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Research

Publications: Ms Ashley Kingston

Le Bert N, Gill US, Hong M, Kunasegaran K, Tan DZM, Ahmad R, Cheng Y, Dutertre CA et al. ( 2020 ) . Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection . Gastroenterology vol. 159 , ( 2 ) 652 - 664 .
Bénéchet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Fumagalli V, Lusito E et al. ( 2019 ) . Dynamics and genomic landscape of CD8<sup>+</sup> T cells undergoing hepatic priming . Nature vol. 574 , ( 7777 ) 200 - 205 .
Le Bert N, Salimzadeh L, Gill US, Dutertre CA, Facchetti F, Tan A, Hung M, Novikov N et al. ( 2019 ) . Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B . Journal of Hepatology
Gill US, Kennedy PTF ( 2019 ) . The impact of currently licensed therapies on viral and immune responses in chronic hepatitis B: Considerations for future novel therapeutics . J Viral Hepat vol. 26 , ( 1 ) 4 - 15 .
Chan HLY, Messinger D, Papatheodoridis GV, Cornberg M, Xie Q, Piratvisuth T, Ren H, Kennedy PT et al. ( 2018 ) . A baseline tool for predicting response to peginterferon alfa-2a in HBeAg-positive patients with chronic hepatitis B . Alimentary Pharmacology and Therapeutics vol. 48 , ( 5 ) 547 - 555 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
ALAZAWI W, Alexander M, Loomis AK, Fairburn-Beech J, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D et al. ( 2018 ) . Real world data reveal a diagnostic gap in non-alcoholic fatty liver disease . Real world data reveal a diagnostic gap in non-alcoholic fatty liver disease vol. 16 , ( 130 )
Koffas A, Dolman GE, Kennedy PTF ( 2018 ) . Hepatitis B virus reactivation in patients treated with immunosuppressive drugs: A practical guide for clinicians . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 18 , ( 3 ) 212 - 218 .
Bertoletti A, Kennedy PTF, Durantel D ( 2018 ) . HBV infection and HCC: The 'dangerous liaisons' . Gut vol. 67 , ( 5 ) 787 - 788 .
Gill US, Pallett LJ, Kennedy PTF, Maini MK ( 2018 ) . Liver sampling: A vital window into HBV pathogenesis on the path to functional cure . Gut vol. 67 , ( 4 ) 767 - 775 .
Gill US, Kennedy PTF ( 2017 ) . Current therapeutic approaches for HBV infected patients . Journal of Hepatology vol. 67 , ( 2 ) 412 - 414 .
Kennedy PTF, Litwin S, Dolman GE, Bertoletti A, Mason WS ( 2017 ) . Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks . Viruses vol. 9 , ( 5 )
Bertoletti A, Kennedy PT ( 2015 ) . The immune tolerant phase of chronic HBV infection: New perspectives on an old concept . Cellular and Molecular Immunology vol. 12 , ( 3 ) 258 - 263 .
Gill US, Kennedy PTF ( 2015 ) . New insights in the management of chronic hepatitis B . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 15 , ( 2 ) 191 - 196 .
Conroy DM, Collins AJ, Kennedy PT ( 2014 ) . Re: Double coaxial microcatheter technique for transarterial aneurysm sac embolization of type II endoleaks after endovascular abdominal aortic repair . J Vasc Interv Radiol vol. 25 , ( 11 ) 1827 - 1828 .
Gill US, Kennedy PTF ( 2014 ) . Chronic hepatitis B virus in young adults: The need for new approaches to management . Expert Review of Anti-Infective Therapy vol. 12 , ( 9 ) 1045 - 1053 .
Sarri G, Westby M, Bermingham S, Hill-Cawthorne G, Thomas H, Guideline Development Group ( 2013 ) . Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance . BMJ vol. 346 ,
Schurich A, Pallett LJ, Lubowiecki M, Singh HD, Gill US, Kennedy PT, Nastouli E, Tanwar S et al. ( 2013 ) . The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells . PLoS Pathogens vol. 9 , ( 3 )
Peppa D, Gil US, Reynolds G, Easom NJW, Pallett LJ, Schurich A, Micco L, Nebbia G et al. ( 2013 ) . Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion . Journal of Experimental Medicine vol. 210 , ( 1 ) 99 - 114 .
Ji C, Sastry KSR, Tiefenthaler G, Cano J, Tang T, Ho ZZ, Teoh D, Bohini S et al. ( 2012 ) . Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies . Hepatology vol. 56 , ( 6 ) 2027 - 2038 .
Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y, Rosenberg W, Dusheiko G et al. ( 2012 ) . Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection . PLoS ONE vol. 7 , ( 10 )
Das A, Ellis G, Pallant C, Lopes AR, Khanna P, Peppa D, Chen A, Blair P et al. ( 2012 ) . IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection . Journal of Immunology vol. 189 , ( 8 ) 3925 - 3935 .
Liu M, Miao T, Zhu H, Symonds ALJ, Li L, Schurich A, Maini MK, Zhang J et al. ( 2012 ) . IL-2-Engineered nano-APC Effectively Activates Viral Antigen-Mediated T Cell Responses from Chronic Hepatitis B Virus-Infected Patients . JOURNAL OF IMMUNOLOGY vol. 188 , ( 3 ) 1534 - 1543 .
Kennedy PTF, Sandalova E, Jo J, Gill U, Ushirolumb I, Tan AT, Naik S, Foster GR et al. ( 2012 ) . Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B . Gastroenterology vol. 143 , ( 3 ) 637 - 645 .
Schurich A, Khanna P, Lopes AR, Han KJ, Peppa D, Micco L, Nebbia G, Kennedy PTF et al. ( 2011 ) . Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection . Hepatology vol. 53 , ( 5 ) 1494 - 1503 .
Sastry KSR, Too CT, Kaur K, Gehring AJ, Low L, Javiad A, Pollicino T, Li L et al. ( 2011 ) . Targeting hepatitis B virus-infected cells with a T-cell receptor-like antibody . Journal of Virology vol. 85 , ( 5 ) 1935 - 1942 .
Malik R, Kennedy P, Suri D, Brown A, Goldin R, Main J, Thomas H, Thursz M ( 2011 ) . The role of liver fibrosis assessment in the management of patients with chronic hepatitis B infection: lessons learned from a single centre experience . Hepat Res Treat vol. 2011 ,
Peppa D, Micco L, Javaid A, Kennedy PTF, Schurich A, Dunn C, Pallant C, Ellis G et al. ( 2010 ) . Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection . PLoS Pathogens vol. 6 , ( 12 )
Kennedy PTF, Russo E, Kumar N, Powell N, Bansi D, Thillainayagam A, Vlavianos P, Westaby D ( 2010 ) . The safety and utility of prophylactic pancreatic duct stents in the prevention of post-ERCP pancreatitis: an analysis of practice in a single UK tertiary referral center . Surg Endosc vol. 24 , ( 8 ) 1923 - 1928 .
Pasha Y, Blunt D, Kennedy PTF ( 2010 ) . The pea, the yeast and the prostate . QJM vol. 103 , ( 4 ) 265 - 266 .
McConville RM, Kennedy PT, Collins AJ, Ellis PK ( 2009 ) . Failed retrieval of an inferior vena cava filter during pregnancy because of filter tilt: report of two cases . Cardiovasc Intervent Radiol vol. 32 , ( 1 ) 174 - 177 .
Kennedy PTF, Gehring AJ, Nowbath A, Selden C, Quaglia A, Dhillon A, Dusheiko G, Bertoletti A ( 2008 ) . The expression and function of NKG2D molecule on intrahepatic CD8+ T cells in chronic viral hepatitis . Journal of Viral Hepatitis vol. 15 , ( 12 ) 901 - 909 .
Das A, Hoare M, Davies N, Lopes AR, Dunn C, Kennedy PTF, Alexander G, Finney H et al. ( 2008 ) . Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection . Journal of Experimental Medicine vol. 205 , ( 9 ) 2111 - 2124 .
Kennedy PTF, Phillips N, Chandrasekhar J, Jacobs R, Jacobs M, Dusheiko G ( 2008 ) . Potential and limitations of lamivudine monotherapy in chronic hepatitis B: Evidence from genotyping . Liver International vol. 28 , ( 5 ) 699 - 704 .
PATRICK KENNEDY, KINGSTON AL ( 2008 ) . NICE guidelines and a treatment algorithm for the management of chronic hepatitis B: a review of 12 years experience in west London . NICE guidelines and a treatment algorithm for the management of chronic hepatitis B: a review of 12 years experience in west London
Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR et al. ( 2007 ) . Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage . Journal of Experimental Medicine vol. 204 , ( 3 ) 667 - 680 .
Gehring AJ, Sun D, Kennedy PTF, Nolte-'T Hoen E, Lim SG, Wasser S, Selden C, Maini MK et al. ( 2007 ) . The level of viral antigen presented by hepatocytes influences CD8 T-cell function . Journal of Virology vol. 81 , ( 6 ) 2940 - 2949 .
Johnston PW, Kennedy PT, Blair PH ( 2007 ) . Periaortitis complicating chronic aortic dissection . Eur Heart J vol. 28 , ( 4 )
Kennedy PTF, Zakaria N, Modawi SB, Papadopoulou AM, Murray-Lyon I, Du Bois RM, Jervoise H, Devlin J ( 2006 ) . Natural history of hepatic sarcoidosis and its response to treatment . European Journal of Gastroenterology and Hepatology vol. 18 , ( 7 ) 721 - 726 .
Kennedy PTF, Urbani S, Moses RA, Amadei B, Fisicaro P, Lloyd J, Maini MK, Dusheiko G et al. ( 2006 ) . The influence of T cell cross-reactivity on HCV-peptide specific human T cell response . Hepatology vol. 43 , ( 3 ) 602 - 611 .
Franzese O, Kennedy PTF, Gehring AJ, Gotto J, Williams R, Maini MK, Bertoletti A ( 2005 ) . Modulation of the CD8<sup>+</sup>-T-cell response by CD4<sup>+</sup> CD25<sup>+</sup> regulatory T cells in patients with hepatitis B virus infection . Journal of Virology vol. 79 , ( 6 ) 3322 - 3328 .
KENNEDY PATRICK, KINGSTON AL ( 2005 ) . Percutaneous ultrasound-guided thrombin injection of endoleaks . Percutaneous ultrasound-guided thrombin injection of endoleaks
Sun Z, Winder RJ, Kelly BE, Ellis PK, Kennedy PT, Hirst DG ( 2004 ) . Diagnostic value of CT virtual intravascular endoscopy in aortic stent-grafting . J Endovasc Ther vol. 11 , ( 1 ) 13 - 25 .
Sun Z, Winder JR, Kelly BE, Ellis PK, Kennedy PT, Hirst DG ( 2004 ) . Assessment of VIE image quality using helical CT angiography: in vitro phantom study . Comput Med Imaging Graph vol. 28 , ( 1-2 ) 3 - 12 .
Ellis PK, Kennedy PT, Collins AJ, Blair PH ( 2003 ) . The use of direct thrombin injection to treat a type II endoleak following endovascular repair of abdominal aortic aneurysm . Cardiovasc Intervent Radiol vol. 26 , ( 5 ) 482 - 484 .
Lewis HG, Morrison CM, Kennedy PT, Herbert KJ ( 2003 ) . Arterial reconstruction using the basilic vein from the zone of injury in pediatric supracondylar humeral fractures: a clinical and radiological series . Plast Reconstr Surg vol. 111 , ( 3 ) 1159 - 1163 .
KENNEDY PATRICK, KINGSTON AL ( 2003 ) . Image-guided 25-gauge needle biopsy for thoracic lesions: diagnostic feasibility and safety . Image-guided 25-gauge needle biopsy for thoracic lesions: diagnostic feasibility and safety.
Kennedy PT, Goodacre BW, Wittich GR, VanSonnenberg E ( 2002 ) . Transosseous access for decompression of an obstructed pelvic kidney . Cardiovasc Intervent Radiol vol. 25 , ( 4 ) 337 - 339 .
Ellis PK, Kennedy PT, Barros D'Sa AAB ( 2002 ) . Successful exclusion of a high internal carotid pseudoaneurysm using the Wallgraft endoprosthesis . Cardiovasc Intervent Radiol vol. 25 , ( 1 ) 68 - 69 .
Wittich GR, Goodacre BW, Kennedy PT, Mathew P ( 2001 ) . Anchoring a migrating inferior vena cava stent with use of a T-fastener . J Vasc Interv Radiol vol. 12 , ( 8 ) 994 - 996 .
Kennedy PT, Kelly IM, Loan WC, Boyd CS ( 2000 ) . Conscious sedation and analgesia for routine aortofemoral arteriography: a prospective evaluation . Radiology vol. 216 , ( 3 ) 660 - 664 .
Kelly IM, Boyd CS, Kennedy PT ( 1999 ) . Adjuvant urokinase therapy in percutaneous drainage of a multiloculated splenic abscess . J Vasc Interv Radiol vol. 10 , ( 7 ) 919 - 923 .
Kennedy PT, Gillespie JS, Acheson AG ( 1999 ) . An unlucky break . Br J Radiol vol. 72 , ( 854 ) 219 - 220 .
KENNEDY PATRICK, KINGSTON AL ( 1999 ) . Early experience using duplex ultrasonography in the diagnosis of deep venous thrombosis; a prospective evaluation . Early experience using duplex ultrasonography in the diagnosis of deep venous thrombosis; a prospective evaluation
KENNEDY PATRICK, KINGSTON AL ( 1999 ) . Ultrasonography of intratesticular lesions: its role in clinical management . Ultrasonography of intratesticular lesions: its role in clinical management
KENNEDY PATRICK, KINGSTON AL ( 1998 ) . Association of posterior fossa dermoid cyst and Klippel-Feil syndrome . Association of posterior fossa dermoid cyst and Klippel-Feil syndrome
KENNEDY PATRICK, KINGSTON AL ( 1996 ) . Synovial chondromatosis of the cubometatarsal joint . Synovial chondromatosis of the cubometatarsal joint.