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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Marilena Crescente

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Sahli KA, Flora GD, Sasikumar P, Maghrabi AH, Holbrook L-M, AlOuda SK, Elgheznawy A, Sage T et al. ( 2021 ) . Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets . Blood vol. 137 , ( 6 ) 830 - 843 .
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R et al. ( 2020 ) . Cyclooxygenases and the cardiovascular system . Pharmacology & Therapeutics vol. 217 ,
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al. ( 2020 ) . Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin . The FASEB Journal
Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A et al. ( 2020 ) . Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy . Journal of Thrombosis and Haemostasis
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL et al. ( 2020 ) . Identification of a homozygous recessive variant in <i>PTGS1</i> resulting in a congenital aspirin-like defect in platelet function . Haematologica vol. 106 , ( 5 ) 1423 - 1432 .
Flora GD, Sahli KA, Sasikumar P, Holbrook L-M, Stainer AR, AlOuda SK, Crescente M, Sage T et al. ( 2019 ) . Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis . Scientific Reports vol. 9 , ( 1 )
Izzi B, Gianfagna F, Yang W-Y, Cludts K, De Curtis A, Verhamme P, Di Castelnuovo A, Cerletti C et al. ( 2019 ) . Variation of PEAR1 DNA methylation influences platelet and leukocyte function . Clinical Epigenetics vol. 11 , ( 1 )
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al. ( 2019 ) . Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox . Circulation Research vol. 125 , ( 9 ) 847 - 854 .
Noro F, Gianfagna F, Gialluisi A, De Curtis A, Di Castelnuovo A, Napoleone E, Cerletti C, Donati MB et al. ( 2019 ) . ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort . Clinical Epigenetics vol. 11 , ( 1 )
Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD ( 2018 ) . Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond) . British Journal of Pharmacology vol. 176 , ( 8 ) 988 - 999 .
Crescente M, Di Castelnuovo A, Iacoviello L, de Gaetano G, Cerletti C ( 2017 ) . Rebuttal to "Aspirin response variability assessed with the PFA-100 device" by Reny et al . Thrombosis and Haemostasis vol. 99 , ( 05 ) 969 - 969 .
Crescente M, Di Castelnuovo A, Iacoviello L, de Gaetano G, Cerletti C ( 2017 ) . PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3,003 patients . Thrombosis and Haemostasis vol. 99 , ( 06 ) 1129 - 1131 .
Crescente M, Cerletti C, de Gaetano G ( 2017 ) . Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: Preliminary in-vitro findings . Thrombosis and Haemostasis vol. 97 , ( 06 ) 1054 - 1056 .
Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD ( 2017 ) . ADAMTS13 exerts a thrombolytic effect in microcirculation . Thrombosis and Haemostasis vol. 108 , ( 03 ) 527 - 532 .
Crescente M, Di Castelnuovo A, Iacoviello L, Vermylen J, Cerletti C, de Gaetano G ( 2017 ) . Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100 . Thrombosis and Haemostasis vol. 99 , ( 01 ) 14 - 26 .
Crescente M, Jessen G, Momi S, Höltje H-D, Gresele P, Cerletti C, de Gaetano G ( 2017 ) . Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level Functional and modelling studies . Thrombosis and Haemostasis vol. 102 , ( 02 ) 336 - 346 .
Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M et al. ( 2017 ) . Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets . Arterioscler Thromb Vasc Biol vol. 37 , ( 8 ) 1482 - 1493 .
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al. ( 2017 ) . PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM . HEART . Conference: BCS Annual Conference, ‘Cardiology at the Extremes' vol. 103 , A108 - A109 .
Unsworth AJ, Flora GD, Sasikumar P, Bye AP, Sage T, Kriek N, Crescente M, Gibbins JM ( 2017 ) . RXR Ligands Negatively Regulate Thrombosis and Hemostasis . Arterioscler Thromb Vasc Biol vol. 37 , ( 5 ) 812 - 822 .
Fantacuzzi M, Giampietro L, Crescente M ( 2016 ) . Synthetic Approach to Phenylalanine-Proline, and Tyrosine-Proline Hybrid Amino Acids . Current Bioactive Compounds vol. 12 , ( 3 ) 168 - 181 .
Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S et al. ( 2016 ) . Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases . Arteriosclerosis Thrombosis and Vascular Biology vol. 36 , ( 6 ) 1164 - 1173 .
Vaiyapuri S, Roweth H, Ali MS, Unsworth AJ, Stainer AR, Flora GD, Crescente M, Jones CI et al. ( 2015 ) . Pharmacological actions of nobiletin in the modulation of platelet function . British Journal of Pharmacology vol. 172 , ( 16 ) 4133 - 4145 .
Crescente M, Pluthero FG, Schenk MP, Li L, Lo RW, Ali MS, Vaiyapuri S, Holbrook L-M et al. ( 2015 ) . Biogenesis, subcellular localization and mobilization of two abundant platelet thiol isomerases . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 445 - 445 .
Crescente M, Pluthero F, Schenk M, Ali, Kahr W, Gibbins J ( 2014 ) . PDI AND ERP57 CO-CLUSTER IN PLATELETS AND THEIR MOVEMENT IS REGULATED BY ACTIN POLYMERIZATION . Heart . vol. 100 , a15 - a15 .
Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S et al. ( 2012 ) . Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels . Science vol. 337 , ( 6095 ) 738 - 742 .
Gianfagna F, Tamburrelli C, Vohnout B, Crescente M, Izzi B, Pampuch A, De Curtis A, Di Castelnuovo A et al. ( 2012 ) . Heritability, genetic correlation and linkage to the 9p21.3 region of mixed platelet–leukocyte conjugates in families with and without early myocardial infarction . Nutrition Metabolism and Cardiovascular Diseases vol. 23 , ( 7 ) 684 - 692 .
Giordano L, Coletta W, Tamburrelli C, D’Imperio M, Crescente M, Silvestri C, Rapisarda P, Reforgiato Recupero G et al. ( 2011 ) . Four-week ingestion of blood orange juice results in measurable anthocyanin urinary levels but does not affect cellular markers related to cardiovascular risk: a randomized cross-over study in healthy volunteers . European Journal of Nutrition vol. 51 , ( 5 ) 541 - 548 .
Della Corte A, Tamburrelli C, Crescente M, Giordano L, D’Imperio M, Di Michele M, Donati MB, De Gaetano G et al. ( 2011 ) . Platelet proteome in healthy volunteers who smoke . Platelets vol. 23 , ( 2 ) 91 - 105 .
Tamburrelli C, Crescente M, Izzi B, Barisciano M, Donati MB, de Gaetano G, Cerletti C ( 2011 ) . Epoprostenol inhibits human platelet-leukocyte mixed conjugate and platelet microparticle formation in whole blood . Thrombosis Research vol. 128 , ( 5 ) 446 - 451 .
Krishnan S, Gaspari M, Della Corte A, Bianchi P, Crescente M, Cerletti C, Torella D, Indolfi C et al. ( 2011 ) . OFFgel‐based multidimensional LC‐MS/MS approach to the cataloguing of the human platelet proteome for an interactomic profile . Electrophoresis vol. 32 , ( 6‐7 ) 686 - 695 .
Crescente M, Mezzasoma AM, Del Pinto M, Palmerini F, Di Castelnuovo A, Cerletti C, De Gaetano G, Gresele P ( 2011 ) . Incomplete inhibition of platelet function as assessed by the platelet function analyzer (PFA-100) identifies a subset of cardiovascular patients with high residual platelet response while on aspirin . Platelets vol. 22 , ( 3 ) 179 - 187 .
Gianfagna F, Tamburrelli C, Vonhout B, Crescente M, Izzi B, Pampuch A, De Curtis A, Di Castelnuovo A et al. ( 2011 ) . Heritability of platelet-leukocyte conjugates and cell activation markers in families with and without juvenile myocardial infarction . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 798 - 798 .
de Gaetano G, Crescente M, Cerletti C ( 2009 ) . Current concepts about inhibition of platelet aggregation . Platelets vol. 19 , ( 8 ) 565 - 570 .
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