Publications: Dr Thomas Iskratsch

Padilla‐Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H et al. ( 2024 ) . Biocooperative Regenerative Materials by Harnessing Blood‐Clotting and Peptide Self‐Assembly . Advanced Materials

Swiatlowska P, Iskratsch T, Shanahan C ( 2024 ) . Mechano-epigenetic regulation of vascular smooth muscle cell phenotype in atherosclerosis . Atherosclerosis vol. 395 ,

Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N, Cornu D ( 2024 ) . Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications . ChemBioChem vol. 25 , ( 7 )

Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al. ( 2024 ) . Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024) . Advanced Science vol. 11 , ( 9 )

Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T et al. ( 2024 ) . Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness . Circulation Research vol. 134 , ( 3 ) 307 - 324 .

Zheng T, O’Neill C, Marshall JF, Iskratsch T, Palma M ( 2024 ) . Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning . Materials Advances vol. 5 , ( 23 ) 9376 - 9382 .

Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al. ( 2023 ) . Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells . Advanced Science vol. 11 , ( 9 )

Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D et al. ( 2023 ) . Lem2 is essential for cardiac development by maintaining nuclear integrity . Cardiovascular Research vol. 119 , ( 11 ) 2074 - 2088 .

Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M et al. ( 2023 ) . Myonuclear alterations associated with exercise are independent of age in humans . The Journal of Physiology

Swiatlowska P, Iskratsch T ( 2023 ) . Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation . Cardiovascular Drugs and Therapy vol. 38 , ( 2 ) 215 - 222 .

Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S ( 2022 ) . Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids . Biosensors and Bioelectronics vol. 223 ,

Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M et al. ( 2022 ) . Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM . Philosophical Transactions of the Royal Society B: Biological Sciences

Iskratsch T, Wilson D, Tinker A ( 2022 ) . The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction . Communications Biology

Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al. ( 2022 ) . Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching . Science advances vol. 8 , ( 15 )

Wilson DGS, Iskratsch T ( 2022 ) . Factoring in the force: A novel role for eIF6 . The Journal of cell biology vol. 221 , ( 2 )

Swiatlowska P, Iskratsch T ( 2021 ) . Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease . Biophysical Reviews vol. 13 , ( 5 ) 575 - 577 .

Swiatlowska P, Iskratsch T ( 2021 ) . Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales . Biophysical Reviews vol. 13 , ( 5 ) 611 - 623 .

Swiatlowska P, Iskratsch T ( 2021 ) . Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease” . Biophysical Reviews vol. 13 , ( 3 ) 307 - 308 .

Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J et al. ( 2021 ) . Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing . Journal of Experimental and Clinical Cancer Research vol. 40 , ( 1 )

( 2020 ) . Cell scientist to watch – Thomas Iskratsch . Journal of Cell Science vol. 133 , ( 15 )

Di Cio S, Iskratsch T, Connelly JT, Gautrot JE ( 2019 ) . Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing . Biomaterials vol. 232 ,

Sit B, Gutmann D, Iskratsch T ( 2019 ) . Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing . Journal of Muscle Research and Cell Motility vol. 40 , ( 2 ) 197 - 209 .

Xanthis I, Iskratsch T ( 2019 ) . Lamin-A Mechano-Protects the Heart . Developmental Cell

Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al. ( 2019 ) . Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation . Cancer Research

Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T et al. ( 2019 ) . Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control . Faraday Discussions

Ward M, Iskratsch T ( 2019 ) . Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research vol. 1867 , ( 3 )

Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T, Lappalainen P ( 2018 ) . Calponin-3 is critical for coordinated contractility of actin stress fibers . Scientific Reports

Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al. ( 2018 ) . Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions . Dev Cell vol. 44 , ( 3 ) 326 - 336.e3 .

Koldyka O, Pandey P, Iskratsch T, Ehler E ( 2018 ) . Similar Effects of Humoral or Mechanical Stress on Cell-Cell Contacts in Cultured Cardiomyocytes . Biophysical Journal . vol. 114 ,

Pluess M, Koldyka O, Iskratsch T, Bennett P, Dwyer J, Pandey P, dos Remedios C, Ehler E ( 2017 ) . Alterations in cardiac cytoarchitecture due to cellular stress in dilated cardiomyopathy . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 10 - 11 .

Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH ( 2017 ) . Polymer fiber-based models of connective tissue repair and healing . Biomaterials vol. 112 , 303 - 312 .

Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al. ( 2016 ) . Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability . Immunol Cell Biol vol. 94 , ( 10 ) 981 - 993 .

Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al. ( 2016 ) . α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions . Mol Biol Cell vol. 27 , ( 22 ) 3471 - 3479 .

Pluess M, Iskratsch T, Bennett P, Dwyer J, Pandey P, dos Remedios C, Ehler E ( 2016 ) . Cellular Stress Affects the Nucleoskeleton in Dilated Cardiomyopathy . Biophysical Journal . vol. 110 , 366a - 367a .

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al. ( 2015 ) . Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices . Nat Cell Biol vol. 18 , ( 1 ) 33 - 42 .

Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T ( 2015 ) . Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells . Integr Biol (Camb) vol. 7 , ( 10 ) 1272 - 1284 .

Ehler E, Pluess M, Randall T, Dwyer J, Iskratsch T, Dos Remedios C, Bennett P ( 2015 ) . Changes in cardiac cytoarchitecture in human dilated cardiomyopathy . EUROPEAN HEART JOURNAL . vol. 36 , 834 - 834 .

Wolfenson H, Iskratsch T, Sheetz MP ( 2014 ) . Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events . Biophysical Journal vol. 107 , ( 11 ) 2508 - 2514 .

Iskratsch T, Wolfenson H, Sheetz MP ( 2014 ) . Appreciating force and shape—the rise of mechanotransduction in cell biology . Nature reviews. Molecular cell biology vol. 15 , ( 12 ) 825 - 833 .

Iskratsch T, Ehler E ( 2014 ) . Formin-g muscle cytoarchitecture . BioArchitecture vol. 1 , ( 2 ) 66 - 68 .

Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E ( 2014 ) . The formin FHOD1 in cardiomyocytes . Anat Rec (Hoboken) vol. 297 , ( 9 ) 1560 - 1570 .

Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al. ( 2014 ) . FHOD1 at Early Integrin Adhesions Drives Cell Spreading . Biophysical Journal . vol. 106 ,

Zhang X, Moore SW, Iskratsch T, Sheetz MP ( 2014 ) . N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading . Journal of Cell Science vol. 127 , ( 7 ) 1394 - 1405 .

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al. ( 2014 ) . Rigidity sensing by tropomyosin-regulated nanometer steps in local contractions . MOLECULAR BIOLOGY OF THE CELL . vol. 25 ,

Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al. ( 2013 ) . FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration . Developmental Cell vol. 27 , ( 5 ) 545 - 559 .

Meacci G, Stachowiak M, Liu S, Iskratsch T, Mathur A, Wolfenson H, Ghassemi S, Roca-Cusachs P et al. ( 2013 ) . Sarcomere-Like Units Contract Cell Edges . Biophysical Journal . vol. 104 , 477a - 478a .

Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP ( 2012 ) . Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions . Molecular Biology of the Cell vol. 24 , ( 1 ) 21 - 30 .

Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E ( 2012 ) . Two distinct phosphorylation events govern the function of muscle FHOD3 . Cellular and Molecular Life Sciences vol. 70 , ( 5 ) 893 - 908 .

Iskratsch T, Yu C-H, Mathur A, Hone J, Sheetz M ( 2012 ) . Early cell spreading depends on actin polymerisation from integrin clusters by FHOD1 . MOLECULAR BIOLOGY OF THE CELL . vol. 23 ,

Roca-Cusachs P, Iskratsch T, Sheetz MP ( 2012 ) . Finding the weakest link – exploring integrin-mediated mechanical molecular pathways . Journal of Cell Science vol. 125 , ( 13 ) 3025 - 3038 .

Dwyer J, Iskratsch T, Ehler E ( 2011 ) . Actin in striated muscle: recent insights into assembly and maintenance . Biophysical Reviews vol. 4 , ( 1 ) 17 - 25 .

Iskratsch T, Sheetz M ( 2011 ) . Sequential action of formin family proteins during fibroblast adhesion and spreading . MOLECULAR BIOLOGY OF THE CELL . vol. 22 ,

Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD, Ehler E ( 2010 ) . Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance . The Journal of General Physiology vol. 137 , ( 1 ) i1 - i1 .

Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E ( 2010 ) . Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance . Journal of Cell Biology vol. 191 , ( 6 ) 1159 - 1172 .

Herbst R, Iskratsch T, Unger E, Bittner RE ( 2009 ) . Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice . Neuromuscular Disorders vol. 19 , ( 5 ) 366 - 378 .

Gutternigg M, Rendić D, Voglauer R, Iskratsch T, Wilson IBH ( 2009 ) . Mammalian cells contain a second nucleocytoplasmic hexosaminidase . Biochemical Journal vol. 419 , ( 1 ) 83 - 90 .

Iskratsch T, Braun A, Paschinger K, Wilson IBH ( 2008 ) . Specificity analysis of lectins and antibodies using remodeled glycoproteins . Analytical Biochemistry vol. 386 , ( 2 ) 133 - 146 .