Publications: Dr Ana Gutierrez Del Arroyo

Ackland GL, Patel ABU, Miller S, del Arroyo AG, Thirugnanasambanthar J, Ravindran JI, Schroth J, Boot J et al. ( 2025 ) . Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial . European Heart Journal

Ackland G ( 2024 ) . Preoperative activation of the renineangiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial . British Journal of Anaesthesia

Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi A, Konstantinou C et al. ( 2024 ) . Adenosine signalling to astrocytes coordinates brain metabolism and function . Nature vol. 632 , ( 8023 ) 139 - 146 .

Mi Y, Burnham KL, Charles PD, Heilig R, Vendrell I, Whalley J, Torrance HD, Antcliffe DB et al. ( 2024 ) . High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response . Science Translational Medicine vol. 16 , ( 750 )

Halme ALE, Roshanov PS, Tornberg SV, Lavikainen LI, Devereaux PJ, Tikkinen KAO, DeBeer J, Kearon C et al. ( 2024 ) . Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery . JAMA Network Open vol. 7 , ( 4 )

Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J et al. ( 2024 ) . Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction . British Journal of Anaesthesia vol. 132 , ( 5 ) 843 - 848 .

del Arroyo AG, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S et al. ( 2024 ) . Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial . British Journal of Anaesthesia vol. 132 , ( 5 ) 857 - 866 .

Ackland GL, Martin T, Joseph M, Dias P, Hameed R, del Arroyo AG, Hewson R, Abbott TEF et al. ( 2023 ) . Transauricular nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: Protocol for a phase 2A, proof-of-concept, sham-controlled randomised trial . PLOS ONE vol. 18 , ( 12 )

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A et al. ( 2023 ) . Transcriptional response of the heart to vagus nerve stimulation . Physiol Genomics

Ackland G ( 2023 ) . Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial . European Heart Journal Article ehad716 ,

Ackland GL, Van Duijvenboden S, Abbott TEF, del Arroyo AG, Wilson MJ, David AL, Investigators TE ( 2023 ) . Interleukin-1 Receptor Antagonist, Mode of Analgesia and Risk of Cesarean Delivery After Onset of Labor: A Mendelian Randomization Analysis . Obstetric Anesthesia Digest vol. 43 , ( 3 ) 153 - 154 .

Kopach O, Sylantyev S, Bard L, Michaluk P, Heller JP, del Arroyo AG, Ackland GL, Gourine AV et al. ( 2023 ) . Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release . iScience vol. 26 , ( 7 )

Ackland G, Van Duijvenboden S, ABBOTT T, Gutierrez Del Arroyo A, Wilson M, David A ( 2021 ) . Interleukin-1 receptor antagonist and risk of caesarean delivery after onset of labour: a Mendelian randomisation analysis . British Journal of Anaesthesia

May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S et al. ( 2021 ) . Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study . Brain Behavior & Immunity - Health vol. 16 ,

Tyler EJ, del Arroyo AG, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R et al. ( 2021 ) . Early growth response 2 (EGR2) is a novel regulator of the senescence programme . Aging Cell vol. 20 , ( 3 )

May S, Abbott TEF, Gutierrez Del Arroyo A, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson B et al. ( 2020 ) . MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study . British Journal of Anaesthesia vol. 125 , ( 5 ) 661 - 671 .

Riedel B, Li MHG, Lee CHA, Ismail H, Cuthbertson BH, Wijeysundera DN, Ho KM, Wallace S et al. ( 2020 ) . A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study . British Journal of Anaesthesia

Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A et al. ( 2020 ) . Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study . British Journal of Anaesthesia

Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P et al. ( 2019 ) . Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study . British Journal of Anaesthesia

Walker S, Del Arroyo AG, Sanchez J, Ackland GL ( 2019 ) . P3509Leukocyte derived tumour necrosis factor modulates cardiac function in health and disease . European Heart Journal vol. 40 , ( Supplement_1 )

del Arroyo AG, Cyrus T, Bahelil F, Bliss E, Heywood W, Mills K, Ackland GL, group P-OS ( 2019 ) . Serial proteomic characterisation of skin during the perioperative period . British Journal of Anaesthesia . vol. 123 , e511 - e512 .

del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S et al. ( 2019 ) . NMDA receptor modulation of glutamate release in activated neutrophils . EBioMedicine

Bartoszko J, Thorpe KE, Laupacis A, Wijeysundera DN, Myles PS, Shulman MA, Wallace S, Farrington C et al. ( 2019 ) . Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study . British Journal of Anaesthesia

Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J et al. ( 2018 ) . Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study . Lancet vol. 391 , ( 10140 ) 2631 - 2640 .

Ackland G, del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Sultan P, David A ( 2018 ) . Caspase-1 and epidural-related maternal fever . British Journal of Anaesthesia . vol. 120 , e20 - e21 .

Basalay M, Mastitskaya S, Mrochek A, Ackland GL, Arroyo AGD, Sanchez J, Sjoquist P-O, Pernow J et al. ( 2017 ) . Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning . Cardiovasc Res vol. 113 , ( 1 ) 13 - 14 .

Turovsky E, Theparambil SM, Kasymov V, Deitmer JW, del Arroyo AG, Ackland GL, Corneveaux JJ, Allen AN et al. ( 2016 ) . Mechanisms of CO2/H+ Sensitivity of Astrocytes . Journal of Neuroscience vol. 36 , ( 42 ) 10750 - 10758 .

Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, del Arroyo AG, Sanchez J, Sjoquist P-O, Pernow J et al. ( 2016 ) . Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning . Cardiovascular Research vol. 112 , ( 3 ) 669 - 676 .

Ackland GL, Whittle J, Toner A, Machhada A, Del Arroyo AG, Sciuso A, Jenkins N, Dyson A et al. ( 2016 ) . Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness . Crit Care Med vol. 44 , ( 8 ) e614 - e624 .

Edwards MR, Sultan P, del Arroyo AG, Whittle J, Karmali SN, Moonesinghe SR, Haddad FS, Mythen MG et al. ( 2015 ) . Metabolic dysfunction in lymphocytes promotes postoperative morbidity . Clinical Science vol. 129 , ( 5 ) 423 - 437 .

Cain DJ, del Arroyo AG, Ackland GL ( 2015 ) . Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis . Journal of the Intensive Care Society vol. 16 , ( 2 ) 154 - 163 .

del Arroyo AG, El Messaoudi S, Clark PA, James M, Stott F, Bracken A, Helin K, Peters G ( 2014 ) . E2F-Dependent Induction of p14ARF During Cell Cycle Re-entry in Human T Cells . Cell Cycle vol. 6 , ( 21 ) 2697 - 2705 .

Sultan P, Edwards MR, del Arroyo AG, Cain D, Sneyd JR, Struthers R, Minto G, Ackland GL ( 2014 ) . Cardiopulmonary Exercise Capacity and Preoperative Markers of Inflammation . Mediators of Inflammation vol. 2014 , ( 1 )

Deas E, Piipari K, Machhada A, Li A, Gutierrez-Del-Arroyo A, Withers DJ, Wood NW, Abramov AY ( 2014 ) . PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice . Open Biology vol. 4 , ( MAY )

Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW, Abramov AY ( 2014 ) . PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice . Open Biology vol. 4 , ( 5 )

Cain DJ, del Arroyo AG, Ackland GL ( 2014 ) . Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine . Intensive Care Medicine Experimental vol. 2 , ( 1 )

Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV ( 2010 ) . Low-molecular-weight polyethylene glycol improves survival in experimental sepsis* . Critical Care Medicine vol. 38 , ( 2 ) 629 - 636 .

del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C et al. ( 2009 ) . Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients . The Journal of Immunology vol. 183 , ( 3 ) 2194 - 2194 .

Del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C et al. ( 2009 ) . Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: Demonstration in isolated monocytes from cystic fibrosis patients (Journal of Immunology (2009) 182, (6494-6507)) . Journal of Immunology vol. 182 , ( 11 )

del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C et al. ( 2009 ) . Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients . The Journal of Immunology vol. 182 , ( 10 ) 6494 - 6507 .

Del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C et al. ( 2009 ) . Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: Demonstration in isolated monocytes from cystic fibrosis patients. (Journal of Immunology (2009) 182, (6494-6507)) . Journal of Immunology vol. 182 , ( 10 )

Irelan JT, del Arroyo AG, Gutierrez A, Peters G, Quon KC, Miraglia L, Chanda SK ( 2009 ) . A Functional Screen for Regulators of CKDN2A Reveals MEOX2 as a Transcriptional Activator of INK4a . PLOS ONE vol. 4 , ( 4 )

Hong Y, Wang G, del Arroyo AG, Hernandez J, Skene C, Erusalimsky JD ( 2006 ) . Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: selectivity of anagrelide for the megakaryocytic lineage . Leukemia vol. 20 , ( 6 ) 1117 - 1122 .

Brookes S, Rowe J, del Arroyo AG, Bond J, Peters G ( 2004 ) . Contribution of p16INK4a to replicative senescence of human fibroblasts . Experimental Cell Research vol. 298 , ( 2 ) 549 - 559 .

Gutiérrez del Arroyo A, Del Carmen de Marco M, Silva A ( 2003 ) . IL-3 is unable to rescue IL-3-dependent scid cells after exposure to X-ray irradiation . Inmunologia vol. 22 , ( 2 ) 183 - 189 .

Gutiérrez del Arroyo A, Gil-Lamagniere C, Lazaro I, de Marco MC, Layunta I, Silva A ( 2000 ) . Involvement of p53 and interleukin 3 in the up-regulation of CD95 (APO-1/Fas) by X-ray irradiation . Oncogene vol. 19 , ( 32 ) 3647 - 3655 .

Palacios C, del Arroyo AG, Silva A, Collins MK ( 2000 ) . The role of p53 in death of IL-3-dependent cells in response to cytotoxic drugs . Oncogene vol. 19 , ( 31 ) 3556 - 3559 .

Lazo PA, Cuevas L, del Arroyo AG, Orúe E ( 1997 ) . Ligation of CD53/OX44, a Tetraspan Antigen, Induces Homotypic Adhesion Mediated by Specific Cell–Cell Interactions . Cellular Immunology vol. 178 , ( 2 ) 132 - 140 .