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Research

Publications: Prof Morris Brown

Mackenzie IS, Rogers A, Poulter NR, Williams B, Brown MJ, Webb DJ, Ford I, Rorie DA et al. ( 2022 ) . Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial . The Lancet vol. 400 , ( 10361 ) 1417 - 1425 .
Mackenzie IS, Hawkey CJ, Ford I, Greenlaw N, Pigazzani F, Rogers A, Struthers AD, Begg AG et al. ( 2022 ) . Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial . The Lancet vol. 400 , ( 10359 ) 1195 - 1205 .
Silins I, Sundin A, Lubberink M, O’Sullivan L, Gurnell M, Aigbirhio F, Brown M, Wall A et al. ( 2022 ) . First-in-human evaluation of [<sup>18</sup>F]CETO: a novel tracer for adrenocortical tumours . European Journal of Nuclear Medicine and Molecular Imaging
Rahimi K, Bidel Z, Nazarzadeh M, Copland E, Canoy D, Wamil M, Majert J, McManus R et al. ( 2021 ) . Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis . The Lancet vol. 398 , ( 10305 ) 1053 - 1064 .
Brown MJ, Alazawi W, Kanoni S ( 2021 ) . Interleukin-6 receptor antagonists in critically ill patients with covid-19 . New England Journal of Medicine vol. 385 , ( 12 )
Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L et al. ( 2021 ) . Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause . Nature Genetics
Sander K, Gendron T, Cybulska KA, Sirindil F, Zhou J, Kalber TL, Lythgoe MF, Kurzawinski TR et al. ( 2021 ) . Development of [<sup>18</sup>F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism . Journal of Medicinal Chemistry vol. 64 , ( 13 ) 9321 - 9329 .
Kulkarni S, Dominiczak AF, Touyz RM, Spence JD, Batlle D, Barigou M, Brown M, Carey RM et al. ( 2021 ) . CONNed in Pregnancy . Hypertension vol. 78 , ( 1 ) 241 - 249 .
Adler A, Agodoa L, Algra A, Asselbergs FW, Beckett NS, Berge E, Black H, Brouwers FPJ et al. ( 2021 ) . Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis . The Lancet vol. 397 , ( 10285 ) 1625 - 1636 .
Copland E ( 2021 ) . Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis . The Lancet Oncology
Guthrie G, Poulter N, Macdonald T, Ford I, Mackenzie I, Findlay E, Williams B, Brown M et al. ( 2020 ) . Chronotherapy in hypertension: The devil is in the details . European Heart Journal vol. 41 , ( 16 ) 1606 - 1607 .
Azizan E, Brown M ( 2020 ) . Ace2 role in SARS-CoV-2 infectivity and covid-19 severity . Malaysian Journal of Pathology vol. 42 , ( 3 ) 363 - 367 .
Maniero C, Scudieri P, Haris Shaikh L, Zhao W, Gurnell M, Galietta LJV, Brown MJ ( 2019 ) . ANO4 (Anoctamin 4) is a novel marker of zona glomerulosa that regulates stimulated aldosterone secretion . Hypertension vol. 74 , ( 5 ) 1152 - 1159 .
Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al. ( 2019 ) . Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids . Nature Genetics vol. 51 , ( 4 ) 636 - 648 .
O'Toole SM, Brown MJ, Drake WM ( 2019 ) . Established endocrine practice . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 19 , ( 1 )
Williams B, Brown MJ ( 2018 ) . Investigation of primary aldosteronism in patients with resistant hypertension – Authors' reply . The Lancet Diabetes and Endocrinology vol. 6 , ( 8 ) 600 - 601 .
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .
Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK et al. ( 2018 ) . Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies . The Lancet Diabetes and Endocrinology vol. 6 , ( 6 ) 464 - 475 .
BROWN MJ ( 2018 ) . Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study . Lancet Diabetes and Endocrinology vol. 6 , ( 6 ) 464 - 475 .
Pinggera A, Negro G, Tuluc P, Brown MJ, Lieb A, Striessnig J ( 2018 ) . Gating defects of disease-causing de novo mutations in ca<inf>v</inf>1.3 ca<sup>2+</sup> channels . Channels vol. 12 , ( 1 ) 388 - 402 .
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in &gt;300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .
MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P et al. ( 2017 ) . Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial . J Am Heart Assoc vol. 6 , ( 11 )
Selvarajah V, Mäki-Petäjä KM, Pedro L, Bruggraber SFA, Burling K, Goodhart AK, Brown MJ, McEniery CM et al. ( 2017 ) . Novel Mechanism for Buffering Dietary Salt in Humans: Effects of Salt Loading on Skin Sodium, Vascular Endothelial Growth Factor C, and Blood Pressure . Hypertension vol. 70 , ( 5 ) 930 - 937 .
Wain LV, Vaez A, Jansen R, Joehanes R, Van Der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .
Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L et al. ( 2017 ) . Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort . The Lancet Diabetes and Endocrinology vol. 5 , ( 9 ) 689 - 699 .
Maniero C, Garg S, Zhao W, Johnson TI, Zhou J, Gurnell M, Brown MJ ( 2017 ) . NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone . Hypertension vol. 70 , ( 2 ) 357 - 364 .
Brown MJ ( 2017 ) . Rapid Diagnosis of Primary Aldosteronism: Oxymoron or One Small Step? . Hypertension vol. 70 , ( 2 ) 247 - 249 .
Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ ( 2017 ) . 11 C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling . Journal of Human Hypertension vol. 31 , ( 7 ) 483 - 484 .
Tan GC, Negro G, Pinggera A, Laim NMST, Rose IM, Ceral J, Ryska A, Chin LK et al. ( 2017 ) . Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation . Hypertension vol. 70 , ( 1 ) 129 - 136 .
Teo AED, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ ( 2017 ) . Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin) . Hypertension vol. 69 , ( 6 ) 1207 - 1216 .
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .
Bogman K, Schwab D, Delporte ML, Palermo G, Amrein K, Mohr S, De Vera Mudry MC, Brown MJ et al. ( 2017 ) . Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2) . Hypertension vol. 69 , ( 1 ) 189 - 196 .
Brown MJ, Drake WM ( 2016 ) . Primary aldosteronism as a public health issue – Authors' reply . The Lancet Diabetes and Endocrinology vol. 4 , ( 12 ) 973 - 974 .
Zhou J, Lam B, Neogi SG, Yeo GSH, Azizan EAB, Brown MJ ( 2016 ) . Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues . Hypertension vol. 68 , ( 6 ) 1424 - 1431 .
Brown MJ, Drake WM ( 2016 ) . Splitting atoms: the Endocrine Society guideline for the management of primary aldosteronism . The Lancet Diabetes and Endocrinology vol. 4 , ( 10 ) 805 - 807 .
MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics
Petruzzelli M, Taylor KP, Koo B, Brown MJ ( 2016 ) . Telling Tails: Very High Plasma Renin Levels Prompt the Diagnosis of Renal Artery Stenosis, Despite Initial Negative Imaging . Hypertension vol. 68 , ( 1 ) 11 - 16 .
Teo AED, Garg S, Haris Shaikh L, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A et al. ( 2016 ) . Effect of somatic CTNNB1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause . Annales d'Endocrinologie vol. 77 , ( 2 ) 161 - 162 .
Azizan EAB, Brown MJ ( 2016 ) . Novel genetic determinants of adrenal aldosterone regulation . Current Opinion in Endocrinology, Diabetes and Obesity vol. 23 , ( 3 ) 209 - 217 .
Xie CB, Haris Shaikh L, Garg S, Tanriver G, Teo AED, Zhou J, Maniero C, Zhao W et al. ( 2016 ) . Regulation of aldosterone secretion by Ca v 1.3 . Scientific Reports vol. 6 ,
Teo AED, Brown MJ ( 2016 ) . The authors reply . New England Journal of Medicine vol. 374 , ( 15 )
Williams B, Macdonald TM, Morant SV, Brown MJ ( 2016 ) . PATHWAY-2: Spironolactone for resistant hypertension - Authors' reply . The Lancet vol. 387 , ( 10026 ) 1373 - 1374 .
Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G et al. ( 2016 ) . Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): A parallel-group, double-blind randomised phase 4 trial . The Lancet Diabetes and Endocrinology vol. 4 , ( 2 ) 136 - 147 .
Rorie DA, Rogers A, MacKenzie IS, Ford I, Webb DJ, Willams B, Brown M, Poulter N et al. ( 2016 ) . Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: The Treatment in Morning versus Evening (TIME) study . BMJ Open vol. 6 , ( 2 )
Williams B, Macdonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK et al. ( 2015 ) . Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): A randomised, double-blind, crossover trial . The Lancet vol. 386 , ( 10008 ) 2059 - 2068 .
Teo AED, Garg S, Shaikh LH, Zhou J, Frankl FEK, Gurnell M, Happerfield L, Marker A et al. ( 2015 ) . Pregnancy, primary aldosteronism, and adrenal CTNNB1 mutations . New England Journal of Medicine vol. 373 , ( 15 ) 1429 - 1436 .
Powlson AS, Gurnell M, Brown MJ ( 2015 ) . Nuclear imaging in the diagnosis of primary aldosteronism . Current Opinion in Endocrinology, Diabetes and Obesity vol. 22 , ( 3 ) 150 - 156 .
Shaikh LH, Zhou J, Teo AED, Garg S, Neogi SG, Figg N, Yeo GS, Yu H et al. ( 2015 ) . LGR5 activates noncanonical Wnt signaling and inhibits aldosterone production in the human adrenal . Journal of Clinical Endocrinology and Metabolism vol. 100 , ( 6 ) E836 - E844 .
Brown MJ ( 2015 ) . Primary Aldosteronism: The spectre of cure . Clinical Endocrinology vol. 82 , ( 6 ) 785 - 788 .
Zhou J, Shaikh LH, Neogi SG, Mcfarlane I, Zhao W, Figg N, Brighton CA, Maniero C et al. ( 2015 ) . DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion . Hypertension vol. 65 , ( 5 ) 1103 - 1110 .
Jennings CG, MacDonald TM, Wei L, Brown MJ, McConnachie L, Mackenzie IS ( 2015 ) . Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants? . Trials vol. 16 , ( 1 )
Agodoa L, Estacio R, Schrier R, Lubsen J, Chalmers J, Cutler J, Davis B, Wing L et al. ( 2015 ) . Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: A meta-analysis of randomised trials . The Lancet vol. 385 , ( 9971 ) 867 - 874 .
Brown MJ, Williams B, MacDonald TM, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ et al. ( 2015 ) . Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): Protocol for a randomised double-blind trial in patients with essential hypertension . BMJ Open vol. 5 , ( 8 )
MacDonald TM, Williams B, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ, MacKenzie IS et al. ( 2015 ) . Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): A randomised doubleblind controlled trial . BMJ Open vol. 5 , ( 8 )
Williams B, MacDonald TM, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ, Salsbury J et al. ( 2015 ) . Prevention And Treatment of HypertensionWith Algorithm-based therapy (PATHWAY) number 2: Protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension . BMJ Open vol. 5 , ( 8 )
Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV et al. ( 2014 ) . Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations . American Journal of Human Genetics vol. 95 , ( 1 ) 49 - 65 .
Brown MJ ( 2014 ) . Resistant hypertension: Resistance to treatment or resistance to taking treatment . Heart vol. 100 , ( 11 ) 821 - 822 .
Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T et al. ( 2014 ) . Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci . American Journal of Human Genetics vol. 94 , ( 3 ) 349 - 360 .
Rossi GP, Auchus RJ, Brown M, Lenders JWM, Naruse M, Plouin PF, Satoh F, Young WF ( 2014 ) . An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism . Hypertension vol. 63 , ( 1 ) 151 - 160 .
Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, Baigent C, Emberson J et al. ( 2014 ) . Blood pressure-lowering treatment based on cardiovascular risk: A meta-analysis of individual patient data . The Lancet vol. 384 , ( 9943 ) 591 - 598 .
Brown MJ ( 2014 ) . Clinical value of plasma renin estimation in the management of hypertension . American Journal of Hypertension vol. 27 , ( 8 ) 1013 - 1016 .
Murthy M, Azizan EAB, Brown MJ, O'Shaughnessy KM ( 2014 ) . Erratum: Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-production adenoma (J Hypertens (2012) 30 (1827-1833)) . Journal of Hypertension vol. 32 , ( 4 )
Arking DE, Pulit SL, Crotti L, Van Der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ et al. ( 2014 ) . Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization . Nature Genetics vol. 46 , ( 8 ) 826 - 836 .
Brown MJ ( 2014 ) . Ins and outs of aldosterone-producing adenomas of the adrenal: From channelopathy to common curable cause of hypertension . Hypertension vol. 63 , ( 1 ) 24 - 26 .
Auchus RJ, Brown M, Lenders JWM, Naruse M, Plouin PF, Satoh F, Young WF, Rossi GP ( 2014 ) . Response to implementation of rapid cortisol during adrenal vein sampling . Hypertension vol. 63 , ( 4 )
Van Meurs JBJ, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X et al. ( 2013 ) . Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease . American Journal of Clinical Nutrition vol. 98 , ( 3 ) 668 - 676 .
O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AM, Köttgen A, Stoudmann C et al. ( 2013 ) . Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations . PLoS Genetics vol. 9 , ( 9 )
Azizan EAB, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S et al. ( 2013 ) . Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension . Nature Genetics vol. 45 , ( 9 ) 1055 - 1060 .
Shaw KC, McEniery CM, Wilkinson IB, Brown MJ ( 2013 ) . Unsafe health and safety: Sphygmomanometer cuffs are not interchangeable . Journal of Human Hypertension vol. 27 , ( 7 ) 434 - 436 .
Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K et al. ( 2013 ) . Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease . PLoS ONE vol. 8 , ( 4 )
Bramham K, Nelson-Piercy C, Brown MJ, Chappell LC ( 2013 ) . Postpartum management of hypertension . BMJ (Online) vol. 346 , ( 7897 )
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al. ( 2013 ) . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . Nature Genetics vol. 45 , ( 2 ) 145 - 154 .
Alvarez-Madrazo S, MacKenzie SM, Davies E, Fraser R, Lee WK, Brown M, Caulfield MJ, Dominiczak AF et al. ( 2013 ) . Common polymorphisms in the CYP11B1 and CYP11B2 genes: Evidence for a digenic influence on hypertension . Hypertension vol. 61 , ( 1 ) 232 - 239 .
Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H et al. ( 2012 ) . Seven newly identified loci for autoimmune thyroid disease . Human Molecular Genetics vol. 21 , ( 23 ) 5202 - 5208 .
Brown M ( 2012 ) . Classification and naming of drugs . Clinical Pharmacology: Eleventh Edition ,
Bennett PN, Brown MJ, Sharma P ( 2012 ) . Clinical Pharmacology: Eleventh Edition .
Bennett PN, Brown MJ, Sharma P ( 2012 ) . Preface .
Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S et al. ( 2012 ) . Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations . Nature Genetics vol. 44 , ( 8 ) 904 - 909 .
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2012 ) . Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)) . American Journal of Human Genetics vol. 90 , ( 6 ) 1116 - 1117 .
Stears AJ, Woods SH, Watts MM, Burton TJ, Graggaber J, Mir FA, Brown MJ ( 2012 ) . A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension . Hypertension vol. 59 , ( 5 ) 934 - 942 .
Azizan EAB, Lam BYH, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A et al. ( 2012 ) . Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors . Journal of Clinical Endocrinology and Metabolism vol. 97 , ( 5 )
Azizan EAB, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, Brown MJ, O'Shaughnessy KM ( 2012 ) . Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas . Hypertension vol. 59 , ( 3 ) 587 - 591 .
Brown MJ ( 2012 ) . Author's reply to Rogers . BMJ (Online) vol. 344 , ( 7845 )
Brown MJ, Cruickshank JK, MacDonald T ( 2012 ) . Navigating the shoals in hypertension: Discovery and guidance . BMJ (Online) vol. 344 , ( 7841 )
Murthy M, Azizan EAB, Brown MJ, O'Shaughnessy KM ( 2012 ) . Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma . Journal of Hypertension vol. 30 , ( 9 ) 1827 - 1833 .
Burton TJ, Mackenzie IS, Balan K, Koo B, Bird N, Soloviev DV, Azizan EAB, Aigbirhio F et al. ( 2012 ) . Evaluation of the sensitivity and specificity of <sup>11</sup>C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas . Journal of Clinical Endocrinology and Metabolism vol. 97 , ( 1 ) 100 - 109 .
Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I et al. ( 2011 ) . Blood pressure loci identified with a gene-centric array . American Journal of Human Genetics vol. 89 , ( 6 ) 688 - 700 .
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . Nature Genetics vol. 43 , ( 11 ) 1131 - 1138 .
Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD et al. ( 2011 ) . Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk . Nature vol. 478 , ( 7367 ) 103 - 109 .
Brown MJ ( 2011 ) . Personalised medicine for hypertension . BMJ (Online) vol. 343 , ( 7825 )
Brown MJ ( 2011 ) . The choice of diuretic in hypertension: Saving the baby from the bathwater . Heart vol. 97 , ( 19 ) 1547 - 1551 .
Burton TJ, Azizan EAB, Brown MJ ( 2011 ) . Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients . European Journal of Pharmacology vol. 657 , ( 1-3 ) 184 - 189 .
Eiriksdottir G, Harris TB, Launer LJ, Gudnason V, Folsom AR, Andrews G, Ballantyne CM, Samani NJ et al. ( 2011 ) . Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data . BMJ vol. 342 , ( 7794 )
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H et al. ( 2011 ) . Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height . American Journal of Human Genetics vol. 88 , ( 1 ) 6 - 18 .
Brown MJ, McInnes GT, Papst CC, Zhang J, MacDonald TM ( 2011 ) . Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): A randomised, parallel-group trial . The Lancet vol. 377 , ( 9762 ) 312 - 320 .
Burton TJ, Salsbury J, Hood S, Brown MJ ( 2011 ) . Conn's syndrome unmasked by thiazide-induced hypokalaemia . British Journal of Hospital Medicine vol. 72 , ( 9 ) 530 - 531 .
Brown MJ, McInnes GI, MacDonald TM ( 2011 ) . Initial combination therapy for treatment of hypertension - Authors' reply . The Lancet vol. 377 , ( 9776 )
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR et al. ( 2011 ) . Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease . Nature Genetics vol. 43 , ( 4 ) 333 - 340 .
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM et al. ( 2010 ) . Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index . Nature Genetics vol. 42 , ( 11 ) 937 - 948 .
Brown MJ ( 2010 ) . Heterogeneity of blood pressure response to therapy . American Journal of Hypertension vol. 23 , ( 9 ) 926 - 928 .
Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, Faire UD, Leander K et al. ( 2010 ) . Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility . Circulation vol. 122 , ( 5 ) 470 - 477 .
Brown M ( 2010 ) . Biological clocks advance . Dialogues in Cardiovascular Medicine vol. 15 , ( 1 ) 3 - 5 .
Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA et al. ( 2010 ) . Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables . Statistics in Medicine vol. 29 , ( 12 ) 1298 - 1311 .
Chambers JC, Zhang W, Lord GM, Van Der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN et al. ( 2010 ) . Genetic loci influencing kidney function and chronic kidney disease . Nature Genetics vol. 42 , ( 5 ) 373 - 375 .
Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C et al. ( 2010 ) . Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension . PLoS Genetics vol. 6 , ( 10 ) 1 - 11 .
Cheriyan J, O'Shaughnessy KM, Brown MJ ( 2010 ) . Primary prevention of CVD: treating hypertension . BMJ clinical evidence vol. 2010 ,
Brown MJ ( 2009 ) . Impact of EU directive 2001/20/EC on investigator-led clinical trials in the UK . EJHP Practice vol. 15 , ( 5 ) 28 - 30 .
Brown MJ, Grossman AB, Bornstein SR ( 2009 ) . Editorial: Pheochromocytoma . Hormone and Metabolic Research vol. 41 , ( 9 ) 655 - 657 .
Brown M ( 2009 ) . Circles of Hell: Researchers' nightmare or laps of the regulatory pentathlon? . British Journal of Clinical Pharmacology vol. 68 , ( 5 ) 775 - 777 .
Burton TJ, Cope G, Wang J, Sim JC, Azizan EAB, O'Shaughnessy KM, Brown MJ ( 2009 ) . Corrigendum to: "Expression of the epithelial Na<sup>+</sup> channel and other components of an aldosterone response pathway in human adrenocortical cells" [European Journal of Pharmacology 613 (2009) 176-181] (DOI:10.1016/j.ejphar.2009.04.005) . European Journal of Pharmacology vol. 617 , ( 1-3 )
MacKenzie IS, McEniery CM, Dhakam Z, Brown MJ, Cockcroft JR, Wilkinson IB ( 2009 ) . Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension . Hypertension . vol. 54 , 409 - 413 .
Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P et al. ( 2009 ) . Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association studies . PLoS ONE vol. 4 , ( 7 )
Sõber S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, Lichtner P, Klopp N et al. ( 2009 ) . Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array . PLoS ONE vol. 4 , ( 6 )
Burton TJ, Cope G, Wang J, Sim JC, Azizan EAB, O'Shaughnessy KM, Brown MJ ( 2009 ) . Expression of the epithelial Na<sup>+</sup> channel and other components of an aldosterone response pathway in human adrenocortical cells . European Journal of Pharmacology vol. 613 , ( 1-3 ) 176 - 181 .
Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, Veldre G, Döring A et al. ( 2009 ) . Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations . Human Molecular Genetics vol. 18 , ( 12 ) 2288 - 2296 .
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH et al. ( 2009 ) . Genome-wide association study identifies eight loci associated with blood pressure . Nature Genetics vol. 41 , ( 6 ) 666 - 676 .
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Sharma P, Hingorani A, Haiyan J, Hopper R, Brown MJ ( 1999 ) . Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension . Journal of Hypertension vol. 17 , ( 9 ) 1281 - 1287 .
Wang T, Plumpton C, Brown MJ ( 1999 ) . Selective β<inf>1</inf>-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium . British Journal of Pharmacology vol. 128 , ( 1 ) 135 - 141 .
Yasmin, Brown MJ ( 1999 ) . Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness . QJM - Monthly Journal of the Association of Physicians vol. 92 , ( 10 ) 595 - 600 .
Brown MJ ( 1998 ) . Irbesartan treatment in hypertension . Hospital Medicine vol. 59 , ( 10 ) 808 - 811 .
Yasmin, Mascie-Taylor CGN, Brown MJ, Hughes M ( 1998 ) . The effect of dietary intervention on changes in total cholesterol, blood pressure and weight in a Cambridge study . International Journal of Clinical Practice vol. 52 , ( 4 ) 241 - 245 .
Brown MJ ( 1998 ) . Who manages hypertensive patients? The primary care-hospital interface . American Journal of Hypertension . vol. 11 , 740 - 743 .
Sharma P, Lu F, Rut A, Brown MJ ( 1998 ) . Structure of human endothelin-2 gene and demonstration of common expression in human right atrial tissue . Biochemical and Biophysical Research Communications vol. 245 , ( 3 ) 709 - 712 .
Sharma P, Hingorani A, Jia H, Ashby M, Hopper R, Clayton D, Brown MJ ( 1998 ) . Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension . Hypertension vol. 32 , ( 4 ) 676 - 682 .
Black H, Boissel JP, Brenner B, Brown M, Bulpitt C, Chalmers J, Collins R, Cutler J et al. ( 1998 ) . Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments . Journal of Hypertension vol. 16 , ( 2 ) 127 - 137 .
Brown MJ, Castaigne A, De Leeuw PW, Mancia G, Rosenthal T, Ruilope LM ( 1998 ) . Study population and treatment titration in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) . Journal of Hypertension vol. 16 , ( 12 SUPPL. ) 2113 - 2116 .
Brown M, Castaigne A ( 1997 ) . INSIGHT - the baseline characteristics of randomised patients . International Journal of Clinical Practice, Supplement . 72 - 73 .
Brown MJ, Castaigne A, De Leeuw PW, Mancia G, Rosenthal T, Ruilope LM ( 1997 ) . INSIGHT - study rationale and design . International Journal of Clinical Practice, Supplement ( 92 ) 39 - 40 .
Sharma P, Smith I, Maguire G, Stewart S, Shneerson J, Brown MJ ( 1997 ) . Clinical value of ACE genotyping in diagnosis of sarcoidosis . Lancet vol. 349 , ( 9065 ) 1602 - 1603 .
Sharma P, Pathan S, Fatibene J, Jia H, Thompson D, Monteith S, Clayton D, O’Shaughnessy K et al. ( 1997 ) . 1.1 Genome wide search for susceptibility loci in essential hypertension: Early results . Journal of Hypertension vol. 15 , ( 12 )
Dickerson JEC, Hingorani AD, Brown MJ ( 1997 ) . 2.3 Sequential monotherapy as a method of optimal treatment selection for young patients with hypertension . Journal of Hypertension vol. 15 , ( 12 ) 1534 - 1535 .
Ferro A, Hall JA, Dickerson JEC, Brown MJ ( 1997 ) . A prospective study of the effects of prolonged timolol therapy on α- and β-adrenoceptor and angiotensin II receptor mediated responses in normal subjects . British Journal of Clinical Pharmacology vol. 43 , ( 3 ) 301 - 308 .
Sharma P, Pathan S, Fatibene J, Jia H, Thompson D, Monteith S, Clayton D, O'Shaughnessy K et al. ( 1997 ) . Annual Scientific Meeting of the British Hypertension Society. Wills Hall, University of Bristol, 15-17 September 1997. Genome wide search for susceptibility loci in essential hypertension: Early results . Journal of Hypertension . vol. 15 ,
Longmore J, Hargreaves RJ, Boulanger CM, Brown MJ, Desta B, Ferro A, Schofield WN, Taylor AA et al. ( 1997 ) . Comparison of the vasoconstrictor properties of the 5-HT(1D)-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: Outcome of two independent studies using different experimental protocols . Functional Neurology vol. 12 , ( 1 ) 3 - 9 .
Medina R, Cardona-Sanclemente LE, Born GVR, Brown MJ ( 1997 ) . Effect of captopril and losartan on blood pressure and accumulation of LDL and fibrinogen by aortic wall and other tissues in normotensive and hypertensive rats . Journal of Cardiovascular Pharmacology vol. 29 , ( 1 ) 125 - 129 .
Medina RA, Cardona-Sanclemente LE, Born GVR, Brown MJ ( 1997 ) . Effect of deoxycorticosterone acetate on blood pressure in relation to accumulation of low-density lipoprotein and fibrinogen by aorta and other tissues of normotensive Wistar rats . Journal of Hypertension vol. 15 , ( 5 ) 531 - 536 .
Brown MJ ( 1997 ) . Hypertension . British Medical Journal vol. 314 , ( 7089 ) 1258 - 1261 .
Jia H, Lloyd D, Trutwein D, Brown MJ ( 1996 ) . Levels of GTPγS-stimulated adenylyl cyclase activity in human lymphocytes: Effects of G<inf>s</inf>α genotype . British Journal of Clinical Pharmacology vol. 41 , ( 5 )
Brown MJ, Castaigne A, Ruilope LM, Mancia G, Rosenthal T, De Leeuw PW, Ebner F ( 1996 ) . INSIGHT: International Nifedipine GITS Study Intervention as a Goal in Hypertension Treatment . Journal of Human Hypertension vol. 10 , ( SUPPL. 3 )
Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, Brown MJ ( 1996 ) . Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) . Lancet vol. 347 , ( 9004 ) 781 - 786 .
Wang T, Kaumann AJ, Brown MJ ( 1996 ) . (-)-Timolol is a more potent antagonist of the positive inotropic effects of (-)-adrenaline than of those of (-)-noradrenaline in human atrium . British Journal of Clinical Pharmacology vol. 42 , ( 2 ) 217 - 223 .
Hingoram AD, Sharma P, Jia H, Hopper R, Brown MJ ( 1996 ) . Blood pressure and the M235T polymorphism of the angiotensinogen gene . Hypertension . vol. 28 , 907 - 911 .
Oliver S, Mann SJ, Elliot HL, Meredith PA, Brown M, Trenkwalder P, James MA ( 1996 ) . Calcium-channel blockers and cancer [1] . Lancet vol. 348 , ( 9035 ) 1165 - 1168 .
Brown M ( 1996 ) . Calcium-channel blockers and cancer . Lancet vol. 348 , ( 9035 )
Hingorani AD, Brown MJ ( 1996 ) . Erratum: A simple molecular assay for the C<sup>1166</sup> variant of the angiotensin II type 1 receptor gene (Biochemical and Biophysical Research Communications (1995) 213 (725-729)) . Biochemical and Biophysical Research Communications vol. 218 , ( 1 )
Hingorani AD, Brown MJ ( 1996 ) . Identifying the genes for human hypertension . Nephrology Dialysis Transplantation vol. 11 , ( 4 ) 575 - 586 .
Harach HR, Wheatley T, Smellie WAB, Brown MJ ( 1996 ) . Phaeochromocytoma of the organ of Zuckerkandl invading inferior vena cava . Histopathology vol. 28 , ( 6 ) 556 - 559 .
Brown MJ ( 1996 ) . The causes of essential hypertension . British Journal of Clinical Pharmacology . vol. 42 , 21 - 27 .
Brown MJ ( 1995 ) . Stress, Catecholamines, and Cardiovascular Disease . BMJ vol. 311 , ( 7019 )
Messerli FH, Macdonald G, Brown MJ, Poole-Wilson PA, Horton R ( 1995 ) . Are calcium antagonists safe? . The Lancet vol. 346 , ( 8977 ) 767 - 770 .
Brown MJ ( 1995 ) . To (β) block or better block? . BMJ vol. 311 , ( 7007 )
Dickerson JEC, Brown MJ ( 1995 ) . Influence of age on general practitioners' definition and treatment of hypertension . BMJ vol. 310 , ( 6979 )
Hingorani AD, Brown MJ ( 1995 ) . A simple molecular assay for the C<sup>1166</sup> variant of the angiotensin II type 1 receptor gene . Biochemical and Biophysical Research Communications vol. 213 , ( 2 ) 725 - 729 .
Brown MJ, Dickerson JEC ( 1995 ) . Alpha-blockade and calcium antagonism: An effective and well-tolerated combination for the treatment of resistant hypertension . Journal of Hypertension vol. 13 , ( 6 ) 701 - 707 .
Monteith MS, Wang T, Brown MJ ( 1995 ) . Differences in transcription and translation of long and short G(s)α, the stimulatory G-protein, in human atrium . Clinical Science vol. 89 , ( 5 ) 487 - 495 .
Jia H, Monteith S, Brown MJ ( 1995 ) . Expression of the α- and β-subunits of the stimulatory and inhibitory G-proteins in β<inf>1</inf>-adrenoceptor-blocked and non-β-adrenoceptor-blocked human atrium . Clinical Science vol. 88 , ( 5 ) 571 - 580 .
Stevens PA, Brown MJ ( 1995 ) . Genetic variability of the ET-1 and the ET<inf>A</inf>receptor genes in essential hypertension . Journal of Cardiovascular Pharmacology vol. 26 , S9 - S12 .
Dickerson JEC, Garratt CJ, Brown MJ ( 1995 ) . Management of hypertension in general practice: Agreements with and variations from the British Hypertension Society guidelines . Journal of Human Hypertension vol. 9 , ( 10 ) 835 - 839 .
Fernandez-Durango R, Nunez DJR, Brown MJ ( 1995 ) . Messenger RNAs encoding the natriuretic peptides and their receptors are expressed in the eye . Experimental Eye Research vol. 61 , ( 6 ) 723 - 729 .
Hingorani AD, Jia H, Stevens PA, Hopper R, Claire Dickerson JE, Brown MJ ( 1995 ) . Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition . Journal of Hypertension . vol. 13 , 1602 - 1609 .
Ferro A, Kaumann AJ, Brown MJ ( 1995 ) . β-adrenoceptor subtypes in human coronary artery: Desensitization of β<inf>2</inf>-adrenergic vasorelaxation by chronic β<inf>1</inf>-adrenergic stimulation in vitro . Journal of Cardiovascular Pharmacology vol. 25 , ( 1 ) 134 - 141 .
Karet FE, Dickerson JEC, Brown J, Brown MJ ( 1994 ) . Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure . The Lancet vol. 344 , ( 8932 ) 1263 - 1265 .
Brown MJ, Clayton D, Caulfield M, Farrall M, Clark AJL ( 1994 ) . Linkage of the angiotensinogen gene to essential hypertension . New England Journal of Medicine vol. 331 , ( 16 ) 1096 - 1097 .
Tsakayannis D, Li WW, Razvi S, Spirito N, Brown MJ ( 1994 ) . Sucralfate and chronic venous stasis ulcers . The Lancet vol. 343 , ( 8894 ) 424 - 425 .
Cheung BMY, Dickerson JEC, Ashby MJ, Brown MJ, Brown J ( 1994 ) . Effects of physiological increments in human α-atrial natriuretic peptide and human brain natriuretic peptide in normal male subjects . Clinical Science vol. 86 , ( 6 ) 723 - 730 .
Sun B, Plumpton C, Sinclair JH, Brown MJ ( 1994 ) . In vitro expression of calcitonin gene-related peptide in human endothelial cells transfected with plasmid and retroviral vectors . Neuropeptides vol. 26 , ( 3 ) 167 - 173 .
Karet FE, Brown MJ ( 1994 ) . Phaeochromocytoma: Diagnosis and management . Postgraduate Medical Journal vol. 70 , ( 823 ) 326 - 328 .
Cheung BM, Brown MJ ( 1994 ) . Plasma brain natriuretic peptide and c-type natriuretic peptide in essential hypertension . Journal of Hypertension vol. 12 , ( 4 ) 449 - 454 .
Brown MJ ( 1993 ) . Angiotensin receptor blockers in essential hypertension . The Lancet vol. 342 , ( 8884 ) 1374 - 1375 .
Laidlaw ST, Snowden JA, Brown MJ ( 1993 ) . Aplastic anaemia and remoxipride . Lancet vol. 342 , ( 8881 )
Cheung BMY, Brown MJ ( 1993 ) . "New" natriuretic peptides and blood pressure . The Lancet vol. 342 , ( 8877 )
Philpott NJ, Marsh JCW, Gordon-Smith EC, Bolton JS, Laidlaw ST, Snowden JA, Brown MJ ( 1993 ) . Aplastic anaemia and remoxipride [22] . Lancet vol. 342 , ( 8881 ) 1244 - 1245 .
Brown MJ ( 1993 ) . Causes of essential hypertension: Can it be cured? . Journal of Human Hypertension vol. 7 , ( 4 ) 387 - 390 .
Sun B, Plumpton C, Sinclair JH, Brown MJ ( 1993 ) . Comparison of plasmid- and retrovirus-mediated gene expression in cultured human endothelial cells . British Journal of Clinical Pharmacology . vol. 35 ,
Ferro A, Plumpton C, Brown MJ ( 1993 ) . Is receptor cross-regulation in human heart caused by alterations in cardiac guanine nucleotide-binding proteins? . Clinical Science vol. 85 , ( 4 ) 393 - 399 .
Sun B, Davenport AP, Brown MJ ( 1993 ) . Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small intramyocardial compared with large epicardial coronary arteries . Clinical Science vol. 84 , ( 1 ) 55 - 60 .
Brown MJ ( 1993 ) . What do beta-blockers really do? A view from both sides of the receptor: Based on the Oliver Sharpey Lecture 1992 . Journal of the Royal College of Physicians of London vol. 27 , ( 4 ) 420 - 427 .
Ferro A, Kaumann AJ, Brown MJ ( 1993 ) . β <inf>1</inf>‐ and β<inf>2</inf>‐adrenoceptor‐mediated relaxation in human internal mammary artery and saphenous vein: unchanged β‐ and α‐adrenoceptor responsiveness after chronic β<inf>1</inf>‐adrenoceptor blockade . British Journal of Pharmacology vol. 109 , ( 4 ) 1053 - 1058 .
Hall JA, Ferro A, Dickerson JEC, Brown MJ ( 1993 ) . β Adrenoceptor subtype cross regulation in the human heart . British Heart Journal vol. 69 , ( 4 ) 332 - 337 .
Ferro A, Hall JA, Brown MJ ( 1993 ) . β<inf>1</inf>-adrenoceptor blocker-induced β<inf>2</inf>-adrenoceptor sensitisation is prevented by β<inf>2</inf>-adrenoceptor blockade . British Journal of Clinical Pharmacology . vol. 35 ,
Brown MJ, Hughes M, White R, Ashby-Swain J, Trutwein D, Bailie M, Hopper R, Molton OR ( 1992 ) . Blood pressure, cholesterol and height. The birth weight hypothesis revisited in 15696 adults . Journal of Hypertension . vol. 10 ,
Cameron IT, Davenport AP, Van Papendorp C, Barker PJ, Huskisson NS, Gilmour RS, Brown MJ, Smith SK ( 1992 ) . Endothelin-like immunoreactivity in human endometrium . Journal of Reproduction and Fertility vol. 95 , ( 2 ) 623 - 628 .
Nunez DJR, Dickson MC, Brown MJ ( 1992 ) . Natriuretic peptide receptor mRNAs in the rat and human heart . Journal of Clinical Investigation vol. 90 , ( 5 ) 1966 - 1971 .
Healy D, Paykel ES, White W, Whitehouse AM, Ashby M, Brown M, Theodorou AE, Lawrence KM et al. ( 1992 ) . Plasma noradrenaline, adrenaline and DHPG responses to clonidine in control and depressed subjects . Human Psychopharmacology: Clinical and Experimental vol. 7 , ( 3 ) 167 - 173 .
Nunez DJ, Vassilikioti S, Brown MJ ( 1992 ) . The human atrial natriuretic factor (ANF) 'C' receptor is encoded by two messenger RNAs . Journal of Physiology . vol. 446 ,
Kaumann AJ, Sanders L, Brown AM, Murray KJ, Brown MJ ( 1991 ) . A 5-HT<inf>4</inf>-like receptor in human right atrium . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 344 , ( 2 ) 150 - 159 .
Davenport AP, Cameron IT, Smith SK, Brown MJ ( 1991 ) . Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography . Journal of Endocrinology vol. 129 , ( 1 ) 149 - 154 .
Nunez DJR, Taylor EA, Oh VMS, Schofield JP, Brown MJ ( 1991 ) . Endothelin-1 mRNA expression in the rat kidney . Biochemical Journal vol. 275 , ( 3 ) 817 - 819 .
Cameron IT, Davenport AP, Brown MJ, Smith SK ( 1991 ) . Endothelin-1 stimulates prostaglandin F<inf>2α</inf> release from human endometrium . Prostaglandins, Leukotrienes and Essential Fatty Acids vol. 42 , ( 3 ) 155 - 157 .
Hall JA, Petch MC, Brown MJ ( 1991 ) . In vivo demonstration of cardiac β<inf>2</inf>-adrenoreceptor sensitization by β<inf>1</inf>-antagonist treatment . Circulation Research vol. 69 , ( 4 ) 959 - 964 .
Van Papendorp CL, Cameron IT, Davenport AP, King A, Barker PJ, Huskisson NS, Gilmour RS, Brown MJ et al. ( 1991 ) . Localization and endogenous concentration of endothelin-like immunoreactivity in human placenta . Journal of Endocrinology vol. 131 , ( 3 ) 507 - 511 .
Davenport AP, Morton AJ, Brown MJ ( 1991 ) . Localization of endothelin-1 (ET-1), ET-2, and ET-3, mouse VIC, and sarafotoxin S6b binding sites in mammalian heart and kidney . Journal of Cardiovascular Pharmacology . vol. 17 , S152 - S155 .
Nunez DJR, Davenport AP, Brown MJ ( 1991 ) . Molecular aspects of atrial natriuretic factor physiology . Annals of the Academy of Medicine Singapore vol. 20 , ( 1 ) 19 - 25 .
Price JS, Kenny AJ, Huskisson NS, Brown MJ ( 1991 ) . Neuropeptide Y (NPY) metabolism by endopeptidase‐2 hinders characterization of NPY receptors in rat kidney . British Journal of Pharmacology vol. 104 , ( 2 ) 321 - 326 .
Shawket SA, Brown MJ ( 1991 ) . Pathogenetic and therapeutic implications of calcitonin-gene-related peptide in the cardiovascular system . Trends in Cardiovascular Medicine vol. 1 , ( 5 ) 211 - 215 .
Tan KKC, Brown MJ ( 1991 ) . Selected side effects: 3. Angiotensin-converting enzyme inhibitors and cough . Prescribers' Journal vol. 31 , ( 4 ) 146 - 149 .
Brown MJ, Claire Dickerson JE ( 1991 ) . Synergism between alpha<inf>1</inf>-blockade and angiotensin converting enzyme inhibition in essential hypertension . Journal of Hypertension . vol. 9 , S362 - S363 .
Price JS, Brown MJ ( 1990 ) . <sup>125</sup>I-neuropeptide Y binding activity of pig spleen cell membranes: Effect of solubilisation . Life Sciences vol. 47 , ( 24 ) 2299 - 2306 .
Kaumann AJ, Sanders L, Brown AM, Murray KJ, Brown MJ ( 1990 ) . A 5-hydroxytryptamine receptor in human atrium . British Journal of Pharmacology vol. 100 , ( 4 ) 879 - 885 .
Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C, Nunez DJ, Capper SJ et al. ( 1990 ) . A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: Comparison of levels in patients with essential hypertension and normotensive control subjects . Clinical Science vol. 78 , ( 3 ) 261 - 264 .
Nunez DJR, Davenport AP, Brown MJ ( 1990 ) . Atrial natriuretic factor mRNA and binding sites in the adrenal gland . Biochemical Journal vol. 271 , ( 2 ) 555 - 558 .
Shawket S, Dickerson JEC, Hazleman B, Brown MJ ( 1990 ) . Double-blind comparison of CGRP and prostacyclin in primary Raynaud's phenomenon: Prolonged hand rewarming after CGRP . British Journal of Clinical Pharmacology . vol. 29 ,
Brown MJ, Sanders L ( 1990 ) . Effects of dilevalol on human atrial muscle . Journal of Human Hypertension vol. 4 , ( SUPPL. 2 ) 55 - 58 .
Brown MJ ( 1990 ) . Efficacy and tolerance of doxazosin: A review . Journal of Human Hypertension vol. 4 , ( SUPPL. 3 ) 34 - 38 .
Nunez DJR, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK ( 1990 ) . Endothelin-1 mRNA is widely expressed in porcine and human tissues . Journal of Clinical Investigation vol. 85 , ( 5 ) 1537 - 1541 .
Taylor EA, Oh VMS, Nunez DJ, Balment R, Schofield JP, Brown MJ ( 1990 ) . Expression of endothelin-1 messenger RNA in kidneys of hypertensive and normotensive rats . European Journal of Pharmacology . vol. 183 , 2061 - 2062 .
Davenport AP, Nunez DJ, Brown MJ ( 1990 ) . Localisation of binding sites for iodinated endothelin and sarafotoxin peptides in mammalian tissues using quantitative receptor autoradiography . European Journal of Pharmacology . vol. 183 ,
Hall JA, Kaumann AJ, Brown MJ ( 1990 ) . Selective β<inf>1</inf>-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through β<inf>2</inf>-adrenoceptors in human atrial myocardium . Circulation Research vol. 66 , ( 6 ) 1610 - 1623 .
Shawket S, Hazleman B, Dickerson C, Brown MJ ( 1989 ) . SELECTIVE SUPRASENSITIVITY TO CALCITONIN-GENE-RELATED PEPTIDE IN THE HANDS IN RAYNAUD'S PHENOMENON . The Lancet vol. 334 , ( 8676 ) 1354 - 1357 .
Brown MJ ( 1989 ) . Investigation of alpha<inf>2</inf>-adrenoceptors in humans . The American Journal of Medicine vol. 87 , ( 3 SUPPL. 3 )
Kaumann AJ, Hall JA, Murray KJ, Wells FC, Brown MJ ( 1989 ) . A comparison of the effects of adrenaline and noradrenaline on human heart: The role of β<inf>1</inf>- and β<inf>2</inf>-adrenoceptors in the stimulation of adenylate cyclase and contractile force . European Heart Journal vol. 10 , ( SUPPL. B ) 29 - 37 .
Nunez DJ, Davenport P, Emson PC, Brown MJ ( 1989 ) . A quantitative 'in-situ' hybridization method using computer assisted image analysis. Validation and measurement of atrial-natriuretic-factor mRNA in the rat heart . Biochemical Journal vol. 263 , ( 1 ) 121 - 127 .
Davenport AP, Nunez DJ, Hall JA, Kaumann AJ, Brown MJ ( 1989 ) . Autoradiographical localization of binding sites for porcine [<sup>125</sup>I]endothelin-1 in humans, pigs, and rats: Functional relevance in humans . Journal of Cardiovascular Pharmacology vol. 13 , S166 - S170 .
Davenport AP, Nunez DJ, Brown MJ ( 1989 ) . Binding sites for <sup>125</sup>I-labelled endothelin-1 in the kidneys: Differential distribution in rat, pig and man demonstrated by using quantitative autoradiography . Clinical Science vol. 77 , ( 2 ) 129 - 131 .
Hall JA, Petch MC, Brown MJ ( 1989 ) . Intracoronary injections of salbutamol demonstrate the presence of functional β<inf>2</inf>-adrenoceptors in the human heart . Circulation Research vol. 65 , ( 3 ) 546 - 553 .
Barker PM, Brown MJ, Ramsden CA, Strang LB, Walters DV ( 1988 ) . The effect of thyroidectomy in the fetal sheep on lung liquid reabsorption induced by adrenaline or cyclic AMP . The Journal of Physiology vol. 407 , ( 1 ) 373 - 383 .
Brown MJ ( 1988 ) . Sites of action of alpha<inf>2</inf> agonists and antagonists . The American Journal of Cardiology vol. 61 , ( 7 )
Brown MJ ( 1988 ) . Adrenaline and alpha2-adrenoceptors in hypertension . Pharmacology and Toxicology vol. 63 , ( SUPPL. 1 ) 16 - 20 .
Causon R, Davies D, Brown M ( 1987 ) . Bio-medical applications of high performance liquid chromatography (HPLC) with amperometric detection . Life Sciences vol. 41 , ( 7 ) 909 - 912 .
Cockcroft JR, Ritter JM, Allison DJ, Causon R, Brown MJ ( 1987 ) . Location of extra-adrenal catecholamine secreting tumours by selective venous sampling and nuclear magnetic resonance scanning . Postgraduate Medical Journal vol. 63 , ( 740 ) 451 - 453 .
Allen JM, Yeats JC, Causon R, Brown MJ, Bloom SR ( 1987 ) . Neuropeptide Y and Its Flanking Peptide in Human Endocrine Tumors and Plasma . Journal of Clinical Endocrinology and Metabolism vol. 64 , ( 6 ) 1199 - 1204 .
Glazier JJ, Chierchia S, Brown MJ, Maseri A ( 1986 ) . Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris . The American Journal of Cardiology vol. 58 , ( 9 ) 667 - 672 .
Brown MJ, Brown J ( 1986 ) . DOES ANGIOTENSIN-II PROTECT AGAINST STROKES? . The Lancet vol. 328 , ( 8504 ) 427 - 429 .
Dunn GD, Sapsford RN, Hemingway AP, Brown MJ, Mansfield AO, Sever PS, Allison DJ ( 1986 ) . FUNCTIONING MIDDLE MEDIASTINAL PARAGANGLIOMA (PHAEOCHROMOCYTOMA) ASSOCIATED WITH INTERCAROTID PARAGANGLIOMAS . The Lancet vol. 327 , ( 8489 ) 1061 - 1064 .
Brown MJ, Harland D ( 1986 ) . B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors . British Journal of Pharmacology vol. 87 , ( 2 ) 361 - 370 .
Struthers AD, Burrin JM, Brown MJ ( 1986 ) . Exercise-induced increases in plasma catecholamines and growth hormone are augmented by selective α<inf>2</inf>-adrenoceptor blockade in man . Neuroendocrinology vol. 44 , ( 1 ) 22 - 28 .
Barnes PJ, Brown MJ, Dollery CT, Fuller RW, Heavey DJ, Ind PW ( 1986 ) . Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex . British Journal of Pharmacology vol. 88 , ( 4 ) 741 - 745 .
Corr L, Grounds RM, Brown MJ, Whitwam JG ( 1986 ) . Plasma catecholamine changes during cardiopulmonary bypass: A randomised double blind comparison of trimetaphan camsylate and sodium nitroprusside . British Heart Journal vol. 56 , ( 1 ) 89 - 93 .
Brown MJ, Causon RC, Brennan P, Greenberg G ( 1985 ) . Adrenaline and noradrenaline excretion in placebo treated patients in the medical research council hypertension trial and in matched normotensive controls . Journal of Hypertension vol. 3 , ( SUPPL. 3 )
Brown MJ ( 1985 ) . Hypokalemia from beta<inf>2</inf>-receptor stimulation by circulating epinephrine . The American Journal of Cardiology vol. 56 , ( 6 )
Wind P, Causon RC, Brown MJ, Barnes PJ ( 1985 ) . Circulating catecholamines in acute asthma . British Medical Journal (Clinical research ed.) vol. 290 , ( 6464 ) 267 - 269 .
Brown MJ, Struthers AD, Di Silvio L ( 1985 ) . Peripheral α<inf>2</inf> adrenoceptor stimulation contributes to the sympatholytic effect of guanfacine in humans . Journal of Cardiovascular Pharmacology vol. 7 , S159 - S161 .
Ind PW, Barnes PJ, Brown MJ, Dollery CT ( 1985 ) . Plasma histamine concentration during propranolol induced bronchoconstriction . Thorax vol. 40 , ( 12 ) 903 - 909 .
Causon RC, Brown MJ, Davies DS ( 1985 ) . Reversed-phase high-performance liquid chromatography and amperometric detection of 3-O-methyl isoprenaline sulphate: application to studies on the presystemic metabolism of d-isoprenaline in man . Journal of Chromatography B: Biomedical Sciences and Applications vol. 337 , ( C ) 311 - 320 .
STRUTHERS AD, BROWN DC, BROWN MJ, SCHUMER B, BLOOM SR ( 1985 ) . SELECTIVE α<inf>2</inf> RECEPTOR BLOCKADE FACILITATES THE INSULIN RESPONSE TO ADRENALINE BUT NOT TO GLUCOSE IN MAN . Clinical Endocrinology vol. 23 , ( 5 ) 539 - 546 .
Spencer JA, Brown MJ ( 1985 ) . Treatment with nifedipine for malignant hypertension inducing acute reversible renal impairment . British Medical Journal vol. 290 , ( 6475 )
Brown MJ, Causon RC, Barnes VF, Brennan P, Barnes G, Greenberg G ( 1985 ) . Urinary catecholamines in essential hypertension: Results of 24-hour urine catecholamine analyses from patients in the medical research council trial for mild hypertension and from matched controls . QJM vol. 57 , ( 1 ) 637 - 651 .
Causon RC, Brown MJ ( 1984 ) . High-performance liquid chromatography with amperometric determination of plasma tyramine . Journal of Chromatography A vol. 317 , ( C ) 319 - 325 .
Conci F, Procaccio F, Boselli L, Montoliu J, Martinez-Vea A, López-Pedret J, Revert L, Ball SG et al. ( 1984 ) . Hypokalemia from Beta<inf>2</inf>-Receptor Stimulation by Epinephrine . New England Journal of Medicine vol. 310 , ( 20 ) 1329 - 1331 .
Lee TH, Nagakura T, Cromwell O, Brown MJ, Causon R, Kay AB ( 1984 ) . Neutrophil chemotactic activity and histamine in atopic and nonatopic subjects after exercise-induced asthma . American Review of Respiratory Disease vol. 129 , ( 3 ) 409 - 412 .
Scriven AJI, Brown MJ, Murphy MB, Dollery CT ( 1984 ) . Changes in blood pressure and plasma catecholamines caused by tyramine and cold exposure . Journal of Cardiovascular Pharmacology vol. 6 , ( 5 ) 954 - 960 .
Causon RC, Desjardins R, Brown MJ, Davies DS ( 1984 ) . Determination of d-isoproterenol sulphate by high-performance liquid chromatography with amperometric detection . Journal of Chromatography B: Biomedical Sciences and Applications vol. 306 , ( C ) 257 - 268 .
Brown MJ, Harland D, Murphy MB, Struthers AD ( 1984 ) . Effect of Centrally Acting α-Adrenergic Agonists on Sympathetic Nervous System Function in Humans . Hypertension vol. 6 , ( 5 ) 57 - 62 .
Brown MJ, Harland D ( 1984 ) . Evidence for a peripheral component in the sympatholytic effect of clonidine in rats . British Journal of Pharmacology vol. 83 , ( 3 ) 657 - 665 .
Causon RC, Brown MJ ( 1984 ) . Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection . Journal of Chromatography B: Biomedical Sciences and Applications vol. 310 , ( C ) 11 - 17 .
Murphy MB, Brown MJ, Scriven AJI, Heavey DJ, Dollery CT ( 1984 ) . Nifedipine and alpha adrenoceptor antagonism . Clinical Pharmacology and Therapeutics vol. 36 , ( 6 ) 745 - 749 .
Conway EL, Brown MJ, Dollery CT ( 1984 ) . No evidence for involvement of endogenous opioid peptides in effects of clonidine on blood pressure, heart rate and plasma norepinephrine in anesthetized rats . Journal of Pharmacology and Experimental Therapeutics vol. 229 , ( 3 ) 803 - 808 .
BROWN MJ ( 1984 ) . Simultaneous assay of noradrenaline and its deaminated metabolite, dihydroxyphenylglycol, in plasma: a simplified approach to the exclusion of phaeochromocytoma in patients with borderline elevation of plasma noradrenaline concentration . European Journal of Clinical Investigation vol. 14 , ( 1 ) 67 - 72 .
Conway EL, Brown MJ, Dollery CT ( 1984 ) . Studies on the pharmacology of central opioid-induced increases in plasma catecholamines in conscious rats . Neuropharmacology vol. 23 , ( 11 ) 1291 - 1296 .
Brown MJ, Brown DC, Murphy MB ( 1983 ) . Hypokalemia from Beta<inf>2</inf>-Receptor Stimulation by Circulating Epinephrine . New England Journal of Medicine vol. 309 , ( 23 ) 1414 - 1419 .
Conway EL, Brown MJ, Dollery CT ( 1983 ) . Plasma catecholamine and cardiovascular responses to morphine and D-ala<sup>2</sup>-d-leu<sup>5</sup>-enkephalin in conscious rats . Archives Internationales de Pharmacodynamie et de Therapie vol. 265 , ( 2 ) 244 - 258 .
Murphy MB, Brown MJ, Causon RC, Dollery CT ( 1983 ) . The effects of pentolinium on sympathetic activity in hypertensives and normotensive controls . International Journal of Clinical Pharmacology Research vol. 3 , ( 4 ) 227 - 232 .
Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV ( 1983 ) . Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb . The Journal of Physiology vol. 344 , ( 1 ) 137 - 152 .
Adrian TE, Terenghi G, Brown MJ, Allen JM, Bacarese-Hamilton AJ, Polak JM, Bloom SR ( 1983 ) . NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS . The Lancet vol. 322 , ( 8349 ) 540 - 542 .
Brown MJ, Brown DC, Murphy MB ( 1983 ) . Adrenaline associated hypokalaemia and tachycardia are selectively antagonised by low dose beta2-receptor blockade in man . Clinical Science vol. 64 , ( 2 )
Causon RC, Brown MJ, Boulous PM, Perret D ( 1983 ) . Analytical differences in measurement of plasma catecholamines . Clinical chemistry vol. 29 , ( 4 ) 735 - 737 .
Striven AJI, Dollery CT, Murphy MB, Macquin I, Brown MJ ( 1983 ) . Blood pressure and plasma norepinephrine concentrations after endogenous norepinephrine release by tyramine . Clinical Pharmacology and Therapeutics vol. 33 , ( 6 ) 710 - 716 .
Brown MJ ( 1983 ) . Catecholamine measurements in clinical medicine . Postgraduate Medical Journal vol. 59 , ( 694 ) 479 - 482 .
Ind PW, Miyatake A, Brown MJ, Dollery CT ( 1983 ) . Do human mast cells possess functional beta adrenoceptors in vivo? . Agents and Actions Supplements vol. 13 , 245 - 254 .
Causon RC, Brown MJ, Leenders KL, Wolfson L ( 1983 ) . High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in parkinsonian patients . Journal of Chromatography B: Biomedical Sciences and Applications vol. 277 , ( C ) 115 - 123 .
IND PW, BARNES PJ, BROWN MJ, CAUSON R, DOLLERY CT ( 1983 ) . Measurement of plasma histamine in asthma . Clinical &amp; Experimental Allergy vol. 13 , ( 1 ) 61 - 67 .
Lee TH, Nagy L, Brown MJ, O'Driscoll BR, Causon R, Kay AB ( 1983 ) . Mechanism of antigen-induced late asthmatic reactions . Agents and Actions Supplements vol. 13 , 273 - 277 .
Dollery CT, Brown MJ, Davies DS, Lewis PJ, Strolin-Benedetti M ( 1983 ) . Oral absorption and concentration-effect relationship of tyramine with and without cimoxatone, a type-A specific inhibitor of monoamine oxidase . Clinical Pharmacology and Therapeutics vol. 34 , ( 5 ) 651 - 662 .
Brown MJ ( 1983 ) . Simultaneous assay of noradrenaline and its deaminated metabolite in plasma: Application to diagnosis of phaeochromocytoma . Journal of Hypertension vol. 1 , ( SUPPL. 2 ) 308 - 309 .
Murphy MB, Scriven AJ, Brown MJ, Causon R, Dollery CT ( 1982 ) . The effects of nifedipine and hydralazine induced hypotension on sympathetic activity . European Journal of Clinical Pharmacology vol. 23 , ( 6 ) 479 - 482 .
Brown MJ, Lewis PJ, Halter JB, Beard JC, Pfeifer MA, Metz SA, Bravo EL ( 1982 ) . Clonidine-Suppression Test for Diagnosis of Pheochromocytoma . New England Journal of Medicine vol. 306 , ( 1 ) 49 - 50 .
Brown MJ, Ind PW, Causon R, Lee TH ( 1982 ) . A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics . The Journal of Allergy and Clinical Immunology vol. 69 , ( 1 PART 1 ) 20 - 24 .
Warren JB, Keynes RJ, Brown MJ, Jenner DA, McNicol MW ( 1982 ) . Blunted sympathoadrenal response to exercise in asthmatic subjects . British Journal of Diseases of the Chest vol. 76 , ( C ) 147 - 150 .
Causon RC, Brown MJ ( 1982 ) . Catecholamine measurements in phaeochromocytoma: A review . Annals of Clinical Biochemistry vol. 19 , ( 6 ) 396 - 404 .
Ind PW, Brown MJ, Lhoste FJM, Macquin I, Dollery CT ( 1982 ) . Concentration effect relationships of infused histamine in normal volunteers . Agents and Actions vol. 12 , ( 1-2 ) 12 - 16 .
Causon RC, Murphy MB, Brown MJ ( 1982 ) . Effect of hemolysis on radioenzymic assay of plasma catecholamines . Clinical chemistry vol. 28 , ( 3 ) 548 - 550 .
Ind PW, Brown MJ, Barnes PJ, Dollery CT ( 1982 ) . Effect of propranolol on mediator release in asthmatics . Thorax vol. 37 , ( 3 )
Watkins J, Dargie HJ, Brown MJ, Krikler DM, Dollery CT ( 1982 ) . Effects of histamine type 2 receptor stimulation on myocardial function in normal subjects . British Heart Journal vol. 47 , ( 6 ) 539 - 545 .
Brown MJ, Lhoste FJM, Zamboulis C, Ind PW, Jenner DA, Dollery CT ( 1982 ) . Estimation of sympathetic activity in essential hypertension . Clinical Pharmacology and Therapeutics vol. 31 , ( 1 ) 16 - 22 .
Lee TH, Brown MJ, Nagy L, Causon R, Walport MJ, Kay AB ( 1982 ) . Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics . The Journal of Allergy and Clinical Immunology vol. 70 , ( 2 ) 73 - 81 .
Walters DV, Ramsden CA, Brown MJ ( 1982 ) . Fetal lung liquid absorption during epinephrine infusion and spontaneous labor in the lamb . Chest vol. 81 , ( 5 Suppl. ) 65 - 66 .
Barnes PJ, Ind PW, Brown MJ ( 1982 ) . Plasma histamine and catecholamines in stable asthmatic subjects . Clinical Science vol. 62 , ( 6 ) 661 - 665 .
Brown MJ, Macquin I, Murphy MB, Dollery CT ( 1982 ) . Sustained increase in sympathetic activity due to neuronal uptake of adrenaline: Mechanism for stress-induced hypertension and arrhythmias? . Clinical Science vol. 62 , ( 2 )
Rampton DS, Brown MJ, Sahib M ( 1982 ) . The effect of disodium cromoglycate on rectal mucosal histamine release and eosinophil exudation in active ulcerative colitis . Clinical Science vol. 62 , ( 2 )
RAMPTON DS, BROWN MJ, CAUSON R, SAHIB M ( 1982 ) . The effect of disodium cromoglycate on rectal mucosal histamine release, eosinophil exudation and disease activity in active ulcerative colitis . Clinical &amp; Experimental Allergy vol. 12 , ( 3 ) 243 - 248 .
Brown MJ, Macquin I ( 1981 ) . IS ADRENALINE THE CAUSE OF ESSENTIAL HYPERTENSION? . The Lancet vol. 318 , ( 8255 ) 1079 - 1082 .
Jenner DA, Brown MJ, Lhoste FJM ( 1981 ) . Determination of α-methyldopa, α-methylnoradrenaline, noradrenaline and adrenaline in plasma using high-performance liquid chromatography with electrochemical detection . Journal of Chromatography B: Biomedical Sciences and Applications vol. 224 , ( 3 ) 507 - 512 .
Brown M, Causon R, Holly JMP, Parfrey PS, Goodwin FJ, Ledingham JM ( 1981 ) . "Na" OR "NA" IN HYPERTENSION? . The Lancet vol. 317 , ( 8222 ) 721 - 722 .
Amorim DS, Heer K, Jenner D, Richardson P, Dargie HJ, Brown M, Olsen EGJ, Goodwin JF ( 1981 ) . IS THERE AUTONOMIC IMPAIRMENT IN CONGESTIVE (DILATED) CARDIOMYOPATHY? . The Lancet vol. 317 , ( 8219 ) 525 - 527 .
Weinkove C, Brown M ( 1981 ) . SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS . The Lancet vol. 317 , ( 8218 ) 493 - 494 .
Brown MJ, Jenner DA, Allison DJ, Lewis PJ, Dollery CT ( 1981 ) . INCREASED SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS ACHIEVED BY USE OF PLASMA-ADRENALINE ESTIMATIONS AND A PENTOLINIUM-SUPPRESSION TEST . The Lancet vol. 317 , ( 8213 ) 174 - 177 .
Barnes PJ, Wilson NM, Brown MJ ( 1981 ) . A calcium antagonist, nifedipine, modifies exercise-induced asthma . Thorax vol. 36 , ( 10 ) 726 - 730 .
Barnes PJ, Wilson NM, Brown MJ, Ind P ( 1981 ) . Calcium antagonist nifedipine modifies exercise-induced asthma . Thorax vol. 36 , ( 3 )
Barnes PJ, Brown MJ, Silverman M, Dollery CT ( 1981 ) . Circulating catecholamines in exercise and hyperventilation induced asthma . Thorax vol. 36 , ( 6 ) 435 - 440 .
Lhoste F, Brown M, Jenner D, Dollery CT ( 1981 ) . Methyldopa, methylnoradrenaline and noradrenaline in hypertension . Journal de Pharmacologie vol. 12 , ( 3 )
Brown MJ, Jenner DA ( 1981 ) . Novel double-isotope technique for enzymatic assay of catecholamines, permitting high precision, sensitivity and plasma sample capacity . Clinical Science vol. 61 , ( 5 ) 591 - 598 .
Jenner DA, Brown MJ ( 1981 ) . Simultaneous determination of endogenous catecholamines, α-methyldopa and α-methylnoradrenaline in plasma, using HPLC with electrochemical detection . British Journal of Clinical Pharmacology vol. 11 , ( 4 )
Stevenson JC, Hillyard CJ, Spanos E, MacIntyre I, Ackroyd N, Lynn J, Brown MJ, Stevenson BM ( 1981 ) . Sipple syndrome: Marked variability of the disease within a family and implications for management . Postgraduate Medical Journal vol. 57 , ( 664 ) 104 - 108 .
Brown MJ, Jenner DA, Allison DJ, Dollery CT ( 1981 ) . Variations in individual organ release of noradrenaline measured by an improved radioenzymatic technique; limitations of peripheral venous measurements in the assessment of sympathetic nervous activity . Clinical Science vol. 61 , ( 5 ) 585 - 590 .
Barnes PJ, Brown MJ ( 1981 ) . Venous plasma histamine in exercise- and hyperventilation-induced asthma in man . Clinical Science vol. 61 , ( 2 ) 159 - 162 .
FitzGerald GA, Barnes P, Brown MJ, Dollery CT ( 1980 ) . The circadian variability of circulating adrenaline and bronchomotor reactivity in asthma . Advances in the Biosciences vol. 28 , ( C ) 89 - 94 .
Clark TJH, Hetzel MR, Fairfax AJ, Weitzman ED, Bookman R, Barnes P, Brown M, Dollery C ( 1980 ) . Nocturnal Asthma and Circulating Epinephrine, Histamine, and Cortisol . New England Journal of Medicine vol. 303 , ( 22 ) 1300 - 1301 .
Brown MJ, Ind PW, Jenner DA, Soter NA, Austen KF, Wasserman SI ( 1980 ) . Platelet Histamine . New England Journal of Medicine vol. 303 , ( 13 )
Barnes P, Fitzgerald G, Brown M, Dollery C, Barnes P ( 1980 ) . Nocturnal Asthma and Changes in Circulating Epinephrine, Histamine, and Cortisol . New England Journal of Medicine vol. 303 , ( 5 ) 263 - 267 .
Brown MJ, Dollery CT, Fitzgerald GA, Watkins J, Zamboulis C ( 1980 ) . No evidence for antagonism of clonidine by naloxone in man . British Journal of Clinical Pharmacology vol. 9 , ( 3 )
Brown MJ, Lewis PJ, Dollery CT ( 1980 ) . DIAGNOSIS OF SMALL PHÆOCHROMOCYTOMAS . The Lancet vol. 315 , ( 8179 ) 1185 - 1186 .
Brown MJ ( 1980 ) . PLASMA CATECHOLAMINE ASSAYS . The Lancet vol. 315 , ( 8173 )
Brown MJ, Ind PW, Barnes PJ, Jenner DA, Dollery CT ( 1980 ) . A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals . Analytical Biochemistry vol. 109 , ( 1 ) 142 - 146 .
Watkins J, FitzGerald G, Zamboulis C, Brown MJ, Dollery CT ( 1980 ) . Absence of opiate and histamine H<inf>2</inf> receptor–mediated effects of Clonidine . Clinical Pharmacology &amp; Therapeutics vol. 28 , ( 5 ) 605 - 610 .
Karliner JS, Barnes P, Brown M, Dollery C ( 1980 ) . Chronic heart failure in the guinea pig increases cardiac α<inf>1</inf>- and β-adrenoceptors . European Journal of Pharmacology vol. 67 , ( 1 ) 115 - 118 .
Rossor MN, Watkins J, Brown MJ, Reid JL, Dollery CT ( 1980 ) . Plasma levodopa, dopamine and therapeutic response following levodopa therapy of Parkinsonian patients . Journal of the Neurological Sciences vol. 46 , ( 3 ) 385 - 392 .
Brown MJ, Barnes PJ, Lhoste F ( 1980 ) . Use of a new radioenzymatic assay for plasma histamine to detect abnormal release in asthmatics . European Journal of Clinical Investigation vol. 10 , ( 2 II )
Petty MA, Chalmers JP, Brown M, Reid JL ( 1979 ) . Effect of baroreceptor deafferentation on central catecholamines in the rat . Clinical Science vol. 57 , ( SUPPL. 5 ) 221 - 223 .
Brown MJ, Dollery CT, Reid JL, Rossor M, Watkins J ( 1979 ) . Plasma catecholamines and the acute effects of oral L-dopa in Parkinsonian patients . British Journal of Clinical Pharmacology vol. 8 , ( 4 )
Brown MJ, Davies DS, Dollery CT ( 1979 ) . Quantitative analysis of noradrenaline clearance . British Journal of Pharmacology vol. 67 , ( 3 )
Rossor M, Watkins J, Brown MJ ( 1979 ) . Plasma catecholamines and the acute effects of oral L-dopa by Parkinsonian patients . European Journal of Clinical Investigation vol. 9 , ( 2 II )
Brown M, Chalmers JP, Petty MA, Reid JL ( 1979 ) . The involvement of catecholamines in the central connexions of arterial baroreceptor reflexes in the rat . Journal of Physiology vol. Vol. 292 ,