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Research

Publications: Dr Claire Bourke

Nadimpalli ML, Bourke CD, Robertson RC, Delarocque-Astagneau E, Manges AR, Pickering AJ ( 2020 ) . Can breastfeeding protect against antimicrobial resistance? . BMC Medicine vol. 18 , ( 1 )
Bourke CD, Prendergast AJ ( 2020 ) . The anti-inflammatory effects of cotrimoxazole prophylaxis for people living with human immunodeficiency virus in sub-saharan Africa . Journal of Infectious Diseases vol. 222 , ( 3 ) 347 - 350 .
Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A, Manges AR ( 2020 ) . Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe . Gut Microbes Article KGMI-20190194R1 ,
Bourke C, Evans C ( 2019 ) . Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants . Clinical Infectious Diseases
Bourke C ( 2019 ) . Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth . Journal of Infectious Diseases
Bourke C, Jones KDJ, Prendergast AJ ( 2019 ) . Current understanding of innate immune cell dysfunction in childhood undernutrition . Frontiers in Immunology
BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C, Naheed C ( 2019 ) . Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation . Science Translational Medicine vol. 11 ,
Sturgeon JP, Bourke CD, PRENDERGAST AJ ( 2019 ) . Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses . The Pediatric Infectious Disease Journal1 - 1 .
BOURKE CD, PRENDERGAST A, ROBERTSON R ( 2019 ) . Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study . BMJ Open
Bourke C ( 2019 ) . Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer) . Imperial College Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ ( 2018 ) . Schistosomiasis in the first 1000 days . The Lancet Infectious Diseases vol. 18 , ( 6 ) e193 - e203 .
BOURKE CD, Berkley JA, Prendergast AJ ( 2016 ) . Immune Dysfunction as a Cause and Consequence of Malnutrition . Trends in Immunology vol. 37 , ( 6 ) Article TREIMM_1280 , 386 - 398 .
Sanin DE, Prendergast CT, Bourke CD, Mountford AP ( 2015 ) . Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive . PLoS Pathog vol. 11 , ( 5 )
Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP ( 2015 ) . Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection . Int J Parasitol vol. 45 , ( 4 ) 215 - 224 .
Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ, Mutapi F ( 2015 ) . A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model . Frontiers in Immunology vol. 6 , ( FEB )
Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE et al. ( 2015 ) . Down regulation of the TCR complex CD3ζ-chain on CD3+ T cells: A potential mechanism for helminth-mediated immune modulation . Frontiers in Immunology vol. 6 , ( FEB )
Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F ( 2014 ) . CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1 . PLoS Negl Trop Dis vol. 8 , ( 8 )
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F ( 2014 ) . Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment . PLoS Negl Trop Dis vol. 8 , ( 5 )
Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP ( 2014 ) . Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection . PLoS Negl Trop Dis vol. 8 , ( 4 )
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F ( 2013 ) . Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis . J Infect Dis vol. 208 , ( 1 ) 159 - 169 .
Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K et al. ( 2013 ) . Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products . Parasite Immunol vol. 35 , ( 5-6 ) 147 - 156 .
Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S et al. ( 2012 ) . Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response . Clinical & Experimental Allergy vol. 42 , ( 11 ) 1582 - 1595 .
Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD et al. ( 2012 ) . Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection . PLoS Negl Trop Dis vol. 6 , ( 9 )
Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F ( 2012 ) . Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection . Int Arch Allergy Immunol vol. 158 , ( 3 ) 288 - 298 .
Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F ( 2012 ) . Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children . PLoS Negl Trop Dis vol. 6 , ( 11 )
Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T et al. ( 2012 ) . Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium . Sci Rep vol. 2 ,
Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP ( 2011 ) . The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production . Int J Parasitol vol. 41 , ( 13-14 ) 1335 - 1345 .
Imai N, Rujeni N, Nausch N, Bourke CD, Appleby LJ, Cowan G, Gwisai R, Midzi N et al. ( 2011 ) . Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria . Parasitology vol. 138 , ( 12 ) 1519 - 1533 .
Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ et al. ( 2011 ) . Schistosome infection intensity is inversely related to auto-reactive antibody levels . PLoS One vol. 6 , ( 5 )
Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N, Mduluza T ( 2011 ) . Schistosoma haematobium treatment in 1-5 year old children: safety and efficacy of the antihelminthic drug praziquantel . PLoS Negl Trop Dis vol. 5 , ( 5 )
MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R, MAIZELS RM ( 2011 ) . Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4 . Parasite Immunology vol. 33 , ( 3 ) 181 - 192 .
Bourke CD, Maizels RM, Mutapi F ( 2011 ) . Acquired immune heterogeneity and its sources in human helminth infection . Parasitology vol. 138 , ( 2 ) 139 - 159 .