Publications: Dr Livia Araujo de Carvalho

Souza-Teodoro LH, Andrade LHSG, Carvalho LA ( 2022 ) . Could dehydroepiandrosterone (DHEA) be a novel target for depression? . Journal of Affective Disorders Reports vol. 8 ,

Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB et al. ( 2021 ) . Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort (Molecular Psychiatry, (2020), 25, 7, (1477-1486), 10.1038/s41380-019-0395-3) . Molecular Psychiatry vol. 26 , ( 7 ) 3659 - 3661 .

Hanns L, Radziszewska A, Suffield L, Josephs F, Chaplin H, Peckham H, Sen D, Christie D et al. ( 2020 ) . Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis . Arthritis Care and Research vol. 72 , ( 9 ) 1266 - 1274 .

Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB et al. ( 2020 ) . Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort . Molecular Psychiatry vol. 25 , ( 7 ) 1477 - 1486 .

Wittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B et al. ( 2020 ) . Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders . Molecular Psychiatry vol. 25 , ( 6 ) 1275 - 1285 .

Liljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE, Carvalho LA ( 2020 ) . Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 Years . Journal of Aging and Health vol. 32 , ( 5-6 ) 243 - 251 .

Sforzini L, Pariante CM, Palacios JE, Tylee A, Carvalho LA, Viganò CA, Nikkheslat N ( 2019 ) . Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary study . Brain, Behavior, and Immunity vol. 81 , 659 - 664 .

Lawes S, Demakakos P, Steptoe A, Lewis G, Carvalho LA ( 2019 ) . Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: Evidence for differential effects by gender in the English Longitudinal Study of Ageing . Psychological Medicine vol. 49 , ( 9 ) 1521 - 1531 .

Weston G, Zilanawala A, Webb E, Carvalho LA, McMunn A ( 2019 ) . Long work hours, weekend working and depressive symptoms in men and women: Findings from a UK population-based study . Journal of Epidemiology and Community Health vol. 73 , ( 5 ) 465 - 474 .

Carvalho KMB, Ronca DB, Michels N, Huybrechts I, Cuenca-Garcia M, Marcos A, Molnár D, Dallongeville J et al. ( 2018 ) . Does the mediterranean diet protect against stress-induced inflammatory activation in European adolescents? The HELENA study . Nutrients vol. 10 , ( 11 )

RONALDSON AL, Carvalho LA, Kostich K, Lazzarino AI, Steptoe A ( 2018 ) . The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers . Psychopharmacology vol. 235 , ( 12 ) 3415 - 3422 .

Hanns L, Cordingley L, Galloway J, Norton S, Carvalho LA, Christie D, Sen D, Carrasco R et al. ( 2018 ) . Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study . Rheumatology (United Kingdom) vol. 57 , ( 8 ) 1381 - 1389 .

Michels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K, Carvalho LA ( 2018 ) . Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts . Psychoneuroendocrinology vol. 94 , 104 - 111 .

Steptoe A, Ronaldson A, Kostich K, Lazzarino AI, Urbanova L, Carvalho LA ( 2018 ) . The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress . Brain, Behavior, and Immunity vol. 70 , 369 - 375 .

Leday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC et al. ( 2018 ) . Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder . Biological Psychiatry vol. 83 , ( 1 ) 70 - 80 .

Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE, Walters KR ( 2017 ) . Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: Findings from a 4-year follow-up study . Journal of Epidemiology and Community Health vol. 71 , ( 11 ) 1053 - 1058 .

Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE, Walters K ( 2017 ) . Self-Reported Hearing Impairment and Incident Frailty in English Community-Dwelling Older Adults: A 4-Year Follow-Up Study . Journal of the American Geriatrics Society vol. 65 , ( 5 ) 958 - 965 .

Nikkheslat N, Zunszain PA, Carvalho LA, Anacker C, Pariante CM ( 2017 ) . Antidepressant Actions on Glucocorticoid Receptors . Stress: Neuroendocrinology and Neurobiology , vol. 2 ,

Bell JA, Kivimäki M, Bullmore ET, Steptoe A, Carvalho LA, Vértes PE, Cardinal R, Richardson S et al. ( 2017 ) . Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults . Translational Psychiatry vol. 7 , 1 - 8 .

Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al. ( 2016 ) . Hearing impairment and incident disability and all-cause mortality in older British community-dwelling men . Age and Ageing vol. 45 , ( 5 ) 661 - 666 .

Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al. ( 2016 ) . Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: A cross-sectional study . Journal of Public Health (United Kingdom) vol. 38 , ( 2 ) e21 - e28 .

Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA, Bergink V ( 2016 ) . Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy . Psychopharmacology vol. 233 , ( 9 ) 1679 - 1688 .

Ronaldson A, Gazali AM, Zalli A, Kaiser F, Thompson SJ, Henderson B, Steptoe A, Carvalho L ( 2016 ) . Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women . Psychopharmacology vol. 233 , ( 9 ) 1661 - 1668 .

Zalli A, Jovanova O, Hoogendijk WJG, Tiemeier H, Carvalho LA ( 2016 ) . Low-grade inflammation predicts persistence of depressive symptoms . Psychopharmacology vol. 233 , ( 9 ) 1669 - 1678 .

Fancourt D, Williamon A, Carvalho LA, Steptoe A, Dow R, Lewis I ( 2016 ) . Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers . ecancermedicalscience vol. 10 ,

Fancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A, Williamon A ( 2016 ) . Effects of group drumming interventions on anxiety, depression, social resilience and inflammatory immune response among mental health service users . PLoS ONE vol. 11 , ( 3 )

Souza-Teodoro LH, de Oliveira C, Walters K, Carvalho LA ( 2016 ) . Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA) . Psychoneuroendocrinology vol. 64 , 40 - 46 .

Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al. ( 2016 ) . Sensory impairments and cardiovascular disease incidence and mortality in older british community-dwelling men: A 10-year follow-up study . Journal of the American Geriatrics Society vol. 64 , ( 2 ) 442 - 444 .

Fancourt D, Perkins R, Ascenso S, Atkins L, Kilfeather S, Carvalho L, Steptoe A, Williamon A ( 2016 ) . Group Drumming Modulates Cytokine Response in Mental Health Services Users: A Preliminary Study . Psychotherapy and Psychosomatics vol. 85 , ( 1 ) 53 - 55 .

Endrighi R, Hamer M, Hackett RA, Carvalho LA, Jackson SE, Wardle J, Steptoe A ( 2015 ) . Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women . Stress vol. 18 , ( 5 ) 602 - 606 .

Lazzarino AI, Hamer M, Carvalho L, Gaze D, Collinson P, Steptoe A ( 2015 ) . The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease? . Preventive Medicine vol. 77 , 150 - 154 .

Hackett RA, Lazzarino AI, Carvalho LA, Hamer M, Steptoe A ( 2015 ) . Hostility and physiological responses to acute stress in people with type 2 diabetes . Psychosomatic Medicine vol. 77 , ( 4 ) 458 - 466 .

Grosse L, Carvalho LA, Wijkhuijs AJM, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T et al. ( 2015 ) . Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder . Brain, Behavior, and Immunity vol. 44 , 48 - 56 .

Carvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI, Steptoe A ( 2015 ) . Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes . Psychoneuroendocrinology vol. 51 , 209 - 218 .

Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint AM, Schwarz MJ, Tylee AT et al. ( 2015 ) . Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression . Brain, Behavior, and Immunity vol. 48 , 8 - 18 .

Carvalho LA, Gerdes JM, Strell C, Wallace GR, Martins JO ( 2015 ) . Interplay between the endocrine system and immune cells . BioMed Research International vol. 2015 ,

Stepto A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA, Hamer M ( 2014 ) . Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 44 ) 15693 - 15698 .

Rybka J, Kȩdziora-Kornatowska K, Banaś-Lezańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C, Kȩdziora J ( 2014 ) . Erratum: Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression (Free Radical Biology and Medicine (2013) 63C (187-194)) . Free Radical Biology and Medicine vol. 69 ,

Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A ( 2014 ) . Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 12 ) 4519 - 4524 .

Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA ( 2014 ) . Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder . Translational Psychiatry vol. 4 ,

Kidd T, Carvalho LA, Steptoe A ( 2014 ) . The relationship between cortisol responses to laboratory stress and cortisol profiles in daily life . Biological Psychology vol. 99 , ( 1 ) 34 - 40 .

Petros N, Carvalho LA ( 2014 ) . The role of mineralocorticoid receptors in major depressive disorder . Horizons in Neuroscience Research , vol. 15 ,

Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ, Pariante CM ( 2013 ) . Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system . Journal of Affective Disorders vol. 148 , ( 1 ) 136 - 140 .

Rybka J, Kedziora-Kornatowska K, Banaś-Lezańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C, Kedziora J ( 2013 ) . Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression . Free Radical Biology and Medicine vol. 63 , 187 - 194 .

Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L, Steptoe A ( 2012 ) . Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study . PLoS ONE vol. 7 , ( 10 )

Barbosa IG, Rybka J, Svedberg N, Carvalho LA ( 2012 ) . Neuroinflammation and depression . Neuroinflammation: Pathogenesis, Mechanisms and Management ,

Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM, Teixeira AL ( 2012 ) . Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers . Journal of Affective Disorders vol. 137 , ( 1-3 ) 151 - 155 .

Antonioli M, Rybka J, Carvalho LA ( 2012 ) . Neuroimmune endocrine effects of antidepressants . Neuropsychiatric Disease and Treatment vol. 8 , 65 - 83 .

Barbosa IG, Huguet RB, Sousa LP, Abreu MNS, Rocha NP, Bauer ME, Carvalho LA, Teixeira AL ( 2011 ) . Circulating levels of GDNF in bipolar disorder . Neuroscience Letters vol. 502 , ( 2 ) 103 - 106 .

Antonioli M, Rybka J, Carvalho LA ( 2011 ) . Neuroendocrinological effects of antidepressants: Is there a role for melatonin? . Melatonin in the Promotion of Health: Second Edition ,

Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, Wit HD, van Beveren NJM, Birkenhäger TK, Bergink V et al. ( 2011 ) . TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors . Brain, Behavior, and Immunity vol. 25 , ( 6 ) 1162 - 1169 .

Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM ( 2011 ) . Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor . Molecular Psychiatry vol. 16 , ( 7 ) 738 - 750 .

Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM ( 2011 ) . Glucocorticoids, cytokines and brain abnormalities in depression . Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 35 , ( 3 ) 722 - 729 .

Anacker C, Zunszain PA, Carvalho LA, Pariante CM ( 2011 ) . The glucocorticoid receptor: Pivot of depression and of antidepressant treatment? . Psychoneuroendocrinology vol. 36 , ( 3 ) 415 - 425 .

Rybka J, Kupczyk D, Kedziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Antonioli M et al. ( 2011 ) . Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls . Redox Report vol. 16 , ( 2 ) 71 - 77 .

Goljevscek S, Carvalho LA ( 2011 ) . Current management of obsessive and phobic states . Neuropsychiatric Disease and Treatment vol. 7 , ( 1 ) 599 - 610 .

Rybka J, Kupczyk D, Kędziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H et al. ( 2011 ) . Glutathione-related antioxidant defense system in elderly patients treated for hypertension . Cardiovascular Toxicology vol. 11 , ( 1 ) 1 - 9 .

Markus RP, Franco DG, Carvalho LA, Gentil V, Gorenstein C ( 2010 ) . Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement . Journal of Psychopharmacology vol. 24 , ( 6 ) 855 - 860 .

Carvalho LA, Garner BA, Dew T, Fazakerley H, Pariante CM ( 2010 ) . Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms . European Neuropsychopharmacology vol. 20 , ( 6 ) 379 - 387 .

Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Cleare AJ, Pariante CM ( 2009 ) . Reply: 'Clomipramine and Glucocorticoid Receptor Function' . Neuropsychopharmacology vol. 34 , ( 9 ) 2194 - 2195 .

Carvalho LA, Gorenstein C, Moreno R, Pariante C, Markus RP ( 2009 ) . Effect of antidepressants on melatonin metabolite in depressed patients . Journal of Psychopharmacology vol. 23 , ( 3 ) 315 - 321 .

Carvalho LA, Pariante CM ( 2008 ) . In vitro modulation of the glucocorticoid receptor by antidepressants . Stress vol. 11 , ( 6 ) 411 - 424 .

Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Kerwin R, Cleare AJ, Pariante CM ( 2008 ) . Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression . Neuropsychopharmacology vol. 33 , ( 13 ) 3182 - 3189 .

Carvalho LA, Gorenstein C, Moreno RA, Markus RP ( 2006 ) . Melatonin levels in drug-free patients with major depression from the southern hemisphere . Psychoneuroendocrinology vol. 31 , ( 6 ) 761 - 768 .

Reno LAC, Zago W, Markus RP ( 2004 ) . Release of [³H]-L-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices . Neuroscience vol. 124 , ( 3 ) 647 - 653 .

Markus RP, Santos JM, Zago W, Renó LAC ( 2003 ) . Melatonin nocturnal surge modulates nicotinic receptors and nicotine-induced [³H]glutamate release in rat cerebellum slices . Journal of Pharmacology and Experimental Therapeutics vol. 305 , ( 2 ) 525 - 530 .

Carvalho LA, Carmona-Ribeiro AM ( 1998 ) . Interactions between cationic vesicles and serum proteins . Langmuir vol. 14 , ( 21 ) 6077 - 6081 .