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Research

Publications: Dr Aisah Aubdool

Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez-Ternero C, Aubdool AA et al. ( 2022 ) . Multidrug resistance proteins preferentially regulate natriuretic peptide-driven cGMP signalling in the heart and vasculature . British Journal of Pharmacology vol. 179 , ( 11 ) 2443 - 2459 .
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ ( 2022 ) . C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 13 )
Argunhan F, Thapa D, Aubdool AA, Carlini E, Arkless K, Hendrikse ER, De Sousa Valente J, Kodji X et al. ( 2021 ) . Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide in Vivo . Hypertension vol. 77 , ( 4 ) 1178 - 1190 .
Argunhan F, Thapa D, Aubdool AA, Brain SD ( 2020 ) . alpha CGRP can act independently of NO to rescue blood flow in the mesenteric microvasculature in vivo . BRITISH JOURNAL OF PHARMACOLOGY . vol. 177 , 2592 - 2593 .
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al. ( 2020 ) . C-type natriuretic peptide co-ordinates cardiac structure and function . European Heart Journal vol. 41 , ( 9 ) 1006 - 1020 .
( 2019 ) . Correction . FASEB J vol. 33 , ( 12 )
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease . Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
( 2019 ) . correction . FASEB J vol. 33 , ( 12 )
Perez-Ternero C, Aubdool AA, Moyes AJ, Hobbs AJ ( 2019 ) . C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling . CIRCULATION . Conference: American Heart Association vol. 140 ,
Preedy ME, Baliga RS, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2019 ) . Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3008 - 3009 .
Kodji X, Arkless KL, Kee Z, Cleary SJ, Aubdool AA, Evans E, Caton P, Pitchford SC et al. ( 2019 ) . Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis . FASEB Journal vol. 33 , ( 2 ) 1578 - 1594 .
Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC et al. ( 2018 ) . Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling . Circulation
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2018 ) . Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure . Proc Natl Acad Sci U S A
Pan Y, Thapa D, Baldissera L, Argunhan F, Aubdool AA, Brain SD ( 2018 ) . Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature . Pflugers Archiv European Journal of Physiology vol. 470 , ( 5 ) 779 - 786 .
Aubdool AA, Argunhan F, Thakore P, Brain SD ( 2018 ) . Response by Aubdool et al to Letters Regarding Article, "A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure" . Circulation vol. 137 , ( 11 ) 1201 - 1202 .
Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ, Greenwood IA ( 2018 ) . Angiotensin II promotes KV7.4 channels degradation through reduced interaction with HSP90 (Heat Shock Protein 90) . Hypertension vol. 71 , ( 6 ) 1091 - 1100 .
Aubdool AA, Kodji X, Brain SD ( 2018 ) . Calcitonin gene-related peptide (CGRP) . Encyclopedia of Endocrine Diseases ,
Aubdool AA, Bubb KJ, Moyes AJ, Drayton JP, Mehta V, Zachary IC, Tsui J, Abraham DJ et al. ( 2017 ) . Endothelium-Derived C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodelling . CIRCULATION . vol. 136 ,
Wilde E, Aubdool AA, Thakore P, Baldissera L, Alawi KM, Keeble J, Nandi M, Brain SD ( 2017 ) . Tail-Cuff Technique and Its Influence on Central Blood Pressure in the Mouse . J Am Heart Assoc vol. 6 , ( 6 )
Aubdool AA, Thakore P, Argunhan F, Smillie SJ, Schnelle M, Srivastava S, Alawi KM, Wilde E et al. ( 2017 ) . A novel α-calcitonin gene-related peptide analogue protects against end-organ damage in experimental hypertension, cardiac hypertrophy, and heart failure . Circulation vol. 136 , ( 4 ) 367 - 383 .
Srivastava S, Blower PJ, Aubdool AA, Hider RC, Mann GE, Siow RC ( 2016 ) . Cardioprotective effects of Cu((II))ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1 . Sci Rep vol. 6 , ( 1 ) 7 - 7 .
Kodji X, Aubdool AA, Brain SD ( 2016 ) . Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin . Current Research in Translational Medicine vol. 64 , ( 4 ) 195 - 201 .
Hajna Z, Sághy É, Payrits M, Aubdool AA, Szőke É, Pozsgai G, Bátai IZ, Nagy L et al. ( 2016 ) . Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release . Journal of Molecular Neuroscience
Aubdool AA, Kodji X, Abdul-Kader N, Heads R, Fernandes ES, Bevan S, Brain SD ( 2016 ) . TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO . British Journal of Pharmacology vol. 173 , ( 15 ) 2419 - 2433 .
Alawi K, Russell FA, Aubdool AA, Riffo-Vasquez Y, Baldissera L, Thakore P, Fernandes ES, Brain SD ( 2016 ) . AB0095 Investigating The Role of Transient Receptor Potential Canonical 5 (TRPC5) in Complete Freund's Adjuvant (CFA)-Induced Arthritis . Annals of the Rheumatic Diseases . vol. 75 ,
Alawi KM, Russell FA, Aubdool AA, Srivastava S, Riffo-Vasquez Y, Baldissera L, Thakore P, Saleque N et al. ( 2016 ) . Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation . Annals of the Rheumatic Diseasesannrheumdis-2015-208 - annrheumdis-2015-208 .
Fernandes ES, Russell FA, Alawi KM, Sand C, Liang L, Salamon R, Bodkin JV, Aubdool AA et al. ( 2016 ) . Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner . Arthritis Research and Therapy vol. 18 , ( 1 )
Alawi KM, Aubdool AA, Liang L, Wilde E, Vepa A, Psefteli MP, Brain SD, Keeble JE ( 2015 ) . The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature . FASEB Journal vol. 29 , ( 10 ) 4285 - 4298 .
Aubdool A ( 2015 ) . The Young Life Scientists' Symposia 2014: Current progress on the physiology and pharmacology of TRP channels: 4 October 2014, King's College London, UK . Biochemist vol. 37 , ( 1 ) 36 - 37 .
Aubdool AA, Graepel R, Kodji X, Alawi KM, Bodkin JV, Srivastava S, Gentry C, Heads R et al. ( 2014 ) . TRPA1 is essential for the vascular response to environmental cold exposure . Nature Communications vol. 5 ,
Bodkin JV, Thakore P, Aubdool AA, Liang L, Fernandes ES, Nandi M, Spina D, Clark JE et al. ( 2014 ) . Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension . Pharmacology Research and Perspectives vol. 2 , ( 4 )
Fernandes ES, Vong CT, Quek S, Cheong J, Awal S, Gentry C, Aubdool AA, Liang L et al. ( 2013 ) . Superoxide generation and leukocyte accumulation: Key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 . FASEB Journal vol. 27 , ( 4 ) 1664 - 1673 .
Graepel R, Aubdool AA, Kodji X, Fernandes ES, Bevan S, Brain SD ( 2013 ) . TRPA1 channels play a critical role in cold‐induced vasodilatation . The FASEB Journal . vol. 27 , lb601 - lb601 .
Alexander R, Kerby A, Aubdool AA, Power AR, Grover S, Gentry C, Grant AD ( 2013 ) . 4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4 . British Journal of Pharmacology vol. 168 , ( 3 ) 761 - 772 .
Aubdool AA, Brain SD ( 2011 ) . Neurovascular aspects of skin neurogenic inflammation . Journal of Investigative Dermatology Symposium Proceedings vol. 15 , ( 1 ) 33 - 39 .
Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, Fairman E, Hashizume Y et al. ( 2011 ) . Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel . Bioorganic and Medicinal Chemistry Letters vol. 21 , ( 16 ) 4857 - 4859 .
Aubdool AA, Graepel R, Brain SD ( 2011 ) . A POTENTIAL LINK BETWEEN THE TRPA1 AND TRPV1 RECEPTORS IN VIVO . INFLAMMATION RESEARCH . vol. 60 , 203 - 203 .
Graepel R, Fernandes ES, Aubdool AA, Andersson DA, Bevan S, Brain SD ( 2011 ) . 4-Oxo-2-nonenal (4-ONE): Evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo . Journal of Pharmacology and Experimental Therapeutics vol. 337 , ( 1 ) 117 - 124 .