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Research

Publications: Dr Benjamin Stieglitz

Green JL, Wu Y, Stieglitz B ( 2020 ) . Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development . PLoS Pathogens vol. 16 , ( 6 ) e1008640 - e1008640 .
Burlina F, Abdel-Aal A-BM, Raz R, Pinzuti I, Papageorgiou G, Li J, Antrobus R, Martin SR et al. ( 2019 ) . Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP . Communications Chemistry vol. 2 , ( 1 ) Article 111 ,
Kliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, STIEGLITZ B, Macek B, Husnjak K ( 2017 ) . Internally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass Spectrometry . Nature Methods
Oregioni A, STIEGLITZ B, Kelly G, Rittinger K, Frenkiel T ( 2017 ) . Determination of the pKa of the N-terminal amino group of ubiquitin by NMR . Scientific Reports1 - 8 .
Dove KK, Stieglitz B, Duncan ED, Rittinger K, Klevit RE ( 2016 ) . Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms . EMBO Reports
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR et al. ( 2013 ) . Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP . Nature vol. 503 , ( 7476 ) 422 - 426 .
Stieglitz B, Morris-Davies AC, Koliopoulos MG, Christodoulou E, Rittinger K ( 2012 ) . LUBAC synthesizes linear ubiquitin chains via a thioester intermediate . EMBO Reports vol. 13 , ( 9 ) 840 - 846 .
Stieglitz B, Rittinger K, Haire LF ( 2012 ) . Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization . Acta Crystallographica Section F: Structural Biology and Crystallization Communications vol. 68 , ( 7 ) 816 - 819 .
Stieglitz B, Haire LF, Dikic I, Rittinger K ( 2012 ) . Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold . Journal of Biological Chemistry vol. 287 , ( 25 ) 20823 - 20829 .
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H et al. ( 2011 ) . Novel sources of IL-9 in lung inflammation . IMMUNOLOGY . vol. 135 , 128 - 128 .
Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H et al. ( 2011 ) . An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation . Nature Immunology vol. 12 , ( 11 ) 1071 - 1077 .
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, Van Wijk SJL, Goswami P et al. ( 2011 ) . SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis . Nature vol. 471 , ( 7340 ) 637 - 641 .
Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A, Herrmann C ( 2010 ) . Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation . Journal of Biological Chemistry vol. 285 , ( 21 ) 16258 - 16266 .
Stieglitz B, Bee C, Schwarz D, Yildiz O, Moshnikova A, Khokhlatchev A, Herrmann C ( 2008 ) . Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II . EMBO Journal vol. 27 , ( 14 ) 1995 - 2005 .
Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A, Aktories K ( 2008 ) . Crystal structure of the Clostridium limosum C3 exoenzyme . FEBS Lett vol. 582 , ( 7 ) 1032 - 1036 .