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Research

Publications: Dr Bela Wrench

Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al. ( 2020 ) . Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients . British Journal of Haematology
WRENCH BR ( 2017 ) . Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia . Nature Communications vol. 7 , Article 13331 ,
WRENCH BR ( 2016 ) . Pegylated-asparaginase during induction therapy for adult acute lymphoblastic leukaemia: toxicity data from the UKALL14 trial . leukaemia
Dey A, Zhang Y, Castleton AZ, Bailey K, Beaton B, Patel B, Fielding AK ( 2016 ) . The role of neutrophils in measles virus-mediated oncolysis differs between B-cell malignancies and is not always enhanced by GCSF . Molecular Therapy vol. 24 , ( 1 ) 184 - 192 .
Roberts KG, Payne-Turner D, McCastlain K, Gu Z, Iacobucci I, Harvey RC, Chen I-M, Valentine M et al. ( 2015 ) . High Frequency and Poor Outcome of Ph-like Acute Lymphoblastic Leukemia in Adults . Blood . vol. 126 , 2618 - 2618 .
Patel B, Dey A, Castleton AZ, Schwab C, Samuel E, Sivakumaran J, Beaton B, Zareian N et al. ( 2014 ) . Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology . Blood vol. 124 , ( 1 ) 96 - 105 .
Castleton A, Dey A, Beaton B, Patel B, Aucher A, Davis DM, Fielding AK ( 2014 ) . Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity . Blood vol. 123 , ( 9 ) 1327 - 1335 .
Fielding AK, Rowe JM, Buck G, Foroni L, Gerrard G, Litzow MR, Lazarus H, Luger SM et al. ( 2014 ) . UKALLXII/ECOG2993: Addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia . Blood vol. 123 , ( 6 ) 843 - 850 .
Moorman AV, Schwab C, Ensor HM, Russell LJ, Morrison H, Jones L, Masic D, Patel B et al. ( 2012 ) . IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia . Journal of Clinical Oncology vol. 30 , ( 25 ) 3100 - 3108 .
Zhang Y, Patel B, Dey A, Ghorani E, Rai L, Elham M, Castleton AZ, Fielding AK ( 2012 ) . Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function . Journal of Immunology vol. 188 , ( 3 ) 1002 - 1010 .
Patel B, Dey A, Ghorani E, Kumar S, Malam Y, Rai L, Steele AJ, Thomson J et al. ( 2011 ) . Differential cytopathology and kinetics of measles oncolysis in two primary B-cell malignancies provides mechanistic insights . Molecular Therapy vol. 19 , ( 6 ) 1034 - 1040 .
Patel B, Rai L, Buck G, Richards SM, Mortuza Y, Mitchell W, Gerrard G, Moorman AV et al. ( 2010 ) . Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: Final results of the international trial UKALL XII/ECOG2993 . British Journal of Haematology vol. 148 , ( 1 ) 80 - 89 .
Patel B, Kirkland KE, Szydlo R, Pearce RM, Clark RE, Craddock C, Liakopoulou E, Fielding AK et al. ( 2009 ) . Favorable outcomes with alemtuzumab-conditioned unrelated donor stem cell transplantation in adults with high-risk Philadelphia chromosome-negative acute lymphoblastic leukemia in first complete remission . Haematologica vol. 94 , ( 10 ) 1399 - 1406 .
Mansour MR, Duke V, Foroni L, Patel B, Allen CG, Ancliff PJ, Gale RE, Linch DC ( 2007 ) . Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia . Clinical Cancer Research vol. 13 , ( 23 ) 6964 - 6969 .