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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Meng-Lay Lin

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Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G et al. ( 2022 ) . Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus . Gastroenterology vol. 162 , ( 4 ) 1197 - 1209.e13 .
Passman A, Haughey M, Carlotti E, Williams M, Cereser B, Lin M, Devkumar S, Gabrield J et al. ( 2021 ) . Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium .
Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM et al. ( 2017 ) . The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1 . Oncotarget vol. 8 , ( 13 ) 21609 - 21625 .
Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos-Garcia L, Lai C-F, Metodieva G, de Giorgio A et al. ( 2016 ) . Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer . Oncogene Article August , 1 - 11 .
Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW et al. ( 2016 ) . LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner . Nucleic Acids Research vol. 44 , Article 2 , 582 - 594 .
Lin M-L, Patel H, Remenyi J, Banerji CRS, Lai C-F, Periyasamy M, Lombardo Y, Busonero C et al. ( 2015 ) . Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer . Oncotarget vol. 6 , Article 25 ,
Pavlopoulos GA, Kumar P, Sifrim A, Sakai R, Lin ML, Voet T, Moreau Y, Aerts J ( 2013 ) . Meander: Visually exploring the structural variome using space-filling curves . Nucleic Acids Research vol. 41 , Article 11 ,
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin ML, Esteki MZ, Van Der Aa N et al. ( 2013 ) . Single-cell paired-end genome sequencing reveals structural variation per cell cycle . Nucleic Acids Research vol. 41 , Article 12 , 6119 - 6138 .
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al. ( 2011 ) . Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma . Nature vol. 469 , ( 7331 ) 539 - 542 .
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al. ( 2011 ) . Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma . nature vol. 186 , Article 3 , 1150 - 1150 .
Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW et al. ( 2011 ) . Massive genomic rearrangement acquired in a single catastrophic event during cancer development . Cell vol. 144 , Article 1 , 27 - 40 .
Pleasance ED, Stephens PJ, O Meara S, McBride DJ, Meynert A, Jones D, Lin M-L, Beare D et al. ( 2010 ) . A small-cell lung cancer genome with complex signatures of tobacco exposure . Nature vol. 463 , Article 7278 , 184 - 190 .
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S et al. ( 2010 ) . Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes . Nature vol. 463 , Article 7279 , 360 - 3 .
Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C et al. ( 2010 ) . The patterns and dynamics of genomic instability in metastatic pancreatic cancer . Nature vol. 467 , Article 7319 , 1 - 5 .
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, Greenman CD, Varela I, Lin M-L et al. ( 2009 ) . A comprehensive catalogue of somatic mutations from a human cancer genome . Nature vol. 463 , Article 7278 , 191 - 196 .
Kim JW, Akiyama M, Park JH, Lin ML, Shimo A, Ueki T, Daigo Y, Tsunoda T et al. ( 2009 ) . Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer . Cancer Science vol. 100 , Article 8 , 1468 - 1478 .
Stephens PJ, McBride DJ, Lin M-L, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C et al. ( 2009 ) . Complex landscapes of somatic rearrangement in human breast cancer genomes . Nature vol. 462 , Article 7276 , 1005 - 10 .
Lin ML, Fukukawa C, Park JH, Naito K, Kijima K, Shimo A, Ajiro M, Nishidate T et al. ( 2009 ) . Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis . Cancer Science vol. 100 , Article 8 , 1443 - 1450 .
Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T et al. ( 2009 ) . Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells . International Journal of Oncology vol. 35 , Article 4 , 673 - 681 .
van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C et al. ( 2009 ) . Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer . Nature genetics vol. 41 , Article 5 , 521 - 3 .
Ueki T, Nishidate T, Park JH, Lin ML, Shimo A, Hirata K, Nakamura Y, Katagiri T ( 2008 ) . Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells . Oncogene vol. 27 , Article 43 , 5672 - 5683 .
Shimo A, Tanikawa C, Nishidate T, Lin ML, Matsuda K, Park JH, Ueki T, Ohta T et al. ( 2008 ) . Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis . Cancer Science vol. 99 , Article 1 , 62 - 70 .
Lin M-L, Park J-H, Nishidate T, Nakamura Y, Katagiri T ( 2007 ) . Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family . Breast cancer research : BCR vol. 9 , Article 1 , R17 - R17 .
Park JH, Lin ML, Nishidate T, Nakamura Y, Katagiri T ( 2006 ) . PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer . Cancer Research vol. 66 , Article 18 , 9186 - 9195 .
Nishidate T, Katagiri T, Lin ML, Mano Y, Miki Y, Kasumi F, Yoshimoto M, Tsunoda T et al. ( 2004 ) . Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis . International journal of oncology vol. 25 , Article 4 , 797 - 819 .
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