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Research

Publications: Dr Helen Ross-Adams

Sivapalan L, Thorn GJ, Gadaleta E, Kocher HM, Ross-Adams H, Chelala C ( 2022 ) . Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer . BMC Cancer vol. 22 , ( 1 )
Gadaleta E, Thorn GJ, Ross-Adams H, Jones LJ, Chelala C ( 2022 ) . Field cancerization in breast cancer . Journal of Pathology vol. 257 , ( 4 ) 561 - 574 .
Sivapalan L, Kocher HM, Ross-Adams H, Chelala C ( 2021 ) . Molecular profiling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application . Pancreatology vol. 21 , ( 2 ) 363 - 378 .
Sivapalan L, Thorn G, Gadaleta E, Kocher H, Ross-Adams H, Chelala C ( 2021 ) . Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer .
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al. ( 2021 ) . The transcriptomic landscape of prostate cancer development and progression: An integrative analysis . Cancers vol. 13 , ( 2 ) 1 - 24 .
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . NPJ Breast Cancer vol. 6 , ( 1 )
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Lalonde E, Alkallas R, Chua MLK, Fraser M, Haider S, Meng A, Zheng J, Yao CQ et al. ( 2017 ) . Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors . European Urology vol. 72 , ( 1 ) 22 - 31 .
Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R et al. ( 2017 ) . Corrigendum to "Integration of Copy Number and Transcriptomics Provides Risk Stratification in Prostate Cancer: A Discovery and Validation Cohort Study" [EBioMedicine 2 (9) (2015) 1133-1144] . EBioMedicine vol. 17 , 238 - 238 .
Luca B-A, Brewer DS, Edwards DR, Edwards S, Whitaker HC, Merson S, Dennis N, Cooper RA et al. ( 2017 ) . DESNT: A Poor Prognosis Category of Human Prostate Cancer . European urology focus
Dunning MJ, Vowler SL, Lalonde E, Ross-Adams H, Boutros P, Mills IG, Lynch AG, Lamb AD ( 2017 ) . Mining Human Prostate Cancer Datasets: The "camcAPP" Shiny App . EBioMedicine vol. 17 , 5 - 6 .
Ross-Adams H, Ball S, Lawrenson K, Halim S, Russell R, Wells C, Strand SH, Ørntoft TF et al. ( 2016 ) . HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer . Oncotarget vol. 7 , ( 46 ) 74734 - 74746 .
Shaw GL, Whitaker H, Corcoran M, Dunning MJ, Luxton H, Kay J, Massie CE, Miller JL et al. ( 2016 ) . The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer . European Urology vol. 70 , ( 2 ) 214 - 218 .
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z et al. ( 2016 ) . A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population . Oncotarget vol. 7 , ( 16 ) 21393 - 21403 .
Whitington T, Gao P, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D et al. ( 2016 ) . Gene regulatory mechanisms underpinning prostate cancer susceptibility . Nature Genetics vol. 48 , ( 4 ) 387 - 397 .
Ross-Adams H, Lamb AD ( 2016 ) . The genetic classification of prostate cancer: What's on the horizon? . Future Oncology vol. 12 , ( 6 ) 729 - 733 .
Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R et al. ( 2015 ) . Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study . EBioMedicine vol. 2 , ( 9 ) 1133 - 1144 .
Massie CE, Spiteri I, Ross-Adams H, Luxton H, Kay J, Whitaker HC, Dunning MJ, Lamb AD et al. ( 2015 ) . HES5 silencing is an early and recurrent change in prostate tumourigenesis . Endocrine-Related Cancer vol. 22 , ( 2 ) 131 - 144 .
Bon H, Wadhwa K, Schreiner A, Osborne M, Carroll T, Ramos-Montoya A, Ross-Adams H, Visser M et al. ( 2015 ) . Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer . Molecular Cancer Research vol. 13 , ( 4 ) 620 - 635 .
Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning M, Lamb AD et al. ( 2014 ) . Heterogeneity analyses using genomics and the tumour microenvironment to predict prostate cancer recurrence . GENOME . vol. 57 , 380 - 380 .
Ramos-Montoya A, Lamb AD, Russell R, Carroll T, Jurmeister S, Galeano-Dalmau N, Massie CE, Boren J et al. ( 2014 ) . HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network . EMBO Molecular Medicine vol. 6 , ( 5 ) 651 - 661 .
Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Halim S et al. ( 2014 ) . Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: A retrospective cohort study . The Lancet Oncology vol. 15 , ( 13 ) 1521 - 1532 .
Kote-Jarai Z, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Dadaev T, Jugurnauth-Little S, Ross-Adams H, Olama AAA et al. ( 2013 ) . Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression . Human Molecular Genetics vol. 22 , ( 20 ) 4239 - 4239 .
Kote-Jarai Z, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Dadaev T, Jugurnauth-Little S, Ross-Adams H, Al Olama AA et al. ( 2013 ) . Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression . Hum Mol Genet vol. 22 , ( 12 ) 2520 - 2528 .
Lamb ADG, Sharma NL, Russell R, Ramos-Montoya A, Ross-Adams H, Whittaker H, Shaw G, Wadhwa K et al. ( 2013 ) . Towards derivation of a distinct signature permitting personalised treatment in prostate cancer . BRITISH JOURNAL OF SURGERY . vol. 100 , 68 - 68 .
Kote-Jarai Z, Saunders E, Leongamornlert D, Tymrakiewicz M, Dadaev T, Jugurnauth S, Benlloch S, Amin Al Olama A et al. ( 2013 ) . Abstract 2546: Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression . Cancer Research . vol. 73 , 2546 - 2546 .
Kote-Jarai Z, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Dadaev T, Jugurn-Little S, Ross-Adams H, Al Olama AA et al. ( 2013 ) . Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression . Human Molecular Genetics vol. 22 , ( 12 ) 2520 - 2528 .
Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM, Yamada H, Sooriakumaran P, Robinson BD et al. ( 2012 ) . Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis . Proceedings of the National Academy of Sciences of the United States of America vol. 109 , ( 28 ) 11252 - 11257 .
Lamb AD, Sharma NL, Russell R, Ramos-Montoya A, Whittaker H, Ross-Adams H, Shaw G, Wadhwa K et al. ( 2012 ) . Towards derivation of a distinct signature permitting personalised treatment in prostate cancer . BJU INTERNATIONAL . vol. 109 , 27 - 27 .
Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, Jackson CA, Traylor M et al. ( 2012 ) . Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke . Nature Genetics vol. 44 , ( 3 ) 328 - 333 .
Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Eeles R, Neal DE ( 2011 ) . The RS10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine . BRITISH JOURNAL OF SURGERY . vol. 98 , 16 - 16 .
Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Burge J, George A, Bancroft E, Jhavar S et al. ( 2010 ) . The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine . PLoS ONE vol. 5 , ( 10 )
Dichgans M, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E et al. ( 2009 ) . Sequence Variants on Chromosome 9p21 Confer Risk of Large Vessel Stroke . STROKE . vol. 40 , E109 - E109 .
Ross-Adams H, Pasdar A, Mayer C-D, Macleod MJ ( 2009 ) . Validation of MAP2K6 as a Novel Stroke Candidate Gene . STROKE . vol. 40 , E179 - E179 .
Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E et al. ( 2009 ) . Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke . Annals of Neurology vol. 65 , ( 5 ) 531 - 539 .
Ross-Adams H, Pasdar A, Mayer C-D, Macleod MJ ( 2008 ) . Validation of stroke candidate genes identified with DNA pools and SNP chips . STROKE . vol. 39 , 630 - 631 .
Pasdar A, Ross-Adams H, Cumming A, Cheung J, Whalley L, St Clair D, MacLeod MJ ( 2006 ) . Paraoxonase gene polymorphisms and haplotype analysis in a stroke population . BMC Medical Genetics vol. 7 ,
Ross-Adams H, Cumming A, St Clair D, Doney A, Macleod MJ ( 2006 ) . An association between PPP1R3 and ischemic stroke in a Scottish population . STROKE . vol. 37 , 718 - 718 .