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Research

Publications: Dr Louisa James

Hemmings O, Niazi U, Kwok M, James LK, Lack G, Santos AF ( 2021 ) . Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children . J Allergy Clin Immunol
King HW, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA, James LK ( 2021 ) . Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics . Science immunology vol. 6 , ( 56 )
Kariyawasam HH, James LK ( 2021 ) . B cells and upper airway disease: allergic rhinitis and chronic rhinosinusitis with nasal polyps evaluated . Expert Review of Clinical Immunology
Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,
Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O¿Rourke C, Bahnson HT et al. ( 2020 ) . IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE . Allergy: European Journal of Allergy and Clinical Immunology vol. 75 , ( 9 ) 2309 - 2318 .
Herman LS, James LK ( 2020 ) . Moving with the kines: Chemokine receptor expression regulates the migration and differentiation of IgG4-expressing B cells . European Journal of Immunology vol. 50 , ( 8 ) 1109 - 1112 .
Gould HJ, James LK ( 2020 ) . IgG<sup>+</sup> memory B cells: Friends or foes in allergic disease? . Journal of Allergy and Clinical Immunology vol. 146 , ( 1 ) 77 - 79 .
Baker D, Pryce G, James LK, Marta M, Schmierer K ( 2020 ) . The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis . Multiple Sclerosis and Related Disorders Article 102279 , 102279 - 102279 .
James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR et al. ( 2020 ) . Distinct microbial and immune niches of the human colon . Nature Immunology vol. 21 , ( 3 ) 343 - 353 .
Baker D, Pryce G, James LK, Schmierer K, Giovannoni G ( 2020 ) . Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis . European Journal of Neurology vol. 27 , ( 2 ) 221 - 228 .
Kariyawasam HH, James LK ( 2020 ) . Chronic rhinosinusitis with nasal polyps: Targeting ige with anti-ige omalizumab therapy . Drug Design, Development and Therapy vol. 14 , 5483 - 5494 .
Kariyawasam HH, James LK, Gane SB ( 2020 ) . Dupilumab: Clinical efficacy of blocking IL-4/IL-13 signalling in chronic rhinosinusitis with nasal polyps . Drug Design, Development and Therapy vol. 14 , 1757 - 1769 .
Santos AF, James LK, Kwok M, McKendry RT, Anagnostou K, Clark AT, Lack G ( 2020 ) . Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE . Journal of Allergy and Clinical Immunology vol. 145 , ( 1 ) 440 - 443.e5 .
Bucaite G, Kang-Pettinger T, Moreira J, Gould HJ, James LK, Sutton BJ, McDonnell JM ( 2019 ) . Interplay between affinity and valency in effector cell degranulation: A model system with polcalcin allergens and human patient–derived IgE antibodies . Journal of Immunology vol. 203 , ( 7 ) 1693 - 1700 .
Mckendry RT, Kwok M, Hemmings O, James L, Santos AF ( 2019 ) . Basophil and mast cell responses to food allergens in sensitised but tolerant patients are not mediated via the FcgRIIa and FcgRIIb receptors . ALLERGY . vol. 74 , 97 - 97 .
Gould HJ, James LK ( 2019 ) . Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine . Journal of Allergy and Clinical Immunology
Upton NEG, Hayday TS, James LK ( 2019 ) . Isolation and characterization of lymphocytes from human mucosal biopsies . Methods in Molecular Biology , vol. 2020 ,
Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ et al. ( 2018 ) . Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition . Proceedings of the National Academy of Sciences of the United States of America vol. 115 , ( 37 ) E8707 - E8716 .
Dhaliwal B, Pang MOY, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ ( 2017 ) . IgE binds asymmetrically to its B cell receptor CD23 . Scientific Reports vol. 7 ,
Chen J-B, James LK, Davies AM, Wu Y-CB, Rimmer J, Lund VJ, Chen J-H, McDonnell JM et al. ( 2016 ) . Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps . Journal of Allergy and Clinical Immunology vol. 139 , ( 4 ) 1195 - 1204.e11 .
James LK, Till SJ ( 2016 ) . Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions . Current Allergy and Asthma Reports vol. 16 , ( 3 ) 1 - 7 .
Gadermaier E, James LK, Shamji MH, Blatt K, Fauland K, Zieglmayer P, Garmatiuk T, Focke-Tejkl M et al. ( 2016 ) . Epitope specificity determines cross-protection of a SIT-induced IgG<inf>4</inf> antibody . Allergy: European Journal of Allergy and Clinical Immunology vol. 71 , ( 1 ) 36 - 46 .
James LK ( 2016 ) . The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy . Current Allergy and Asthma Reports vol. 16 , ( 2 ) 1 - 9 .
Steveling EH, Lao-Araya M, Koulias C, Scadding G, Eifan A, James LK, Dumitru A, Penagos M et al. ( 2015 ) . Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: Time course of nasal, cutaneous and immunological outcomes . Clinical and Translational Allergy vol. 5 , ( 1 )
Santos AF, James LK, Bahnson HT, Shamji MH, Couto-Francisco NC, Islam S, Houghton S, Clark AT et al. ( 2015 ) . IgG<inf>4</inf> inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens . Journal of Allergy and Clinical Immunology vol. 135 , ( 5 ) 1249 - 1256 .
Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ et al. ( 2015 ) . Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class . Allergy: European Journal of Allergy and Clinical Immunology vol. 70 , ( 6 ) 720 - 724 .
Dodev TS, Karagiannis P, Gilbert AE, Josephs DH, Bowen H, James LK, Bax HJ, Beavil R et al. ( 2014 ) . A tool kit for rapid cloning and expression of recombinant antibodies . Scientific Reports vol. 4 ,
Wu YCB, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ ( 2014 ) . Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis . Journal of Allergy and Clinical Immunology vol. 134 , ( 3 ) 604 - 612 .
James LK, Bowen H, Calvert RA, Dodev TS, Shamji MH, Beavil AJ, McDonnell JM, Durham SR et al. ( 2012 ) . Allergen specificity of IgG<inf>4</inf>-expressing B cells in patients with grass pollen allergy undergoing immunotherapy . Journal of Allergy and Clinical Immunology vol. 130 , ( 3 )
Shamji MH, James LK, Durham SR ( 2011 ) . Serum Immunologic Markers for Monitoring Allergen-Specific Immunotherapy . Immunology and Allergy Clinics of North America vol. 31 , ( 2 ) 311 - 323 .
James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I et al. ( 2011 ) . Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies . Journal of Allergy and Clinical Immunology vol. 127 , ( 2 )
James LK, Durham SR ( 2009 ) . Rhinitis with negative skin tests and absent serum allergen-specific IgE: More evidence for local IgE? . Journal of Allergy and Clinical Immunology vol. 124 , ( 5 ) 1012 - 1013 .
Thrower SL, James L, Hall W, Green KM, Arif S, Allen JS, Van-Krinks C, Lozanoska-Ochser B et al. ( 2009 ) . Proinsulin peptide immunotherapy in type 1 diabetes: Report of a first-in-man Phase I safety study . Clinical and Experimental Immunology vol. 155 , ( 2 ) 156 - 165 .
James LK, Durham SR ( 2008 ) . Update on mechanisms of allergen injection immunotherapy . Clinical and Experimental Allergy vol. 38 , ( 7 ) 1074 - 1088 .
Francis JN, James LK, Paraskevopoulos G, Wong C, Calderon MA, Durham SR, Till SJ ( 2008 ) . Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity . Journal of Allergy and Clinical Immunology vol. 121 , ( 5 )
Wiggam S, James L, Arif S, Peakman M, Dayan C ( 2007 ) . Proinsulin peptide administration: A phase 1 study initial report . ACTA DIABETOLOGICA . vol. 44 , S55 - S55 .
Pilette C, Nouri-Aria KT, Jacobson MR, Wilcock LK, Detry B, Walker SM, Francis JN, Durham SR ( 2007 ) . Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-β expression . Journal of Immunology vol. 178 , ( 7 ) 4658 - 4666 .
Senna G, Passalacqua G, Schiappoli M, Lombardi C, Wilcock L ( 2007 ) . Correlation among FEV, nitric oxide and asthma control test in newly diagnosed asthma . Allergy vol. 62 , ( 2 ) 207 - 208 .
Shamji MH, Wilcock LK, Wachholz PA, Dearman RJ, Kimber I, Wurtzen PA, Larché M, Durham SR et al. ( 2006 ) . The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses . Journal of Immunological Methods vol. 317 , ( 1-2 ) 71 - 79 .
Wilcock LK, Francis JN, Paraskevopolous G, Till SJ, Durham SR ( 2006 ) . Induction and maintenance of regulatory humoral responses during grass pollen immunotherapy . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 36 , 1205 - 1205 .
Wilcock LK, Francis JN, Durham SR ( 2006 ) . IgE-Facilitated Antigen Presentation: Role in Allergy and the Influence of Allergen Immunotherapy . Immunology and Allergy Clinics of North America vol. 26 , ( 2 ) 333 - 347 .
Wilcock LK, Francis JN, Paraskavopoulos G, Till SJ, Durham SR ( 2006 ) . Induction of IL-10 Occurs Early and Precedes Serum IgG Blocking Activity During a Cluster Regimen of Grass Pollen Immunotherapy . Journal of Allergy and Clinical Immunology . vol. 117 ,
Shamji MH, Wilcock LK, Larche M, Francis JN, Durham SR ( 2006 ) . Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Efficacy of Immunotherapy . Journal of Allergy and Clinical Immunology . vol. 117 ,
Shamji M, Wilcock L, Larche M, Durham S, Francis J ( 2005 ) . Analytical validation of a novel flow cytometric-based Facilitated Allergen Presentation (FAP) assay as a tool for monitoring allergen-specific immunotherapy . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 35 , 1415 - 1415 .
Francis J, Wilcock L, Puggioni F, Durham S ( 2004 ) . Adjuvants in allergy immunotherapy; comparison of in vitro responses to old and new adjuvants . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 34 , 1810 - 1810 .
Wilcock LK, Francis JN, Durham SR ( 2004 ) . Aluminium hydroxide down-regulates T helper 2 responses by allergen-stimulated human peripheral blood mononuclear cells . Clinical and Experimental Allergy vol. 34 , ( 9 ) 1373 - 1378 .
Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, Wilcock LK, Staple SQ, Aalberse RC et al. ( 2004 ) . Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity . Journal of Immunology vol. 172 , ( 5 ) 3252 - 3259 .