Publications: Dr Georgina Thorborn
Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al.
(
2022
)
.
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
.
Scientific Data
vol.
9
,
(
1
)
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al.
(
2022
)
.
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
.
Nature Medicine
vol.
28
,
(
6
)
1256
-
1268
.
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al.
(
2022
)
.
OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB
.
Annals of the Rheumatic Diseases
vol.
81
,
(
Suppl 1
)
56.2
-
5657
.
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al.
(
2021
)
.
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial
.
The Lancet
vol.
397
,
(
10271
)
305
-
317
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Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al.
(
2020
)
.
Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis
.
ARTHRITIS & RHEUMATOLOGY
.
vol.
72
,
Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al.
(
2020
)
.
OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS
.
Annals of the Rheumatic Diseases
.
vol.
79
,
134.1
-
13135
.
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al.
(
2020
)
.
A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients
.
Frontiers in Immunology
vol.
11
,
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al.
(
2020
)
.
B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure
.
Arthritis and Rheumatology
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al.
(
2018
)
.
The RA-MAP Consortium: a working model for academia-industry collaboration
.
Nat Rev Rheumatol
vol.
14
,
(
1
)
53
-
60
.
RA-MAP Consortium
(
2018
)
.
Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data
.
RMD Open
vol.
4
,
(
2
)
Merkenschlager J, Ploquin MJ, Eksmond U, Andargachew R, Thorborn G, Filby A, Pepper M, Evavold B et al.
(
2016
)
.
Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
.
Nature Communications
vol.
7
,
Thorborn G, Ploquin MJ, Eksmond U, Pike R, Bayer W, Dittmer U, Hasenkrug KJ, Pepper M et al.
(
2014
)
.
Clonotypic composition of the CD4<sup>+</sup> T cell response to a vectored retroviral antigen is determined by its speed
.
Journal of Immunology
vol.
193
,
(
4
)
1567
-
1577
.
Thorborn G, Young GR, Kassiotis G
(
2014
)
.
Effective T helper cell responses against retroviruses: Are all clonotypes equal?
.
Journal of Leukocyte Biology
vol.
96
,
(
1
)
27
-
37
.
Thorborn GS, Pomeroy L, Ishohanni H, Peters BS, Vyakarnam A
(
2012
)
.
Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV <sup>+</sup> asymptomatic subjects from progressors
.
European Journal of Immunology
vol.
42
,
(
1
)
138
-
146
.
Alvarez RA, Thorborn G, Reading JL, Reddy SK, Vyakarnam A
(
2011
)
.
WFDC1 expression identifies memory CD4 T- lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions
.
Retrovirology
vol.
8
,
Thorborn G, Pomeroy L, Isohanni H, Perry M, Vyakarnam A, Peters B
(
2010
)
.
Novel insights into how quality as well as quantity of 'T-regulatory cells' might explain current disease patterns in HIV
.
HIV MEDICINE
.
vol.
11
,
38
-
38
.
Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, Vyakarnam A
(
2010
)
.
Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ treg suppression compensates for reduced treg number in asymptomatic HIV-1 infection
.
PLoS ONE
vol.
5
,
(
2
)