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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Sabarinath Vallath

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Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al. ( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . The Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .
Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S et al. ( 2018 ) . Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells . eLife vol. 7 ,
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 10 ) 2427 - 2427 .
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 1 ) 259 - 273 .
Vallath S, Reader C, Morton J, Sansom O, Evans J, Biankin A, Barry ST, Kocher H et al. ( 2016 ) . Abstract B53: The integrin αvβ6 is a promising therapeutic target for treating PDAC . Cancer Research . vol. 76 , b53 - b53 .
Agrawal T, Chan W-Y, Sage E, Kolluri K, Sladen P, Sturges G, Vallath S, Janes S et al. ( 2016 ) . Epithelial ErbB2 activity determines thymus homeostasis and T cell maturation . The Journal of Immunology vol. 196 , ( 1_Supplement ) 194.11 - 194.11 .
Whilding LM, Vallath S, Maher J ( 2016 ) . The integrin αvβ6: a novel target for CAR T-cell immunotherapy? . Biochemical Society Transactions vol. 44 , ( 2 ) 349 - 355 .
Vallath S, Sage EK, Kolluri KK, Lourenco SN, Teixeira VS, Chimalapati S, George PJ, Janes SM et al. ( 2016 ) . CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity . Scientific Reports vol. 6 , ( 1 )
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al. ( 2016 ) . Abstract B129: Chimeric antigen receptor T-cells targeting the αvβ6 integrin demonstrate potent antitumor activity in multiple solid tumors . Cancer Immunology Research . vol. 4 , b129 - b129 .
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF ( 2015 ) . Abstract B87: Cell lines generated from PDAC transgenic mice reveal integrin αvβ6 modifies the invasive phenotype of pancreatic cancer . Cancer Research . vol. 75 , b87 - b87 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer . Molecular Cancer Research vol. 11 , ( 10_Supplement ) b046 - b046 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Therapeutic Targeting of Integrin αvβ6 in Breast Cancer . Journal of the National Cancer Institute vol. 106 , ( 8 )
Vallath S, Gadaletta E, Chelala C, Scarpa A, Hart IR, Kocher HM, Marshall JF ( 2012 ) . Abstract B42: Toward targeting integrin αvβ6 for the therapy of pancreatic cancer . Conference: Therapyb42 - b42 .
( 2014 ) . Correction . Thorax vol. 69 , ( 3 )
Vallath S, Hynds RE, Succony L, Janes SM, Giangreco A ( 2014 ) . Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities . European Respiratory Journal vol. 44 , ( 2 ) 513 - 522 .
Vallath S, Sage E, Teixeira V, Janes S, Giangreco A ( 2013 ) . S130 Role of CADM1 in squamous cell carcinoma progression . Thorax vol. 68 , ( Suppl 3 )
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al. ( 2013 ) . Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence . Clin Cancer Res vol. 20 , ( 2 ) 344 - 357 .
Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M et al. ( 2012 ) . Combined Fiber Modifications Both to Target αvβ6 and Detarget the Coxsackievirus–Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5 . Human Gene Therapy vol. 23 , ( 9 ) 960 - 979 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . J Pathol vol. 223 , ( 4 ) 470 - 481 .
Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch‐Smith H et al. ( 2011 ) . Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell‐surface marker of the basal phenotype that promotes tumour cell invasion . The Journal of Pathology vol. 223 , ( 5 ) 646 - 658 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . The Journal of Pathology vol. 223 , ( 4 ) 470 - 481 .
Marsh D, Suchak K, Moutasim K, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . J Pathol vol. 4 , ( 223 ) 470 - 481 .
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ ( 2010 ) . Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein – peptide interactions . Chemical Communications vol. 46 , ( 40 ) 7533 - 7535 .
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF ( 2010 ) . High‐resolution in vivo imaging of breast cancer by targeting the pro‐invasive integrin αvβ6 . The Journal of Pathology vol. 222 , ( 1 ) 52 - 63 .
Filipović A, Gronau JH, Green AR, Wang J, Vallath S, Shao D, Rasul S, Ellis IO et al. ( 2010 ) . Biological and clinical implications of nicastrin expression in invasive breast cancer . Breast Cancer Research and Treatment vol. 125 , ( 1 ) 43 - 53 .
Jones J, Allen M, Thomas G, Dawoud M, Vallath S, Payne S, Edwards D, Pennington C et al. ( 2009 ) . DCIS-Associated Myoepithelial Cells Expressing the αvβ6 Integrin Modify Tumour Cell Behaviour: A Predictor of Invasive Progression? . Cancer Research vol. 69 , ( 24_Supplement ) 4159 - 4159 .
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al. ( 2009 ) . In Vivo Retargeting of Adenovirus Type 5 to αvβ6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery . Journal of Virology vol. 83 , ( 13 ) 6416 - 6428 .
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