Publications: Prof Morris Brown

Watson A, Syme H, Brown M ( 2024 ) . Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors . Hypertension vol. 81 , ( 12 ) 2489 - 2500 .

Aminuddin A, Brown MJ, Azizan EA ( 2024 ) . Evaluating the role of aldosterone synthesis on adrenal cell fate . Frontiers in Endocrinology vol. 15 ,

Silins I, Moreno A, Wall A, Aigbirhio F, Gurnell M, Brown M, Roslin S, Antoni G et al. ( 2024 ) . Radiation dosimetry of para-chloro-2-[18F]fluoroethyl-etomidate: a PET tracer for adrenocortical imaging . EJNMMI Research vol. 14 , ( 1 )

Bohoran TA, Parke KS, Graham-Brown MPM, Meisuria M, Singh A, Wormleighton J, Adlam D, Gopalan D et al. ( 2023 ) . Resource efficient aortic distensibility calculation by end to end spatiotemporal learning of aortic lumen from multicentre multivendor multidisease CMR images . Scientific Reports vol. 13 , ( 1 )

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

Azizan EAB, Drake WM, Brown MJ ( 2023 ) . Primary aldosteronism: molecular medicine meets public health . Nature Reviews Nephrology vol. 19 , ( 12 ) 788 - 806 .

Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, Fernandes-Rosa FL, Boulkroun S et al. ( 2023 ) . Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production . Nature Genetics vol. 55 , ( 6 ) 1009 - 1021 .

Kida Y ( 2023 ) . Baxdrostat for Treatment-Resistant Hypertension . New England Journal of Medicine vol. 388 , ( 19 ) 1820 - 1822 .

Wu X, Senanayake R, Goodchild E, Bashari WA, Salsbury J, Cabrera CP, Argentesi G, O’Toole SM et al. ( 2023 ) . [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial . Nature Medicine vol. 29 , ( 1 ) 190 - 202 .

MacDonald TM, Mackenzie IS, Rogers A, Poulter NR, Williams B, Brown MJ, Webb DJ, Ford I et al. ( 2023 ) . S-28-1: CARDIOVASCULAR OUTCOMES IN ADULTS WITH HYPERTENSION WITH EVENING VERSUS MORNING DOSING OF USUAL ANTIHYPERTENSIVES IN THE UK. THE TIME STUDY . Journal of Hypertension vol. 41 , ( Suppl 1 )

Freeman MW, Halvorsen Y-D, Marshall W, Pater M, Isaacsohn J, Pearce C, Murphy B, Alp N et al. ( 2022 ) . Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension . New England Journal of Medicine vol. 388 , ( 5 ) 395 - 405 .

Mackenzie IS, Rogers A, Poulter NR, Williams B, Brown MJ, Webb DJ, Ford I, Rorie DA et al. ( 2022 ) . Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial . The Lancet vol. 400 , ( 10361 ) 1417 - 1425 .

Mackenzie IS, Hawkey CJ, Ford I, Greenlaw N, Pigazzani F, Rogers A, Struthers AD, Begg AG et al. ( 2022 ) . Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial . The Lancet vol. 400 , ( 10359 ) 1195 - 1205 .

Silins I, Sundin A, Lubberink M, O’Sullivan L, Gurnell M, Aigbirhio F, Brown M, Wall A et al. ( 2022 ) . First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours . European Journal of Nuclear Medicine and Molecular Imaging vol. 50 , ( 2 ) 398 - 409 .

Collaboration TBPLTT, Rahimi K, Bidel Z, Nazarzadeh M, Copland E, Canoy D, Wamil M, Majert J et al. ( 2021 ) . Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis . The Lancet vol. 398 , ( 10305 ) 1053 - 1064 .

Brown MJ, Alazawi W, Kanoni S ( 2021 ) . Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 . New England Journal of Medicine vol. 385 , ( 12 ) 1147 - 1149 .

Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L et al. ( 2021 ) . Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause . Nature Genetics

Sander K, Gendron T, Cybulska KA, Sirindil F, Zhou J, Kalber TL, Lythgoe MF, Kurzawinski TR et al. ( 2021 ) . Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism . Journal of Medicinal Chemistry vol. 64 , ( 13 ) 9321 - 9329 .

Kulkarni S, Dominiczak AF, Touyz RM, Spence JD, Batlle D, Barigou M, Brown M, Carey RM et al. ( 2021 ) . CONNed in Pregnancy . Hypertension vol. 78 , ( 1 ) 241 - 249 .

Rahimi K, Bidel Z, Nazarzadeh M, Copland E, Canoy D, Ramakrishnan R, Pinho-Gomes A-C, Woodward M et al. ( 2021 ) . Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis . The Lancet vol. 397 , ( 10285 ) 1625 - 1636 .

Copland E ( 2021 ) . Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis . The Lancet Oncology

Azizan E, Brown M ( 2020 ) . ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity . The Malaysian Journal of Pathology vol. 42 , ( 3 ) 363 - 367 .

Guthrie G, Poulter N, Macdonald T, Ford I, Mackenzie I, Findlay E, Williams B, Brown M et al. ( 2020 ) . Chronotherapy in hypertension: the devil is in the details . European Heart Journal vol. 41 , ( 16 ) 1606 - 1607 .

Causon RC, Murphy MB, Brown MJ ( 2019 ) . Effect of hemolysis on radioenzymic assay of plasma catecholamines . Clinical Chemistry vol. 28 , ( 3 ) 548 - 550 .

Maniero C, Scudieri P, Shaikh LH, Zhao W, Gurnell M, Galietta LJV, Brown MJ ( 2019 ) . ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion . Hypertension vol. 74 , ( 5 ) 1152 - 1159 .

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al. ( 2019 ) . Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids . Nature Genetics vol. 51 , ( 4 ) 636 - 648 .

Yehya A, Rajagopal V, Meduri C, Kauten J, Brown M, Dean L, Webster J, Krishnamoorthy A et al. ( 2019 ) . Short-term results with transcatheter aortic valve replacement for treatment of left ventricular assist device patients with symptomatic aortic insufficiency . The Journal of Heart and Lung Transplantation vol. 38 , ( 9 ) 920 - 926 .

O'Toole SM, Brown MJ, Drake WM ( 2019 ) . Established endocrine practice . Clinical Medicine vol. 19 , ( 1 )

Pinggera A, Negro G, Tuluc P, Brown MJ, Lieb A, Striessnig J ( 2018 ) . Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels . Channels vol. 12 , ( 1 ) 388 - 402 .

Williams B, Brown MJ ( 2018 ) . Investigation of primary aldosteronism in patients with resistant hypertension – Authors' reply . The Lancet Diabetes & Endocrinology vol. 6 , ( 8 ) 600 - 601 .

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK et al. ( 2018 ) . Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies . Lancet Diabetes Endocrinol vol. 6 , ( 6 ) 464 - 475 .

BROWN MJ ( 2018 ) . Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study . Lancet Diabetes and Endocrinology vol. 6 , ( 6 ) 464 - 475 .

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P et al. ( 2017 ) . Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial . J Am Heart Assoc vol. 6 , ( 11 )

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Selvarajah V, Mäki-Petäjä KM, Pedro L, Bruggraber SFA, Burling K, Goodhart AK, Brown MJ, McEniery CM et al. ( 2017 ) . Novel Mechanism for Buffering Dietary Salt in Humans . Hypertension vol. 70 , ( 5 ) 930 - 937 .

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .

Brown MJ ( 2017 ) . Rapid Diagnosis of Primary Aldosteronism . Hypertension vol. 70 , ( 2 ) 247 - 249 .

Tan GC, Negro G, Pinggera A, Tizen Laim NMS, Mohamed Rose I, Ceral J, Ryska A, Chin LK et al. ( 2017 ) . Aldosterone-Producing Adenomas . Hypertension vol. 70 , ( 1 ) 129 - 136 .

Maniero C, Garg S, Zhao W, Johnson TI, Zhou J, Gurnell M, Brown MJ ( 2017 ) . NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)–Mediated Secretion of Aldosterone . Hypertension vol. 70 , ( 2 ) 357 - 364 .

Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L et al. ( 2017 ) . Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort . The Lancet Diabetes & Endocrinology vol. 5 , ( 9 ) 689 - 699 .

Teo AED, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ ( 2017 ) . Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin) . Hypertension vol. 69 , ( 6 ) 1207 - 1216 .

Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ ( 2017 ) . 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling . Journal of Human Hypertension vol. 31 , ( 7 ) 483 - 484 .

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .

Brown MJ, Drake WM ( 2016 ) . Primary aldosteronism as a public health issue – Authors' reply . The Lancet Diabetes & Endocrinology vol. 4 , ( 12 ) 973 - 974 .

Bogman K, Schwab D, Delporte M-L, Palermo G, Amrein K, Mohr S, De Vera Mudry MC, Brown MJ et al. ( 2016 ) . Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2) . Hypertension vol. 69 , ( 1 ) 189 - 196 .

Zhou J, Lam B, Neogi SG, Yeo GSH, Azizan EAB, Brown MJ ( 2016 ) . Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues . Hypertension vol. 68 , ( 6 ) 1424 - 1431 .

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Brown MJ, Drake WM ( 2016 ) . Splitting atoms: the Endocrine Society guideline for the management of primary aldosteronism . The Lancet Diabetes & Endocrinology vol. 4 , ( 10 ) 805 - 807 .

Teo AED, Garg S, Shaikh LH, Zhou J, Frankl FEK, Gurnell M, Happerfield L, Marker A et al. ( 2016 ) . Effect of somatic CTNNB1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause . Annales d Endocrinologie vol. 77 , ( 2 ) 161 - 162 .

Azizan EAB, Brown MJ ( 2016 ) . Novel genetic determinants of adrenal aldosterone regulation . Current Opinion in Endocrinology Diabetes and Obesity vol. 23 , ( 3 ) 209 - 217 .

Petruzzelli M, Taylor KP, Koo B, Brown MJ ( 2016 ) . Telling Tails . Hypertension vol. 68 , ( 1 ) 11 - 16 .

Xie CB, Haris Shaikh L, Garg S, Tanriver G, Teo AED, Zhou J, Maniero C, Zhao W et al. ( 2016 ) . Regulation of aldosterone secretion by Cav1.3 . Scientific Reports vol. 6 , ( 1 )

Murtha TD, Carling T, Scholl UI ( 2016 ) . Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations . New England Journal of Medicine vol. 374 , ( 15 ) 1492 - 1493 .

Williams B, MacDonald TM, Morant SV, Brown MJ ( 2016 ) . PATHWAY-2: spironolactone for resistant hypertension – Authors' reply . The Lancet vol. 387 , ( 10026 ) 1373 - 1374 .

Rorie DA, Rogers A, Mackenzie IS, Ford I, Webb DJ, Willams B, Brown M, Poulter N et al. ( 2016 ) . Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study . BMJ Open vol. 6 , ( 2 )

Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G et al. ( 2015 ) . Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial . The Lancet Diabetes & Endocrinology vol. 4 , ( 2 ) 136 - 147 .

Teo AED, Garg S, Shaikh LH, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A et al. ( 2015 ) . Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations . New England Journal of Medicine vol. 373 , ( 15 ) 1429 - 1436 .

Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK et al. ( 2015 ) . Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial . The Lancet vol. 386 , ( 10008 ) 2059 - 2068 .

Brown MJ, Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ et al. ( 2015 ) . Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension . BMJ Open vol. 5 , ( 8 )

MacDonald TM, Williams B, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Mackenzie IS et al. ( 2015 ) . Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial . BMJ Open vol. 5 , ( 8 )

Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J et al. ( 2015 ) . Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension . BMJ Open vol. 5 , ( 8 )

Powlson AS, Gurnell M, Brown MJ ( 2015 ) . Nuclear imaging in the diagnosis of primary aldosteronism . Current Opinion in Endocrinology Diabetes and Obesity vol. 22 , ( 3 ) 150 - 156 .

Brown MJ ( 2015 ) . Primary Aldosteronism: the spectre of cure . Clinical Endocrinology vol. 82 , ( 6 ) 785 - 788 .

Shaikh LH, Zhou J, Teo AED, Garg S, Neogi SG, Figg N, Yeo GS, Yu H et al. ( 2015 ) . LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal . The Journal of Clinical Endocrinology & Metabolism vol. 100 , ( 6 ) e836 - e844 .

Zhou J, Shaikh LH, Neogi SG, McFarlane I, Zhao W, Figg N, Brighton CA, Maniero C et al. ( 2015 ) . DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-&bgr; Signaling and Suppresses Aldosterone Secretion . Hypertension vol. 65 , ( 5 ) 1103 - 1110 .

Jennings CG, MacDonald TM, Wei L, Brown MJ, McConnachie L, Mackenzie IS ( 2015 ) . Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants? . Trials vol. 16 , ( 1 )

Ying A, Arima H, Czernichow S, Woodward M, Huxley R, Turnbull F, Perkovic V, Neal B ( 2014 ) . Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: a meta-analysis of randomised trials . The Lancet vol. 385 , ( 9971 ) 867 - 874 .

Brown MJ ( 2014 ) . Clinical Value of Plasma Renin Estimation in the Management of Hypertension . American Journal of Hypertension vol. 27 , ( 8 ) 1013 - 1016 .

Collaboration TBPLTT ( 2014 ) . Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data . The Lancet vol. 384 , ( 9943 ) 591 - 598 .

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . American Journal of Human Genetics vol. 95 , ( 1 ) 49 - 65 .

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ et al. ( 2014 ) . Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization . Nature Genetics vol. 46 , ( 8 ) 826 - 836 .

Brown MJ ( 2014 ) . Resistant hypertension: resistance to treatment or resistance to taking treatment? . Heart vol. 100 , ( 11 )

Auchus RJ, Brown M, Lenders JWM, Naruse M, Plouin PF, Satoh F, Young WF, Rossi GP ( 2014 ) . Response to Implementation of Rapid Cortisol During Adrenal Vein Sampling . Hypertension vol. 63 , ( 4 )

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T et al. ( 2014 ) . Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci . American Journal of Human Genetics vol. 94 , ( 3 ) 349 - 360 .

Murthy M, Azizan EAB, Brown MJ, O'Shaughnessy KM ( 2014 ) . Erratum: Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-production adenoma (J Hypertens (2012) 30 (1827-1833)) . Journal of Hypertension vol. 32 , ( 4 )

Rossi GP, Auchus RJ, Brown M, Lenders JWM, Naruse M, Plouin PF, Satoh F, Young WF ( 2013 ) . An Expert Consensus Statement on Use of Adrenal Vein Sampling for the Subtyping of Primary Aldosteronism . Hypertension vol. 63 , ( 1 ) 151 - 160 .

Brown MJ ( 2013 ) . Ins and Outs of Aldosterone-Producing Adenomas of the Adrenal . Hypertension vol. 63 , ( 1 ) 24 - 26 .

O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AM, Köttgen A, Stoudmann C et al. ( 2013 ) . Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations . PLOS Genetics vol. 9 , ( 9 )

Azizan EAB, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S et al. ( 2013 ) . Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension . Nature Genetics vol. 45 , ( 9 ) 1055 - 1060 .

van Meurs JBJ, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X et al. ( 2013 ) . Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease 1 , 2 , 3 , 4 , 5 . American Journal of Clinical Nutrition vol. 98 , ( 3 ) 668 - 676 .

Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K et al. ( 2013 ) . Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease . PLOS ONE vol. 8 , ( 4 )

Bramham K, Nelson-Piercy C, Brown MJ, Chappell LC ( 2013 ) . Postpartum management of hypertension . The BMJ vol. 346 , ( feb25 1 )

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . Nature Genetics vol. 45 , ( 2 ) 145 - 154 .

Shaw KC, McEniery CM, Wilkinson IB, Brown MJ ( 2012 ) . Unsafe health and safety: sphygmomanometer cuffs are not interchangeable . Journal of Human Hypertension vol. 27 , ( 7 ) 434 - 436 .

Alvarez-Madrazo S, MacKenzie SM, Davies E, Fraser R, Lee W-K, Brown M, Caulfield MJ, Dominiczak AF et al. ( 2012 ) . Common Polymorphisms in the CYP11B1 and CYP11B2 Genes . Hypertension vol. 61 , ( 1 ) 232 - 239 .

Brown MJ, Haydock S ( 2012 ) . Pathoaetiology, Epidemiology and Diagnosis of Hypertension . Drugs vol. 59 , ( Suppl 2 ) 1 - 12 .

Brown MJ ( 2012 ) . Therapeutic Potential of Vaccines in the Management of Hypertension . Drugs vol. 68 , ( 18 ) 2557 - 2560 .

Murthy M, Azizan EAB, Brown MJ, O'Shaughnessy KM ( 2012 ) . Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma . Journal of Hypertension vol. 30 , ( 9 ) 1827 - 1833 .

Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H et al. ( 2012 ) . Seven newly identified loci for autoimmune thyroid disease . Human Molecular Genetics vol. 21 , ( 23 ) 5202 - 5208 .

Brown M ( 2012 ) . Classification and naming of drugs . Clinical Pharmacology: Eleventh Edition ,

Bennett PN, Brown MJ, Sharma P ( 2012 ) . Clinical Pharmacology: Eleventh Edition .

Bennett PN, Brown MJ, Sharma P ( 2012 ) . Preface .

Perucca E, Richens A ( 2012 ) . Water intoxication produced by carbamazepine and its reversal by phenytoin [proceedings] . British Journal of Clinical Pharmacology vol. 9 , ( 3 ) 302p - 304p .

Kaumann AJ, Sanders L, Brown AM, Murray KJ, Brown MJ ( 2012 ) . A 5‐hydroxytryptamine receptor in human atrium . British Journal of Pharmacology vol. 100 , ( 4 ) 879 - 885 .

Brown MJ, Harland D ( 2012 ) . B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors . British Journal of Pharmacology vol. 87 , ( 2 ) 361 - 370 .

Brown MJ, Harland D ( 2012 ) . Evidence for a peripheral component in the sympatholytic effect of clonidine in rats . British Journal of Pharmacology vol. 83 , ( 3 ) 657 - 665 .

Barnes PJ, Brown MJ, Dollery CT, Fuller RW, Heavey DJ, Ind PW ( 2012 ) . Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex . British Journal of Pharmacology vol. 88 , ( 4 ) 741 - 745 .

Price JS, Kenny AJ, Huskisson NS, Brown MJ ( 2012 ) . Neuropeptide Y (NPY) metabolism by endopeptidase‐2 hinders characterization of NPY receptors in rat kidney . British Journal of Pharmacology vol. 104 , ( 2 ) 321 - 326 .

Ferro A, Kaumann AJ, Brown MJ ( 2012 ) . β1‐ and β2‐adrenoceptor‐mediated relaxation in human internal mammary artery and saphenous vein: unchanged β‐ and α‐adrenoceptor responsiveness after chronic β1‐adrenoceptor blockade . British Journal of Pharmacology vol. 109 , ( 4 ) 1053 - 1058 .

Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, Takahashi A, Maeda S et al. ( 2012 ) . Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations . Nature Genetics vol. 44 , ( 8 ) 904 - 909 .

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2012 ) . Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height . American Journal of Human Genetics vol. 90 , ( 6 ) 1116 - 1117 .

Stears AJ, Woods SH, Watts MM, Burton TJ, Graggaber J, Mir FA, Brown MJ ( 2012 ) . A Double-Blind, Placebo-Controlled, Crossover Trial Comparing the Effects of Amiloride and Hydrochlorothiazide on Glucose Tolerance in Patients With Essential Hypertension . Hypertension vol. 59 , ( 5 ) 934 - 942 .

Azizan EAB, Lam BYH, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A et al. ( 2012 ) . Microarray, qPCR, and KCNJ5 Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors . The Journal of Clinical Endocrinology & Metabolism vol. 97 , ( 5 ) e819 - e829 .

Brown MJ ( 2012 ) . Author’s reply to Rogers . The BMJ vol. 344 , ( feb21 1 )

Azizan EAB, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, Brown MJ, O'Shaughnessy KM ( 2012 ) . Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas . Hypertension vol. 59 , ( 3 ) 587 - 591 .

Brown MJ, Cruickshank JK, MacDonald TM ( 2012 ) . Navigating the shoals in hypertension: discovery and guidance . The BMJ vol. 344 , ( jan13 1 )

Burton TJ, Mackenzie IS, Balan K, Koo B, Bird N, Soloviev DV, Azizan EAB, Aigbirhio F et al. ( 2011 ) . Evaluation of the Sensitivity and Specificity of 11C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas . The Journal of Clinical Endocrinology & Metabolism vol. 97 , ( 1 ) 100 - 109 .

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I et al. ( 2011 ) . Blood Pressure Loci Identified with a Gene-Centric Array . American Journal of Human Genetics vol. 89 , ( 6 ) 688 - 700 .

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . Nature Genetics vol. 43 , ( 11 ) 1131 - 1138 .

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD et al. ( 2011 ) . Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk . Nature vol. 478 , ( 7367 ) 103 - 109 .

Brown MJ ( 2011 ) . The choice of diuretic in hypertension: saving the baby from the bathwater . Heart vol. 97 , ( 19 )

Burton TJ, Salsbury J, Hood S, Brown MJ ( 2011 ) . Conn's syndrome unmasked by thiazide-induced hypokalaemia . British Journal of Hospital Medicine vol. 72 , ( 9 ) 530 - 531 .

Brown MJ ( 2011 ) . Personalised medicine for hypertension . The BMJ vol. 343 , ( jul28 2 )

Brown MJ, McInnes GI, MacDonald TM, Party FTBHSRW ( 2011 ) . Initial combination therapy for treatment of hypertension – Authors' reply . The Lancet vol. 377 , ( 9776 )

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR et al. ( 2011 ) . Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease . Nature Genetics vol. 43 , ( 4 ) 333 - 338 .

Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T, Engert JC, Clarke R et al. ( 2011 ) . Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data . The BMJ vol. 342 , ( feb15 2 )

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Lewis CJ, Gong H, Brown MJ, Harding SE ( 2004 ) . Overexpression of β1‐adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for ‘putative’β4‐adrenoceptor pharmacology . British Journal of Pharmacology . vol. 141 , 813 - 824 .

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Hood SJ, Taylor KP, Ashby MJ, Brown MJ ( 2007 ) . The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio . Circulation vol. 116 , ( 3 ) 268 - 275 .

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Neal DAJ, Brown MJ, Wilkinson IB, Alexander GJM ( 2005 ) . Mechanisms of Hypertension After Liver Transplantation . Transplantation vol. 79 , ( 8 ) 935 - 940 .

Standridge JB, Sealey JE, Laragh JH, Houston MC, Gavras H, Johnson RJ, Blumenfeld JD, Brown M et al. ( 2005 ) . A free-ranging roundtable discussion on hypertension . Journal of Human Hypertension vol. 19 , ( 4 ) 259 - 266 .

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de Leeuw PW, Ruilope LM, Palmer CR, Brown MJ, Castaigne A, Mancia G, Rosenthal T, Wagener G ( 2004 ) . Clinical Significance of Renal Function in Hypertensive Patients at High Risk: Results From the INSIGHT Trial . JAMA Internal Medicine vol. 164 , ( 22 ) 2459 - 2464 .

Healy D, Paykel ES, White W, Whitehouse AM, Ashby M, Brown M, Theodorou AE, Lawrence KM et al. ( 2004 ) . Plasma noradrenaline, adrenaline and DHPG responses to clonidine in control and depressed subjects . Human Psychopharmacology Clinical and Experimental vol. 7 , ( 3 ) 167 - 173 .

Wang T, Brown MJ ( 2004 ) . Differential expression of adenylyl cyclase subtypes in human cardiovascular system . Molecular and Cellular Endocrinology vol. 223 , ( 1-2 ) 55 - 62 .

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Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, Sever PS, Thom SM ( 2004 ) . British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary . The BMJ vol. 328 , ( 7440 )

Neal DAJ, Brown MJ, Wilkinson IB, Byrne CD, Alexander GJM ( 2004 ) . Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation1 . Transplantation vol. 77 , ( 5 ) 748 - 750 .

Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, Sever PS, McG Thom S ( 2004 ) . Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV . Journal of Human Hypertension vol. 18 , ( 3 ) 139 - 185 .

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WANG T, KAUMANN AJ, BROWN MJ ( 2003 ) . (−)‐Timolol is a more potent antagonist of the positive inotropic effects of (−)‐adrenaline than of those of (−)‐noradrenaline in human atrium . British Journal of Clinical Pharmacology vol. 42 , ( 2 ) 217 - 223 .

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Brown MJ ( 2003 ) . A RATIONAL BASIS FOR SELECTION AMONG DRUGS OF THE SAME CLASS . Heart vol. 89 , ( 6 )

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Mancia G, Brown M, Castaigne A, de Leeuw P, Palmer CR, Rosenthal T, Wagener G, Ruilope LM ( 2003 ) . Outcomes With Nifedipine GITS or Co-Amilozide in Hypertensive Diabetics and Nondiabetics in Intervention as a Goal in Hypertension (INSIGHT) . Hypertension vol. 41 , ( 3 ) 431 - 436 .

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Sadhra S, Jackson CA, Ryder T, Brown MJ ( 2002 ) . Noise Exposure and Hearing Loss among Student Employees Working in University Entertainment Venues . Annals of Work Exposures and Health vol. 46 , ( 5 ) 455 - 463 .

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Brown MJ ( 2001 ) . Matching the right drug to the right patient in essential hypertension . Heart vol. 86 , ( 1 )

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Brown MJ ( 2001 ) . Blood-pressure-lowering treatment . The Lancet vol. 357 , ( 9257 ) 715 - 716 .

Sharma P, Brown MJ ( 2001 ) . Neurovascular lessons from a pair of identical twins with cerebral aneurysms . Postgraduate Medical Journal vol. 77 , ( 905 ) 197 - 198 .

Kloner RA, Brown M, Prisant LM, Collins M ( 2001 ) . Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy . American Journal of Hypertension vol. 14 , ( 1 ) 70 - 73 .

Mulrow CD ( 2001 ) . Long acting nifedipine was as effective as hydrochlorothiazide plus amiloride for reducing mortality and morbidity in hypertension . BMJ Evidence-Based Medicine vol. 6 , ( 1 )

Zusman RM, Prisant LM, Brown MJ ( 2000 ) . Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication . Journal of Hypertension vol. 18 , ( 12 ) 1865 - 1869 .

Neal B, MacMahon S, Chapman N ( 2000 ) . Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials . The Lancet vol. 356 , ( 9246 ) 1955 - 1964 .

García-López FJ, de Álvaro F ( 2000 ) . INSIGHT and NORDIL . The Lancet vol. 356 , ( 9245 )

Wang T, Sharma SD, Fox N, Rossor M, Brown MJ, Sharma P ( 2000 ) . Description of a simple test for CADASIL disease and determination of mutation frequencies in sporadic ischaemic stroke and dementia patients . Journal of Neurology Neurosurgery & Psychiatry vol. 69 , ( 5 )

O'SHAUGHNESSY KM, FU B, DICKERSON C, THURSTON D, BROWN MJ ( 2000 ) . The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects . Clinical Science vol. 99 , ( 3 ) 233 - 238 .

Brown MJ ( 2000 ) . Error: Morbidity and mortality in patients randomised to double-blind treatment with long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) (The Lancet (July 29) (366)) . Lancet vol. 356 , ( 9228 )

Brown MJ, Palmer CR, Castaigne A, de Leeuw PW, Mancia G, Rosenthal T, Ruilope LM ( 2000 ) . Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) . The Lancet vol. 356 , ( 9227 ) 366 - 372 .

Sharma P, Fatibene J, Ferraro F, Jia H, Monteith S, Brown C, Clayton D, O’Shaughnessy K et al. ( 2000 ) . A Genome-Wide Search For Susceptibility Loci to Human Essential Hypertension . Hypertension vol. 35 , ( 6 ) 1291 - 1296 .

Jia H, Sharma P, Hopper R, Dickerson C, Lloyd DD, Brown MJ ( 2000 ) . β2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians . Journal of Hypertension vol. 18 , ( 6 ) 687 - 693 .

Brown MJ, Castaigne A, de Leeuw PW, Mancia G, Palmer CR, Rosenthal T, Ruilope LM ( 2000 ) . Influence of Diabetes and Type of Hypertension on Response to Antihypertensive Treatment . Hypertension vol. 35 , ( 5 ) 1038 - 1042 .

Lowe MD, Rowland E, Brown MJ, Grace AA ( 2000 ) . β<inf>2</inf>-Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium . Heart vol. 83 , ( SUPPL. 1 )

Wang JG, Gasowski J, Fagard R, Staessen JA ( 2000 ) . What does STOP-2 tell us about management of hypertension? . The Lancet vol. 355 , ( 9204 )

Brown MJ, Sharma P, Stevens PA ( 2000 ) . Association Between Diastolic Blood Pressure and Variants of the Endothelin-1 and Endothelin-2 Genes . Journal of Cardiovascular Pharmacology . vol. 35 , s41 - s43 .

Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A, Haydock S, Hopper RV et al. ( 1999 ) . A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK . Circulation . vol. 100 , 1515 - 1520 .

Yasmin, Brown MJ ( 1999 ) . Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness . QJM vol. 92 , ( 10 ) 595 - 600 .

Hockly E, Brown MJ ( 1999 ) . Homocysteine, vitamins and sex . European Heart Journal vol. 20 , ( 17 ) 1222 - 1223 .

Sharma P, Hingorani A, Jia H, Hopper R, Brown MJ ( 1999 ) . Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension . Journal of Hypertension vol. 17 , ( 9 ) 1281 - 1287 .

Brown M ( 1999 ) . Do vitamin E and fish oil protect against ischaemic heart disease? . The Lancet vol. 354 , ( 9177 ) 441 - 442 .

Jia H, Hingorani AD, Sharma P, Hopper R, Dickerson C, Trutwein D, Lloyd DD, Brown MJ ( 1999 ) . Association of the Gsα Gene With Essential Hypertension and Response to β-Blockade . Hypertension vol. 34 , ( 1 ) 8 - 14 .

Dickerson JC, Hingorani AD, Ashby MJ, Palmer CR, Brown MJ ( 1999 ) . Optimisation of antihypertensive treatment by crossover rotation of four major classes . The Lancet vol. 353 , ( 9169 ) 2008 - 2013 .

Brown J, Brown M ( 1999 ) . CAPPP trial . The Lancet vol. 353 , ( 9166 )

Brown MJ, Hopper RV ( 1999 ) . Calcium-channel blockade can mask the diagnosis of Conn's syndrome . Postgraduate Medical Journal vol. 75 , ( 882 ) 235 - 236 .

Wang T, Brown MJ ( 1999 ) . mRNA Quantification by Real Time TaqMan Polymerase Chain Reaction: Validation and Comparison with RNase Protection . Analytical Biochemistry vol. 269 , ( 1 ) 198 - 201 .

Mitchinson MJ, Stephens NG, Parsons A, Bligh E, Schofield PM, Brown MJ ( 1999 ) . Mortality in the CHAOS trial . The Lancet vol. 353 , ( 9150 ) 381 - 382 .

Brown MJ, Castaigne A, de Leeuw PW, Mancia G, Rosenthal T, Ruilope LM ( 1998 ) . Study population and treatment titration in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) . Journal of Hypertension vol. 16 , ( 12 Pt 2 ) 2113 - 2116 .

Brown MJ ( 1998 ) . Irbesartan treatment in hypertension . British Journal of Hospital Medicine vol. 59 , ( 10 ) 808 - 811 .

Sharma P, Hingorani A, Jia H, Ashby M, Hopper R, Clayton D, Brown MJ ( 1998 ) . Positive Association of Tyrosine Hydroxylase Microsatellite Marker to Essential Hypertension . Hypertension vol. 32 , ( 4 ) 676 - 682 .

Yasmin, Mascie‐Taylor C, Brown M, Hughes M ( 1998 ) . THE EFFECT OF DIETARY INTERVENTION ON CHANGES IN TOTAL CHOLESTEROL, BLOOD PRESSURE AND WEIGHT IN A CAMBRIDGE STUDY . International Journal of Clinical Practice vol. 52 , ( 4 ) 241 - 245 .

Brown MJ ( 1998 ) . Who Manages Hypertensive Patients?* . American Journal of Hypertension . vol. 11 , 740 - 743 .

Sharma P, Lu F, Rut A, Brown MJ ( 1998 ) . Structure of Human Endothelin-2 Gene and Demonstration of Common Expression in Human Right Atrial Tissue . Biochemical and Biophysical Research Communications vol. 245 , ( 3 ) 709 - 712 .

( 1998 ) . Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments. World Health Organization-International Society of Hypertension Blood Pressure Lowering Treatment Trialists' Collaboration . Journal of Hypertension vol. 16 , ( 2 ) 127 - 137 .

Sharma P, Pathan S, Fatibene J, Jia H, Thompson D, Monteith S, Clayton D, O'Shaughnessy K et al. ( 1997 ) . 1.1 Genome wide search for susceptibility loci in essential hypertension . Journal of Hypertension vol. 15 , ( 12 )

Dickerson JEC, Hingorani AD, Brown MJ ( 1997 ) . 2.3 Sequential monotherapy as a method of optimal treatment selection for young patients with hypertension . Journal of Hypertension vol. 15 , ( 12 ) 1534 - 1535 .

Brown M, Castaigne A ( 1997 ) . INSIGHT - the baseline characteristics of randomised patients . International Journal of Clinical Practice, Supplement . 72 - 73 .

Brown MJ, Castaigne A, De Leeuw PW, Mancia G, Rosenthal T, Ruilope LM ( 1997 ) . INSIGHT - study rationale and design . International Journal of Clinical Practice, Supplement ( 92 ) 39 - 40 .

Ferro A, Hall JA, Dickerson JE, Brown MJ ( 1997 ) . A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects . British Journal of Clinical Pharmacology vol. 43 , ( 3 ) 301 - 308 .

Sharma P, Smith I, Maguire G, Stewart S, Shneerson J, Brown MJ ( 1997 ) . Clinical value of ACE genotyping in diagnosis of sarcoidosis . The Lancet vol. 349 , ( 9065 ) 1602 - 1603 .

Medina RA, Cardona-Sanclemente LE, Born GVR, Brown MJ ( 1997 ) . Effect of deoxycorticosterone acetate on blood pressure in relation to accumulation of low-density lipoprotein and fibrinogen by aorta and other tissues of normotensive Wistar rats . Journal of Hypertension vol. 15 , ( 5 ) 531 - 536 .

Brown MJ ( 1997 ) . Science, medicine, and the future : Hypertension . The BMJ vol. 314 , ( 7089 )

Sharma P, Pathan S, Fatibene J, Jia H, Thompson D, Monteith S, Clayton D, O'Shaughnessy K et al. ( 1997 ) . Annual Scientific Meeting of the British Hypertension Society. Wills Hall, University of Bristol, 15-17 September 1997. Genome wide search for susceptibility loci in essential hypertension: Early results . Journal of Hypertension . vol. 15 ,

Longmore J, Hargreaves RJ, Boulanger CM, Brown MJ, Desta B, Ferro A, Schofield WN, Taylor AA et al. ( 1997 ) . Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols . Functional Neurology vol. 12 , ( 1 ) 3 - 9 .

Medina R, E. C-SL, Born GVR, J. BM ( 1997 ) . Effect of Captopril and Losartan on Blood Pressure and Accumulation of LDL and Fibrinogen by Aortic Wall and Other Tissues in Normotensive and Hypertensive Rats . Journal of Cardiovascular Pharmacology vol. 29 , ( 1 ) 125 - 129 .

Jia H, Lloyd D, Trutwein D, Brown MJ ( 1996 ) . Levels of GTPγS-stimulated adenylyl cyclase activity in human lymphocytes: Effects of G<inf>s</inf>α genotype . British Journal of Clinical Pharmacology vol. 41 , ( 5 )

Hingorani AD, Sharma P, Jia H, Hopper R, Brown MJ ( 1996 ) . Blood pressure and the M235T polymorphism of the angiotensinogen gene . Hypertension . vol. 28 , 907 - 911 .

Oliver S ( 1996 ) . Calcium-channel blockers and cancer . The Lancet vol. 348 , ( 9035 )

Brown MJ, Castaigne A, Ruilope LM, Mancia G, Rosenthal T, de Leeuw PW, Ebner F ( 1996 ) . INSIGHT: international nifedipine GITS study intervention as a goal in hypertension treatment . Journal of Human Hypertension vol. 10 Suppl 3 , s157 - s160 .

Hingorani AD, Brown MJ ( 1996 ) . Identifying the genes for human hypertension . Nephrology Dialysis Transplantation vol. 11 , ( 4 ) 575 - 586 .

Stephens NG, Parsons A, Brown MJ, Schofield PM, Kelly F, Cheeseman K, Mitchinson M ( 1996 ) . Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) . The Lancet vol. 347 , ( 9004 ) 781 - 786 .

( 1996 ) . ERRATUM . Biochemical and Biophysical Research Communications vol. 218 , ( 1 )

Brown MJ ( 1995 ) . Stress, Catecholamines, and Cardiovascular Disease . The BMJ vol. 311 , ( 7019 )

Fernandez-Durango R, Nunez DJR, Brown MJ ( 1995 ) . Messenger RNAs encoding the natriuretic peptides and their receptors are expressed in the eye . Experimental Eye Research vol. 61 , ( 6 ) 723 - 729 .

Hingorani AD, Stevens PA, Brown MJ, Jia H, Hopper R, Dickerson JEC ( 1995 ) . Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition . Journal of Hypertension . vol. 13 , 1602 - 1609 .

Monteith MS, Wang T, Brown MJ ( 1995 ) . Differences in transcription and translation of long and short Gs alpha, the stimulatory G-protein, in human atrium . Clinical Science vol. 89 , ( 5 ) 487 - 495 .

Dickerson JE, Garratt CJ, Brown MJ ( 1995 ) . Management of hypertension in general practice: agreements with and variations from the British Hypertension Society guidelines . Journal of Human Hypertension vol. 9 , ( 10 ) 835 - 839 .

Brown MJ ( 1995 ) . To (β) block or better block? . The BMJ vol. 311 , ( 7007 )

Messerli F, Macdonald G, Brown MJ, Poole-Wilson P, Horton R ( 1995 ) . Are calcium antagonists safe? . The Lancet vol. 346 , ( 8977 ) 767 - 770 .

Hingorani AD, Brown MJ ( 1995 ) . A Simple Molecular Assay for the C1166 Variant of the Angiotensin II Type 1 Receptor Gene . Biochemical and Biophysical Research Communications vol. 213 , ( 2 ) 725 - 729 .

Brown MJ, Dickerson JEC ( 1995 ) . Alpha-blockade and calcium antagonism: an effective and well-tolerated combination for the treatment of resistant hypertension . Journal of Hypertension vol. 13 , ( 6 ) 701 - 707 .

Jia H, Monteith S, Brown MJ ( 1995 ) . Expression of the alpha- and beta-subunits of the stimulatory and inhibitory G-proteins in beta 1-adrenoceptor-blocked and non-beta-adrenoceptor-blocked human atrium . Clinical Science vol. 88 , ( 5 ) 571 - 580 .

Dickerson JEC, Brown MJ ( 1995 ) . Influence of age on general practitioners' definition and treatment of hypertension . The BMJ vol. 310 , ( 6979 )

Stevens PA, Brown MJ ( 1995 ) . Genetic Variability of the ET-1 and the ETA Receptor Genes in Essential Hypertension . Journal of Cardiovascular Pharmacology vol. 26 , s9 - 12 .

Ferro A, Kaumann AJ, Brown MJ ( 1995 ) . β-Adrenoceptor Subtypes in Human Coronary Artery . Journal of Cardiovascular Pharmacology vol. 25 , ( 1 ) 134 - 141 .

Karet FE, Dickerson JEC, Brown J, Brown MJ ( 1994 ) . Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure . The Lancet vol. 344 , ( 8932 ) 1263 - 1265 .

Brown MJ, Clayton D ( 1994 ) . Linkage of the Angiotensinogen Gene to Essential Hypertension . New England Journal of Medicine vol. 331 , ( 16 ) 1096 - 1097 .

Cheung BMY, Dickerson JEC, Ashby MJ, Brown MJ, Brown J ( 1994 ) . Effects of physiological increments in human alpha-atrial natriuretic peptide and human brain natriuretic peptide in normal male subjects . Clinical Science vol. 86 , ( 6 ) 723 - 730 .

Karet FE, Brown MJ ( 1994 ) . Phaeochromocytoma: diagnosis and management . Postgraduate Medical Journal vol. 70 , ( 823 ) 326 - 328 .

Cheung BM, Brown MJ ( 1994 ) . Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension . Journal of Hypertension vol. 12 , ( 4 ) 449 - 454 .

Sun B, Plumpton C, Sinclair JH, Brown MJ ( 1994 ) . In vitro expression of calcitonin gene-related peptide in human endothelial cells transfected with plasmid and retroviral vectors . Neuropeptides vol. 26 , ( 3 ) 167 - 173 .

Tsakayannis D, Li W, Razvi S, Spirito N, Brown M ( 1994 ) . Sucralfate and chronic venous stasis ulcers . The Lancet vol. 343 , ( 8894 ) 424 - 425 .

Brown MJ ( 1993 ) . Angiotensin receptor blockers in essential hypertension . The Lancet vol. 342 , ( 8884 ) 1374 - 1375 .

Kerstens PSM, Stolk J, Hilbrands L, van de Putte LA, De Abreu R, Boerbooms AT ( 1993 ) . 5-nucleotidase and azathioprine-related bone-marrow toxicity . The Lancet vol. 342 , ( 8881 ) 1245 - 1246 .

Philpott N, Marsh JCW, Gordon-Smith EC, Bolton JS, Laidlaw ST, Snowden JA, Brown MJ ( 1993 ) . Aplastic anaemia and remoxipride . The Lancet vol. 342 , ( 8881 ) 1244 - 1245 .

Cheung BMY, Brown MJ ( 1993 ) . "New" natriuretic peptides and blood pressure . The Lancet vol. 342 , ( 8877 )

Ferro A, Plumpton C, Brown MJ ( 1993 ) . Is receptor cross-regulation in human heart caused by alterations in cardiac guanine nucleotide-binding proteins? . Clinical Science vol. 85 , ( 4 ) 393 - 399 .

Brown MJ ( 1993 ) . What do beta-blockers really do? A view from both sides of the receptor. Based on the Oliver Sharpey Lecture 1992 . Clinical Medicine vol. 27 , ( 4 ) 420 - 427 .

Brown MJ ( 1993 ) . Causes of essential hypertension: can it be cured? . Journal of Human Hypertension vol. 7 , ( 4 ) 387 - 390 .

Hall JA, Ferro A, Dickerson JE, Brown MJ ( 1993 ) . Beta adrenoreceptor subtype cross regulation in the human heart . Heart vol. 69 , ( 4 )

Sun B, Plumpton C, Sinclair JH, Brown MJ ( 1993 ) . Comparison of plasmid- and retrovirus-mediated gene expression in cultured human endothelial cells . British Journal of Clinical Pharmacology . vol. 35 ,

Sun B, Davenport AP, Brown MJ ( 1993 ) . Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small intramyocardial compared with large epicardial coronary arteries . Clinical Science vol. 84 , ( 1 ) 55 - 60 .

Ferro A, Hall JA, Brown MJ ( 1993 ) . β<inf>1</inf>-adrenoceptor blocker-induced β<inf>2</inf>-adrenoceptor sensitisation is prevented by β<inf>2</inf>-adrenoceptor blockade . British Journal of Clinical Pharmacology . vol. 35 ,

Brown MJ, Hughes M, White R, Ashby-Swain J, Trutwein D, Bailie M, Hopper R, Molton OR ( 1992 ) . 6 Blood pressure, cholesterol and height. The birth weight hypothesis revisited in 15696 adults . Journal of Hypertension . vol. 10 ,

Nunez DJ, Dickson MC, Brown MJ ( 1992 ) . Natriuretic peptide receptor mRNAs in the rat and human heart . Journal of Clinical Investigation vol. 90 , ( 5 ) 1966 - 1971 .

Cameron IT, Davenport AP, van Papendorp C, Barker PJ, Huskisson NS, Gilmour RS, Brown MJ, Smith SK ( 1992 ) . Endothelin-like immunoreactivity in human endometrium . J Reprod Fertil vol. 95 , ( 2 ) 623 - 628 .

Nunez DJ, Vassilikioti S, Brown MJ ( 1992 ) . The human atrial natriuretic factor (ANF) 'C' receptor is encoded by two messenger RNAs . Journal of Physiology . vol. 446 ,

van Papendorp CL, Cameron IT, Davenport AP, King A, Barker PJ, Huskisson NS, Gilmour RS, Brown MJ et al. ( 1991 ) . Localization and endogenous concentration of endothelin-like immunoreactivity in human placenta . Journal of Endocrinology vol. 131 , ( 3 ) 507 - np .

Brown MJ, Dickerson JE ( 1991 ) . Synergism between alpha 1-blockade and angiotensin converting enzyme inhibition in essential hypertension . Journal of Hypertension . vol. 9 , s362 - s363 .

Hall JA, Petch MC, Brown MJ ( 1991 ) . In vivo demonstration of cardiac beta 2-adrenoreceptor sensitization by beta 1-antagonist treatment . Circulation Research vol. 69 , ( 4 ) 959 - 964 .

Kaumann AJ, Sanders L, Brown AM, Murray KJ, Brown MJ ( 1991 ) . A 5-HT4-like receptor in human right atrium . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 344 , ( 2 ) 150 - 159 .

Shawket SA, Brown MJ ( 1991 ) . Pathogenetic and therapeutic implications of calcitonin-gene-related peptide in the cardiovascular system . Trends in Cardiovascular Medicine vol. 1 , ( 5 ) 211 - 215 .

Nunez DJR, Taylor EA, Oh VMS, Schofield JP, Brown MJ ( 1991 ) . Endothelin-1 mRNA expression in the rat kidney . Biochemical Journal vol. 275 , ( 3 ) 817 - 819 .

Davenport AP, Cameron IT, Smith SK, Brown MJ ( 1991 ) . Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography . Journal of Endocrinology vol. 129 , ( 1 ) 149 - np .

Cameron IT, Davenport AP, Brown MJ, Smith SK ( 1991 ) . Endothelin-1 stimulates prostaglandin F2α release from human endometrium . Prostaglandins Leukotrienes and Essential Fatty Acids vol. 42 , ( 3 ) 155 - 157 .

Davenport AP, Morton AJ, Brown MJ ( 1991 ) . Localization of Endothelin-1 (ET-1), ET-2, and ET-3, Mouse VIC, and Sarafotoxin S6b Binding Sites in Mammalian Heart and Kidney . Journal of Cardiovascular Pharmacology . vol. 17 , s152 - s155 .

Nunez DJ, Davenport AP, Brown MJ ( 1991 ) . Molecular aspects of atrial natriuretic factor physiology . Annals, Academy of Medicine, Singapore vol. 20 , ( 1 ) 19 - 25 .

Tan KKC, Brown MJ ( 1991 ) . Selected side effects: 3. Angiotensin-converting enzyme inhibitors and cough . Prescribers' Journal vol. 31 , ( 4 ) 146 - 149 .

Nunez DJR, Davenport AP, Brown MJ ( 1990 ) . Atrial natriuretic factor mRNA and binding sites in the adrenal gland . Biochemical Journal vol. 271 , ( 2 ) 555 - 558 .

Brown MJ ( 1990 ) . Efficacy and tolerance of doxazosin: a review . Journal of Human Hypertension vol. 4 Suppl 3 , 34 - 38 .

Taylor EA, Oh VMS, Nunez DJ, Balment R, Schofield JP, Brown MJ ( 1990 ) . Expression of endothelin-1 messenger RNA in kidneys of hypertensive and normotensive rats . European Journal of Pharmacology . vol. 183 , 2061 - 2062 .

Davenport AP, Nunez DJ, Brown MJ ( 1990 ) . Localisation off binding sites for iodinated endothelin and saraffotoxin peptides in mammalian tissues using quantitative receptor autoradiography . European Journal of Pharmacology . vol. 183 ,

Brown MJ, Sanders L ( 1990 ) . Effects of dilevalol on human atrial muscle . Journal of Human Hypertension vol. 4 Suppl 2 , 55 - 58 .

Hall JA, Kaumann AJ, Brown MJ ( 1990 ) . Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium . Circulation Research vol. 66 , ( 6 ) 1610 - 1623 .

Nunez DJ, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK ( 1990 ) . Endothelin-1 mRNA is widely expressed in porcine and human tissues . Journal of Clinical Investigation vol. 85 , ( 5 ) 1537 - 1541 .

Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C, Nunez DJ, Capper SJ et al. ( 1990 ) . A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects . Clinical Science vol. 78 , ( 3 ) 261 - 264 .

Price JS, Brown MJ ( 1990 ) . 125I-neuropeptide Y binding activity of pig spleen cell membranes: Effect of solubilisation . Life Sciences vol. 47 , ( 24 ) 2299 - 2306 .

Shawket S, Dickerson JEC, Hazleman B, Brown MJ ( 1990 ) . Double-blind comparison of CGRP and prostacyclin in primary Raynaud's phenomenon: Prolonged hand rewarming after CGRP . British Journal of Clinical Pharmacology . vol. 29 ,

Shawket S, Hazleman B, Dickerson C, Brown MJ ( 1989 ) . SELECTIVE SUPRASENSITIVITY TO CALCITONIN-GENE-RELATED PEPTIDE IN THE HANDS IN RAYNAUD'S PHENOMENON . The Lancet vol. 334 , ( 8676 ) 1354 - 1357 .

Nunez DJ, Davenport AP, Emson PC, Brown MJ ( 1989 ) . A quantitative ‘in-situ’ hybridization method using computer-assisted image analysis. Validation and measurement of atrial-natriuretic-factor mRNA in the rat heart . Biochemical Journal vol. 263 , ( 1 ) 121 - 127 .

Hall JA, Petch MC, Brown MJ ( 1989 ) . Intracoronary injections of salbutamol demonstrate the presence of functional beta 2-adrenoceptors in the human heart . Circulation Research vol. 65 , ( 3 ) 546 - 553 .

Brown MJ ( 1989 ) . Investigation of alpha2-adrenoceptors in humans . The American Journal of Medicine vol. 87 , ( 3 ) s6 - s9 .

Davenport AP, Nunez DJ, Brown MJ ( 1989 ) . Binding sites for 125I-labelled endothelin-1 in the kidneys: differential distribution in rat, pig and man demonstrated by using quantitative autoradiography . Clinical Science vol. 77 , ( 2 ) 129 - 131 .

Kaumann AJ, Hall JA, Murray KJ, Wells FC, Brown MJ ( 1989 ) . A comparison of the effects of adrenaline and noradrenaline on human heart: the role of β1- and β2-adrenoceptors in the stimulation of adenylate cyclase and contractile force . European Heart Journal vol. 10 , ( suppl_B ) 29 - 37 .

Davenport AP, Nunez DJ, Hall JA, Kaumann AJ, Brown MJ ( 1989 ) . Autoradiographical Localization of Binding Sites for Porcine [125I]Endothelin-1 in Humans, Pigs, and Rats . Journal of Cardiovascular Pharmacology vol. 13 , s166 - s170 .

Barker PM, Brown MJ, Ramsden CA, Strang LB, Walters DV ( 1988 ) . The effect of thyroidectomy in the fetal sheep on lung liquid reabsorption induced by adrenaline or cyclic AMP . The Journal of Physiology vol. 407 , ( 1 ) 373 - 383 .

Brown MJ ( 1988 ) . Sites of action of alpha2 agonists and antagonists . The American Journal of Cardiology vol. 61 , ( 7 ) d18 - d21 .

Causon R, Davies D, Brown M ( 1987 ) . Bio-medical applications of high performance liquid chromatography (HPLC) with amperometric detection . Life Sciences vol. 41 , ( 7 ) 909 - 912 .

Cockcroft JR, Ritter JM, Allison DJ, Causon R, Brown MJ ( 1987 ) . Location of extra-adrenal catecholamine secreting tumours by selective venous sampling and nuclear magnetic resonance scanning . Postgraduate Medical Journal vol. 63 , ( 740 ) 451 - 453 .

ALLEN JM, YEATS JC, CAUSON R, BROWN MJ, BLOOM SR ( 1987 ) . Neuropeptide Y and Its Flanking Peptide in Human Endocrine Tumors and Plasma . The Journal of Clinical Endocrinology & Metabolism vol. 64 , ( 6 ) 1199 - 1204 .

Glazier JJ, Chierchia S, Brown MJ, Maseri A ( 1986 ) . Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris . The American Journal of Cardiology vol. 58 , ( 9 ) 667 - 672 .

Brown MJ, Brown J ( 1986 ) . DOES ANGIOTENSIN-II PROTECT AGAINST STROKES? . The Lancet vol. 328 , ( 8504 ) 427 - 429 .

Corr L, Grounds RM, Brown MJ, Whitwam JG ( 1986 ) . Plasma catecholamine changes during cardiopulmonary bypass: a randomised double blind comparison of trimetaphan camsylate and sodium nitroprusside . Heart vol. 56 , ( 1 )

Dunn GD, Sapsford RN, Hemingway A, Brown MJ, Mansfield A, Sever PS, Allison DJ ( 1986 ) . FUNCTIONING MIDDLE MEDIASTINAL PARAGANGLIOMA (PHAEOCHROMOCYTOMA) ASSOCIATED WITH INTERCAROTID PARAGANGLIOMAS . The Lancet vol. 327 , ( 8489 ) 1061 - 1064 .

Brown MJ, Causon RC, Brennan P, Greenberg G ( 1985 ) . Adrenaline and noradrenaline excretion in placebo treated patients in the Medical Research Council Hypertension Trial and in matched normotensive controls . Journal of Hypertension vol. 3 , ( 3 ) s87 - s88 .

Ind PW, Barnes PJ, Brown MJ, Dollery CT ( 1985 ) . Plasma histamine concentration during propranolol induced bronchoconstriction . Thorax vol. 40 , ( 12 )

Brown MJ, Causon RC, Barnes VF, Brennan P, Barnes G, Greenberg G ( 1985 ) . Urinary catecholamines in essential hypertension: results of 24-hour urine catecholamine analyses from patients in the Medical Research Council trial for mild hypertension and from matched controls . QJM vol. 57 , ( 222 ) 637 - 651 .

Brown MJ ( 1985 ) . Hypokalemia from beta2-receptor stimulation by circulating epinephrine . The American Journal of Cardiology vol. 56 , ( 6 ) d3 - d9 .

Ind PW, Causon RC, Brown MJ, Barnes PJ ( 1985 ) . Circulating catecholamines in acute asthma . The BMJ vol. 290 , ( 6464 )

Brown MJ, Struthers AD, di Silvio L ( 1985 ) . Peripheral α2 Adrenoceptor Stimulation Contributes to the Sympatholytic Effect of Guanfacine in Humans . Journal of Cardiovascular Pharmacology vol. 7 , s159 - s161 .

Causon RC, Brown MJ, Davies DS ( 1985 ) . Reversed-phase high-performance liquid chromatography and amperometric detection of 3-O-methyl isoprenaline sulphate: application to studies on the presystemic metabolism of d-isoprenaline in man . Journal of chromatography vol. 337 , ( 2 ) 311 - 320 .

Spencer JA, Brown MJ ( 1985 ) . Treatment with nifedipine for malignant hypertension inducing acute reversible renal impairment . British Medical Journal vol. 290 , ( 6475 )

Murphy MB, Brown MJ, Scriven AJI, Heavey DJ, Dollery CT ( 1984 ) . Nifedipine and alpha adrenoceptor antagonism . Clinical Pharmacology & Therapeutics vol. 36 , ( 6 ) 745 - 749 .

Causon RC, Brown MJ ( 1984 ) . High-performance liquid chromatography with amperometric determination of plasma tyramine . Journal of chromatography vol. 317 , 319 - 325 .

Conway EL, Brown MJ, Dollery CT ( 1984 ) . Studies on the pharmacology of central opioid-induced increases in plasma catecholamines in conscious rats . Neuropharmacology vol. 23 , ( 11 ) 1291 - 1296 .

Scriven AJI, Brown MJ, Murphy MB, Dollery CT ( 1984 ) . Changes in Blood Pressure and Plasma Catecholamines Caused by Tyramine and Cold Exposure . Journal of Cardiovascular Pharmacology vol. 6 , ( 5 ) 954 - 960 .

Brown MJ, Harland D, Murphy MB, Struthers AD ( 1984 ) . Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans . Hypertension vol. 6 , ( 5_Pt_2 ) ii57 - ii57 .

Conway EL, Brown MJ, Dollery CT ( 1984 ) . No evidence for involvement of endogenous opioid peptides in effects of clonidine on blood pressure, heart rate and plasma norepinephrine in anesthetized rats . Journal of Pharmacology and Experimental Therapeutics vol. 229 , ( 3 ) 803 - 808 .

( 1984 ) . Hypokalemia from Beta2-Receptor Stimulation by Epinephrine . New England Journal of Medicine vol. 310 , ( 20 ) 1329 - 1331 .

Lee TH, Nagakura T, Cromwell O, Brown MJ, Causon R, Kay AB ( 1984 ) . Neutrophil Chemotactic Activity and Histamine in Atopic and Nonatopic Subjects after Exercise-induced Asthma1–3 . American Journal of Respiratory and Critical Care Medicine vol. 129 , ( 3 ) 409 - 412 .

Causon RC, Desjardins R, Brown MJ, Davies DS ( 1984 ) . Determination of d-isoproterenol sulphate by high-performance liquid chromatography with amperometric detection . Journal of chromatography vol. 306 , 257 - 268 .

Causon RC, Brown MJ ( 1984 ) . Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection . Journal of chromatography vol. 310 , ( 1 ) 11 - 17 .

Brown MJ, Brown DC, Murphy MB ( 1983 ) . Hypokalemia from Beta2-Receptor Stimulation by Circulating Epinephrine . New England Journal of Medicine vol. 309 , ( 23 ) 1414 - 1419 .

Dollery CT, Brown MJ, Davies DS, Lewis PJ, Strolin‐Benedetti M ( 1983 ) . Oral absorption and concentration‐effect relationship of tyramine with and without cimoxatone, a type‐A specific inhibitor of monoamine oxidase . Clinical Pharmacology & Therapeutics vol. 34 , ( 5 ) 651 - 662 .

Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV ( 1983 ) . Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb . The Journal of Physiology vol. 344 , ( 1 ) 137 - 152 .

Conway EL, Brown MJ, Dollery CT ( 1983 ) . Plasma catecholamine and cardiovascular responses to morphine and D-ala2-d-leu5-enkephalin in conscious rats . Arch Int Pharmacodyn vol. 265 , ( 2 ) 244 - 258 .

Adrian TE, Terenghi G, Brown MJ, Allen JM, Bacarese-Hamilton AJ, Polak JM, Bloom SR ( 1983 ) . NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS . The Lancet vol. 322 , ( 8349 ) 540 - 542 .

Brown MJ ( 1983 ) . Catecholamine measurements in clinical medicine . Postgraduate Medical Journal vol. 59 , ( 694 ) 479 - 482 .

Scriven AJI, Dollery CT, Murphy MB, Macquin I, Brown MJ ( 1983 ) . Blood pressure and plasma norepinephrine concentrations after endogenous norepinephrine release by tyramine . Clinical Pharmacology & Therapeutics vol. 33 , ( 6 ) 710 - 716 .

Causon RC, Brown MJ, Boulous PM, Perret D ( 1983 ) . Analytical differences in measurement of plasma catecholamines . Clinical Chemistry vol. 29 , ( 4 ) 735 - 737 .

Brown MJ, Brown DC, Murphy MB ( 1983 ) . Adrenaline associated hypokalaemia and tachycardia are selectively antagonised by low dose beta2-receptor blockade in man . Clinical Science vol. 64 , ( 2 )

Ind PW, Miyatake A, Brown MJ, Dollery CT ( 1983 ) . Do human mast cells possess functional beta adrenoceptors in vivo? . Agents and actions supplements vol. 13 , 245 - 254 .

Causon RC, Brown MJ, Leenders KL, Wolfson L ( 1983 ) . High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in parkinsonian patients . Journal of chromatography vol. 277 , 115 - 123 .

Lee TH, Nagy L, Brown MJ, O'Driscoll BR, Causon R, Kay AB ( 1983 ) . Mechanism of antigen-induced late asthmatic reactions . Agents and actions supplements vol. 13 , 273 - 277 .

Brown MJ ( 1983 ) . Simultaneous assay of noradrenaline and its deaminated metabolite in plasma: Application to diagnosis of phaeochromocytoma . Journal of Hypertension vol. 1 , ( SUPPL. 2 ) 308 - 309 .

Murphy MB, Brown MJ, Causon RC, Dollery CT ( 1983 ) . The effects of pentolinium on sympathetic activity in hypertensives and normotensive controls . Clinical pharmacology research vol. 3 , ( 4 ) 227 - 232 .

Causon RC, Brown MJ ( 1982 ) . Catecholamine Measurements in Phaeochromocytoma: A Review . Annals of Clinical Biochemistry International Journal of Laboratory Medicine vol. 19 , ( 6 ) 396 - 404 .

Murphy MB, Scriven AJ, Brown MJ, Causon R, Dollery CT ( 1982 ) . The effects of nifedipine and hydralazine induced hypotension on sympathetic activity . European Journal of Clinical Pharmacology vol. 23 , ( 6 ) 479 - 482 .

Lee TH, Brown MJ, Nagy L, Causon R, Walport MJ, Kay AB ( 1982 ) . Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics . Journal of Allergy and Clinical Immunology vol. 70 , ( 2 ) 73 - 81 .

Watkins J, Dargie HJ, Brown MJ, Krikler DM, Dollery CT ( 1982 ) . Effects of histamine type 2 receptor stimulation on myocardial function in normal subjects . Heart vol. 47 , ( 6 )

Barnes PJ, Ind PW, Brown MJ ( 1982 ) . Plasma Histamine and Catecholamines in Stable Asthmatic Subjects . Clinical Science vol. 62 , ( 6 ) 661 - 665 .

Walters DV, Ramsden CA, Brown MJ, Olver RE, Strang LB ( 1982 ) . Fetal Lung Liquid Absorption during Epinephrine Infusion and Spontaneous Labor in the Lamb . CHEST Journal vol. 81 , ( 5 ) 65 - 66 .

Ind PW, Brown MJ, Lhoste FJM, Macquin I, Dollery CT ( 1982 ) . Concentration effect relationships of infused histamine in normal volunteers . Inflammation Research vol. 12 , ( 1-2 ) 12 - 16 .

Brown MJ, MacQuin I, Murphy MB, Dollery CT ( 1982 ) . Sustained Increase in Sympathetic Activity Due to Neuronal Uptake of Adrenaline: Mechanism for Stress-Induced Hypertension and Arrhythmias? . Clinical Science vol. 62 , ( 2 ) 32p - 32p .

Rampton DS, Brown MJ, Sahib M ( 1982 ) . The Effect of Disodium Cromoglycate on Rectal Mucosal Histamine Release and Eosinophil Exudation in Active Ulcerative Colitis . Clinical Science vol. 62 , ( 2 ) 47p - 47p .

( 1982 ) . Clonidine-Suppression Test for Diagnosis of Pheochromocytoma . New England Journal of Medicine vol. 306 , ( 1 ) 49 - 50 .

Brown MJ, Ind PW, Causon R, Lee TH ( 1982 ) . A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics . Journal of Allergy and Clinical Immunology vol. 69 , ( 1 ) 20 - 24 .

Warren JB, Keynes RJ, Brown MJ, Jenner DA, McNicol MW ( 1982 ) . Blunted sympathoadrenal response to exercise in asthmatic subjects . Respiratory Medicine vol. 76 , ( 2 ) 147 - 150 .

Ind PW, Brown MJ, Barnes PJ, Dollery CT ( 1982 ) . Effect of propranolol on mediator release in asthmatics . Thorax vol. 37 , ( 3 )

Brown MJ, Lhoste FJM, Zamboulis C, Ind PW, Jenner DA, Dollery CT ( 1982 ) . Estimation of sympathetic activity in essential hypertension . Clinical Pharmacology & Therapeutics vol. 31 , ( 1 ) 16 - 22 .

Brown MJ, Macquin I ( 1981 ) . IS ADRENALINE THE CAUSE OF ESSENTIAL HYPERTENSION? . The Lancet vol. 318 , ( 8255 ) 1079 - 1082 .

Brown MJ, Jenner DA ( 1981 ) . Novel Double-Isotope Technique for Enzymatic Assay of Catecholamines, Permitting High Precision, Sensitivity and Plasma Sample Capacity . Clinical Science vol. 61 , ( 5 ) 591 - 598 .

Brown MJ, Jenner DA, Allison DJ, Dollery CT ( 1981 ) . Variations in Individual Organ Release of Noradrenaline Measured by An Improved Radioenzymatic Technique; Limitations of Peripheral Venous Measurements in the Assessment of Sympathetic Nervous Activity . Clinical Science vol. 61 , ( 5 ) 585 - 590 .

Barnes PJ, Wilson NM, Brown MJ ( 1981 ) . A calcium antagonist, nifedipine, modifies exercise-induced asthma . Thorax vol. 36 , ( 10 )

Jenner DA, Brown MJ, Lhoste FJM ( 1981 ) . Determination of α-methyldopa, α-methylnoradrenaline, noradrenaline and adrenaline in plasma using high-performance liquid chromatography with electrochemical detection . Journal of Chromatography B vol. 224 , ( 3 ) 507 - 512 .

Barnes PJ, Brown MJ ( 1981 ) . Venous Plasma Histamine in Exercise- and Hyperventilation Induced Asthma in Man . Clinical Science vol. 61 , ( 2 ) 159 - 162 .

Barnes PJ, Brown MJ, Silverman M, Dollery CT ( 1981 ) . Circulating catecholamines in exercise and hyperventilation induced asthma . Thorax vol. 36 , ( 6 )

Brown M, Causon R, Holly JMP, Parfrey PS, Goodwin FJ, Ledingham JM ( 1981 ) . "Na" OR "NA" IN HYPERTENSION? . The Lancet vol. 317 , ( 8222 ) 721 - 722 .

Amorim DS, Heer K, Jenner D, Richardson P, Dargie HJ, Brown M, Olsen EGJ, Goodwin JF ( 1981 ) . IS THERE AUTONOMIC IMPAIRMENT IN CONGESTIVE (DILATED) CARDIOMYOPATHY? . The Lancet vol. 317 , ( 8219 ) 525 - 527 .

Weinkove C, Brown M ( 1981 ) . SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS . The Lancet vol. 317 , ( 8218 ) 493 - 494 .

Stevenson JC, Hillyard CJ, Spanos E, MacIntyre I, Ackroyd N, Lynn J, Brown MJ, Stevenson BM ( 1981 ) . Sipple syndrome: marked variability of the disease within a family and implications for management . Postgraduate Medical Journal vol. 57 , ( 664 ) 104 - 108 .

Barnes PJ, Wilson NM, Brown MJ, Ind P ( 1981 ) . Calcium antagonist nifedipine modifies exercise-induced asthma . Thorax vol. 36 , ( 3 )

Brown MJ, Jenner DA, Allison DJ, Lewis PJ, Dollery CT ( 1981 ) . INCREASED SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS ACHIEVED BY USE OF PLASMA-ADRENALINE ESTIMATIONS AND A PENTOLINIUM-SUPPRESSION TEST . The Lancet vol. 317 , ( 8213 ) 174 - 177 .

Lhoste F, Brown M, Jenner D, Dollery CT ( 1981 ) . Methyldopa, methylnoradrenaline and noradrenaline in hypertension . Journal de Pharmacologie vol. 12 , ( 3 )

Jenner DA, Brown MJ ( 1981 ) . Simultaneous determination of endogenous catecholamines, α-methyldopa and α-methylnoradrenaline in plasma, using HPLC with electrochemical detection . British Journal of Clinical Pharmacology vol. 11 , ( 4 )

FitzGerald GA, Barnes P, Brown MJ, Dollery CT ( 1980 ) . The circadian variability of circulating adrenaline and bronchomotor reactivity in asthma . Advances in the Biosciences vol. 28 , ( C ) 89 - 94 .

Fairfax AJ ( 1980 ) . Nocturnal Asthma and Circulating Epinephrine, Histamine, and Cortisol . New England Journal of Medicine vol. 303 , ( 22 ) 1300 - 1301 .

Brown MJ, Ind PW, Barnes PJ, Jenner DA, Dollery CT ( 1980 ) . A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals . Analytical Biochemistry vol. 109 , ( 1 ) 142 - 146 .

Watkins J, FitzGerald G, Zamboulis C, Brown MJ, Dollery CT ( 1980 ) . Absence of opiate and histamine H2 receptor–mediated effects of Clonidine . Clinical Pharmacology & Therapeutics vol. 28 , ( 5 ) 605 - 610 .

Karliner JS, Barnes P, Brown M, Dollery C ( 1980 ) . Chronic heart failure in the guinea pig increases cardiac α1- and β-adrenoceptors . European Journal of Pharmacology vol. 67 , ( 1 ) 115 - 118 .

Brown MJ, Ind PW, Jenner DA ( 1980 ) . Platelet Histamine . New England Journal of Medicine vol. 303 , ( 13 )

Barnes P, FitzGerald G, Brown M, Dollery C ( 1980 ) . Nocturnal Asthma and Changes in Circulating Epinephrine, Histamine, and Cortisol . New England Journal of Medicine vol. 303 , ( 5 ) 263 - 267 .

Rossor MN, Watkins J, Brown MJ, Reid JL, Dollery CT ( 1980 ) . Plasma levodopa, dopamine and therapeutic response following levodopa therapy of Parkinsonian patients . Journal of the Neurological Sciences vol. 46 , ( 3 ) 385 - 392 .

Brown MJ, Lewis PJ, Dollery CT ( 1980 ) . DIAGNOSIS OF SMALL PHÆOCHROMOCYTOMAS . The Lancet vol. 315 , ( 8179 ) 1185 - 1186 .

Brown MJ ( 1980 ) . PLASMA CATECHOLAMINE ASSAYS . The Lancet vol. 315 , ( 8173 )

Brown MJ, Barnes PJ, Lhoste F ( 1980 ) . Use of a new radioenzymatic assay for plasma histamine to detect abnormal release in asthmatics . European Journal of Clinical Investigation vol. 10 , ( 2 II )

Petty MA, Chalmers JP, Brown M, Reid JL ( 1979 ) . Effect of Baroreceptor Deafferentation on Central Catecholamines in the Rat . Clinical Science vol. 57 , ( s5 ) 221s - 223s .

Brown MJ, Davies DS, Dollery CT ( 1979 ) . Quantitative analysis of noradrenaline clearance [proceedings] . British Journal of Pharmacology vol. 67 , ( 3 ) 452p - 453p .

Brown MJ, Dollery CT, Reid JL, Rossor M, Watkins J ( 1979 ) . Plasma catecholamines and the acute effects of oral L-dopa in Parkinsonian patients [proceedings] . British Journal of Clinical Pharmacology vol. 8 , ( 4 )

Brown M, Chalmers JP, Petty MA, Reid JL ( 1979 ) . The involvement of catecholamines in the central connexions of arterial baroreceptor reflexes in the rat [proceedings] . The Journal of Physiology vol. 292 , 42p - 43p .

Rossor M, Watkins J, Brown MJ ( 1979 ) . Plasma catecholamines and the acute effects of oral L-dopa by Parkinsonian patients . European Journal of Clinical Investigation vol. 9 , ( 2 II )