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Research

Publications: Dr Fiona Lewis

Ruchaya PJ, Lewis-McDougall FC, Sornkarn N, Amin S, Grimsdell B, Shaalan A, Gritti G, Soe KT et al. ( 2022 ) . Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction . Cells vol. 11 , ( 24 )
Smith AJ, Ruchaya P, Walmsley R, Wright KE, Lewis-McDougall FC, Bond J, Ellison-Hughes GM ( 2022 ) . Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells . Scientific Reports vol. 12 , ( 1 )
Suzuki K, Ito T, Lewis F ( 2021 ) . Epicardial Placement of Fibrin Sealant Film-incorporating Human Mesenchymal Stromal Cells for the Treatment of Heart Failure: Towards Clinical Translation and Mechanistic Implication . Molecular Therapy
Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, Yamashita K, Kobayashi K et al. ( 2021 ) . Cell barrier function of resident peritoneal macrophages in post-operative adhesions . Nature Communications vol. 12 , ( 1 )
Podaru MN, Fields L, Kainuma S, Ichihara Y, Hussain M, Lewis F, Ito T, Kazuya K et al. ( 2019 ) . 2419Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy . European Heart Journal . Conference: ESC vol. 40 ,
Podaru MN, Fields L, Kainuma S, Ichihara Y, Hussain M, Lewis F, Ito T, Kazuya K et al. ( 2019 ) . Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy . EUROPEAN HEART JOURNAL . Conference: European Society of Cardiology vol. 40 , 1386 - 1386 .
Podaru M-N, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kazuya K, D'Aquisto F et al. ( 2019 ) . Abstract 718: Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy . Circulation Research . Conference: AHA vol. 125 ,
Podaru M-N, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kazuya K, D'Aquisto F et al. ( 2019 ) . Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy . CIRCULATION RESEARCH . Conference: American Heart Association vol. 125 ,
Suzuki K, Podaru M, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kobayashi K et al. ( 2019 ) . Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy . Basic Research in Cardiology
Kobayashi K, Ichihara Y, Sato N, Umeda N, Fields L, Fukumitsu M, Tago Y, Ito T et al. ( 2019 ) . On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure . Biomaterials vol. 209 , 41 - 53 .
Lewis‐McDougall FC, Ruchaya PJ, Domenjo‐Vila E, Teoh TS, Prata L, Cottle BJ, Clark JE, Punjabi PP et al. ( 2019 ) . Aged‐senescent cells contribute to impaired heart regeneration . Aging Cell vol. 18 , ( 3 )
Kobayashi K, Ichihara Y, Sato N, Umeda N, Fields L, Fukumitsu M, Ito T, Podaru M et al. ( 2018 ) . On-Site, Instant Production of Bi-Layered Bio-Dressing Incorporating Mesenchymal Stromal Cells for the Treatment of Heart Failure . CIRCULATION . Conference: AHA vol. 138 ,
Kobayashi K, Ichihara Y, Tano N, Fields L, Murugesu N, Ito T, Ikebe C, Lewis F et al. ( 2018 ) . Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure . Scientific Reports vol. 8 , ( 1 )
LEWIS F, Cottle BJ, Shone V, Marazzi G, Sassoon D, Tseng CCS, Dankers PYW, Chamuleau SAJ et al. ( 2017 ) . Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells (PICs) Enhance Endogenous Repair of Injured Porcine Skeletal Muscle . JACC: Basic to Translational Science vol. 2 , ( 6 ) 717 - 736 .
Ellison-Hughes GM, Lewis FC ( 2017 ) . Progenitor Cells from the Adult Heart . Cardiac Regeneration , vol. 4 , Springer Nature
LEWIS F, Agley C, Jaka O, Lazarus N, Velloso C, Francis-West P, Ellison-Hughes G, Harridge S ( 2017 ) . Active GSK3β and an intact β-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells . Scientific Reports
LEWIS F, Deva Kumar S, Ellison-Hughes GM ( 2017 ) . Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart . Pharmacological Research vol. 127 , 33 - 40 .
Vicinanza C, Aquila I, Scalise M, Cristiano F, Marino M, Cianflone E, Mancuso T, Marotta P et al. ( 2017 ) . Adult Cardiac Stem Cells are Multipotent and Robustly Myogenic: c-kit Expression is Necessary but not Sufficient for their Identification . Cell Death and Differentiation
Henning BJ, Lewis FC, Shone V, Ellison-Hughes GM ( 2017 ) . Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing and multi-potent in vitro and in vivo . Stem Cell Research and Therapy
Attias J, Bieles J, Carvil P, Laing C, Lewis F, Jaka O, O'Brien K, Ruchaya P ( 2017 ) . Altitude exposure and increased heart rate: the role of the parasympathetic nervous system . The Journal of Physiology vol. 595 , ( 14 ) 4589 - 4590 .
Smith A, Wright K, Lewis F, Ellison G ( 2016 ) . P44 Tyrosine kinase inhibitor cardiotoxicity and cardiac stem cells . Heart vol. 102 , ( Suppl 8 )
Lewis FC, Teoh T, Domenjo-Vila E, Theologou T, Field M, Awad W, Yasin M, Nadal-Ginard B et al. ( 2016 ) . Canonical wnt signaling reverses the 'aged/senescent' human endogenous cardiac stem cell phenotype . CARDIOVASCULAR RESEARCH . Conference: American Heart Association vol. 111 , S92 - S92 .
Smith AJ, Lewis FC, Aquila I, Waring CD, Nocera A, Agosti V, Nadal-Ginard B, Torella D et al. ( 2014 ) . Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart . Nature Protocols vol. 9 , ( 7 ) 1662 - 1681 .
Lewis FC, Henning BJ, Marazzi G, Sassoon D, Ellison GM, Nadal-Ginard B ( 2014 ) . Porcine Skeletal Muscle‐Derived Multipotent PW1pos/Pax7neg Interstitial Cells: Isolation, Characterization, and Long‐Term Culture . Stem Cells Translational Medicine vol. 3 , ( 6 ) 702 - 712 .
Torella D, Ellison GM, Torella M, Vicinanza C, Aquila I, Iaconetti C, Scalise M, Marino F et al. ( 2014 ) . Carbonic Anhydrase Activation Is Associated With Worsened Pathological Remodeling in Human Ischemic Diabetic Cardiomyopathy . Journal of the American Heart Association vol. 3 , ( 2 )
Ellison GM, Smith AJ, Waring CD, Henning BJ, Burdina AO, Polydorou J, Vicinanza C, Lewis FC et al. ( 2013 ) . Adult Cardiac Stem Cells: Identity, Location and Potential . Adult Stem Cells , Springer Nature
Bryan N, Lewis FC, Bond D, Stanley C, Hunt JA ( 2013 ) . Evaluation of a Novel Non-Destructive Catch and Release Technology for Harvesting Autologous Adult Stem Cells . PLOS ONE vol. 8 , ( 1 )
Lewis F, Henning B, Sassoon D, Marazzi G, Ellison G, Nadal-Ginard B ( 2013 ) . Identification and characterisation of multipotent porcine PW1<SUP>+</SUP>/Pax7<SUP>-</SUP> skeletal muscle-derived interstitial cells (PICs) . HUMAN GENE THERAPY . vol. 24 , A30 - A30 .
Lewis FC, Bryan N, Hunt JA ( 2012 ) . A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro . Cell Regeneration vol. 1 , ( 1 )
Lewis FC, Rhodes NP, Hunt JA ( 2011 ) . A novel, feeder free, autologous system for maintenance of human embryonic stem cell phenotype . European Cells and Materials . vol. 22 ,