Publications: Dr Loic Rolas

Kono Y, Pack C-G, Ichikawa T, Komatsubara A, Adam SA, Miyazawa K, Rolas L, Nourshargh S et al. ( 2024 ) . Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture . PNAS Nexus vol. 3 , ( 12 )

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .

Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ et al. ( 2024 ) . Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells . Proceedings of the National Academy of Sciences

Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR et al. ( 2021 ) . Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome . Circulation vol. 144 , ( 22 ) 1777 - 1794 .

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al. ( 2021 ) . Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation . Immunity vol. 54 , ( 9 ) 1989 - 2004.e9 .

Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, Ortega-Nogales FJ, Balabasquer M, Gonzalo P, Khiar-Fernández N, Rolas L et al. ( 2021 ) . Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome . ACS Central Science vol. 7 , ( 8 ) 1300 - 1310 .

Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al. ( 2021 ) . Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage . Immunity vol. 54 , ( 7 ) 1494 - 1510.e7 .

Dang PM-C, Rolas L, El-Benna J ( 2020 ) . The Dual Role of Reactive Oxygen Species-Generating Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Gastrointestinal Inflammation and Therapeutic Perspectives . Antioxidants & Redox Signaling vol. 33 , ( 5 ) 354 - 373 .

Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M et al. ( 2020 ) . Local microvascular leakage promotes trafficking of activated neutrophils to remote organs . Journal of Clinical Investigation

Madjene LC, Danelli L, Dahdah A, Vibhushan S, Bex-Coudrat J, Pacreau E, Vaugier C, Claver J et al. ( 2019 ) . Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment . Kidney International vol. 97 , ( 3 ) 516 - 527 .

Arabi-Derkawi R, O'Dowd Y, Cheng N, Rolas L, Boussetta T, Raad H, Marzaioli V, Pintard C et al. ( 2019 ) . The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes . The Journal of Immunology vol. 202 , ( 5 ) 1549 - 1558 .

NOURSHARGH S, ROLAS L, BARKAWAY A ( 2019 ) . Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome . Nature Medicine423 - 426 .

Reglero-Real N, Rolas L, Nourshargh S ( 2019 ) . Leukocyte Trafficking: Time to Take Time Seriously . Immunity vol. 50 , ( 2 ) 273 - 275 .

GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E et al. ( 2018 ) . Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis . Immunity

Belambri SA, Rolas L, Raad H, Hurtado‐Nedelec M, Dang PM, El‐Benna J ( 2018 ) . NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits . European Journal of Clinical Investigation vol. 48 , ( S2 )

Rolas L, Boussif A, Weiss E, Lettéron P, Haddad O, El-Benna J, Rautou P-E, Moreau R et al. ( 2017 ) . NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation . Gut vol. 67 , ( 8 )

Boussif A, Rolas L, Weiss E, Bouriche H, Moreau R, Périanin A ( 2015 ) . Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis . Journal of Hepatology vol. 64 , ( 5 ) 1041 - 1048 .

Rolas L, Makhezer N, Hadjoudj S, El‐Benna J, Djerdjouri B, Elkrief L, Moreau R, Périanin A ( 2013 ) . Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis . Hepatology vol. 57 , ( 3 ) 1163 - 1171 .