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Research

Publications: Dr Viji Draviam Sastry

Conti D, Gul P, Islam A, Martín-Durán JM, Pickersgill RW, Draviam VM ( 2019 ) . Kinetochores attached to microtubule-ends are stabilised by astrin bound pp1 to ensure proper chromosome segregation . eLife vol. 8 ,
Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I, Draviam VM ( 2019 ) . MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly . Open Biology vol. 9 , ( 6 )
Zulkipli I, Clark J, HART M, Shrestha R, GUL P, DANG D, Kasichiwin T, Kujawiak I et al. ( 2018 ) . Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle centering mechanism . Journal of Cell Biology
Zulkipli I, Shrestha RL, Clark J, Draviam VM ( 2017 ) . Proper rotation of the mitotic spindle requires an equatorial spindle centering mechanism in human cells . MOLECULAR BIOLOGY OF THE CELL . Conference: ASCB vol. 28 ,
Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J, Draviam VM ( 2017 ) . Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells . Nat Commun vol. 8 , ( 1 ) 150 - 150 .
Conti D, Cieslinski KA, Ries J, Draviam VM ( 2017 ) . Outer kinetochore phosphatases-PP2A-B56 and PP1-differently contribute to the establishment of chromosome-microtubule attachments . MOLECULAR BIOLOGY OF THE CELL . vol. 28 ,
Patel H, Stavrou I, Shrestha RL, Draviam V, Frame MC, Brunton VG ( 2016 ) . Kindlin1 regulates microtubule function to ensure normal mitosis . Journal of Molecular Cell Biology vol. 8 , ( 4 ) 338 - 348 .
Hiroi N, Draviam VM, Funahashi A ( 2016 ) . Editorial: Quantitative Biology: Dynamics of Living Systems . Front Physiol vol. 7 , Article 196 ,
Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J, Draviam VM ( 2015 ) . A semi-supervised approach for refining transcriptional signatures of drug response and repositioning predictions . PLoS ONE vol. 10 , ( 10 )
Corrigan AM, Shrestha R, Draviam VM, Donald AM ( 2015 ) . Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation . Biophysical Journal vol. 109 , ( 7 ) 1398 - 1409 .
Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A, Draviam VM ( 2015 ) . A proteomic study of mitotic phase-Specific interactors of EB1 reveals a role for SXIP-Mediated protein interactions in anaphase onset . Biology Open vol. 4 , ( 2 ) 155 - 169 .
Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q et al. ( 2015 ) . PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair . Science vol. 347 , ( 6218 ) 185 - 188 .
Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S et al. ( 2015 ) . High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes . Review of Scientific Instruments vol. 86 , ( 1 )
Shrestha RL, Draviam VM ( 2014 ) . Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK . MOLECULAR BIOLOGY OF THE CELL . vol. 25 ,
Conti D, Draviam VM ( 2014 ) . Role of phosphatases in chromosome segregation . MOLECULAR BIOLOGY OF THE CELL . vol. 25 ,
Shrestha RL, Tamura N, Fries A, Levin N, Clark J, Draviam VM ( 2014 ) . TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes . Open Biology vol. 4 , ( JUNE )
Chin-Hui-Men S, Nandra K, Clark J, Draviam VM ( 2014 ) . Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganisation in solid cancers . Frontiers in Physiology vol. 5 JUL ,
Shrestha RL, Draviam VM ( 2013 ) . Erratum: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK (Current Biology (2013) 23 (1514-1526)) . Current Biology vol. 23 , ( 23 ) 2440 - 2441 .
Shrestha RL, Draviam VM ( 2013 ) . Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins cenp-e and MCAK . Current Biology vol. 23 , ( 16 ) 1514 - 1526 .
Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J et al. ( 2013 ) . Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance . Cell Cycle vol. 12 , ( 16 ) 2643 - 2655 .
Draviam VM, Funahashi A, Hiroi N, Kimura A, Kobayashi TJ ( 2013 ) . Meeting report of the international workshop on quantitative biology 2012: Mesoscopic and microscopic worlds meet . Frontiers in Physiology vol. 3 JAN ,
Tamura N, Draviam VM ( 2012 ) . Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles . Open Biology vol. 2 , ( NOV )
Tamura N, Shrestha RL, Draviam VM ( 2012 ) . Microtubule-end bound complexes power chromosome movement during chromosome segregation . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,
Shrestha RL, Draviam VM ( 2012 ) . TAO1 maintains genome integrity by mediating the timely maturation of chromosome attachments made to lateral walls of microtubules . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,
Shrestha RL, Tamura N, Zulkipli I, Draviam VM ( 2011 ) . A mechanism linking microtubule destabilisation to maturation of chromosome-microtubule attachments . MOLECULAR BIOLOGY OF THE CELL . vol. 22 ,
Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P ( 2009 ) . Roles for the conserved Spc105p/Kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint . PLoS ONE vol. 4 , ( 10 )
McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK ( 2009 ) . The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (The EMBO Journal (2006) 25 (4033-4049) DOI:10.1038/sj.emboj.7601293) . EMBO Journal vol. 28 , ( 9 )
Foijer F, Draviam VM, Sorger PK ( 2008 ) . Studying chromosome instability in the mouse . Biochimica et Biophysica Acta - Reviews on Cancer vol. 1786 , ( 1 ) 73 - 82 .
Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ et al. ( 2007 ) . Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities . Nature vol. 447 , ( 7141 ) 876 - 881 .
Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK et al. ( 2007 ) . A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling . Nature Cell Biology vol. 9 , ( 5 ) 556 - 564 .
Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ et al. ( 2007 ) . Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities . Nature vol. 446 , ( 7138 ) 876 - 881 .
Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW ( 2007 ) . Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans . Journal of Cell Science vol. 120 , ( 7 ) 1278 - 1287 .
McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK ( 2006 ) . The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation . EMBO Journal vol. 25 , ( 17 ) 4033 - 4049 .
Draviam VM, Shapiro I, Aldridge B, Sorger PK ( 2006 ) . Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells . EMBO Journal vol. 25 , ( 12 ) 2814 - 2827 .
Draviam VM, Stegmeier F, Nalepa G, Sowa M, Hannon G, Harper W, Elledge S, Sorger P ( 2006 ) . Functional Genomic Screen Reveals the Role of a Novel Checkpoint Kinase, TAO1 in Mitosis and Cell Cycle Progression . MOLECULAR BIOLOGY OF THE CELL . vol. 17 ,
Meraldi P, Draviam VM, Sorger PK ( 2004 ) . Timing and checkpoints in the regulation of mitotic progression . Developmental Cell vol. 7 , ( 1 ) 45 - 60 .
Draviam VM, Xie S, Sorger PK ( 2004 ) . Chromosome segregation and genomic stability . Current Opinion in Genetics and Development vol. 14 , ( 2 ) 120 - 125 .
Gergely F, Draviam VM, Raff JW ( 2003 ) . The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells . Genes and Development vol. 17 , ( 3 ) 336 - 341 .
Draviam VM, Orrechia S, Lowe M, Pardi R, Pines J ( 2001 ) . The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus . Journal of Cell Biology vol. 152 , ( 5 ) 945 - 958 .