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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Meng-Lay Lin

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López-Gil JC, García-Silva S, Ruiz-Cañas L, Navarro D, Palencia-Campos A, Giráldez-Trujillo A, Earl J, Dorado J et al. ( 2024 ) . The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells . Gut vol. 73 , ( 9 ) 1489 - 1508 .
Lin M-L, Hickey JW, Passman AM, Carlotti E, Derwa YH, Devkumar S, Gascard PD, Schürch CM et al. ( 2024 ) . Su1246 USING MASSIVE MULTIPLEX IMMUNOFLUORESENCE (CODEX) TO DEFINE THE INTRAEPITHELIAL IMMUNE CELL MICROENVIRONMENT IN BARRETT'S ESOPHAGUS IN PATIENTS THAT HAVE PROGRESSED TO CANCER . Gastroenterology vol. 166 , ( 5 ) s - 707 .
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT et al. ( 2024 ) . A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer . Advanced Healthcare Materials vol. 13 , ( 17 )
Lin M-L, Hickey JW, Schürch CM, Passman AM, Carlotti E, Devkumar S, Hackett RJ, Rodriguez-Justo M et al. ( 2023 ) . 223 IMMUNE CELL PHENOTYPING IN BARRETT'S ESOPHAGUS IN PATIENTS PRIOR AND AT TIME OF PROGRESSION . Gastroenterology vol. 164 , ( 6 ) s - 41 .
Hackett RJ, Carlotti E, Passman AM, Devkumar S, Lin M-L, Mossner M, Whiting F, Chin-Aleong J et al. ( 2023 ) . 225 MITOTIC AGE OF NON-DYSPLASTIC BARRETT'S ESOPHAGUS DEFINES RISK OF PROGRESSION TO ESOPHAGEAL ADENOCARCINOMA USING A NOVEL TARGETED ALLELE SPECIFIC METHYLATION SEQUENCING ARRAY . Gastroenterology vol. 164 , ( 6 ) s - 42 .
Passman AM, Carlotti E, Lin M-L, Devkumar S, Hackett RJ, McLean M, Underwood T, Chin-Aleong J et al. ( 2023 ) . Tu1269 DEEP GLAND PHENOTYPING IN BARRETT'S ESOPHAGUS GLANDS REVEALS POTENTIAL BIOMARKERS OF CANCER RISK . Gastroenterology vol. 164 , ( 6 ) s - 1011 .
Carlotti E, Passman AM, Lin M-L, Devkumar S, Hackett RJ, McLean M, Aleong J-AC, Underwood T et al. ( 2023 ) . Tu1280 GLAND PHENOTYPIC DIVERSITY OVER TIME AND SPACE AS A PREDICTOR OF PROGRESSION TO DYSPLASIA IN BARRETT'S ESOPHAGUS . Gastroenterology vol. 164 , ( 6 ) s - 1018 .
Passman AM, Haughey MJ, Carlotti E, Williams MJ, Cereser B, Lin M-L, Devkumar S, Gabriel JP et al. ( 2023 ) . Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver . Journal of Hepatology vol. 79 , ( 2 ) 417 - 432 .
Lin M-L, Hickey JW, Schürch CM, Carlotti E, Passman AM, Hackett RJ, Devkumar S, Evans JA et al. ( 2022 ) . Tu1165: THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS . Gastroenterology vol. 162 , ( 7 ) s - 332 .
Evans JA, Carlotti E, Lin M-L, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G et al. ( 2021 ) . Clonal Transitions and Phenotypic Evolution in Barrett’s Esophagus . Gastroenterology vol. 162 , ( 4 ) 1197 - 1209.e13 .
Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin M-L, Singh P, Raguz S, Ali S et al. ( 2018 ) . Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer . Breast Cancer Research and Treatment vol. 167 , ( 2 ) 605 - 606 .
Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin M-L, Singh P, Raguz S, Ali S et al. ( 2017 ) . Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer . Breast Cancer Research and Treatment vol. 163 , ( 3 ) 461 - 474 .
Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin M-L, Begum J, Baker A-M et al. ( 2017 ) . The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1 . Oncotarget vol. 5 , ( 0 ) 21609 - 21625 .
Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos-Garcia L, Lai C-F, Metodieva G, de Giorgio A et al. ( 2016 ) . Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer . Oncogene Article August , 1 - 11 .
Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW et al. ( 2016 ) . LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner . Nucleic Acids Research vol. 44 , Article 2 , 582 - 594 .
Lin M-L, Patel H, Remenyi J, Banerji CRS, Lai C-F, Periyasamy M, Lombardo Y, Busonero C et al. ( 2015 ) . Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer . Oncotarget vol. 6 , Article 25 ,
Pavlopoulos GA, Kumar P, Sifrim A, Sakai R, Lin ML, Voet T, Moreau Y, Aerts J ( 2013 ) . Meander: Visually exploring the structural variome using space-filling curves . Nucleic Acids Research vol. 41 , Article 11 ,
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin ML, Esteki MZ, Van Der Aa N et al. ( 2013 ) . Single-cell paired-end genome sequencing reveals structural variation per cell cycle . Nucleic Acids Research vol. 41 , Article 12 , 6119 - 6138 .
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al. ( 2011 ) . Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma . Nature vol. 469 , ( 7331 ) 539 - 542 .
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al. ( 2011 ) . Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma . nature vol. 186 , Article 3 , 1150 - 1150 .
Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW et al. ( 2011 ) . Massive genomic rearrangement acquired in a single catastrophic event during cancer development . Cell vol. 144 , Article 1 , 27 - 40 .
Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C et al. ( 2010 ) . The patterns and dynamics of genomic instability in metastatic pancreatic cancer . Nature vol. 467 , ( 7319 ) 1109 - 1113 .
Pleasance ED, Stephens PJ, O Meara S, McBride DJ, Meynert A, Jones D, Lin M-L, Beare D et al. ( 2010 ) . A small-cell lung cancer genome with complex signatures of tobacco exposure . Nature vol. 463 , Article 7278 , 184 - 190 .
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S et al. ( 2010 ) . Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes . Nature vol. 463 , Article 7279 , 360 - 3 .
Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C et al. ( 2010 ) . The patterns and dynamics of genomic instability in metastatic pancreatic cancer . Nature vol. 467 , Article 7319 , 1 - 5 .
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, Greenman CD, Varela I, Lin M-L et al. ( 2009 ) . A comprehensive catalogue of somatic mutations from a human cancer genome . Nature vol. 463 , Article 7278 , 191 - 196 .
Kim JW, Akiyama M, Park JH, Lin ML, Shimo A, Ueki T, Daigo Y, Tsunoda T et al. ( 2009 ) . Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer . Cancer Science vol. 100 , Article 8 , 1468 - 1478 .
Stephens PJ, McBride DJ, Lin M-L, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C et al. ( 2009 ) . Complex landscapes of somatic rearrangement in human breast cancer genomes . Nature vol. 462 , Article 7276 , 1005 - 10 .
Lin ML, Fukukawa C, Park JH, Naito K, Kijima K, Shimo A, Ajiro M, Nishidate T et al. ( 2009 ) . Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis . Cancer Science vol. 100 , Article 8 , 1443 - 1450 .
Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T et al. ( 2009 ) . Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells . International Journal of Oncology vol. 35 , Article 4 , 673 - 681 .
van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C et al. ( 2009 ) . Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer . Nature genetics vol. 41 , Article 5 , 521 - 3 .
Ueki T, Nishidate T, Park JH, Lin ML, Shimo A, Hirata K, Nakamura Y, Katagiri T ( 2008 ) . Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells . Oncogene vol. 27 , Article 43 , 5672 - 5683 .
Shimo A, Tanikawa C, Nishidate T, Lin ML, Matsuda K, Park JH, Ueki T, Ohta T et al. ( 2008 ) . Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis . Cancer Science vol. 99 , Article 1 , 62 - 70 .
Shimo A, Tanikawa C, Nishidate T, Lin M-L, Matsuda K, Park J-H, Ueki T, Ohta T et al. ( 2007 ) . Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis . Cancer Science vol. 0 , ( 0 ) 071113200227002 - ??? .
Lin M-L, Park J-H, Nishidate T, Nakamura Y, Katagiri T ( 2007 ) . Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family . Breast cancer research : BCR vol. 9 , Article 1 , R17 - R17 .
Park JH, Lin ML, Nishidate T, Nakamura Y, Katagiri T ( 2006 ) . PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer . Cancer Research vol. 66 , Article 18 , 9186 - 9195 .
Nishidate T, Katagiri T, Lin ML, Mano Y, Miki Y, Kasumi F, Yoshimoto M, Tsunoda T et al. ( 2004 ) . Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis . International journal of oncology vol. 25 , Article 4 , 797 - 819 .
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