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Research

Publications: Dr Stefaan Verbruggen

Verbruggen SW ( 2024 ) . Role of the osteocyte in bone metastasis – The importance of networking . Journal of Bone Oncology vol. 44 ,
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM ( 2023 ) . A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells . Advanced Science vol. 11 , ( 2 )
Verbruggen SW, Sittichokechaiwut A, Reilly GC ( 2023 ) . Osteocytes and Primary Cilia . Current Osteoporosis Reports
Asbai-Ghoudan R, Nasello G, Pérez MÁ, Verbruggen SW, Ruiz de Galarreta S, Rodriguez-Florez N ( 2023 ) . In silico assessment of the bone regeneration potential of complex porous scaffolds . Computers in Biology and Medicine vol. 165 ,
Sutton MM, Duffy MP, Verbruggen SW, Jacobs CR ( 2023 ) . Osteoclastogenesis requires primary cilia disassembly and can be inhibited by promoting primary cilia formation pharmacologically . Cells Tissues Organs1 - 10 .
Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW ( 2023 ) . Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK . Cancers vol. 15 , ( 3 )
Schurman CA, Verbruggen SW, Alliston T ( 2021 ) . Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling . Proceedings of the National Academy of Sciences of the United States of America vol. 118 , ( 25 )
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM ( 2021 ) . Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype . Cancers vol. 13 , ( 12 )
Schurman C, Verbruggen S, Alliston T ( 2020 ) . Disrupted Lacunar-Canalicular Networks and Osteocyte Mechanosensation in Bone with Aging and Disrupted TGFb Signaling . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 35 , 5 - 5 .
Schurman C, Verbruggen S, Alliston T ( 2019 ) . Age-related suppression of osteocyte lacuna/canalicular networks, PLR gene expression, and pericellular fluid flow . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 34 , 383 - 383 .
Schurman C, Verbruggen S, Alliston T ( 2019 ) . Age-related suppression of osteocyte lacuna/canalicular networks, PLR gene expression, and pericellular fluid flow . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 34 , 383 - 383 .
Verbruggen SW, Kainz B, Shelmerdine SC, Arthurs OJ, Hajnal JV, Rutherford MA, Phillips ATM, Nowlan NC ( 2018 ) . European Society of Biomechanics S.M. Perren Award 2018: Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors . Journal of Biomechanics vol. 78 , 1 - 9 .
Verbruggen SW, Kainz B, Shelmerdine SC, Hajnal JV, Rutherford MA, Arthurs OJ, Phillips ATM, Nowlan NC ( 2018 ) . Stresses and strains on the human fetal skeleton during development . Journal of The Royal Society Interface vol. 15 , ( 138 )
Verbruggen SW, McNamara LM ( 2018 ) . Bone mechanobiology in health and disease . Mechanobiology in Health and Disease ,
Dolan EB, Verbruggen SW, Rolfe RA ( 2018 ) . Chapter 1 Techniques for studying mechanobiology . Mechanobiology in Health and Disease , Elsevier
Verbruggen SW, McNamara LM ( 2018 ) . Chapter 6 Bone mechanobiology in health and disease . Mechanobiology in Health and Disease , Elsevier
Verbruggen SW ( 2018 ) . Mechanobiology in health and disease .
Dolan EB, Verbruggen SW, Rolfe RA ( 2018 ) . Techniques for studying mechanobiology . Mechanobiology in Health and Disease ,
Verbruggen SW, Oyen ML, Phillips ATM, Nowlan NC ( 2017 ) . Function and failure of the fetal membrane: Modelling the mechanics of the chorion and amnion . PLoS One vol. 12 , ( 3 ) e0171588 - e0171588 .
Verbruggen SW, Nowlan NC ( 2017 ) . Ontogeny of the Human Pelvis . The Anatomical Record vol. 300 , ( 4 ) 643 - 652 .
Giorgi M, Verbruggen SW, Lacroix D ( 2016 ) . In silico bone mechanobiology: modeling a multifaceted biological system . WIREs Mechanisms of Disease vol. 8 , ( 6 ) 485 - 505 .
Verbruggen SW, Vaughan TJ, McNamara LM ( 2016 ) . Mechanisms of osteocyte stimulation in osteoporosis . Journal of the Mechanical Behavior of Biomedical Materials vol. 62 , 158 - 168 .
Verbruggen SW, Loo JHW, Hayat TTA, Hajnal JV, Rutherford MA, Phillips ATM, Nowlan NC ( 2015 ) . Modeling the biomechanics of fetal movements . Biomechanics and Modeling in Mechanobiology vol. 15 , ( 4 ) 995 - 1004 .
Verbruggen SW, Garrigle MJM, Haugh MG, Voisin MC, McNamara LM ( 2015 ) . Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis . Biophysical Journal vol. 108 , ( 7 ) 1587 - 1598 .
Vaughan TJ, Mullen CA, Verbruggen SW, McNamara LM ( 2014 ) . Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia . Biomechanics and Modeling in Mechanobiology vol. 14 , ( 4 ) 703 - 718 .
Vaughan TJ, Verbruggen SW, McNamara LM ( 2013 ) . Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes . International Journal for Numerical Methods in Biomedical Engineering vol. 29 , ( 12 ) 1361 - 1372 .
Verbruggen SW, Vaughan TJ, McNamara LM ( 2012 ) . Loading-Induced Interstitial Fluid Flow in Bone Mechanobiology: An FSI Approach to the Osteocyte Environment . Conference: ASME 2012 Summer Bioengineering Conference, Parts A and B517 - 518 .
Verbruggen SW, Vaughan TJ, McNamara LM ( 2013 ) . Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach . Biomechanics and Modeling in Mechanobiology vol. 13 , ( 1 ) 85 - 97 .
Verbruggen SW, Vaughan TJ, McNamara LM ( 2012 ) . Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes . Journal of The Royal Society Interface vol. 9 , ( 75 ) 2735 - 2744 .