Skip to main content
Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Alessandra Nerviani

Back to Search
Faust HJ, Cheng T-Y, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH et al. ( 2024 ) . Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis . Nature Communications vol. 15 , ( 1 )
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al. ( 2024 ) . Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis . Arthritis & Rheumatology vol. 76 , ( 12 ) 1705 - 1718 .
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 632 , ( 8025 ) e6 - e6 .
Apostolo D, D’Onghia D, Nerviani A, Ghirardi GM, Sola D, Perazzi M, Tonello S, Colangelo D et al. ( 2024 ) . Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis? . Current Issues in Molecular Biology vol. 46 , ( 7 ) 7486 - 7504 .
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 631 , ( 8022 ) 857 - 866 .
Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K et al. ( 2024 ) . Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium . Nature Communications vol. 15 , ( 1 )
Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z et al. ( 2024 ) . The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )
Perera J, Delrosso CA, Nerviani A, Pitzalis C ( 2024 ) . Clinical Phenotypes, Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review . Cells vol. 13 , ( 9 )
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z et al. ( 2024 ) . Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles . Nature Genetics vol. 56 , ( 4 ) 615 - 626 .
Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )
Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis & Rheumatology vol. 76 , ( 5 ) 763 - 776 .
Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D, Network AMPPRS, Rao DA et al. ( 2024 ) . Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States . Arthritis & Rheumatology vol. 76 , ( 3 ) 356 - 362 .
Ghirardi GM, Delrosso CA, Nerviani A, Boutet M-A ( 2024 ) . Molecular portrait of chronic joint diseases: Defining endotypes toward personalized medicine . Joint Bone Spine vol. 91 , ( 3 )
Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA et al. ( 2023 ) . Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution . Nature Genetics vol. 55 , ( 12 ) 2255 - 2268 .
Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F, Pitzalis C ( 2023 ) . Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features . Osteoarthritis and Cartilage vol. 32 , ( 2 ) 166 - 176 .
Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W et al. ( 2023 ) . Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes . Nature vol. 623 , ( 7987 ) 616 - 624 .
Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F et al. ( 2023 ) . Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials . The Lancet Rheumatology vol. 5 , ( 11 ) e648 - e659 .
Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C et al. ( 2023 ) . AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD . 1212.2 - 121213 .
Rivellese F, Currado D, Giorli G, Prediletto E, Nerviani A, Khmelevskaya A, Micheroli R, Ospelt C et al. ( 2023 ) . AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL . 1353 - 1354 .
Sobrado M, Nerviani A, Eldaw T, Cainap J, Denton CP, Ong VH ( 2023 ) . P020 Audit of bosentan use in Rapid Access to Digital Ulcer Clinic (RADUC) in systemic sclerosis: a single-centre experience . Rheumatology vol. 62 , ( Supplement_2 )
Wang J, Conlon D, Rivellese F, Nerviani A, Lewis MJ, Housley W, Levesque MC, Cao X et al. ( 2022 ) . Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients . Arthritis & Rheumatology vol. 74 , ( 12 ) 1916 - 1927 .
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .
Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299.2 - 29300 .
Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 475.2 - 47476 .
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .
Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2022 ) . High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership . Rheumatology vol. 61 , ( 11 ) 4335 - 4343 .
Rivellese F, Pontarini E, Cubuk C, Nerviani A, Fossati-Jimack L, Surace A, Sciacca E, Goldmann K et al. ( 2022 ) . Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3345 - 3347 .
Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 1242 - 1244 .
Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2021 ) . Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network . Lupus Science & Medicine vol. 8 , ( 1 )
Boutet M-A, Nerviani A, Lliso-Ribera G, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response . Frontiers in Immunology vol. 12 ,
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .
Fanelli G, Romano M, Nova-Lamperti E, Sunderland MW, Nerviani A, Scottà C, Bombardieri M, Quezada SA et al. ( 2021 ) . PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype . PLOS Biology vol. 19 , ( 4 )
Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F et al. ( 2021 ) . Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis . Frontiers in Immunology vol. 12 ,
Pitzalis C, Humby F, Rivellese F, Nerviani A, Lewis M ( 2021 ) . Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes Article (Randomised Controlled Trial) . The Lancet
Boutet M-A, Courties G, Nerviani A, Le Goff B, Apparailly F, Pitzalis C, Blanchard F ( 2021 ) . Novel insights into macrophage diversity in rheumatoid arthritis synovium . Autoimmunity Reviews vol. 20 , ( 3 )
Sainaghi PP, Bellan M, Nerviani A ( 2021 ) . Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target . Disease Markers vol. 2021 , ( 1 )
Boutet MA, Nerviani A, Ribera GL, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 66 - 66 .
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .
Nerviani A, Boutet M-A, Tan WSG, Goldmann K, Purkayastha N, Lajtos T, Hands R, Lewis M et al. ( 2020 ) . IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors . Annals of the Rheumatic Diseases
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al. ( 2020 ) . Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis . Nature Medicine vol. 26 , ( 8 ) 1295 - 1306 .
Bellan M, Quaglia M, Nerviani A, Mauro D, Lewis M, Goegan F, Gibbin A, Pagani S et al. ( 2020 ) . Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis . Clinical and Experimental Rheumatology vol. 39 , ( 1 ) 132 - 138 .
Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .
Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .
Bellan M, Dimagli A, Piccinino C, Giubertoni A, Ianniello A, Grimoldi F, Sguazzotti M, Nerviani A et al. ( 2020 ) . Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders . Disease Markers vol. 2020 ,
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology
Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al. ( 2020 ) . New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis . Disease Markers vol. 2020 , Article 1614627 ,
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,
Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .
Bellan M, Patrucco F, Barone-Adesi F, Gavelli F, Castello LM, Nerviani A, Andreoli L, Cavagna L et al. ( 2019 ) . Targeting CD20 in the treatment of interstitial lung diseases related to connective tissue diseases: A systematic review . Autoimmunity Reviews vol. 19 , ( 2 )
Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al. ( 2019 ) . Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases vol. 78 , ( 12 )
Bellan M, Andreoli L, Nerviani A, Piantoni S, Avanzi GC, Soddu D, Hayden E, Pirisi M et al. ( 2019 ) . Is cholecalciferol a potential disease-modifying anti-rheumatic drug for the management of rheumatoid arthritis? . Clinical and Experimental Rheumatology vol. 38 , ( 2 ) 343 - 349 .
Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology
Rodríguez-Ubreva J, de la Calle-Fabregat C, Li T, Ciudad L, Ballestar ML, Català-Moll F, Morante-Palacios O, Garcia-Gomez A et al. ( 2019 ) . Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 78 , ( 11 )
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis . Nature Immunology vol. 20 , ( 8 ) 1012 - 1022 .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .
Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . Conference: Oral Presentations130 - 131 .
Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . Conference: Oral Presentations134 - 134 .
Nerviani A, Humby F, Ribera GL, Rivellese F, Kelly S, Hands R, Pitzalis C ( 2019 ) . THU0092 DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON . Conference: Poster Presentations317.1 - 31317 .
Boutet M-A, Nerviani A, Pitzalis C ( 2019 ) . IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential . International Journal of Molecular Sciences vol. 20 , ( 6 )
Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2019 ) . P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Abstracts vol. 78 ,
Rivellese F, Lliso-Ribera G, Nerviani A, Humby F, Pitzalis C ( 2019 ) . Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Mauro D, Macaluso F, Nerviani A, Boutet M-A, Rizzo A, Alessandro R, Guggino G, Pitzalis C et al. ( 2019 ) . The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1517 - 1518 .
Bellan M, Nerviani A, Sainaghi PP ( 2018 ) . The Enigma of Vitamin D Role in Inflammation . The Open Rheumatology Journal vol. 12 , ( 1 ) 197 - 200 .
Nerviani A, Mauro D, Gilio M, Grembiale RD, Lewis MJ ( 2018 ) . To supplement or not to supplement? The rationale of vitamin D supplementation in systemic lupus erythematosus . Open Rheumatology Journal vol. 12 , 226 - 247 .
Cecchinato V, D'Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M et al. ( 2018 ) . Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis . Frontiers in Immunology vol. 9 , 2118 - 2118 .
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 )
Mauro D, Nerviani A ( 2018 ) . Endothelial Dysfunction in Systemic Lupus Erythematosus: Pathogenesis, Assessment and Therapeutic Opportunities . Rev Recent Clin Trials vol. 13 , ( 3 ) 192 - 198 .
Nerviani A, Pitzalis C ( 2018 ) . Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer . Journal of Leukocyte Biology vol. 104 , ( 2 ) 333 - 341 .
Mauro D, Tsang V, Lucey-Clayton I, Rivellese F, Pagani S, Alam F, Pontarini E, Nerviani A et al. ( 2018 ) . FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle . Annals of the Rheumatic Diseases . Conference: FRIDAY, 15 JUNE 2018 vol. 77 ,
Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: WEDNESDAY, 13 JUNE 2018 vol. 77 ,
Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2018 ) . SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,
Rivellese F, Nerviani A, Mauro D, Pagani S, Humby F, Pitzalis C ( 2018 ) . SAT0076 Synovial mast cells and responses to synthetic and biologic dmards in early and established rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,
Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,
Purkayastha N, Tan WS, Mahto A, Lewis M, Lliso G, Nerviani A, Rocher V, Humby F et al. ( 2018 ) . THU0122 Imaging characterisation of remission in rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )
Boutet M-A, Nerviani A, Afflitto GG, Pitzalis C ( 2018 ) . Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints . International Journal of Molecular Sciences vol. 19 , ( 2 )
Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,
Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
Ribera GL, Humby F, Kelly S, Lewis M, Bornbardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . THE CLINICAL PHENOTYPE OF INFLAMMATORY ARTHRITIS CORRELATES WITH SYNOVIAL IMMUNE CELL INFILTRATION: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,
NERVIANI A ( 2017 ) . TAM receptors in rheumatoid arthritis: focus on synovial expression, relationship with synovial histopathology and association with clinical evolution and response to treatment . Supervisors: PITZALIS, C, BOMBARDIERI, M ,
Rivellese F, Humby F, Nerviani A, Pagani S, Mauro D, de Paulis A, Marone G, Pitzalis C ( 2017 ) . FRI0030 Synovial mast cells identify patients with a severe phenotype in a cohort of dmard naÏve patients with early rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,
Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,
Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,
Rivellese F, Nerviani A, Rossi FW, Marone G, Matucci-Cerinic M, de Paulis A, Pitzalis C ( 2017 ) . Mast cells in rheumatoid arthritis: friends or foes? . Autoimmunity Reviews vol. 16 , ( 6 ) 557 - 563 .
Rivellese F, Humby F, Pagani S, Nerviani A, Pitzalis C ( 2017 ) . Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Mauro D, Tsang V, Clayton-Lucey IA, Pagani S, Alam F, Pontarini E, Nerviani A, Pakozdi A et al. ( 2017 ) . Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Nerviani A, Pagani S, Mauro D, Humby F, Kelly S, Rivellese F, Ribera GL, Lewis MJ et al. ( 2017 ) . Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Corsiero E, Nerviani A, Bombardieri M, Pitzalis C ( 2016 ) . Ectopic Lymphoid Structures: Powerhouse of Autoimmunity . Front Immunol vol. 7 , Article 00430 , 430 - 430 .
Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. ( 2016 ) . FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology . Annals of the Rheumatic Diseases . vol. 75 ,
Nerviani A, Tan WS, Mahto A, Di Cicco M, Lazarou I, Ng N, Purkayastha N, Bellan M et al. ( 2016 ) . FRI0442 Histopathology of Treatment-Naïve Psoriatic Synovitis: A Comparison with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 75 ,
Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . Presented at: EULAR 2016 ,
Nerviani A, DiCicco M, Kelly S, Humby F, Hands R, Zou L, Lewis M, Rocher V et al. ( 2016 ) . FIBROID SYNOVIAL PATHOTYPE AND TYROSINE KINASE AXL CORRELATE WITH POOR CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS PATIENTS . Rheumatology . Conference: Rheumatology 2016 from: 26/09/2016 to: 28/04/2016 , vol. 55 , 61 - 61 .
Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . 069 T Follicular Helper–Like Cells in the Rheumatoid Arthritis Synovium are Selectively Associated with Interleukin-21 Production and Ectopic Lymphoid Structures . Rheumatology vol. 55 , ( suppl_1 ) i89 - i89 .
Sorice M, Iannuccelli C, Manganelli V, Capozzi A, Alessandri C, Lococo E, Garofalo T, Di Franco M et al. ( 2016 ) . Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies . Rheumatologykew178 - kew178 .
Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . A2.30 TFH-like cells in the ra synovium are selectively associated with IL-21 production and ectopic lymphoid structures . Annals of the Rheumatic Diseases . vol. 75 ,
Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2016 ) . Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 1024 - 1024 .
Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES . RHEUMATOLOGY . vol. 55 , 89 - 89 .
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )
Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2015 ) . Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis . Journal of Experimental Medicine vol. 212 , ( 11 ) 1793 - 1802 .
Decourcey J, Nerviani A, Melgar S, Bulfone-Paus S, Loscher CE, Bombardieri M, Pitzalis C ( 2015 ) . OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,
Tan WS, Bellan M, Nerviani A, Di Cicco M, Mahto A, Lazarou I, Hands R, Humby F et al. ( 2015 ) . OP0208 Synovial Immunopathology Defines Clinical Responsiveness to Dmard Therapy in Early Psoriatic Arthritis: A Pre- and Post-Treatment Mechanistic Study Using a Minimally Invasive Ultrasound-Guided Synovial Biopsy Procedure . Annals of the Rheumatic Diseases . vol. 74 ,
Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C ( 2015 ) . THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,
Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . Young Investigator AwadrI32. Synovial Pathotype Predicts Response to TNF-Alpha Inhibitors In Patients With Rheumatoid Arthritis . Rheumatology vol. 54 , ( suppl_1 ) i6 - i6 .
Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . SYNOVIAL PATHOTYPE PREDICTS RESPONSE TO TNF-ALPHA INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 54 , 6 - 6 .
Astorri E, Nerviani A, Bombardieri M, Pitzalis C ( 2015 ) . Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology . Current Pharmaceutical Design vol. 21 , ( 17 ) 2216 - 2224 .
Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. ( 2014 ) . SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study) . Annals of the Rheumatic Diseases . vol. 73 ,
Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . 101. Synovial Ectopic Lymphoneogenesis Predicts Primary Clinical Response to Certolizumab Pegol in Patients with Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i95 - i95 .
Sola D, Sainaghi PP, Coccetta A, Bellan M, Molinari R, Nerviani A, Pirisi M ( 2014 ) . AB0228 Gas6/tam-system in systemic sclerosis and sjÖgren syndrome: SMER as an indicator of pulmonary hypertension . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Sola D, Nerviani A, Molinari R, Rossi L, Cerutti C, Bellan M, Menegatti M, Pirisi M et al. ( 2014 ) . AB0346 Safety and efficacy of rheumatoid arthritis treatment with modified-release prednisone (mr-pdn), experience in “real life” . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Nerviani A, Cerutti C, Molinari R, Deidda S, Sola D, Steffanini M, Bellan M, Pirisi M et al. ( 2014 ) . AB0923 Subclinical entheseal involvement in patients with psoriasis: A case-control ultrasound study . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 95 - 95 .
Sola D, Sainaghi PP, Coccetta A, Bellan M, Molinari R, Nerviani A, Pirisi M ( 2013 ) . Gas6/tam-system in systemic sclerosis and sjogren syndrome: SMER as an indicator of pulmonary hypertension . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 ,
Sola D, Nerviani A, Molinari R, Rossi L, Cerutti C, Bellan M, Menegatti M, Pirisi M et al. ( 2013 ) . SAFETY AND EFFICACY OF RHEUMATOID ARTHRITIS TREATMENT WITH MODIFIED-RELEASE PREDNISONE (MR-PDN), EXPERIENCE IN "REAL LIFE" . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , 893 - 893 .
Di Cicco M, Kelly S, Humby F, Ng N, Dadoun S, Hands R, Rocher V, Nerviani A et al. ( 2013 ) . Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis . ARTHRITIS AND RHEUMATISM . vol. 65 , S556 - S556 .
Sainaghi PP, Bellan M, Nerviani A, Sola D, Molinari R, Cerutti C, Pirisi M ( 2012 ) . Superiority of a High Loading Dose of Cholecalciferol to Correct Hypovitaminosis D in Patients with Inflammatory/Autoimmune Rheumatic Diseases . The Journal of Rheumatology vol. 40 , ( 2 ) 166 - 172 .
Sainaghi PP, Bellan M, Carda S, Cerutti C, Sola D, Nerviani A, Molinari R, Cisari C et al. ( 2011 ) . Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases . Rheumatology International vol. 32 , ( 11 ) 3365 - 3372 .
Back to Search