Publications: Dr Anna de Simoni

Li X, Vaghi E, Pasi G, Coulson N, Karampatakis G, Wood H, Griffiths C, Panzarasa P et al. ( 2025 ) . Understanding the Engagement and Interaction of Superusers and Regular Users in UK Respiratory Online Health Communities: Deep Learning–Based Sentiment Analysis . JMIR

Khoshnaw S, Panzarasa P, De Simoni A ( 2024 ) . Metaphor diffusion in online health communities (OHCs): an infodemiology study in a stroke OHC . JMIR Cardio

Karampatakis GD, Kimber S, Wood HE, Griffiths CJ, Taylor SJC, Li X, Day B, Mant J et al. ( 2024 ) . Development of the face-to-face component and recruitment strategy of a primary care digital social intervention for patients with asthma: Qualitative focus groups and interviews with stakeholders . Eur J Gen Pract vol. 30 , ( 1 ) 2407594 - 2407594 .

Li X, Gill A, Panzarasa P, Bestwick J, Schrag A, Noyce A, De Simoni A ( 2024 ) . Web Application to Enable Online Social Interactions in a Parkinson Disease Risk Cohort: Feasibility Study and Social Network Analysis . JMIR Formative Research

Xie CX, De Simoni A, Eldridge S, Pinnock H, Relton C ( 2024 ) . Development of a conceptual framework for defining trial efficiency . PLOS ONE vol. 19 , ( 5 )

Howdle C, Wright WJA, Mant J, De Simoni A ( 2024 ) . Factors Influencing Recovery From Pediatric Stroke Based on Discussions From a UK-Based Online Stroke Community: Qualitative Thematic Study . Journal of Medical Internet Research vol. 26 ,

Wright WJA, Howdle C, Coulson NS, De Simoni A ( 2024 ) . Exploring the Types of Social Support Exchanged by Survivors of Pediatric Stroke and Their Families in an Online Peer Support Community: Qualitative Thematic Analysis . Journal of Medical Internet Research vol. 26 ,

Wood HE, Karampatakis GD, Coulson NS, Nishanth S, Li X, Taylor SJ, Griffiths CJ, De Simoni A ( 2024 ) . Moderators’ experiences of safety and effectiveness of patients’ engagement in an asthma online health community: an exploratory, qualitative interview study (Preprint) . Journal of Medical Internet Research

Jacobs A, Wu R, Tomini F, De Simoni A, Mihaylova B ( 2023 ) . Strong and graded associations between level of asthma severity and all-cause hospital care use and costs in the UK . BMJ Open Respiratory Research

Xie CX, Sun L, Ingram E, De Simoni A, Eldridge S, Pinnock H, Relton C . Use of routine healthcare data in randomised implementation trials: a methodological mixed-methods systematic review . Implementation Science . vol. 18 ,

Karampatakis GD, Wood HE, Griffiths CJ, Lea N, Ashcroft R, Day B, Walker N, Coulson N et al. ( 2023 ) . Ethical and information governance considerations for promoting digital social interventions in primary care . Journal of Medical Internet Research

Pfeffer PE, Rupani H, De Simoni A ( 2023 ) . Bringing the treatable traits approach to primary care asthma management . Frontiers in Allergy vol. 4 ,

Byrne C, Pfeffer PE, De Simoni A ( 2023 ) . Experiences of Diagnosis, Symptoms and Use of Reliever Inhalers in Patients with Asthma and Concurrent Inducible Laryngeal Obstruction (ILO) or Breathing Pattern Disorder (BPD): qualitative analysis of a UK asthma online community . JMIR

Hine J, Lee B, Bush A, De Simoni A, Griffiths C, Judah G, Fleming L ( 2023 ) . Patient financial incentives to improve asthma management: a systematic review . BMJ Open

Karampatakis GD, Wood HE, Griffiths CJ, Taylor SJC, Toffolutti V, Bird VJ, Lea NC, Ashcroft R et al. ( 2023 ) . Non-randomised feasibility study testing a primary care intervention to promote engagement in an online health community for adults with troublesome asthma: protocol . BMJ Open

Emsley E, Szilassy E, Dowrick A, Dixon S, De Simoni A, Downes L, Johnson M, Feder G et al. ( 2023 ) . Adapting domestic abuse training to remote delivery during the COVID-19 pandemic: perspectives from general practice and support services . British Journal of General Practice vol. 73 , ( 732 )

Dixon S, De Simoni A, Szilassy E, Emsley E, Wileman V, Feder G, Downes L, Capelas Barbosa E et al. ( 2023 ) . General Practice wide adaptations to support patients affected by DVA during the COVID-19 pandemic: a rapid qualitative study . BMC Primary Care

De Simoni A, Jackson T, Inglis Humphrey W, Preston J, Mah H, Wood HE, Kinley E, Gonzalez Rienda L et al. ( 2023 ) . Patient and public involvement in research: the need for budgeting PPI staff costs in funding applications . Research Involvement and Engagement

Pfeffer P, Hajmohammadi H, Cole J, Griffiths C, Hull S, De Simoni A ( 2023 ) . Characteristics of asthma patients overprescribed short-acting beta-agonist (SABA) reliever inhalers stratified by blood eosinophil count in North East London – a cross-sectional observational study . BJGP Open vol. 7 , ( 2 )

Chan A, De Simoni A, Wileman V, Holliday L, Newby C, Chisari C, Ali S, Zhu N et al. ( 2022 ) . P204 Digital interventions to improve adherence to maintenance medication in asthma: a Cochrane systematic review . Conference: ‘WALL-E’ – The future of digital healthcare deliverya190.2 - a1a191 .

Hajmohammadi H, Pfeffer P, De Simoni A, Cole JN, Griffiths CJ, Hull SA, Heydecker B ( 2022 ) . Association between short-term NO x exposure and asthma exacerbations in East London: A time series regression model . Urban Climate vol. 44 ,

De Simoni A, Hajmohammadi H, Pfeffer P, Cole J, Griffiths C, Hull SA ( 2022 ) . Reducing SABA overprescribing in asthma: lessons from a Quality Improvement prescribing project in East London . British Journal of General Practice vol. 72 , ( 722 )

Chan A, De Simoni A, Wileman V, Holliday L, Newby CJ, Chisari C, Ali S, Zhu N et al. ( 2022 ) . Digital interventions to improve adherence to maintenance medication in asthma . Cochrane Database of Systematic Reviews vol. 2022 , ( 6 )

Ow N, Sadek Attalla S, Davies G, Griffiths C, De Simoni A ( 2022 ) . Experiences and behaviours of patients with asthma requesting prescriptions from primary care during medication shortages linked to the COVID-19-lockdown: insights from a qualitative analysis of a UK asthma online community . British Journal of General Practice Open

Andreou A, Dhand A, Vassilev I, Griffiths C, Panzarasa P, De Simoni A ( 2022 ) . Understanding online and offline social networks in illness management of elderly patients with asthma and Chronic Obstructive Pulmonary Disease: mixed-method study using quantitative social network assessment and qualitative analysis . Jmir Formative Research

Sadek Attalla S, Ow NL, McNarry M, De Simoni A ( 2022 ) . Experiences of exercise in patients with asthma: qualitative analysis of discussions in a UK asthma online community . BJGP Open

Panovska-Griffiths J, Szilassy E, Johnson M, Dixon S, De Simoni A, Wileman V, Dowrick A, Emsley E et al. ( 2022 ) . Impact of the first national COVID-19 lockdown on referral of women experiencing domestic violence and abuse in England and Wales . BMC Public Health vol. 22 , ( 1 )

Kassavou A, Mirzaei V, Shpendi S, Brimicombe J, Chauhan J, Bhattacharya D, Hardeman W, Naughton F et al. ( 2022 ) . THE PAM INTERVENTION TO SUPPORT MEDICATION ADHERENCE IN PRIMARY CARE. PROTOCOL AND BASELINE DATA FROM THE RCT . ANNALS OF BEHAVIORAL MEDICINE . vol. 56 , S578 - S578 .

De Simoni A, Fleming L, Holliday L, Horne R, Priebe S, Bush A, Sheikh A, GRIFFITHS C ( 2021 ) . Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care . BMJ Open

Szilassy E, Barbosa EC, Dixon S, Feder G, Griffiths C, Johnson M, De Simoni A, Wileman V et al. ( 2021 ) . PRimary care rEsponse to domestic violence and abuse in the COvid-19 panDEmic (PRECODE): protocol of a rapid mixed-methods study in the UK . BMC Primary Care vol. 22 , ( 1 )

Kassavou A, Mirzaei V, Shpendi S, Brimicombe J, Chauhan J, Bhattacharya D, Naughton F, Hardeman W et al. ( 2021 ) . The feasibility of PAM intervention to support treatment adherence in people with hypertension in primary care. A randomised controlled trial . Scientific Reports

Kassavou A, Mirzaei V, Shpendi S, Brimicombe J, Chauhan J, Bhattacharya D, Naughton F, Hardeman W et al. ( 2021 ) . THE PROGRAMME ON ADHERENCE TO MEDICATION (PAM) IN PRIMARY CARE. A POST-STUDY EVALUATION OF THE MECHANISMS OF BEHAVIOUR CHANGE . ANNALS OF BEHAVIORAL MEDICINE . Conference: Conference presentation vol. 55 , S471 - S471 .

Panzarasa P, Griffiths C, Sastry N, De Simoni A ( 2020 ) . Social medical capital: How patients and caregivers can benefit from online social interactions . Journal of Medical Internet Research

De Simoni A, Shah AT, Fulton O, Parkinson J, Sheikh A, Panzarasa P, Pagliari C, Coulson NS et al. ( 2020 ) . Superusers’ Engagement in Asthma Online Communities: Asynchronous Web-Based Interview Study . Journal of Medical Internet Research

Antalffy T, De Simoni A, Griffiths C ( 2020 ) . Promising peak flow diary compliance with an electronic peak flow meter and linked mobile smartphone app . npj Primary Care Respiratory Medicine

Jackson T, Pinnock H, Liew SM, Horne E, Ehlrich E, Fulton O, Worth A, Sheikh A et al. ( 2020 ) . Patient and Public involvement in research From tokenistic box ticking to valued team members . BMC Medicine

Balasooriya-Smeekens C, Mant J, Bateman A, De Simoni A ( 2020 ) . How primary care can help survivors of transient ischaemic attack and stroke return to work: focus groups with stakeholders from a UK community . British Journal of General Practice

Smith FE, Jones C, Gracey F, Mullis R, Coulson NS, De Simoni A ( 2019 ) . Emotional adjustment post-stroke: a qualitative study of an online stroke community . Neuropsychological Rehabilitation

Vaghela U, Moss J, Partridge M, De Simoni A, Bush A ( 2019 ) . Digitalising the personalised asthma action plan (PAAP) - a multi-perspective qualitative study . EUROPEAN RESPIRATORY JOURNAL . Conference: ERS International Congress 2019 from: 28/09/2019 to: 02/10/2019 , vol. 54 ,

Thomas K, Gamlin C, De Simoni A, Mullis R, Mant J ( 2019 ) . How is poststroke fatigue understood by stroke survivors and carers? A thematic analysis of an online discussion forum . BMJ Open vol. 9 , ( 7 )

DE SIMONI A, TAYLOR S, GRIFFITHS C, PANZARASA P, SHEIKH A ( 2018 ) . Online "superusers" as allies of the health care workforce . NEJM Catalyst

Joglekar S, Sastry N, Coulson NS, TAYLOR S, PATEL A, Duschinsky R, Anand A, Jameson Evans M et al. ( 2018 ) . Addendum to the Acknowledgements: How Online Communities of People With Long-Term Conditions Function and Evolve: Network Analysis of the Structure and Dynamics of the Asthma UK and British Lung Foundation Online Communities . JMIR

Sagar J, Sastry N, Coulson NS, TAYLOR SJC, Patel A, Duschinsky R, Anand A, Jameson Evans M et al. ( 2018 ) . How Online Communities of People With Long-Term Conditions Function and Evolve: Network Analysis of the Structure and Dynamics of the Asthma UK and British Lung Foundation Online Communities . JMIR

Chan AHY, DE SIMONI A, Wileman V, Holliday L, Chisari C, NEWBY C, TAYLOR S, Fleming LJ et al. ( 2018 ) . Digital interventions to improve adherence to maintenance medication in asthma . Cochrane Database of Systematic Reviews

Holender A, Sutton S, DE SIMONI A ( 2018 ) . Opinions on the use of technology to improve tablet taking in >65-year-old patients on cardiovascular medications . Journal of International Medical Research

MCKIBBEN S, DE SIMONI A, Bush A, Thomas M, GRIFFITHS C ( 2018 ) . The use of electronic alerts in primary care computer systems to identify the excessive prescription of short-acting beta2-agonists for people with asthma: a systematic review . npj Primary Care Respiratory Medicine

Jamison J, Sutton S, Mant J, DE SIMONI A ( 2018 ) . An online stroke forum as source of data for qualitative research: insights from a comparison with patients’ interviews . BMJ Open

Jamison J, AYERBE GARCIA-MONZON L, DI TANNA GL, Sutton S, Mant J, DE SIMONI A ( 2018 ) . Evaluating practical support stroke survivors get with medicines and unmet needs in primary care: A survey . BMJ Open

Thomas K, Gamlin C, De Simoni A, Mant J, Mullis R ( 2018 ) . Post-stroke fatigue: insights of stroke survivors and their caregivers from an online forum . INTERNATIONAL JOURNAL OF STROKE . vol. 13 , 27 - 27 .

Mckibben S, De Simoni A, Bush A, Thomas M, Griffiths C ( 2017 ) . The use of electronic alerts in primary care to identify the over-prescription of short-acting beta2-agonists in people with asthma: a systematic review . Conference: General Practice and Primary Care

De Simoni A, Joglekar S, Taylor SJC, Patel A, Duschinsky R, Coulson N, Griffiths C, Panzarasa P et al. ( 2017 ) . Structure and dynamics of online patients' communities: the case of Asthma UK and BLF online fora . EUROPEAN RESPIRATORY JOURNAL . Conference: ERS International Congress 2017 vol. 50 ,

Jamison J, Sutton S, Mant J, DE SIMONI A ( 2017 ) . Barriers and facilitators to adherence to secondary stroke prevention medications after stroke: Analysis of survivors’ and caregivers’ views from an online stroke forum . BMJ Open

DE SIMONI A, Horne R, Fleming L, Bush A, Griffiths CJ ( 2017 ) . What do adolescents with asthma really think about adherence to inhalers? Insights from a qualitative analysis of a UK online forum . BMJ Opene015245 - e015245 .

Izuka NJ, Alexander MAW, Balasooriya-Smeekens C, Mant J, De Simoni A ( 2017 ) . How do stroke survivors and their carers use practitioners’ advice on secondary prevention medications? Qualitative study of an online forum . Family Practice

DE SIMONI A ( 2017 ) . Teaching medical professionalism: a lesson in perspective from Plato's Protagoras . British Journal of General Practice

DE SIMONI A, Griffiths CJ, Taylor SJC ( 2016 ) . Improving access to primary care: can online communities contribute? . British Journal of General Practice vol. 66 , ( 652 ) 559 - 559 .

( 2016 ) . Correction . BMJ Open vol. 6 , ( 5 )

DE SIMONI A, Balasooriya-Smeekens C, Bateman A, Mant J ( 2016 ) . Barriers and facilitators to staying in work after stroke: insight from an online forum . BMJ Open vol. 6 , ( e009974 )

DE SIMONI A, Shanks A, Balasooriya-Smeekens C, Mant J ( 2016 ) . Stroke survivors and their families receive information and support on an individual basis from an online forum: descriptive analysis of a population of 2,348 patients and qualitative study of a sample of participants . BMJ Open vol. 6 , ( e010501 )

De Simoni A, Mant J, Sutton S ( 2015 ) . Adherence to medication in stroke survivors dependent on caregivers . British Journal of General Practice vol. 65 , ( 640 ) e789 - e791 .

Das A, Davis B, Sarma N, Sugden H, Stone G, Arshad E, Shanks A, De Simoni A et al. ( 2015 ) . Women who suffered COC-related cerebrovascular events: views on CVD risk communication from a UK stroke forum . British Journal of General Practice vol. eLetter , ( March 2015 )

Hardeman W, Lamming L, Kellar I, De Simoni A, Graffy J, Boase S, Sutton S, Farmer A et al. ( 2014 ) . Implementation of a nurse-led behaviour change intervention to support medication taking in type 2 diabetes: Beyond hypothesised active ingredients (SAMS Consultation Study) . Implementation Science vol. 9 , ( 1 )

De Simoni A, Shanks A, Mant J, Skelton JR ( 2014 ) . Making sense of patients' internet forums: a systematic method using discourse analysis . Br J Gen Pract vol. 64 , ( 620 ) e178 - e180 .

De Simoni A ( 2014 ) . Improving out-of-hours handovers . Br J Gen Pract vol. 64 , ( 618 ) 15 - 16 .

De Simoni A, Hardeman W, Mant J, Farmer AJ, Kinmonth AL ( 2013 ) . Trials to improve blood pressure through adherence to antihypertensives in stroke/TIA: systematic review and meta-analysis . J Am Heart Assoc vol. 2 , ( 4 ) e000251 - e000251 .

De Simoni A, Mullis R, Clyne W, Blenkinsopp A ( 2012 ) . Medicines optimisation in primary care: can community pharmacies deliver? . Br J Gen Pract vol. 62 , ( 601 ) 398 - 399 .

Alfarez DN, De Simoni A, Velzing EH, Bracey E, Joëls M, Edwards FA, Krugers HJ ( 2009 ) . Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons . Hippocampus vol. 19 , ( 9 ) 828 - 836 .

De Simoni A, Allen NJ, Attwell D ( 2008 ) . Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current . Eur J Neurosci vol. 28 , ( 6 ) 1146 - 1156 .

De Simoni A, Edwards FA ( 2006 ) . Pathway specificity of dendritic spine morphology in identified synapses onto rat hippocampal CA1 neurons in organotypic slices . Hippocampus vol. 16 , ( 12 ) 1111 - 1124 .

De Simoni A, Yu LMY ( 2006 ) . Preparation of organotypic hippocampal slice cultures: interface method . Nat Protoc vol. 1 , ( 3 ) 1439 - 1445 .

Rodighiero S, De Simoni A, Formenti A ( 2004 ) . The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques . Biochimica et Biophysica Acta - Biomembranes vol. 1660 , ( 1-2 ) 164 - 170 .

Rodighiero S, De Simoni A, Formenti A ( 2004 ) . The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques . Biochim Biophys Acta vol. 1660 , ( 1-2 ) 164 - 170 .

De Simoni A, Fernandes F, Edwards FA ( 2004 ) . Spines and dendrites cannot be assumed to distribute dye evenly . Trends Neurosci vol. 27 , ( 1 ) 15 - 16 .

De Simoni A, Griesinger CB, Edwards FA ( 2003 ) . Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity . J Physiol vol. 550 , ( Pt 1 ) 135 - 147 .

De Simoni A, Griesinger CB, Edwards FA ( 2002 ) . Correlation between morphology and spontaneous synaptic activity of CA1 neurones during development in acute and organotypic slices . JOURNAL OF PHYSIOLOGY-LONDON . vol. 543 , 23P - 23P .

Formenti A, De Simoni A, Arrigoni E, Martina M ( 2001 ) . Changes in extracellular Ca2+ can affect the pattern of discharge in rat thalamic neurons . J Physiol vol. 535 , ( Pt 1 ) 33 - 45 .

Formenti A, De Simoni A ( 2000 ) . Effects of extracellular Ca2+ on membrane and seal resistance in patch-clamped rat thalamic and sensory ganglion neurons . Neurosci Lett vol. 279 , ( 1 ) 49 - 52 .

De Simoni A, Mancia M, Formenti A ( 2000 ) . The calcium sensitive cation current in rat thalamic neurons is G protein-regulated . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY . vol. 440 , R24 - R24 .

Gaggianesi C, Rodighiero S, De Simoni A, Arduini A, Mancia M, Formenti A ( 2000 ) . Whole-cell and perforated-patch recordings of a voltage-dependent outward cation current in human red blood cells . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY . vol. 440 , R25 - R25 .

Martina M, De Simoni A, Ceccarelli P, Formenti A, Mancia H ( 1998 ) . Extracellular Ca<SUP>2+</SUP> ions induced a decrease in an inward current in thalamic neurons . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY . vol. 436 , R14 - R14 .

Formenti A, Arrigoni E, Plebani A, DeSimoni A, Mancia M ( 1997 ) . Effects of cerebrospinal-fluid Ca2+-concentration changes on the electroencephalogram: Cellular mechanisms . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY . vol. 434 , 48 - 48 .