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Research

Publications: Prof Steven Thornton

David AL, Ahmadzia H, Ashcroft R, Bucci-Rechtweg C, Spencer RN, Thornton S ( 2022 ) . Improving Development of Drug Treatments for Pregnant Women and the Fetus . Therapeutic Innovation and Regulatory Science vol. 56 , ( 6 ) 976 - 990 .
Spencer RN, Hecher K, Norman G, Marsal K, Deprest J, Flake A, Figueras F, Lees C et al. ( 2022 ) . Development of standard definitions and grading for Maternal and Fetal Adverse Event Terminology . Prenatal Diagnosis vol. 42 , ( 1 ) 15 - 26 .
Norman JE, Norrie J, MacLennan G, Cooper D, Whyte S, Chowdhry S, Cunningham-Burley S, Neilson AR et al. ( 2022 ) . The Arabin Pessary to Prevent Preterm Birth in Women With a Twin Pregnancy and a Short Cervix: The STOPPIT 2 RCT . Obstetrical and Gynecological Survey vol. 77 , ( 1 ) 1 - 3 .
Saade G, Shennan A, Beach KJ, Hadar E, Parilla BV, Snidow J, Powell M, Montague TH et al. ( 2021 ) . Erratum: Randomized trials of retosiban versus placebo or atosiban in spontaneous preterm labor (American Journal of Perinatology DOI: 10.1055/s-0040-1710034) . American Journal of Perinatology vol. 38 ,
Norman JE, Norrie J, MacLennan G, Cooper D, Whyte S, Chowdhry S, Cunningham-Burley S, Mei XW et al. ( 2021 ) . Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis . PLoS Medicine vol. 18 , ( 3 )
Powell M, Saade G, Thornton S, Pimenta JM, Haque N, Miller D, Beach KJ, Snidow J et al. ( 2021 ) . Safety and Outcomes in Infants Born to Mothers Participating in Retosiban Treatment Trials: ARIOS Follow-Up Study . American Journal of Perinatology
Norman JE, Norrie J, Maclennan G, Cooper D, Whyte S, Chowdhry S, Cunningham-Burley S, Neilson AR et al. ( 2021 ) . The arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: The stoppit 2 rct . Health Technology Assessment vol. 25 , ( 44 )
Poon LC, Wright D, Thornton S, Akolekar R, Brocklehurst P, Nicolaides KH ( 2020 ) . Mini-combined test compared with NICE guidelines for early risk-assessment for pre-eclampsia: the SPREE diagnostic accuracy study . Efficacy and Mechanism Evaluation vol. 7 , ( 8 ) 1 - 156 .
Spencer R, David AL ( 2020 ) . VP22.01: Delphi consensus on adverse event severity grading for clinical trials of maternal and fetal therapies . Ultrasound in Obstetrics and Gynecology vol. 56 , ( S1 ) 148 - 148 .
Allen M, Villeneuve E, Pitt M, Thornton S ( 2020 ) . How can consultant-led childbirth care at time of delivery be maximised? A modelling study . BMJ Open vol. 10 , ( 7 )
Shennan A, Chandiramani M, Bennett P, David AL, Girling J, Ridout A, Seed PT, Simpson N et al. ( 2020 ) . MAVRIC: A Multicenter Randomized Controlled Trial of Transabdominal vs Transvaginal Cervical Cerclage . Obstetrical and Gynecological Survey vol. 75 , ( 7 ) 392 - 394 .
Saade G, Shennan A, Beach KJ, Hadar E, Parilla BV, Snidow J, Powell M, Montague TH et al. ( 2020 ) . Randomized Trials of Retosiban Versus Placebo or Atosiban in Spontaneous Preterm Labor . American Journal of Perinatology
Shennan A, Chandiramani M, Bennett P, David AL, Girling J, Ridout A, Seed PT, Simpson N et al. ( 2020 ) . MAVRIC: a multicenter randomized controlled trial of transabdominal vs transvaginal cervical cerclage . American Journal of Obstetrics and Gynecology vol. 222 , ( 3 ) 261.e1 - 261.e9 .
Norman JE, Norrie J, MacLennan G, Cooper D, Whyte S, Chowdhry S, Cunningham-Burley S, Mei X et al. ( 2020 ) . LB 1: Randomized controlled trial: Arabin pessary to prevent preterm birth in twin pregnancies with short cervix . American Journal of Obstetrics and Gynecology vol. 222 , ( 1 )
Norman JE, Marlow N, Messow C-M, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al. ( 2019 ) . Corrigendum: Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM) . Health Technology Assessment vol. 22 , ( 35 ) 305 - 334 .
Norman JE, Norrie J, Maclennan G, Cooper D, Whyte S, Burley SC, Smith JBE, Shennan A et al. ( 2018 ) . Open randomised trial of the (Arabin) pessary to prevent preterm birth in twin pregnancy with health economics and acceptability: STOPPIT-2-a study protocol . BMJ Open vol. 8 , ( 12 )
Villeneuve E, Landa P, Allen M, Spencer A, Prosser S, Gibson A, Kelsey K, Mujica-Mota R et al. ( 2018 ) . A framework to address key issues of neonatal service configuration in England: the NeoNet multimethods study . Health Services and Delivery Research vol. 6 , ( 35 ) 1 - 160 .
Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al. ( 2018 ) . Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM) . Health Technology Assessment vol. 22 , ( 35 ) 1 - 304 .
Dowell J, Cleland J, Fitzpatrick S, McManus C, Nicholson S, Oppé T, Petty-Saphon K, King OS et al. ( 2018 ) . The UK medical education database (UKMED) what is it? Why and how might you use it? . BMC Med Educ vol. 18 , ( 1 ) 6 - 14 .
Thornton S ( 2017 ) . UK medical education database: An issue of assumed Consent . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 17 , ( 2 )
Thornton S, Valenzuela G, Baidoo C, Fossler MJ, Montague TH, Clayton L, Powell M, Snidow J et al. ( 2017 ) . Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose-ranging study . British Journal of Clinical Pharmacology vol. 83 , ( 10 ) 2283 - 2291 .
Knight B, Smith H, Tregarthen A, Lapointe J, Shennan A, Taylor MJO, Thornton S ( 2016 ) . Quantitative fetal fibronectin as a predictor of time to delivery in women undergoing induction of labour: a pilot study . BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 123 , ( 13 ) E5 - E5 .
Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al. ( 2016 ) . Vaginal Progesterone Prophylaxis for Preterm Birth (the OPPTIMUM Study): A Multicentre, Randomized, Double-Blind Trial . Obstetrical and Gynecological Survey vol. 71 , ( 9 ) 517 - 518 .
Knight HE, van der Meulen JH, Gurol-Urganci I, Smith GC, Kiran A, Thornton S, Richmond D, Cameron A et al. ( 2016 ) . Birth “Out-of-Hours”: An Evaluation of Obstetric Practice and Outcome According to the Presence of Senior Obstetricians on the Labour Ward . PLoS Medicine vol. 13 , ( 4 )
Norman JE, Marlow N, Messow C-M, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al. ( 2016 ) . Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial . Lancet vol. 387 , ( 10033 ) 2106 - 2116 .
Kim SH, MacIntyre DA, Hanyaloglu AC, Blanks AM, Thornton S, Bennett PR, Terzidou V ( 2016 ) . The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G<inf>αi</inf> signalling . Molecular and Cellular Endocrinology vol. 420 , 11 - 23 .
Norman JE, Messow CM, Shennan A, Bennett P, Thornton S, Robson SC, Marlow N, Norrie J et al. ( 2016 ) . LB2: Opptimum . American Journal of Obstetrics and Gynecology vol. 214 , ( 1 ) s452 - s453 .
Norman JE, Messow CM, Shennan A, Bennett P, Thornton S, Robson SC, Marlow N, Norrie J et al. ( 2016 ) . Opptimum . AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY . vol. 214 , S452 - S453 .
Thornton S, Miller H, Valenzuela G, Snidow J, Stier B, Fossler MJ, Montague TH, Powell M et al. ( 2015 ) . Treatment of spontaneous preterm labour with retosiban: A phase 2 proof-of-concept study . British Journal of Clinical Pharmacology vol. 80 , ( 4 ) 740 - 749 .
Kim SH, Tulsyan S, Da Silva FMA, Blanks A, Thornton S, Bennett PR, Terzidou V ( 2015 ) . The proinflammatory effects of oxytocin in human myometrium require both Gaq and Gai proteins and are not inhibited by the oxytocin receptor antagonist- atosiban . BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 122 , 356 - 356 .
Kim SH, MacIntyre DA, Firmino Da Silva M, Blanks AM, Lee YS, Thornton S, Bennett PR, Terzidou V ( 2015 ) . Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues . Molecular and Cellular Endocrinology vol. 403 , 64 - 77 .
Mccloskey C, Rada C, Bailey E, Mccavera S, van den Berg HA, Atia J, Rand DA, Shmygol A et al. ( 2014 ) . The inwardly rectifying K<sup>+</sup> channel KIR7.1 controls uterine excitability throughout pregnancy . EMBO Molecular Medicine
Kim S, Blanks A, Thornton S, Bennett P, Terzidou V ( 2014 ) . 6.2 Atosiban activates NF-κB and pro-inflammatory pathways in human amnion via Gαi signalling . Archives of Disease in Childhood - Fetal and Neonatal Edition vol. 99 , ( Suppl 1 )
Hughes A, Greisen G, Arce J-C, Thornton S ( 2014 ) . Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at one year . BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 121 , ( 7 ) E6 - E6 .
Kay O, Hughes A, Saade G, Bennett P, Terzidou V, Thornton S ( 2014 ) . Recent advances in the prevention and treatment of preterm labour: Oxytocin antagonists and the silicone (Arabin) pessary . Fetal and Maternal Medicine Review vol. 25 , ( 2 ) 134 - 145 .
Duckitt K, Thornton S, O'Donovan OP, Dowswell T ( 2014 ) . Nitric oxide donors for treating preterm labour . Cochrane Database of Systematic Reviews vol. 2014 , ( 5 )
Kim SH, Blanks A, Thornton S, Bennett PR, Terzidou V ( 2014 ) . Oxytocin Receptor Antagonist, Atosiban, Drives Proinflammatory Effects in Human Amnion Via G(ai) Signaling . REPRODUCTIVE SCIENCES vol. 21 , ( 3 ) 111A - 111A .
Allen M, Thornton S ( 2014 ) . Providing One-to-One Care in Labor. Analysis of “Birthrate Plus” Labor Ward Staffing in Real and Simulated Labor Ward Environments . Obstetric Anesthesia Digest vol. 34 , ( 1 ) 35 - 36 .
Hughes A, Greisen G, Arce JC, Thornton S ( 2014 ) . Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year . Acta Obstetricia et Gynecologica Scandinavica vol. 93 , ( 1 ) 109 - 112 .
Hyde C, Thornton S ( 2013 ) . Does screening for pre-eclampsia make sense? . BJOG: An International Journal of Obstetrics and Gynaecology vol. 120 , ( 10 ) 1168 - 1170 .
Kim SH, Blanks A, Thornton S, Johnson M, Bennett PR, Terzidou V ( 2013 ) . Activation of NF-kappa B in Human Amnion Is Mediated through G(ai) and Is Mimicked by the Oxytocin Receptor Antagonist - Atosiban . REPRODUCTIVE SCIENCES . vol. 20 , 122A - 122A .
Snidow J, Miller H, Valenzuela G, Thornton S, Stier B, Clayton L, Fossler M, Montague T et al. ( 2013 ) . 350: A multicenter, randomized, double-blind, placebo-controlled phase 2 trial of retosiban, a selective oxytocin receptor antagonist, for the management of preterm labor . American Journal of Obstetrics and Gynecology . vol. 208 ,
Allen M, Thornton S ( 2013 ) . Providing one-to-one care in labour. Analysis of 'Birthrate Plus' labour ward staffing in real and simulated labour ward environments . BJOG: An International Journal of Obstetrics and Gynaecology vol. 120 , ( 1 ) 100 - 107 .
Bru-Mercier G, Gullam JE, Thornton S, Blanks AM, Shmygol A ( 2012 ) . Characterization of the tissue-level Ca<sup>2+</sup> signals in spontaneously contracting human myometrium . Journal of Cellular and Molecular Medicine vol. 16 , ( 12 ) 2990 - 3000 .
Norman JE, Shennan A, Bennett P, Thornton S, Robson S, Marlow N, Norrie J, Petrou S et al. ( 2012 ) . Trial protocol OPPTIMUM- Does progesterone prophylaxis for the prevention of preterm labour improve outcome? . BMC Pregnancy and Childbirth vol. 12 ,
Khanjani S, Terzidou V, Lee YS, Thornton S, Johnson MR, Bennett PR ( 2011 ) . Synergistic regulation of human oxytocin receptor promoter by CCAAT/: Enhancer-binding protein and RELA . Biology of Reproduction vol. 85 , ( 5 ) 1083 - 1088 .
Bailey E, Quenby S, Thornton S, Blanks A ( 2011 ) . An investigation into the combination of nifedipine with potassium channel openers as potential tocolytic therapy for preterm labour . Archives of Disease in Childhood - Fetal and Neonatal Edition vol. 96 , ( Suppl 1 )
Shennan AH, Thornton S ( 2011 ) . Clinical research networks and clinical study groups . Obstetrics Gynaecology & Reproductive Medicine vol. 21 , ( 4 ) 118 - 119 .
Fernandes MS, Pierron V, Michalovich D, Astle S, Thornton S, Peltoketo H, Lam EWF, Gellersen B et al. ( 2005 ) . Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues . Journal of Endocrinology vol. 187 , ( 1 ) 89 - 101 .
Duckitt K, Thornton S ( 2002 ) . Nitric oxide donors for the treatment of preterm labour .