientific Reports vol. 10 , ( 1 )

Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al. ( 2020 ) . New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis . Disease Markers vol. 2020 , Article 1614627 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,

Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .

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Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al. ( 2019 ) . Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases vol. 78 , ( 12 )

John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: fast density-aware spectral clustering for single and multi-omic data . Bioinformatics vol. 36 , ( 4 ) 1159 - 1166 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .

Humby F, Lewis M, Townsend MJ, Pitzalis C ( 2019 ) . Response to: ‘Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients’ by Buch et al . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) e141 - e141 .

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of autoimmunity vol. 105 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . Conference: Abstracts Accepted for Publication1548.1 - 151548 .

Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . Conference: Oral Presentations130 - 131 .

Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . Conference: Oral Presentations134 - 134 .

Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M ( 2019 ) . SAT0025 THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS . Conference: SATURDAY, 15 JUNE 20191077.1 - 101077 .

Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . Conference: Poster Presentations394.2 - 39395 .

John CR, Watson D, Barnes M, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: Fast density-aware spectral clustering for single and multi-omic data .

Khan A, Pakozdi A, Rajakariar R, Cove-Smith A, Lewis M, Pyne D ( 2019 ) . E090 Sleep disturbances in lupus patients . Rheumatology vol. 58 , ( Supplement_3 )

Almathkouri A, Pyne D, Rajakariar R, Cove-Smith A, Lewis M, Pakozdi A ( 2019 ) . E091 Prevalence of fibromyalgia in a cohort of renal and non-renal systemic lupus erythematosus patients . Rheumatology vol. 58 , ( Supplement_3 )

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . Conference: Abstractsa174.2 - a1a175 .

Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al. ( 2019 ) . Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells . Nature Immunology vol. 20 , ( 4 ) 458 - 470 .

Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S et al. ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the rheumatic diseases vol. 78 , ( 6 ) 761 - 772 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2019 ) . P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Abstracts vol. 78 ,

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Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .

Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al. ( 2019 ) . The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation . The Journal of Immunology vol. 202 , ( 4 ) 1069 - 1078 .

Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Antbring R, Cunningham M, Bull R, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D ( 2019 ) . Lupus Teledematology: A Pilot Project to Evaluate the Plausibility of a Rapid Access Dermatology Service for Lupus Patients . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Almathkouri A, Pyne D, Rajakariar R, Cove-Smith A, Lewis M, Pakozdi A ( 2019 ) . PREVALENCE OF FIBROMYALGIA IN A COHORT OF RENAL AND NON-RENAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS . RHEUMATOLOGY . vol. 58 , 196 - 196 .

Khan A, Pakozdi A, Rajakariar R, Cove-Smith A, Lewis M, Pyne D ( 2019 ) . SLEEP DISTURBANCES IN LUPUS PATIENTS . RHEUMATOLOGY . vol. 58 ,

Nerviani A, Mauro D, Gilio M, Grembiale RD, Lewis MJ ( 2018 ) . To supplement or not to supplement? The rationale of vitamin D supplementation in systemic lupus erythematosus . Open Rheumatology Journal vol. 12 , 226 - 247 .

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Lewis MJ, Barnes MR ( 2018 ) . RNA sequencing and machine learning as molecular scalpels . Nat Rev Rheumatol vol. 14 , ( 7 ) 388 - 390 .

Almathkouri A, Pyne D, Pakozdi A, Rajkariar R, Cove-smith A, Lewis M, Center OBOBL ( 2018 ) . AB0545 Is lupus more prevalent in world’s most stressed countries? . Annals of the Rheumatic Diseases vol. 77 , ( Suppl 2 )

Mauro D, Tsang V, Lucey-Clayton I, Rivellese F, Pagani S, Alam F, Pontarini E, Nerviani A et al. ( 2018 ) . FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle . Annals of the Rheumatic Diseases . Conference: FRIDAY, 15 JUNE 2018 vol. 77 ,

Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: WEDNESDAY, 13 JUNE 2018 vol. 77 ,

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2018 ) . SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Rivellese F, Congia M, Mauro D, Bombardieri M, Lewis M, Pitzalis C ( 2018 ) . THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Purkayastha N, Tan WS, Mahto A, Lewis M, Lliso G, Nerviani A, Rocher V, Humby F et al. ( 2018 ) . THU0122 Imaging characterisation of remission in rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

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Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Hensor EMA, McKeigue P, Buch MH, Barrett JH, Nam JL, Freeston J, Colombo M, Spiliopoulou A et al. ( 2018 ) . O12 Validity of a2-component imaging-derived disease activity score (2C-DAS28) for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )

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Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

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Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. ( 2016 ) . OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy . Annals of the Rheumatic Diseases . vol. 75 ,

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Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . O37. The Autoimmune Risk Gene UBE2L3 is Highly Expressed During B Cell Proliferation and is Correlated with Plasmablast and Plasma Cell Expansion in SLE . Rheumatology vol. 54 , ( suppl_1 ) i41 - i41 .

Vyse S, Shields A, Boeltz S, Leirer D, Gordon P, Spector T, Lehner P, Walczak H et al. ( 2015 ) . A2.10 SLE associated UBE2L3 haplotype modulates plasma cell differentiation via genotypic regulation of NF-κB . Annals of the Rheumatic Diseases . vol. 74 ,

Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, Lehner P, Walczak H et al. ( 2015 ) . Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus . The Lancet . vol. 385 ,

Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H et al. ( 2015 ) . UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases . American Journal of Human Genetics vol. 96 , ( 2 ) 221 - 234 .

Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE . RHEUMATOLOGY . vol. 54 , 41 - 41 .

Lewis MJ, Vyse S, Boeltz S, Walczak H, Spector TD, Lehner PJ, Vyse TJ ( 2014 ) . O47. SLE Susceptibility Gene UBE2L3 Polymorphism Controls Sensitivity of NF-KB to TNF and CD40 In Vivo . Rheumatology vol. 53 , ( suppl_1 ) i49 - i49 .

McAndrew M, Wheeler C, Koopmann J, Uddin E, Lewis M, Vyse T ( 2014 ) . SAT0528 Novel Autoantibody Biomarkers for the Improved Diagnosis of Systemic Lupus Erythematosus . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon P, Spector TD, Lehner PJ, Walczak H et al. ( 2014 ) . <i>UBE2L3</i> genotype Influences Plasma Cell Proliferation in Systemic Lupus Erythematosus By Regulation of NF-κB By the Linear Ubiquitination Assembly Complex . ARTHRITIS & RHEUMATOLOGY vol. 66 , S384 - S384 .

Lewis MJ, Vyse S, Boeltz S, Walczak H, Spector TD, Lehner PJ, Vyse TJ ( 2014 ) . SLE SUSCEPTIBILITY GENE UBE2L3 POLYMORPHISM CONTROLS SENSITIVITY OF NF-KB TO TNF AND CD40 <i>IN VIVO</i> . RHEUMATOLOGY . vol. 53 , 49 - 49 .

Davies R, Sangle S, Jordan N, Aslam L, Lewis M, Wedgwood R, D’Cruz D ( 2013 ) . Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis . Lupus vol. 22 , ( 6 ) 574 - 582 .

Lewis MJ, Malik TH, Fossati‐Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M ( 2012 ) . Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia . Arthritis & Rheumatism vol. 64 , ( 8 ) 2707 - 2718 .

Haskard D, Talat M, Lewis M, Leung V, Yun S, Boyle JJ, Botto M ( 2011 ) . Bifunctional roles of complement and antibodies in atherosclerosis . IMMUNOLOGY . vol. 135 , 16 - 16 .

Malik TH, Cortini A, Carassiti D, Leung VWY, Lewis MJ, Haskard DO, Botto M ( 2010 ) . FC4 The alternative pathway is critical for pathogenic complement activation in diet -induced and endotoxin-induced atherosclerosis in low-density lipoprotein receptor-deficient mice . Heart vol. 96 , ( 17 )

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2009 ) . Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice . Circulation vol. 120 , ( 5 ) 417 - 426 .

Lewis MJ, Botto M ( 2009 ) . Complement deficiencies in humans and animals: Links to autoimmunity . Autoimmunity vol. 39 , ( 5 ) 367 - 378 .

Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2009 ) . COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND GLOMERULONEPHRITIS IN SLE . RHEUMATOLOGY . vol. 48 , I15 - I16 .

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . Hierarchical contributions of IgM and complement C1q in protection against murine atherosclerosis . The FASEB Journal vol. 22 , ( S1 ) 463.2 - 463.2 .

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . Atheroprotective functions of IgM and complement C1q: do low IgM levels and impaired complement activity provide a new link between atherosclerosis and SLE? . RHEUMATOLOGY . vol. 47 , II7 - II8 .

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2008 ) . IgM deficiency accelerates atherosclerosis: A potential adverse consequence of B cell depletion therapy? . ARTHRITIS AND RHEUMATISM . vol. 58 , S934 - S934 .

Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2008 ) . Lupus phenotype accelerates atherosclerosis in a novel mouse model of SLE . RHEUMATOLOGY . vol. 47 , II97 - II98 .

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO ( 2007 ) . Serum IgM plays an important protective role in murine atherosclerosis . Atherosclerosis . vol. 193 , s3 - s4 .

Kenwright S, Maughan T, Lewis M ( 2005 ) . The Assisted Dying for the Terminally Ill Bill 2004 . Clinical Medicine vol. 5 , ( 2 ) 185 - 186 .

Lewis M, D'cruz D ( 2005 ) . Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus . Lupus vol. 14 , ( 1_suppl ) 17 - 26 .

Lewis M ( 2005 ) . The Assisted Dying for the Terminally Ill Bill 2004 . Clinical Medicine vol. 5 , ( 2 ) 185 - 186 .

Descamps MJL, Lewis MJ, Hart PE, Brew S, Jäger HR, Greenwood R ( 2004 ) . Brainstem Infarction during Long-Haul Air Travel . European Neurology vol. 52 , ( 3 ) 181 - 184 .

Lewis MJ, Greenwood RJ, Brew S, Jäger HR ( 2003 ) . Economy class stroke syndromes: vertebral artery dissection revisited . Journal of Neurology Neurosurgery & Psychiatry vol. 74 , ( 11 )

Lewis M, Gibson T ( 2003 ) . Systemic lupus erythematous with recurrent Guillain -Barré-like syndrome treated with intravenous immunoglobulins . Lupus vol. 12 , ( 11 ) 857 - 859 .

Lewis MJ, Chan YP, Lewis RR ( 2002 ) . Ring Lesions in the Brain and A Mass in the Kidney . Journal of the Royal Society of Medicine vol. 95 , ( 1 ) 34 - 35 .

Lewis MJ, Chan YP, Lewis RR ( 2002 ) . Ring lesions in the brain and a mass in the kidney . Journal of the Royal Society of Medicine vol. 95 , ( 1 ) 34 - 35 .