Publications: Dr Eirini Marouli
Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B et al.
(
2022
)
.
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
.
Nature Communications
vol.
13
,
(
1
)
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al.
(
2022
)
.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
.
Genome Biology
vol.
23
,
(
1
)
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al.
(
2022
)
.
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
.
American Journal of Human Genetics
vol.
109
,
(
8
)
1366
-
1387
.
Kjaergaard AD, Teumer A, Marouli E, Deloukas P, Kuś A, Sterenborg R, Åsvold BO, Medici M et al.
(
2022
)
.
Thyroid function, pernicious anemia and erythropoiesis: A two-sample Mendelian randomization study
.
Human Molecular Genetics
vol.
31
,
(
15
)
2548
-
2559
.
Raghavan S, Huang J, Tcheandjieu C, Huffman JE, Litkowski E, Liu C, Ho YLA, Hunter-Zinck H et al.
(
2022
)
.
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
.
PLoS Genetics
vol.
18
,
(
6
)
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al.
(
2022
)
.
A saturated map of common genetic variants associated with human height
.
Nature
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR et al.
(
2022
)
.
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
.
Nature Genetics
vol.
54
,
(
1
)
18
-
29
.
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
(
2021
)
.
The power of genetic diversity in genome-wide association studies of lipids
.
Nature
vol.
600
,
(
7890
)
675
-
679
.
Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Pathak GA, Andrews SJ et al.
(
2021
)
.
Mapping the human genetic architecture of COVID-19
.
Nature
vol.
600
,
(
7889
)
472
-
477
.
Sulc J, Sonrel A, Mounier N, Auwerx C, Marouli E, Darrous L, Draganski B, Kilpeläinen TO et al.
(
2021
)
.
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
.
Communications Biology
vol.
4
,
(
1
)
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al.
(
2021
)
.
Epigenome-wide association study detects a novel loci associated with central obesity in healthy subjects
.
BMC Medical Genomics
vol.
14
,
(
1
)
Marouli E, Yusuf L, Kjaergaard AD, Omar R, Kuś A, Babajide O, Sterenborg R, Åsvold BO et al.
(
2021
)
.
Thyroid Function and the Risk of Alzheimer's Disease: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
12
)
1794
-
1799
.
Papadopoulou A, Musa H, Sivaganesan M, McCoy D, Deloukas P, Marouli E
(
2021
)
.
COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases
.
PLoS ONE
vol.
16
,
(
9 September
)
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A et al.
(
2021
)
.
Effects of thyroid function on hemostasis, coagulation, and fibrinolysis: A mendelian randomization study
.
Thyroid
vol.
31
,
(
9
)
1305
-
1315
.
Kuś A, Kjaergaard AD, Marouli E, Del Greco M. F, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T et al.
(
2021
)
.
Thyroid Function and Mood Disorders: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
8
)
1171
-
1181
.
Kuś A, Marouli E, Del Greco M. F, Chaker L, Bednarczuk T, Peeters RP, Teumer A, Medici M et al.
(
2021
)
.
Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
5
)
721
-
731
.
Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V et al.
(
2021
)
.
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
.
American Journal of Human Genetics
vol.
108
,
(
4
)
564
-
582
.
Kjaergaard AD, Marouli E, Papadopoulou A, Deloukas P, Kuś A, Sterenborg R, Teumer A, Burgess S et al.
(
2021
)
.
Thyroid function, sex hormones and sexual function: a Mendelian randomization study
.
European Journal of Epidemiology
vol.
36
,
(
3
)
335
-
344
.
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al.
(
2021
)
.
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
.
Frontiers in Genetics
vol.
12
,
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al.
(
2020
)
.
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
.
Molecular Psychiatry
vol.
25
,
(
10
)
2392
-
2409
.
Marouli E, Kus A, Del Greco M F, Chaker L, Peeters R, Teumer A, Deloukas P, Medici M
(
2020
)
.
Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study
.
Journal of Clinical Endocrinology and Metabolism
vol.
105
,
(
8
)
2634
-
2641
.
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al.
(
2019
)
.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
.
Communications Biology
vol.
2
,
(
1
)
Ng N, Willems SM, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
(
2019
)
.
Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation
.
Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF et al.
(
2019
)
.
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
.
JAMA network open
vol.
2
,
(
9
)
e1910915
-
e1910915
.
Murphy AM, Smith CE, Murphy LM, Follis JL, Tanaka T, Richardson K, Noordam R, Lemaitre RN et al.
(
2019
)
.
Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals
.
Molecular Nutrition and Food Research
vol.
63
,
(
22
)
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
(
2019
)
.
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)
.
Nature Genetics
vol.
51
,
(
7
)
1191
-
1192
.
Huang T, Sun D, Heianza Y, Bergholdt HKM, Gao M, Fang Z, Ding M, Frazier-Wood AC et al.
(
2019
)
.
Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies
.
Clinical Chemistry
vol.
65
,
(
6
)
751
-
760
.
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al.
(
2019
)
.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
.
Commun Biol
vol.
2
,
(
1
)
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al.
(
2019
)
.
Epigenome-wide association study (EWAS) of blood lipids in healthy population from STANISLAS family study (SFS)
.
International Journal of Molecular Sciences
vol.
20
,
(
5
)
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al.
(
2019
)
.
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
.
Nature Genetics
vol.
51
,
(
3
)
452
-
469
.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T et al.
(
2019
)
.
Meta-Analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
.
Human Molecular Genetics
vol.
28
,
(
1
)
166
-
174
.
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al.
(
2018
)
.
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
.
Biological Psychiatry
Hackinger S, Prins B, Mamakou V, Zengini E, Marouli E, Brčić L, Serafetinidis I, Lamnissou K et al.
(
2018
)
.
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
.
Translational Psychiatry
vol.
8
,
(
1
)
Mamakou V, Hackinger S, Zengini E, Tsompanaki E, Marouli E, Serafetinidis I, Prins B, Karabela A et al.
(
2018
)
.
Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: The GOMAP study
.
BMC Psychiatry
vol.
18
,
(
1
)
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al.
(
2018
)
.
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
.
Nature Genetics
vol.
50
,
(
4
)
559
-
571
.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
(
2018
)
.
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
.
Nature Genetics
vol.
50
,
(
1
)
26
-
35
.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
(
2017
)
.
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
.
Nat Genet
vol.
50
,
(
5
)
766
-
767
.
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al.
(
2017
)
.
Exome-wide association study of plasma lipids in >300,000 individuals
.
Nature Genetics
vol.
49
,
(
12
)
1758
-
1766
.
Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, Rentari A, Dimitriou M et al.
(
2017
)
.
Evaluating the glucose raising effect of established loci via a genetic risk score
.
PLoS One
vol.
12
,
(
11
)
Article
0186669
,
e0186669
-
e0186669
.
Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I et al.
(
2017
)
.
Association analyses based on false discovery rate implicate new loci for coronary artery disease
.
Nature Genetics
vol.
49
,
(
9
)
1385
-
1391
.
Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K et al.
(
2017
)
.
Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions
.
Circulation
vol.
135
,
(
24
)
2336
-
2353
.
Murphy AM, Murphy L, Smith CE, Follis J, Tanaka T, Helminen M, Lemaitre R, Voortman T et al.
(
2017
)
.
Meta-Analysis of 19,005 Individuals Identifies Interplay Between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome, to Modulate Insulin Resistance and Diabetes Risk
.
FASEB JOURNAL
.
vol.
31
,
Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C et al.
(
2017
)
.
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
.
Journal of the American Society of Nephrology
vol.
28
,
(
3
)
981
-
994
.
Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NGD, Jansen H, Kanoni S, Nelson CP et al.
(
2017
)
.
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
.
J Am Coll Cardiol
vol.
69
,
(
7
)
823
-
836
.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al.
(
2017
)
.
Rare and low-frequency coding variants alter human adult height
.
Nature
vol.
542
,
(
7640
)
186
-
190
.
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC et al.
(
2016
)
.
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
.
Sci Rep
vol.
6
,
35278
-
35278
.
MUNROE PB
(
2016
)
.
Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension
.
Nature Genetics
MUNROE PB
(
2016
)
.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
.
Nature Genetics
Agiannitopoulos K, Bakalgianni A, Marouli E, Zormpa I, Manginas A, Papamenzelopoulos S, Lamnissou K
(
2016
)
.
Gender Specificity of a Genetic Variant of Androgen Receptor and Risk of Coronary Artery Disease
.
Journal of Clinical Laboratory Analysis
vol.
30
,
(
3
)
204
-
207
.
Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR et al.
(
2016
)
.
Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
.
New England Journal of Medicine
vol.
374
,
(
12
)
1134
-
1144
.
Marouli E, Kanoni S, Dimitriou M, Kolovou G, Deloukas P, Dedoussis G
(
2016
)
.
Lifestyle may modify the glucose-raising effect of genetic loci. A study in the Greek population
.
Nutrition, Metabolism and Cardiovascular Diseases
vol.
26
,
(
3
)
201
-
206
.
Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF et al.
(
2015
)
.
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
.
Nature Communications
vol.
6
,