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Research

Publications: Dr Dunja Aksentijevic

McClements L, Richards CI, Patel N, Chen H, Sesperez K, Bubb KJ, Karlstaedt A, Aksentijevic D ( 2023 ) . Impact of reduced uterine perfusion pressure model of preeclampsia on metabolism of placenta, maternal and foetal hearts . Scientific Reports
Hall AR, Karwi QG, Kumar S, Dongworth R, Aksentijević D, Altamimi TR, Fridianto KT, Chinda K et al. ( 2022 ) . Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation . Scientific Reports vol. 12 , ( 1 )
Karatzia L, Aung N, Aksentijevic D ( 2022 ) . Artificial intelligence in cardiology: Hope for the future and power for the present . Frontiers in Cardiovascular Medicine vol. 9 ,
Prag HA, Aksentijevic D, Dannhorn A, Giles AV, Mulvey JF, Sauchanka O, Du L, Bates G et al. ( 2022 ) . Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury . Circulation Research vol. 131 , ( 6 ) 528 - 541 .
Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A et al. ( 2022 ) . Rapid and selective generation of H<inf>2</inf>S within mitochondria protects against cardiac ischemia-reperfusion injury . Redox Biology vol. 55 ,
Patel N, Yaqoob MM, Aksentijevic D ( 2022 ) . Cardiac metabolic remodelling in chronic kidney disease . Nat Rev Nephrol vol. 18 , ( 8 ) 524 - 537 .
McClements L, Aksentijevic D, Garovic V ( 2022 ) . Editorial: New Technologies for Women’s Health . Frontiers in Bioengineering and Biotechnology vol. 10 ,
Coe D, Poobalasingam T, Fu H, Bonacina F, Wang G, Morales V, Moregola A, Mitro N et al. ( 2022 ) . Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells . JCI Insight vol. 7 , ( 10 )
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C et al. ( 2021 ) . Structural basis for a complex I mutation that blocks pathological ROS production . Nature Communications vol. 12 , ( 1 )
Potter JHT, Drinkwater R, Davies KTJ, Nesi N, Lim MCW, Yohe LR, Chi H, Zhang X et al. ( 2021 ) . Nectar-feeding bats and birds show parallel molecular adaptations in sugar metabolism enzymes . Current Biology vol. 31 , ( 20 ) 4667 - 4674.e6 .
Henson SM, Aksentijevic D ( 2021 ) . Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of Old Age? . Frontiers in Pharmacology vol. 12 ,
Aksentijević D, Shattock MJ ( 2021 ) . With a grain of salt: Sodium elevation and metabolic remodelling in heart failure . J Mol Cell Cardiol
Aksentijevic D, Karlstaedt A, Basalay M, O'Brien B, Sanchez-Tatay D, Eminaga S, Thakker A, Tennant D et al. ( 2020 ) . Intracellular sodium elevation reprograms cardiac metabolism . Nature Communications vol. 11 , 4337 - 4337 .
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF et al. ( 2020 ) . Mechanism of succinate efflux upon reperfusion of the ischaemic heart . Cardiovascular Research
Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H et al. ( 2020 ) . Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming . Nature Communications vol. 11 ,
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine
Aksentijevic D, Zervou S, Eykyn TR, McAndrew DJ, Wallis J, Schneider JE, Neubauer S, Lygate CA ( 2020 ) . Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice . Frontiers in Physiology vol. 10 , Article ARTN 1535 ,
Faulkes CG, Eykyn TR, Aksentijevic D ( 2019 ) . Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue . Biology Letters vol. 15 , ( 11 ) 20190710 - 20190710 .
Marelli-Berg FM, Aksentijevic D ( 2019 ) . Immunometabolic cross-talk in the inflamed heart . Cell Stress vol. 3 , ( 8 ) 240 - 266 .
Aksentijevic D, O’Brien BA, Eykyn TR, Shattock MJ ( 2018 ) . Is there a causal link between intracellular na elevation and metabolic remodelling in cardiac hypertrophy? . Biochemical Society Transactions vol. 46 , ( 4 ) 817 - 827 .
Aksentijevic D, Karlstaedt A, Basalay M, O'Brien BA, Thakker A, Tennant D, Fuller W, Taegtmayer H et al. ( 2018 ) . Causal link between intracellular sodium overload and metabolic remodelling in the heart: uncoupling ATP supply and demand? . Presented at: BSCR Autumn Meeting Oxford, UK ,
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Hove MT et al. ( 2017 ) . Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine . Cardiovasc Res
Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC et al. ( 2016 ) . On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury . FASEB J vol. 30 , ( 8 ) 2684 - 2697 .
Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Page LL, Sousa Fialho MDL et al. ( 2016 ) . Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation . Journal of Physiology vol. 594 , ( 2 ) 307 - 320 .
Aksentijević D, Lewis HR, Shattock MJ ( 2015 ) . Is rate-pressure product of any use in the isolated rat heart? Assessing cardiac 'effort' and oxygen consumption in the Langendorff-perfused heart . Exp Physiol vol. 101 , ( 2 ) 282 - 294 .
Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA et al. ( 2015 ) . Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat . Free Radical Biology and Medicine vol. 89 , 883 - 894 .
Eykyn TR, Aksentijević D, Aughton KL, Southworth R, Fuller W, Shattock MJ ( 2015 ) . Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i . J Mol Cell Cardiol vol. 86 , 95 - 101 .
Chouchani EE, Pell V, Gaude E, Aksentijevic D, Sundier S, Duchen M, Shattock M, Frezza C et al. ( 2015 ) . Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS . EUROPEAN JOURNAL OF HEART FAILURE . vol. 17 , 29 - 30 .
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM et al. ( 2014 ) . Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS . Nature vol. 515 , ( 7527 ) 431 - 435 .
Aksentijević D, McAndrew DJ, Karlstädt A, Zervou S, Sebag-Montefiore L, Cross R, Douglas G, Regitz-Zagrosek V et al. ( 2014 ) . Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity . Journal of Molecular and Cellular Cardiology vol. 75 , 76 - 87 .
Aksentijević D, Zervou S, Faller KME, McAndrew DJ, Schneider JE, Neubauer S, Lygate CA ( 2014 ) . Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart . PLoS One vol. 9 , ( 10 ) e109021 - e109021 .
Chouchani E, Pell V, Gaude E, Aksentijevic D, Shattock M, Davidson S, Duchen M, Frezza C et al. ( 2014 ) . P439Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury . Cardiovascular Research . vol. 103 , s81 - s81 .
Pavlovic D, Aksentijevic D, Rumjon A, Newbury L, Fuller W, Seymour AM, Sharpe C, Shattock MJ ( 2014 ) . The role of endogenous cardiotonic steroids in cardiorenal syndrome - Serum cardiotonic steroids contribute to raised intracellular Na and Ca concentrations in the heart . EUROPEAN JOURNAL OF HEART FAILURE . vol. 16 , 211 - 211 .
Aksentijevic D, Medway DJ, Sebag-Montefiore L, Zervou S, Douglas G, Lopaschuk GD, Neubauer S, Lygate CA ( 2014 ) . Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period . Biophysical Journal . vol. 106 ,
pavlovic D, siddiqui S, nagi G, newbury L, fuller W, Seymour A-ML, sharpe C, shattock MJ et al. ( 2014 ) . Pathophysiologically-Relevant Levels of Endogenous Cardiotonic Steroids Inhibit the Cardiac Na/K ATPase and Activate ERK1/2 Hypertrophic Signaling In Vivo and In Vitro . Biophysical Journal . vol. 106 ,
Faller KME, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Schneider JE, Lygate CA, Neubauer S ( 2013 ) . Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart . PLoS One vol. 8 , ( 6 ) e66461 - e66461 .
Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S et al. ( 2013 ) . Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT<sup>-/-</sup> mouse hearts . American Journal of Physiology - Heart and Circulatory Physiology vol. 305 , ( 4 )
Lygate CA, Aksentijevic D, Dawson D, Ten Hove M, Phillips D, De Bono JP, Medway DJ, Sebag-Montefiore L et al. ( 2013 ) . Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice . Circulation Research vol. 112 , ( 6 ) 945 - 955 .
Teh I, Lohezic M, Aksentijevic D, Schneider J ( 2013 ) . Accelerated fast spin echo diffusion spectrum imaging in the mouse heart ex-vivo . Journal of Cardiovascular Magnetic Resonance vol. 15 , ( Suppl 1 )
Kotlyarova S, Mandel M, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S, Vendelin M, Birkedal R ( 2013 ) . Cardiomyocytes from Creatine-Deficient Mice Lacking L-Arginine:Glycine Amidinotransferase (AGAT) Show No Changes in Mitochondrial Organization and Cellular Compartmentation . Biophysical Journal . vol. 104 ,
Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S et al. ( 2013 ) . Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart . Biophysical Journal . vol. 104 , 314a - 315a .
Lygate CA, Bohl S, ten Hove M, Faller KME, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D et al. ( 2012 ) . Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction . Cardiovasc Res vol. 96 , ( 3 ) 466 - 475 .
Lygate CA, Medway DJ, Ostrowski PJ, Aksentijevic D, Sebag-Montefiore L, Hunyor I, Zervou S, Schneider JE et al. ( 2012 ) . Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age . Basic Res Cardiol vol. 107 , ( 5 ) 276 - 276 .
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J et al. ( 2012 ) . Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway . Cell Metabolism vol. 15 , ( 3 ) 361 - 371 .
Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Makinen K, Faller KM, Medway DJ, Sebag-Montefiore L et al. ( 2011 ) . Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging . CIRCULATION . vol. 124 ,
Lygate CA, Bohl S, ten Hove M, Medway DJ, Sebag-Montefiore L, Zervou S, Aksentijevic D, Faller KM et al. ( 2011 ) . Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics . CIRCULATION . vol. 124 ,
Aksentijević D, Lygate CA, Makinen K, Zervou S, Sebag-Montefiore L, Medway D, Barnes H, Schneider JE et al. ( 2010 ) . High-energy phosphotransfer in the failing mouse heart: Role of adenylate kinase and glycolytic enzymes . European Journal of Heart Failure vol. 12 , ( 12 ) 1282 - 1289 .
Pavlovic D, Aksentijevic D, Seymour A-ML, Fuller W, Shattock MJ ( 2010 ) . A Soluble Inhibitor Depresses Na/K ATPase Activity in Cardiomyopathic Hearts from Uremic Rats . CIRCULATION . vol. 122 ,
Zervou S, Aksentijevic D, Lygate C, Neubauer S ( 2010 ) . Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro . CARDIOVASCULAR RESEARCH . vol. 87 , S126 - S126 .
Aksentijevic D, Lygate C, Makinen K, Sebag-Montefiore L, Medway D, Schneider J, Neubauer S ( 2010 ) . High energy phosphotransfer in the failing mouse heart-role of adenylate kinase and glycolytic enzymes . CARDIOVASCULAR RESEARCH . vol. 87 , S115 - S115 .
Smith K, Semple D, Aksentijevic D, Bhandari S, Seymour A-ML ( 2010 ) . Functional and metabolic adaptation in uraemic cardiomyopathy . Front Biosci (Elite Ed) vol. 2 , ( 4 ) 1492 - 1501 .
Aksentijevic D, Lygate C, Makinen K, Sebag-Montefiore L, Medway D, Neubauer S ( 2010 ) . 002 Compensation for impaired myocardial phosphotransfer in guanidinoacetate-N-methyltransferase knockout mice . Heart . vol. 96 ,
Smith K, Semple D, Aksentijevic D, Bhandari S, Seymour AML ( 2010 ) . Functional and metabolic adaptation in uraemic cardiomyopathy . Frontiers in Bioscience - Elite vol. 2 E , ( 4 ) 1492 - 1501 .
Aksentijević D, Bhandari S, Seymour AML ( 2009 ) . Insulin resistance and altered glucose transporter 4 expression in experimental uremia . Kidney International vol. 75 , ( 7 ) 711 - 718 .
Aksentijevic D, Bhandari S, Seymour A-ML ( 2008 ) . Uraemic cardiomyopathy is characterized by altered metabolic substrate transport . CARDIOVASCULAR DRUGS AND THERAPY . vol. 22 , 152 - 153 .
Aksentijević D, Lee KY, Smith K, Bhandari S, Seymour A-ML ( 2007 ) . Altered expression of myocardial [Ca2+] handling proteins in experimental uraemia . Journal of Molecular and Cellular Cardiology . vol. 42 , s139 - s140 .
Aksentijevic D, Bhandari S, Seymour A-ML ( 2007 ) . Myocardial GLUT 4 expression in experimental uraemia . Journal of Molecular and Cellular Cardiology vol. 42 , ( 6 )
Aksentijević D, Bhandari S, Seymour A-ML ( 2007 ) . The effect of increased [Ca2+] on myocardial function and energy provision in experimental uraemia . Journal of Molecular and Cellular Cardiology . vol. 42 ,
Aksentijevic D, Bhandari S, Seymour A-ML ( 2006 ) . Alteration in GLUT 4 expression in experimental uraemia . CARDIOVASCULAR DRUGS AND THERAPY . vol. 20 , 397 - 397 .
Aksentijevic D, Bhandari S, Seymour A-ML ( 2006 ) . The effect of increased calcium on myocardial function in experimental uraemia . CARDIOVASCULAR DRUGS AND THERAPY . vol. 20 , 396 - 396 .
Aksentijević D, Bhandari S, Seymour A-ML ( 2006 ) . The impact of increasing calcium on myocardial function in experimental uraemia . Journal of Molecular and Cellular Cardiology . vol. 40 ,
Aksentijevic D, Bbandari S, Seymour AML ( 2005 ) . Cardiac remodelling in chronic uraemia . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 39 , 191 - 192 .