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Research

Publications: Dr Ana Rita Pedrosa

Gopinathan G, Berlato C, Lakhani A, Szabova L, Pegrum C, Pedrosa AR, Laforets F, Maniati E et al. ( 2022 ) . Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer . Molecular Cancer Therapeutics vol. 21 , ( 6 ) 1030 - 1045 .
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez-Escudero J, Casado P, Rajeeve V et al. ( 2022 ) . Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth . Journal of Pathology vol. 256 , ( 2 ) 235 - 247 .
Newport EL, Pedrosa AR, Njegic A, Hodivala-Dilke KM, Muñoz-Félix JM ( 2021 ) . Improved immunotherapy efficacy by vascular modulation . Cancers vol. 13 , ( 20 )
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM ( 2021 ) . Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression (Angiogenesis, (2021), 24, 3, (471-482), 10.1007/s10456-021-09776-8) . Angiogenesis vol. 24 , ( 3 ) 483 - 487 .
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM ( 2021 ) . Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression . Angiogenesis vol. 24 , ( 3 ) 471 - 482 .
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M et al. ( 2020 ) . Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth . Nature Communications vol. 11 , ( 1 )
D'Amico G, Muñoz-Félix JM, Pedrosa AR, Hodivala-Dilke KM ( 2020 ) . “Splitting the matrix”: intussusceptive angiogenesis meets MT1-MMP . EMBO Molecular Medicine vol. 12 , ( 2 )
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al. ( 2019 ) . Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation . Cancer Research
Pedrosa AR, Trindade A, Duarte A ( 2018 ) . Methods to study angiogenesis in a mouse model of prostate cancer . vol. 1786 , 29 - 54 .
Pedrosa AR, Graça JL, Carvalho S, Peleteiro MC, Duarte A, Trindade A ( 2016 ) . Notch signaling dynamics in the adult healthy prostate and in prostatic tumor development . Prostate vol. 76 , ( 1 ) 80 - 96 .
Duarte A, Pedrosa A-R, Trindade A, Carvalho C, Graça J, Carvalho S, Peleteiro MC, Adams RH ( 2015 ) . Abstract 5225: Endothelial-specific Jagged1 blockade prevents solid tumor growth in pre-clinical models . Conference: Tumor Biology5225 - 5225 .
Pedrosa AR, Trindade A, Fernandes AC, Carvalho C, Gigante J, Tavares AT, Diéguez-Hurtado R, Yagita H et al. ( 2015 ) . Endothelial jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( 5 ) 1134 - 1146 .
Pedrosa AR, Trindade A, Carvalho C, Graça J, Carvalho S, Peleteiro MC, Adams RH, Duarte A ( 2015 ) . Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions . Oncotarget vol. 6 , ( 27 ) 24404 - 24423 .
Pedrosa ARPAA, Trindade A, Fernandes AC, Carvalho C, Gigante JVQGC, Hurtado RD, Gill PS, Adams RH et al. ( 2014 ) . Signals that control angiogenic sprouting . ANGIOGENESIS . vol. 17 , 294 - 295 .
Trindade A, Djokovic D, Gigante J, Badenes M, Pedrosa AR, Fernandes AC, Lopes-da-Costa L, Krasnoperov V et al. ( 2012 ) . Low-Dosage inhibition of DLL4 signaling promotes wound healing by inducing functional Neo-Angiogenesis . PLoS ONE vol. 7 , ( 1 )