Skip to main content
Research

Publications: Prof Antal Rot

Zhang Y, Garcia-Ibanez L, Ulbricht C, Lok LSC, Pike JA, Mueller-Winkler J, Dennison TW, Ferdinand JR et al. ( 2022 ) . Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift . Nature Communications vol. 13 , ( 1 )
Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, von Andrian UH, Megens RTA et al. ( 2022 ) . Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1 . Cell Stem Cell vol. 29 , ( 7 ) 1013 - 1015 .
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C et al. ( 2022 ) . Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics . Cell Reports vol. 38 , ( 5 )
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J et al. ( 2021 ) . The dimeric form of CXCL12 binds to atypical chemokine receptor 1 . Science Signaling vol. 14 , ( 696 ) eabc9012 - eabc9012 .
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al. ( 2021 ) . Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage . Immunity vol. 54 , ( 7 ) 1494 - 1510.e7 .
Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A et al. ( 2021 ) . Expression of ACKR4 demarcates the “peri-marginal sinus,” a specialized vascular compartment of the splenic red pulp . Cell Reports vol. 36 , ( 2 )
Crawford K, Gutjahr J, Rot A, Volkman B ( 2021 ) . Dimeric CXCL12 (SDF‐1) binds to atypical chemokine receptor 1 (ACKR1/DARC) . The FASEB Journal . vol. 35 ,
Bachelerie F, Ben-Baruch A, Burkhardt AM, Charo IF, Combadiere C, Förster R, Farber JM, Graham GJ et al. ( 2020 ) . Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2020 , ( 5 )
Horuk R, Hub E, Middleton J, Rot A ( 2020 ) . Mechanism of Chemokine-Induced Leukocyte Adhesion and Emigration . Chemoattractant Ligands and Their Receptors ,
Bachelerie F, Ben-Baruch A, Charo IF, Combadiere C, Förster R, Farber JM, Graham GJ, Hills R et al. ( 2019 ) . Chemokine receptors (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2019 , ( 5 )
Bachelerie F, Ben-Baruch A, Charo IF, Combadiere C, Förster R, Farber JM, Graham GJ, Hills R et al. ( 2019 ) . Chemokine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database . IUPHAR/BPS Guide to Pharmacology CITE vol. 2019 , ( 4 )
GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E et al. ( 2018 ) . Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis . Immunity
Ameti R, Melgrati S, Radice E, Cameroni E, Hub E, Thelen S, Rot A, Thelen M ( 2018 ) . Characterization of a chimeric chemokine as a specific ligand for ACKR3 . Journal of Leukocyte Biology vol. 104 , ( 2 ) 391 - 400 .
Rot A, Massberg S, Khandoga AG, von Andrian UH ( 2018 ) . Chapter 13 Chemokines and Hematopoietic Cell Trafficking . Hematology ,
Rot A, Massberg S, Khandoga AG, von Andrian UH ( 2018 ) . Chemokines and Hematopoietic Cell Trafficking . Hematology: Basic Principles and Practice ,
Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K et al. ( 2017 ) . Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis . Nature Immunology vol. 18 , ( 7 ) 753 - 761 .
Thiriot A, Perdomo C, Cheng G, Novitzky-Basso I, McArdle S, Kishimoto JK, Barreiro O, Mazo I et al. ( 2017 ) . Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues . BMC Biology vol. 15 , ( 1 )
Patten DA, Wilson GK, Bailey D, Shaw RK, Jalkanen S, Salmi M, Rot A, Weston CJ et al. ( 2017 ) . Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration . Hepatology vol. 65 , ( 1 ) 294 - 309 .
Friess M, Proulx S, Rot A, Halin C ( 2017 ) . Investigating the Role of ACKR4 on Leukocyte Trafficking Within Lymphatic Vessels and on Lymphatic Vessel Biology . JOURNAL OF VASCULAR RESEARCH . vol. 54 , 32 - 32 .
Cordeiro OG, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, Bénézech C, Li Z et al. ( 2016 ) . Integrin-alpha IIb identifies murine lymph node lymphatic endothelial cells responsive to RANKL . PLoS ONE vol. 11 , ( 3 )
Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A et al. ( 2015 ) . MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis . FASEB Journal vol. 29 , ( 11 ) 4497 - 4511 .
Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S et al. ( 2015 ) . An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15 . British Journal of Pharmacology vol. 172 , ( 16 ) 3945 - 3949 .
Lucas B, White AJ, Ulvmar MH, Nibbs RJB, Sitnik KM, Agace WW, Jenkinson WE, Anderson G et al. ( 2015 ) . CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice . European Journal of Immunology vol. 45 , ( 2 ) 574 - 583 .
Ward ST, Li KK, Hepburn E, Weston CJ, Curbishley SM, Reynolds GM, Hejmadi RK, Bicknell R et al. ( 2015 ) . The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer . British Journal of Cancer vol. 112 , ( 2 ) 319 - 328 .
Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH et al. ( 2014 ) . International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (vol 66, pg 1, 2014) . PHARMACOLOGICAL REVIEWS vol. 66 , ( 2 ) 467 - 467 .
Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S et al. ( 2014 ) . New nomenclature for atypical chemokine receptors . Nature Immunology vol. 15 , ( 3 ) 207 - 208 .
Minten C, Alt C, Gentner M, Frei E, Deutsch U, Lyck R, Schaeren-Wiemers N, Rot A et al. ( 2014 ) . DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation . Brain vol. 137 , ( 5 ) 1454 - 1469 .
Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH et al. ( 2014 ) . International union of pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors . Pharmacological Reviews vol. 66 , ( 1 ) 1 - 79 .
Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B et al. ( 2014 ) . The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes . Nature Immunology vol. 15 , ( 7 ) 623 - 630 .
Baldwin HM, Pallas K, King V, Jamieson T, McKimmie CS, Nibbs RJB, Carballido JM, Jaritz M et al. ( 2013 ) . Microarray analyses demonstrate the involvement of type 1 interferons in psoriasiform pathology development in D6-Deficient mice . Journal of Biological Chemistry vol. 288 , ( 51 ) 36473 - 36483 .
Cook SL, George LA, Marshall JL, Zhang Y, Ulvmar MH, Rot A, Toellner K-M ( 2013 ) . A novel role for the atypical chemoattractant receptor CCRL2 in the B cell antibody response . IMMUNOLOGY . vol. 140 , 64 - 64 .
Lucas B, Anderson G, Rot A ( 2013 ) . Expression and function of atypical chemokine receptor CCRL1 in the thymus . IMMUNOLOGY . vol. 140 , 157 - 157 .
Nawaf MG, Ulvmar M, McConnell F, Gaspal F, Yagita H, Allison J, Anderson G, Withers D et al. ( 2013 ) . Successful CD8 driven anti-tumour immunity: a novel approach? . IMMUNOLOGY . vol. 140 , 193 - 193 .
Novitzky-Basso IN, Ulvmar MH, Bacon A, Chaganti S, Moss PA, Rot A ( 2013 ) . The Development Of The Humanized Darc Transgenic Mouse . Blood . vol. 122 , 2188 - 2188 .
Rot A, McKimmie C, Burt CL, Pallas KJ, Jamieson T, Pruenster M, Horuk R, Nibbs RJB et al. ( 2013 ) . Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor . Journal of Immunology vol. 190 , ( 12 ) 6450 - 6456 .
Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J ( 2013 ) . A chemokine self-presentation mechanism involving formation of endothelial surface microstructures . Journal of Immunology vol. 190 , ( 4 ) 1725 - 1736 .
Ward S, Hepburn E, Li K, Curbishley S, Hejmadi R, Ismail T, Bicknell R, Rot A et al. ( 2013 ) . Selective recruitment and retainment of regulatory T cells in human colorectal cancer . The Lancet . vol. 381 ,
Ward ST, Hepburn EA, Li K-K, Curbishley SM, Hejmadi RK, Ismail T, Bicknell R, Rot A et al. ( 2013 ) . Abstract A73: The selective recruitment and retainment of regulatory T cells in human colorectal cancer . Cancer Research . vol. 73 , a73 - a73 .
Novitzky-Basso I, Rot A ( 2012 ) . Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines . Frontiers in Immunology vol. 3 , ( AUG )
Serre K, Cunningham AF, Coughlan RE, Lino AC, Rot A, Hub E, Moser K, Manz R et al. ( 2012 ) . CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines . Blood vol. 120 , ( 23 ) 4552 - 4559 .
Singh MD, King V, Baldwin H, Burden D, Thorrat A, Holmes S, McInnes IB, Nicoll R et al. ( 2012 ) . Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis . American Journal of Pathology vol. 181 , ( 4 ) 1158 - 1164 .
Graham GJ, Locati M, Mantovani A, Rot A, Thelen M ( 2012 ) . The biochemistry and biology of the atypical chemokine receptors . Immunology Letters vol. 145 , ( 1-2 ) 30 - 38 .
Novitzky-Basso IN, Ulvmar MH, Bacon A, Moss PAH, Rot A ( 2012 ) . The development of humanized DARC FYB(ES) transgenic mouse . BRITISH JOURNAL OF HAEMATOLOGY . vol. 157 , 20 - 20 .
Sallmann E, Reininger B, Brandt S, Duschek N, Hoflehner E, Garner-Spitzer E, Platzer B, Dehlink E et al. ( 2011 ) . High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation . Journal of Immunology vol. 187 , ( 1 ) 164 - 171 .
Ulvmar MH, Hub E, Rot A ( 2011 ) . Atypical chemokine receptors . Experimental Cell Research vol. 317 , ( 5 ) 556 - 568 .
Thiriot A, Perdomo C, Omid S, Puyraimond-Zemmour D, Rot A, Siu J, von Andrian U ( 2011 ) . Understanding the role of segmental specialization of venular endothelial cells in the regulation of lymphocyte trafficking . JOURNAL OF VASCULAR RESEARCH . vol. 48 , 252 - 252 .
Cowan J, Desanti G, Jenkinson W, White A, Rot A, Lane P, Jenkinson E, Anderson G ( 2010 ) . Dynamic changes in chemokine receptor expression reveals multiple checkpoints in the intrathymic positive selection of CD4(+) T-cells . IMMUNOLOGY . vol. 131 , 157 - 157 .
Madigan J, Freeman DJ, Menzies F, Forrow S, Nelson SM, Young A, Sharkey A, Moffett A et al. ( 2010 ) . Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients . Journal of Immunology vol. 184 , ( 6 ) 3202 - 3212 .
Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A, Thelen M ( 2010 ) . CXCR7 functions as a scavenger for CXCL12 and CXCL11 . PLoS ONE vol. 5 , ( 2 )
Eller K, Weber T, Pruenster M, Wolf AM, Mayer G, Rosenkranz AR, Rot A ( 2010 ) . CCR7 deficiency exacerbates injury in acute nephritis due to aberrant localization of regulatory T cells . Journal of the American Society of Nephrology vol. 21 , ( 1 ) 42 - 52 .
Rot A ( 2010 ) . Chemokine patterning by glycosaminoglycans and interceptors . Frontiers in Bioscience vol. 15 , ( 2 ) 645 - 660 .
McKimmie CS, Fraser AR, Hansell C, Gutiérrez L, Philipsen S, Connell L, Rot A, Kurowska-Stolarska M et al. ( 2009 ) . Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1 (Journal of Immunology (2008) 181, (3353-3363)) . Journal of Immunology vol. 181 , ( 11 ) 8170 - 8181 .
Rot A, Horuk R ( 2009 ) . Chapter 9 The Duffy Antigen Receptor for Chemokines . Methods in Enzymology vol. 461 , ( B ) 191 - 206 .
Pruenster M, Dimitrova S, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJB, Rot A ( 2009 ) . Duffy antigen/receptor for chemokines transports chemokines and supports their pro-migratory activity 'in vitro' and 'in vivo' . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 39 , 23 - 24 .
Széles L, Keresztes G, Töröcsik D, Balajthy Z, Krenács L, Póliska S, Steinmeyer A, Zuegel U et al. ( 2009 ) . 1,25-Dihydroxyvitamin D<inf>3</inf> Is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype . Journal of Immunology vol. 182 , ( 4 ) 2074 - 2083 .
Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ et al. ( 2009 ) . Erratum: The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity (Nature Immunology (2009) vol. 10 (101-108)) . Nature Immunology vol. 10 , ( 2 )
Vielhauer V, Allam R, Lindenmeyer MT, Cohen CD, Draganovici D, Mandelbaum J, Eltrich N, Nelson PJ et al. ( 2009 ) . Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokines . American Journal of Pathology vol. 175 , ( 1 ) 119 - 131 .
Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ et al. ( 2009 ) . The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity . Nature Immunology vol. 10 , ( 1 ) 101 - 108 .
McKimmie CS, Fraser AR, Hansell C, Gutierrez L, Philipsen S, Connell L, Rot A, Kurowska-Stolarska M et al. ( 2008 ) . Hemopoietic Cell Expression of the Chemokine Decoy Receptor D6 Is Dynamic and Regulated by GATA1 (vol 181, pg 3353, 2008) . JOURNAL OF IMMUNOLOGY vol. 181 , ( 11 ) 8170 - 8181 .
Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwärzler C, Junt T et al. ( 2008 ) . Triggering the succinate receptor GPR91 on dendritic cells enhances immunity . Nature Immunology vol. 9 , ( 11 ) 1261 - 1269 .
McKimmie CS, Fraser AR, Hansell C, Gutiérrez L, Philipsen S, Connell L, Rot A, Kurowska-Stolarska M et al. ( 2008 ) . Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1 . Journal of Immunology vol. 181 , ( 5 ) 3353 - 3363 .
Chamberlain G, Wright K, Rot A, Ashton B, Middleton J ( 2008 ) . Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: Comparison with human . PLoS ONE vol. 3 , ( 8 )
Hochegger K, Rosenkranz A, Rot A ( 2008 ) . CCR7 is essential for regulatory T cell function in anti-GBM glomerulonephritis . WIENER KLINISCHE WOCHENSCHRIFT . vol. 120 , 51 - 51 .
Förster R, Davalos-Misslitz AC, Rot A ( 2008 ) . CCR7 and its ligands: Balancing immunity and tolerance . Nature Reviews Immunology vol. 8 , ( 5 ) 362 - 371 .
Chamberlain G, Rot A, Ashton B, Middleton J ( 2008 ) . Chemokine receptors on human and murine mesenchymal stem cells . RHEUMATOLOGY . vol. 47 , II61 - II62 .
McKimmie CS, Fraser AR, Hansell C, Gutiérrez L, Philipsen S, Connell L, Rot A, Kurowska-Stolarska M et al. ( 2008 ) . Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1 . Journal of immunology (Baltimore, Md. : 1950) vol. 181 , ( 11 ) 8171 - 8181 .
Koehn J, Huesken D, Jaritz M, Rot A, Zurini M, Dwertmann A, Beutler B, Korthäuer U ( 2007 ) . Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response . Human Immunology vol. 68 , ( 11 ) 871 - 878 .
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, Bombosi P, Stingl G et al. ( 2007 ) . Down-modulation of CXCR3 surface expression and function in CD8<sup>+</sup> T cells from cutaneous T cell lymphoma patients . Journal of Immunology vol. 179 , ( 6 ) 4272 - 4282 .
Colditz IG, Schneider MA, Pruenster M, Rot A ( 2007 ) . Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance . Thrombosis and Haemostasis vol. 97 , ( 5 ) 688 - 693 .
Schneider MA, Meingassner JG, Lipp M, Moore HD, Rot A ( 2007 ) . CCR7 is required for the in vivo function of CD4<sup>+</sup> CD25 <sup>+</sup> regulatory T cells . Journal of Experimental Medicine vol. 204 , ( 4 ) 735 - 745 .
Pruenster M, Rot A ( 2006 ) . Throwing light on DARC . Biochemical Society Transactions vol. 34 , ( 6 ) 1005 - 1008 .
Biedermann T, Lametschwandtner G, Tangemann K, Kund J, Hinteregger S, Carballido-Perrig N, Rot A, Schwärzler C et al. ( 2006 ) . IL-12 instructs skin homing of human Th2 cells . Journal of Immunology vol. 177 , ( 6 ) 3763 - 3770 .
Haraldsen G, Rot A ( 2006 ) . Coy decoy with a new ploy: Interceptor controls the levels of homeostatic chemokines . European Journal of Immunology vol. 36 , ( 7 ) 1659 - 1661 .
Floess S, Rot A ( 2006 ) . Chemokines Drive Inflammatory Leukocyte Recruitment . Leukocyte Trafficking: Molecular Mechanisms, Therapeutic Targets, and Methods ,
Jamieson T, Cook DN, Nibbs RJB, Rot A, Nixon C, Mclean P, Alcami A, Lira SA et al. ( 2005 ) . The chemokine receptor D6 limits the inflammatory response in vivo . Nature Immunology vol. 6 , ( 4 ) 403 - 411 .
Rot A ( 2005 ) . Contribution of Duffy antigen to chemokine function . Cytokine and Growth Factor Reviews vol. 16 , ( 6 ) 687 - 694 .
Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M et al. ( 2005 ) . Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells . Nature Immunology vol. 6 , ( 10 ) 1038 - 1046 .
Dar A, Kollet O, Shinder V, Goichberg P, Kalinkovich A, Zsak M, Rot A, Lapidot T ( 2005 ) . CXCR4-dependent internalization and secretion of functional SDF-1 by bone marrow endothelial and stromal cells . EXPERIMENTAL HEMATOLOGY . vol. 33 , 118 - 118 .
Meindl S, Rot A, Hoetzenecker W, Kato S, Cross HS, Elbe-Bürger A ( 2005 ) . Vitamin D receptor ablation alters skin architecture and homeostasis of dendritic epidermal T cells . British Journal of Dermatology vol. 152 , ( 2 ) 231 - 241 .
Kohrgruber N, Gröger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A et al. ( 2004 ) . Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands . Journal of Immunology vol. 173 , ( 11 ) 6592 - 6602 .
McKeever U, Baier K, Pecanka R, Kowalsky E, Rot A ( 2004 ) . Pimecrolimus ameliorates disease in a prophylactic mouse model of lupus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 123 ,
Rot A, Von Andrian UH ( 2004 ) . Chemokines in innate and adaptive host defense: Basic chemokinese grammar for immune cells . Annual Review of Immunology vol. 22 , 891 - 928 .
Weber M, Blair E, Simpson CV, O'Hara M, Blackburn PE, Rot A, Graham GJ, Nibbs RJB ( 2004 ) . The Chemokine Receptor D6 Constitutively Traffics to and from the Cell Surface to Internalize and Degrade Chemokines . Molecular Biology of the Cell vol. 15 , ( 5 ) 2492 - 2508 .
McKeever U, Baier K, Rot A ( 2004 ) . Beneficial effects of Pimecrolimus in the Mrl/lpr mouse lupus model . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 122 , A5 - A5 .
Gruber R, Karreth F, Kandler B, Fuerst G, Rot A, Fischer MB, Watzek G ( 2004 ) . Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions . Platelets vol. 15 , ( 1 ) 29 - 35 .
Zemann B, Rot A ( 2003 ) . What dogs may teach humans about the vertical transmission of allergy predisposition . Immunology vol. 110 , ( 4 ) 427 - 429 .
Gruber R, Karreth F, Kandler B, Rot A, Fischer M, Furst G, Watzek G ( 2003 ) . Platelet-released supernatants are mitogenic and chemoattractant for mesenchymal progenitor cells - involvement of PDGF and mitogen-activated protein kinase signaling . BONE . vol. 33 , S16 - S17 .
Rot A ( 2003 ) . In situ binding assay for studying chemokine interactions with endothelial cells . Journal of Immunological Methods vol. 273 , ( 1-2 ) 63 - 71 .
Bacon K, Baggiolini M, Broxmeyer H, Horuk R, Lindley I, Mantovani A, Matsushima K, Murphy P et al. ( 2003 ) . Chemokine/chemokine receptor nomenclature . Cytokine vol. 21 , ( 1 ) 48 - 49 .
Nibbs R, Graham G, Rot A ( 2003 ) . Chemokines on the move: Control by the chemokine "interceptors" Duffy blood group antigen and D6 . Seminars in Immunology vol. 15 , ( 5 ) 287 - 294 .
Biedermann T, Schwärzler C, Lametschwandtner G, Thoma G, Carballido-Perrig N, Kund J, de Vries JE, Rot A et al. ( 2002 ) . Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo . European Journal of Immunology vol. 32 , ( 11 ) 3171 - 3180 .
Biedermann T, Schwärzler C, Lametschwandtner G, Thoma G, Carballido-Perrig N, Kund J, de Vries JE, Rot A et al. ( 2002 ) . Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo . Eur J Immunol vol. 32 , ( 11 ) 3171 - 3180 .
MIDDLETON J, NEIL S, WINTLE J, ROT A ( 2002 ) . Endothelial presentation of IL‐8 to neutrophils: evidence for chemokine transcytosis . International Journal of Experimental Pathology vol. 79 , ( 5 ) a39 - a40 .
IUIS/WHO Subcommittee on Chemokine Nomenclature ( 2002 ) . Chemokine/chemokine receptor nomenclature . J Immunol Methods vol. 262 , ( 1-2 ) 1 - 3 .
Bacon K, Baggiolini M, Broxmeyer H, Horuk R, Lindley I, Mantovani A, Matsushima K, Murphy P et al. ( 2002 ) . Chemokine/chemokine receptor nomenclature . Journal of Interferon and Cytokine Research vol. 22 , ( 10 ) 1067 - 1068 .
Elbe-Bürger A, Egyed A, Olt S, Klubal R, Mann U, Rappersberger K, Rot A, Stingl G ( 2002 ) . Overexpression of IL-4 alters the homeostasis in the skin . Journal of Investigative Dermatology vol. 118 , ( 5 ) 767 - 778 .
Bednar-Tantscher E, Mudde GC, Rot A ( 2001 ) . Maternal antigen stimulation downregulates via mother's milk the specific immune responses in young mice . International Archives of Allergy and Immunology vol. 126 , ( 4 ) 300 - 308 .
Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ et al. ( 2001 ) . Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues . Journal of Experimental Medicine vol. 194 , ( 9 ) 1361 - 1373 .
Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ et al. ( 2001 ) . Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 117 , 1003 - 1003 .
Jilma-Stohlawetz P, Homoncik M, Drucker C, Marsik C, Rot A, Mayr WR, Seibold B, Jilma B ( 2001 ) . Fy phenotype and gender determine plasma levels of monocyte chemotactic protein . Transfusion vol. 41 , ( 3 ) 378 - 381 .
Nibbs RJ, Kriehuber E, Ponath PD, Parent D, Qin S, Campbell JD, Henderson A, Kerjaschki D et al. ( 2001 ) . The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors . Am J Pathol vol. 158 , ( 3 ) 867 - 877 .
Kopp T, Kieffer JD, Rot A, Strommer S, Stingl G, Kupper TS ( 2001 ) . Inflammatory skin disease in K14/p40 transgenic mice: Evidence for interleukin-12-like activities of p40 . Journal of Investigative Dermatology vol. 117 , ( 3 ) 618 - 626 .
Hoffmann R, Rot A, Niiyama S, Billich A ( 2001 ) . Steroid sulfatase in the human hair follicle concentrates in the dermal papilla . Journal of Investigative Dermatology vol. 117 , ( 6 ) 1342 - 1348 .
Nibbs RJB, Kriehuber E, Ponath PD, Parent D, Qin S, Campbell JDM, Henderson A, Kerjaschki D et al. ( 2001 ) . The β-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors . American Journal of Pathology vol. 158 , ( 3 ) 867 - 877 .
Dawson TC, Lentsch AB, Wang Z, Cowhig JE, Rot A, Maeda N, Peiper SC ( 2000 ) . Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC) . Blood vol. 96 , ( 5 ) 1681 - 1684 .
Rot A, Schwarzinger E, Szakáll S, Radics T, Vályi-Nagy I, Kiss C, Márton IJ ( 2000 ) . Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma . Oral Microbiology and Immunology vol. 15 , ( 1 ) 63 - 65 .
Stein JV, Rot A, Luo Y, Narasimhaswamy M, Nakano H, Gunn MD, Matsuzawa A, Quackenbush EJ et al. ( 2000 ) . The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function- associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules . Journal of Experimental Medicine vol. 191 , ( 1 ) 61 - 75 .
Charbonnier AS, Rot A, Kohrgruber N, Kriehuber E, Stingl G, Maurer D ( 2000 ) . MIP-3 alpha is involved in the constitutive trafficking of epidermal Langerhans cells . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 114 , 226 - 226 .
Charbonnier AS, Kohrgruber N, Kriehuber E, Stingl G, Rot A, Maurer D ( 1999 ) . Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal langerhans cells . Journal of Experimental Medicine vol. 190 , ( 12 ) 1755 - 1767 .
Dawson TC, Maeda N, Wang ZX, Rot A, Peiper SC ( 1999 ) . Evaluation of the pathophysiological role of the Duffy blood group antigen: Generation and characterization of DARC deficient mice . BLOOD . vol. 94 , 369A - 369A .
Charbonnier AS, Rot A, Kohrgruber N, Kriehuber E, Stingl G, Maurer D ( 1999 ) . MIP-3 alpha is involved in the constitutive trafficking of epidermal Langerhans cells . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 113 , 431 - 431 .
Charbonnier A, Rot A, Stingl G, Maurer D ( 1999 ) . The chemokine receptor expression profile and chemokine responsiveness of human dendritic cells is dependent on cell subtype and maturational stage . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 112 , 627 - 627 .
Rot A ( 1999 ) . NEUTROPHIL MIGRATION AND METHODS FOR ITS IN VITRO STUDY . The Neutrophils: New Outlook for Old Cells ,
Wolff B, Burns AR, Middleton J, Rot A ( 1998 ) . Endothelial cell 'memory' of inflammatory stimulation: Human venular endothelial cells store interleukin 8 in Weibel-Palade bodies . Journal of Experimental Medicine vol. 188 , ( 9 ) 1757 - 1762 .
Michie CA, Tantscher E, Schall T, Rot A ( 1998 ) . Physiological secretion of chemokines in human breast milk . European Cytokine Network vol. 9 , ( 2 ) 123 - 129 .
Lam C, Chujor CSN, Schwarzinger E, Morhenn VB, Rot A ( 1998 ) . Co-localization of inducible nitric oxide synthase and nitration of tyrosine residues in psoriatic skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 110 , 634 - 634 .
Hub E, Rot A ( 1998 ) . Binding of RANTES, MCP-1, MCP-3, and MIP-1α to cells in human skin . American Journal of Pathology vol. 152 , ( 3 ) 749 - 757 .
Lam C, Chujor CS, Schwarzinger E, Morhenn VB, Rot A ( 1998 ) . Co-localization of inducible nitric oxide synthase and nitration of tyrosine residues in psoriatic skin . Journal of Dermatological Science vol. 16 ,
Horcher M, Rot A, Aschauer H, Besemer J ( 1998 ) . IL-8 derivatives with a reduced potential to form homodimers are fully active in vitro and in vivo . Cytokine vol. 10 , ( 1 ) 1 - 12 .
Charbonnier AS, Rot A, Stingl G, Maurer D ( 1998 ) . The chemokine receptor expression profile and chemokine responsiveness of human dendritic cells is dependent on cell subtype and maturational stage . JOURNAL OF LEUKOCYTE BIOLOGY . 76 - 76 .
Michie CA, Tantscher E, Rot A ( 1998 ) . The long term effects of breastfeeding: A role for the cells in breast milk? . Journal of Tropical Pediatrics vol. 44 , ( 1 ) 2 - 3 .
Middleton J, Neil S, Wintle J, Clark-Lewis I, Moore H, Lam C, Auer M, Hub E et al. ( 1997 ) . Transcytosis and surface presentation of IL-8 by venular endothelial cells . Cell vol. 91 , ( 3 ) 385 - 395 .
Billich A, Winkler G, Aschauer H, Rot A, Peichl P ( 1997 ) . Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis . Journal of Experimental Medicine vol. 185 , ( 5 ) 975 - 980 .
Middlelon J, Wintle J, Rot A ( 1996 ) . Mechanism of chemokine presentation to leucocytes . Skin Pharmacology vol. 9 , ( 2 )
Hub E, Rot A ( 1996 ) . Methods for Study of Chemokine Receptors in the Tissues . Methods vol. 10 , ( 1 ) 119 - 125 .
Michie CA, Rot A, Fisher C ( 1996 ) . DO CHEMOKINES CAUSE MASTITIS? 60 . Pediatric Research vol. 39 , ( Suppl 4 ) 12 - 12 .
Michie CA, Rot A, Fisher C ( 1996 ) . Do chemokines cause mastitis? . PEDIATRIC RESEARCH . vol. 39 , 60 - 60 .
Rot A ( 1996 ) . In flammatory and physiological roles of chemokines . Pathology &amp; Oncology Research vol. 2 , ( 1-2 ) 16 - 20 .
Rot A, Hub E, Middleton J, Pons F, Rabeck C, Thierer K, Wintle J, Wolff B et al. ( 1996 ) . Some aspects of IL-8 pathophysiology III: Chemokine interaction with endothelial cells . Journal of Leukocyte Biology vol. 59 , ( 1 ) 39 - 44 .
Kukielka GL, Smith CW, LaRosa GJ, Manning AM, Mendoza LH, Daly TJ, Hughes BJ, Youker KA et al. ( 1995 ) . Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo . Journal of Clinical Investigation vol. 95 , ( 1 ) 89 - 103 .
Jones AP, Webb LMC, Anderson AO, Leonard EJ, Rot A ( 1995 ) . Normal human sweat contains interleukin-8 . Journal of Leukocyte Biology vol. 57 , ( 3 ) 434 - 437 .
Rot A, ZaksRot I, EUROPE R ( 1995 ) . Radcure in Russia . RADTECH EUROPE 95 - CONFERENCE PROCEEDINGS . 313 - 320 .
MICHIE CA, WEBB L, ROT A, HARVEY D ( 1994 ) . THE PHYSIOLOGICAL SECRETION OF AN INFLAMMATORY CYTOKINE IN INFANT TEARS . PEDIATRIC RESEARCH . vol. 35 , A188 - A188 .
Michie CA, Soo KS, Schall T, Rot A, Harvey D ( 1994 ) . A MECHANISM FOR MATERNAL MODIFICATION OF INFANT IMMUNITY? . Pediatric Research . vol. 35 , 259 - 259 .
Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan SD, Anderson M, Sunouchi K, Major J et al. ( 1994 ) . Hypoxic induction of interleukin-8 gene expression in human endothelial cells . Journal of Clinical Investigation vol. 93 , ( 4 ) 1564 - 1570 .
ROT A ( 1993 ) . ENDOTHELIAL-CELL BINDING OF NAP-1/IL-8 - ROLE IN NEUTROPHIL EMIGRATION . JOURNAL OF CELLULAR BIOCHEMISTRY . 352 - 352 .
Webb LMC, Ehrengruber MU, Clark-Lewis I, Baggiolini M, Rot A ( 1993 ) . Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8 . Proceedings of the National Academy of Sciences of the United States of America vol. 90 , ( 15 ) 7158 - 7162 .
Auer M, Owens SR, Pfeffer S, Kallen J, Wasserbauer E, Aschauer H, Ehn G, Rot A et al. ( 1993 ) . Elucidation of structure function relationships in the IL-8 family by X- ray crystallography . Advances in Experimental Medicine and Biology vol. 351 , 171 - 182 .
Rot A ( 1993 ) . Endothelial Cell Binding of NAP-1/IL-8: Role in Neutrophil Emigration . The Chemokines , vol. 351 ,
Webb LMC, Moser B, Baggiolini M, Rot A ( 1993 ) . Heparin Binding of NAP-1/IL-8: The Effect of Heparin and Related Glycosaminoglycans on in Vitro Neutrophil Responses to NAP-1/IL-8 . The Chemokines , vol. 351 ,
Zwahlen R, Walz A, Rot A ( 1993 ) . In Vitro and in Vivo Activity and Pathophysiology of Human Interleukin-8 and Related Peptides . vol. 34 , ( PB ) 27 - 42 .
Rot A ( 1993 ) . Neutrophil attractant/activation protein‐1 (interleukin‐8) induces in vitro neutrophil migration by haptotactic mechanism . European Journal of Immunology vol. 23 , ( 1 ) 303 - 306 .
Bischoff SC, Krieger M, Brunner T, Rot A, Tscharner VV, Marco Baggiolini, Dahinden CA ( 1993 ) . RANTES and related chemokines activate human basophil granulocytes through different G protein‐coupled receptors . European Journal of Immunology vol. 23 , ( 3 ) 761 - 767 .
Rot A, Jones AP, Webb LMC ( 1993 ) . Some aspects of NAP-1/IL-8 pathophysiology II: Chemokine secretion by exocrine glands . Advances in Experimental Medicine and Biology vol. 351 , 77 - 85 .
Rot A, Krieger M, Brunner T, Bischoff SC, Schall TJ, Dahinden CA ( 1992 ) . RANTES and macrophage inflammatory protein lot induce the migration and activation of normal human eosinophil granulocytes . Journal of Experimental Medicine vol. 176 , ( 6 ) 1489 - 1495 .
Samonigg H, Wilders-Truschnig M, Stoger H, Loibner H, Rot A, Plot R, Werner G ( 1992 ) . TREATMENT OF COLON CARCINOMA PATIENT WITH SDZ SCV 106 (GOAT-ANTI-ID 17–1A) . Journal of Immunotherapy vol. 11 , ( 2 )
Rot A ( 1992 ) . Binding of neutrophil attractant/activation protein-1 (interleukin 8) to resident dermal cells . Cytokine vol. 4 , ( 5 ) 347 - 352 .
FOSTER CA, MANDAK B, KROMER E, ROT A ( 1992 ) . Calcitonin Gene‐Related Peptide is Chemotactic for Human T Lymphocytes . Annals of the New York Academy of Sciences vol. 657 , ( 1 ) 397 - 404 .
Rot A ( 1992 ) . Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration . Immunology Today vol. 13 , ( 8 ) 291 - 294 .
Samonigg H, Wilders-Truschnig M, Loibner H, Plot R, Rot A, Kuss I, Werner G, Stöger H et al. ( 1992 ) . Immune response to tumor antigens in a patient with colorectal cancer after immunization with anti-idiotype antibody . Clinical Immunology and Immunopathology vol. 65 , ( 3 ) 271 - 277 .
Rot A ( 1992 ) . The role of leukocyte chemotaxis in inflammation . Biochemistry of Inflammation ,
Foster CA, Mandak B, Rot A ( 1991 ) . Calcitonin gene-related peptide is chemotactic for human T cells . Peptides vol. 34 , ( 2 )
FOSTER CA, MANDAK B, KROMER E, ROT A ( 1991 ) . THE NEUROPEPTIDE SUBSTANCE-P IS CHEMOTACTIC FOR HUMAN T-CELLS . CLINICAL RESEARCH . vol. 39 , A535 - A535 .
Leonard EJ, Yoshimura T, Rot A, Noer K, Walz A, Baggiolini M, Walz DA, Goetzl EJ et al. ( 1991 ) . Chemotactic activity and receptor binding of neutrophil attractant/activation protein-1 (NAP-1) and structurally related host defense cytokines: Interaction of NAP-2 with the NAP-1 receptor . Journal of Leukocyte Biology vol. 49 , ( 3 ) 258 - 265 .
Rot A ( 1991 ) . Chemotactic potency of recombinant human neutrophil attractant/activation protein-1 (interleukin-8) for polymorphonuclear leukocytes of different species . Cytokine vol. 3 , ( 1 ) 21 - 27 .
Zalatnai A, Sárosi I, Rot A, Lapsis K ( 1991 ) . Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats . Cancer Letters vol. 57 , ( 1 ) 67 - 73 .
Rot A ( 1991 ) . Some aspects of NAP-1 pathophysiology: Lung damage caused by a blood-borne cytokine . Advances in Experimental Medicine and Biology vol. 305 , 127 - 136 .
Loibner H, Plot R, Rot A, Werner G, Wrann M, Samonigg H, Schmid M, Stöger H et al. ( 1990 ) . Immunoreactivity of patient with colorectal cancer metastasis after immunisation with anti-idiotypes . The Lancet vol. 335 , ( 8682 )
LINDLEY IJD, ASCHAUER H, LAM C, BESEMER J, ROT A ( 1990 ) . INVITRO AND INVIVO ACTIVITY OF MUTAGENIZED VERSIONS OF RECOMBINANT HUMAN NAP-1/IL-8 AND IDENTIFICATION OF FUNCTIONALLY IMPORTANT DOMAINS . MOLECULAR AND CELLULAR BIOLOGY OF CYTOKINES . vol. 10 , 345 - 350 .
Paku S, Rot A, Ladányi A, Lapis K ( 1989 ) . Demonstration of the organ preference of liver selected 'high metastatic' Lewis lung tumor cell line . Clinical &amp; Experimental Metastasis vol. 7 , ( 6 ) 599 - 607 .
Lindley IJD, Aschauer H, Lam C, Besemer J, Rot A ( 1989 ) . In vitro and in vivo activity of mutagenised versions of recombinant human NAP-1/IL-8 and identification of functionally important domains . Cytokine vol. 1 , ( 1 )
Rot A, Henderson LE, Sowder R, Leonard EJ ( 1989 ) . Staphylococcus aureus tetrapeptide with high chemotactic potency and efficacy for human leukocytes . Journal of Leukocyte Biology vol. 45 , ( 2 ) 114 - 120 .
Jaehne J, Meyer H-J, Wittekind C, Maschek H, Pichlmayr R, Jacobi G, Weiermann G, Vitzthum HG et al. ( 1988 ) . Late abstracts 186–187 . Clinical & Experimental Metastasis vol. 6 , ( Suppl 1 ) 1 - 99 .
ROT A, HENDERSON LE, COPELAND TD, LEONARD EJ ( 1987 ) . A NEW SERIES OF LIGANDS FOR THE HUMAN FORMYL PEPTIDE RECEPTOR - TETRAPEPTIDES WITH HIGH CHEMOTACTIC POTENCY AND EFFICACY . JOURNAL OF LEUKOCYTE BIOLOGY . vol. 42 , 387 - 387 .
Rot A, Henderson LE, Copeland TD, Leonard EJ ( 1987 ) . A series of six ligands for the human formyl peptide receptor: Tetrapeptides with high chemotactic potency and efficacy . Proceedings of the National Academy of Sciences of the United States of America vol. 84 , ( 22 ) 7967 - 7971 .
YOSHIMURA T, ROT A, LEONARD EJ ( 1986 ) . CHEMOTACTIC EFFICACY - OXIDATION OF STIMULUS BY RESPONDING CELLS . JOURNAL OF LEUKOCYTE BIOLOGY . vol. 40 , 280 - 281 .
Yoshimura T, Rot A, Leonard EJ ( 1986 ) . Chemoattractant efficacy: Oxidation of stimulus by responding cells . Biochemical and Biophysical Research Communications vol. 138 , ( 1 ) 66 - 71 .
Rot A, Henderson LE, Leonard EJ ( 1986 ) . Staphylococcus aureus-derived chemoattractant activity for human monocytes . Journal of Leukocyte Biology vol. 40 , ( 1 ) 43 - 53 .
Takacs L, Szende B, Rot A, Diamanstein T ( 1985 ) . Expression of MHC class II antigens on bile duct epithelium in experimental graft versus host disease . Clinical and Experimental Immunology vol. 60 , ( 3 ) 449 - 456 .
ROT A, HENDERSON LE, LEONARD EJ ( 1984 ) . CHEMOATTRACTANT ACTIVITY FOR HUMAN-MONOCYTES DERIVED FROM STAPHYLOCOCCUS-AUREUS CULTURE FILTRATES . JOURNAL OF LEUKOCYTE BIOLOGY . vol. 36 , 390 - 391 .
Takacs L, Szende B, Monostori E, Rot A, Lapis K, Szecseny A, Ando I ( 1983 ) . EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT CELLS OF REJECTED LIVER TRANSPLANT . The Lancet vol. 322 , ( 8365-8366 )
TAKACS L, SZENDE B, MONOSTORI E, ROT A, LAPIS K, SZECSENY A, ANDO I ( 1983 ) . EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT CELLS OF REJECTED LIVER-TRANSPLANT . LANCET vol. 2 , ( 8365 ) 1500 - 1500 .