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Research

Publications: Dr Georgina Thorborn

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .
Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNF╬▒-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 1 ) 53 - 60 .
RA-MAP Consortium ( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 )
Merkenschlager J, Ploquin MJ, Eksmond U, Andargachew R, Thorborn G, Filby A, Pepper M, Evavold B et al. ( 2016 ) . Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response . Nature Communications vol. 7 ,
Thorborn G, Ploquin MJ, Eksmond U, Pike R, Bayer W, Dittmer U, Hasenkrug KJ, Pepper M et al. ( 2014 ) . Clonotypic composition of the CD4<sup>+</sup> T cell response to a vectored retroviral antigen is determined by its speed . Journal of Immunology vol. 193 , ( 4 ) 1567 - 1577 .
Thorborn G, Young GR, Kassiotis G ( 2014 ) . Effective T helper cell responses against retroviruses: Are all clonotypes equal? . Journal of Leukocyte Biology vol. 96 , ( 1 ) 27 - 37 .
Thorborn GS, Pomeroy L, Ishohanni H, Peters BS, Vyakarnam A ( 2012 ) . Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV <sup>+</sup> asymptomatic subjects from progressors . European Journal of Immunology vol. 42 , ( 1 ) 138 - 146 .
Alvarez RA, Thorborn G, Reading JL, Reddy SK, Vyakarnam A ( 2011 ) . WFDC1 expression identifies memory CD4 T- lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions . Retrovirology vol. 8 ,
Thorborn G, Pomeroy L, Isohanni H, Perry M, Vyakarnam A, Peters B ( 2010 ) . Novel insights into how quality as well as quantity of 'T-regulatory cells' might explain current disease patterns in HIV . HIV MEDICINE . vol. 11 , 38 - 38 .
Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, Vyakarnam A ( 2010 ) . Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ treg suppression compensates for reduced treg number in asymptomatic HIV-1 infection . PLoS ONE vol. 5 , ( 2 )