Publications: Dr Bela Wrench

Borek WE, Nobre L, Pedicona SF, Campbell AE, Christopher JA, Nawaz N, Perkins DN, Moreno-Cardoso P et al. ( 2024 ) . Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia . EBioMedicine vol. 108 ,

Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .

Patel B, Kirkwood AA, Rowntree CJ, Alapi KZ, Barretta E, Clifton‐Hadley L, Creasey T, Lee S et al. ( 2024 ) . Results from UKALL60+, a phase 2 study in older patients with untreated acute lymphoblastic leukemia . HemaSphere vol. 8 , ( 6 )

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ et al. ( 2023 ) . SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML . Oncogene vol. 42 , ( 50 ) 3670 - 3683 .

Leongamornlert D, Gutiérrez-Abril J, Lee SW, Barretta E, Creasey T, Gundem G, Levine MF, Ossa JEA et al. ( 2023 ) . Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia . Blood Advances vol. 7 , ( 15 ) 3862 - 3873 .

Austin MJ, Kalampalika F, Cawthorn WP, Patel B ( 2023 ) . Turning the spotlight on bone marrow adipocytes in haematological malignancy and non‐malignant conditions . British Journal of Haematology vol. 201 , ( 4 ) 605 - 619 .

Marks DI, Kirkwood AA, Rowntree CJ, Aguiar M, Bailey KE, Beaton B, Cahalin P, Castleton AZ et al. ( 2022 ) . Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial . The Lancet Haematology vol. 9 , ( 4 ) e262 - e275 .

Marks DI, Clifton-Hadley L, Copland M, Hussain J, Menne TF, McMillan A, Moorman AV, Morley N et al. ( 2022 ) . In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial . The Lancet Haematology vol. 9 , ( 4 ) e276 - e288 .

Creasey T, Barretta E, Ryan SL, Butler E, Kirkwood AA, Leongamornlert D, Papaemmanuil E, Patrick P et al. ( 2021 ) . Genetic and genomic analysis of acute lymphoblastic leukaemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials . Haematologica vol. 107 , ( 9 ) 2051 - 2063 .

Moorman AV, Barretta E, Butler ER, Ward EJ, Twentyman K, Kirkwood AA, Enshaei A, Schwab C et al. ( 2022 ) . Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study . Leukemia . vol. 36 , 625 - 636 .

Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al. ( 2021 ) . Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence . Nature Communications

Mitchell RJ, Kirkwood AA, Barretta E, Clifton-Hadley L, Lawrie E, Lee S, Leongamornlert D, Marks DI et al. ( 2021 ) . IKZF1 alterations are not associated with outcome in 498 adults with B-precursor ALL enrolled in the UKALL14 trial . Blood Advances vol. 5 , ( 17 ) 3322 - 3332 .

Paietta E, Roberts KG, Wang V, Gu Z, Buck GAN, Pei D, Cheng C, Levine RL et al. ( 2021 ) . Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL . Blood vol. 138 , ( 11 ) 948 - 958 .

Bartram J, Patel B, Fielding AK ( 2020 ) . Monitoring MRD in ALL: Methodologies, technical aspects and optimal time points for measurement . Seminars in Hematology vol. 57 , ( 3 ) 142 - 148 .

Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al. ( 2020 ) . Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients . British Journal of Haematology

Creasey T, Barretta E, Kirkwood A, Schwab C, Patrick P, Clifton-Hadley L, Patel B, Menne T et al. ( 2020 ) . Genetic and genomic characterisation of older adults with acute lymphoblastic leukemia treated on the UKALL14 and UKALL60+clinical trials . BRITISH JOURNAL OF HAEMATOLOGY . vol. 189 , 58 - 58 .

Patel B, Fernando F ( 2019 ) . Molecular basis of acute lymphoblastic leukemia . Molecular Hematology 4e , Wiley

WRENCH BR ( 2017 ) . Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia . Nature Communications vol. 7 , Article 13331 ,

Warrick N, Miraki-Moud F, Aicher A, McNaughton LA, Casado-Izquierdo P, Nagano A, Carroll R, Bonnet D et al. ( 2017 ) . Adipocyte Induced Antagonism of ALL Growth Highlights a Novel Inhibitory Niche and Potential Therapeutic Opportunity . BLOOD . vol. 130 ,

Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC et al. ( 2016 ) . Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia . Nature Communications vol. 7 , ( 1 )

WRENCH BR ( 2016 ) . Pegylated-asparaginase during induction therapy for adult acute lymphoblastic leukaemia: toxicity data from the UKALL14 trial . leukaemia

Roberts KG, Payne-Turner D, McCastlain K, Gu Z, Iacobucci I, Harvey RC, Chen I-M, Valentine M et al. ( 2015 ) . High Frequency and Poor Outcome of Ph-like Acute Lymphoblastic Leukemia in Adults . Blood . vol. 126 ,

Dey A, Zhang Y, Castleton AZ, Bailey K, Beaton B, Patel B, Fielding AK ( 2015 ) . The Role of Neutrophils in Measles Virus–mediated Oncolysis Differs Between B-cell Malignancies and Is Not Always Enhanced by GCSF . Molecular Therapy vol. 24 , ( 1 ) 184 - 192 .

Dey A, Castleton A, Patel B, Fielding A ( 2015 ) . 430. MVhGCSF Is Therapeutic In-Vivo B Cell Malignancies With Neutrophils (PMNs) Playing Different Roles . Molecular Therapy vol. 23 ,

Patel B, Dey A, Castleton AZ, Schwab C, Samuel E, Sivakumaran J, Beaton B, Zareian N et al. ( 2014 ) . Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology . Blood vol. 124 , ( 1 ) 96 - 105 .

Castleton A, Dey A, Beaton B, Patel B, Aucher A, Davis DM, Fielding AK ( 2013 ) . Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity . Blood vol. 123 , ( 9 ) 1327 - 1335 .

Fielding AK, Rowe JM, Buck G, Foroni L, Gerrard G, Litzow MR, Lazarus H, Luger SM et al. ( 2013 ) . UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia . Blood vol. 123 , ( 6 ) 843 - 850 .

Patel B, Dey A, Castleton AZ, Schwab C, Beaton B, Zareian N, Zhang C, Moorman AV et al. ( 2013 ) . An Optimised In Vivo Modelling System For Adult Acute Lympoblastic Leukaemia (ALL) Enables Sensitive Detection Of Leukaemia Initiating Cells (LIC) and Drug Resistant Clones . Blood vol. 122 , ( 21 )

Zareian N, Patel B, Rai-Shetty L, Rowntree C, McMillan A, Marks DI, Menne T, Smith P et al. ( 2013 ) . Evaluation Of IKZF1 Δ4-7 Deletion As a Suitable Marker For Minimal Residual Disease Monitoring; A Study Of 161 Consecutive Acute Lymphoblastic Leukaemia (ALL) Patients On The On-Going UKALL14 Trial . Blood vol. 122 , ( 21 )

Patel B, Kirkwood A, Dey A, Rowntree C, McMillan A, Marks D, Menne T, Smith P et al. ( 2013 ) . Feasibility Of Pegylated-Asparaginase (PEG-ASP) During Induction In Adults With Acute Lymphoblastic Leukaemia (ALL): Results From The UK Phase 3 Multicentre Trial UKALL 14 . Blood vol. 122 , ( 21 )

Moorman AV, Schwab C, Ensor HM, Russell LJ, Morrison H, Jones L, Masic D, Patel B et al. ( 2012 ) . IGH@ Translocations, CRLF2 Deregulation, and Microdeletions in Adolescents and Adults With Acute Lymphoblastic Leukemia . Journal of Clinical Oncology vol. 30 , ( 25 ) 3100 - 3108 .

Zhang Y, Patel B, Dey A, Ghorani E, Rai L, Elham M, Castleton AZ, Fielding AK ( 2012 ) . Attenuated, Oncolytic, but Not Wild-Type Measles Virus Infection Has Pleiotropic Effects on Human Neutrophil Function . The Journal of Immunology vol. 188 , ( 3 ) 1002 - 1010 .

Patel B, Dey A, Ghorani E, Kumar S, Malam Y, Rai L, Steele AJ, Thomson J et al. ( 2011 ) . Differential Cytopathology and Kinetics of Measles Oncolysis in Two Primary B-cell Malignancies Provides Mechanistic Insights . Molecular Therapy vol. 19 , ( 6 ) 1034 - 1040 .

Patel B, Aditi D, Ghorani E, Malam Y, Andy S, Wickremasinghe R, Lena R, Fielding A ( 2010 ) . Vaccine Measles Virus Has Therapeutic Potential In B Cell Malignancy . Blood vol. 116 , ( 21 )

Patel B, Goldstone AH, Fielding AK ( 2009 ) . Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia (ALL) . Allogeneic Stem Cell Transplantation , Springer Nature

Patel B, Ghorani E, Zhang Y, Gitendra-Wickremasinghe R, Steele A, Fielding AK ( 2009 ) . Attenuated Measles Virus: A Promising Therapeutic Modality for B Cell Malignancy . Blood vol. 114 , ( 22 )

Patel B, Rai L, Buck G, Richards SM, Mortuza Y, Mitchell W, Gerrard G, Moorman AV et al. ( 2009 ) . Minimal residual disease is a significant predictor of treatment failure in non T‐lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993 . British Journal of Haematology vol. 148 , ( 1 ) 80 - 89 .

Patel B, Kirkland KE, Szydlo R, Pearce RM, Clark RE, Craddock C, Liakopoulou E, Fielding AK et al. ( 2009 ) . Favorable outcomes with alemtuzumab-conditioned unrelated donor stem cell transplantation in adults with high-risk Philadelphia chromosome-negative acute lymphoblastic leukemia in first complete remission . Haematologica vol. 94 , ( 10 ) 1399 - 1406 .

Patel BR, Kirkland K, Pearce R, Clark RE, Craddock CF, Liakopolou E, Fielding AK, Mackinnon S et al. ( 2008 ) . T-Cell Depleted Unrelated Donor Stem Cell Transplants Appear to Be of Value for Adult Philadelphia Chromosome Negative ALL Patients and Should Be Evaluated Prospectively in New Large Group Studies . Blood vol. 112 , ( 11 )

Mansour MR, Duke V, Foroni L, Patel B, Allen CG, Ancliff PJ, Gale RE, Linch DC ( 2007 ) . Notch-1 Mutations Are Secondary Events in Some Patients with T-Cell Acute Lymphoblastic Leukemia . Clinical Cancer Research vol. 13 , ( 23 ) 6964 - 6969 .

Patel B, Richards SM, Rowe JM, Goldstone AH, Fielding AK ( 2007 ) . High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysis . Leukemia vol. 22 , ( 2 ) 308 - 312 .

Patel B, Foroni L ( 2006 ) . Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia: A Guide to Therapy . Clinical Leukemia vol. 1 , ( 2 ) 108 - 117 .

Foroni L, Mitchell W, J. L, Casanova A, Gerrard G, Patel B, Richards S, Fielding A et al. ( 2005 ) . Molecular Monitoring of Residual Disease (MRD) during Induction and Intensification Phases in Low Risk Adult B Cell ALL Treated According to the MRC UKALL12 Protocol . Blood vol. 106 , ( 11 )