Publications: Prof Rob Krams
Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW, Bourantas CV
(
2023
)
.
Editorial: Computational modeling for assessing coronary artery pathophysiology
.
Frontiers in Cardiovascular Medicine
vol.
10
,
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al.
(
2022
)
.
JAG1-NOTCH4 mechanosensing drives atherosclerosis
.
Science Advances
vol.
8
,
(
35
)
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al.
(
2022
)
.
TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
.
Journal of the American College of Cardiology
vol.
80
,
(
12
)
Krams IA, Mennerat A, Krama T, Krams R, Joers P, Elferts D, Luoto S, Rantala MJ et al.
(
2022
)
.
Extra-pair paternity explains cooperation in a bird species
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
119
,
(
5
)
Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R et al.
(
2021
)
.
Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
.
Biophysical Reviews
vol.
13
,
(
5
)
787
-
796
.
Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP, De Silva R
(
2021
)
.
Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations
.
European Heart Journal
vol.
42
,
(
Supplement_1
)
(
2021
)
.
Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model
.
Heart
vol.
107
,
(
19
)
e10
-
e10
.
Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM, Krams R
(
2021
)
.
Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis
.
Journal of Biomechanics
vol.
128
,
Naser J, Mein CA, Wozniak E, Carassiti D, Mahomed AS, Krams R, de Silva R
(
2021
)
.
BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model
.
Heart
.
Conference:
Heart
vol.
107
,
a166
-
a167
.
POST AL, CERNOHORSKY P, PEDRIGI RM, STREEKSTRA GJ, D'HOOGHE JNS, ANNEMA JT, STRACKEE SD, KRAMS R et al.
(
2020
)
.
3D co-registration algorithm for catheter-based optical coherence tomography
.
OSA Continuum
vol.
3
,
(
10
)
2707
-
2721
.
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU et al.
(
2020
)
.
Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
.
JACC: Cardiovascular Imaging
vol.
13
,
(
10
)
2206
-
2219
.
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R et al.
(
2020
)
.
Targeted molecular iron oxide contrast agents for imaging atherosclerotic plaque
.
Nanotheranostics
vol.
4
,
(
4
)
184
-
194
.
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J et al.
(
2019
)
.
Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications
.
European Heart Journal
Baumbach A
(
2019
)
.
Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet
.
American Heart Journal
Mohri Z, Del Rio Hernandez A, Krams R
(
2019
)
.
The emerging role of YAP/TAZ in mechanotransduction
.
J Thorac Dis
vol.
9
,
(
5
)
E507
-
E509
.
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR et al.
(
2019
)
.
Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo
.
Sci Rep
vol.
9
,
(
1
)
4738
-
4738
.
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E et al.
(
2019
)
.
Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis
.
EuroIntervention
vol.
14
,
(
10
)
1129
-
1135
.
Evans RJ, Hernández-Gil J, Mohri Z, Chooi KY, Lavin-Plaza B, Phinikaridou A, Pease JE, Krams R et al.
(
2018
)
.
P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES
.
Cardiovascular Research
.
vol.
114
,
s3
-
s4
.
Yang P, Silva R, Pedrigi R, Patel M, Chooi Y, Ahmed R, Naser J, Krams R
(
2018
)
.
P34 FLUID-STRUCTURE INTERACTION MODELLING FOR ANALYSING ADVANCED CORONARY ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC HYPERLIPIDAEMIC MINIPIGS
.
Cardiovascular Research
.
vol.
114
,
s10
-
s10
.
Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C, Krams R
(
2018
)
.
New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress
.
Current Opinion in Biomedical Engineering
vol.
5
,
96
-
104
.
Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T et al.
(
2017
)
.
Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis
.
Circulation
vol.
136
,
(
12
)
1140
-
1154
.
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M et al.
(
2017
)
.
Connexin40 controls endothelial activation by dampening NFκB activation
.
Oncotarget
vol.
8
,
(
31
)
50972
-
50986
.
Poulsen CB, Pedrigi R, Holm N, Pareek N, Kilic I, Post AL, Di Mario C, Bentzon J et al.
(
2017
)
.
COMPARISON OF IN VIVO OPTICAL COHERENCE TOMOGRAPHY DERIVED PLAQUE PHENOTYPE AND BURDEN WITH HISTOLOGY IN A PORCINE MODEL OF ADVANCED CORONARY ATHEROSCLEROSIS
.
Journal of the American College of Cardiology
.
vol.
69
,
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M et al.
(
2016
)
.
Zebrafish Model for Functional Screening of Flow-Responsive Genes
.
Arterioscler Thromb Vasc Biol
vol.
37
,
(
1
)
130
-
143
.
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM et al.
(
2016
)
.
Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB
.
Ann Biomed Eng
vol.
45
,
(
4
)
898
-
909
.
Pedrigi RM, Mehta V, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al.
(
2016
)
.
Influence of shear stress magnitude and direction on atherosclerotic plaque composition
.
Royal Society Open Science
vol.
3
,
(
10
)
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L et al.
(
2016
)
.
Development of a synthetic gene network to modulate gene expression by mechanical forces
.
Sci Rep
vol.
6
,
29643
-
29643
.
Krams RM, Pedrigi RM, Kis Z
(
2016
)
.
A novel assay for regulating transcription factors by flow
.
CARDIOVASCULAR RESEARCH
.
vol.
111
,
S117
-
S117
.
Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M et al.
(
2016
)
.
0109 : Connexin40 controls endothelial activation by dampening NF B activation
.
Archives of Cardiovascular Diseases Supplements
vol.
8
,
(
3
)
203
-
203
.
Antonacci G, Pedrigi R, Krams R, Török P
(
2016
)
.
Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation)
.
Proceedings of SPIE
.
Conference:
Optical Elastography and Tissue Biomechanics III
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW et al.
(
2016
)
.
Comparison between direct and reverse electroporation of cells in situ: A simulation study
.
Physiological Reports
vol.
4
,
(
6
)
1
-
14
.
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al.
(
2016
)
.
Corrigendum to "Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques" [J Mol Cell Cardiol, 89B (2015) 168-172]
.
Journal of Molecular and Cellular Cardiology
vol.
91
,
Maimari N, Pedrigi RM, Russo A, Broda K, Krams R
(
2016
)
.
Integration of flow studies for robust selection of mechanoresponsive genes
.
Thrombosis and Haemostasis
vol.
115
,
(
3
)
474
-
483
.
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al.
(
2015
)
.
Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques
.
Journal of Molecular and Cellular Cardiology
vol.
89
,
168
-
172
.
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, De Silva R, Paterson C, Krams R, Török P
(
2015
)
.
Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma
.
Journal of the Royal Society Interface
vol.
12
,
(
112
)
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV et al.
(
2015
)
.
Shear stress-induced atherosclerotic plaque composition in ApoE<sup>-/-</sup> mice is modulated by connexin37
.
Atherosclerosis
vol.
243
,
(
1
)
1
-
10
.
Poulsen CB, Mehta VV, Holm NR, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G et al.
(
2015
)
.
Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs
.
Circulation
vol.
132
,
(
11
)
1003
-
1012
.
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R, Choi JJ
(
2015
)
.
Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow
.
Ultrasound in Medicine and Biology
vol.
41
,
(
9
)
2435
-
2448
.
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA et al.
(
2015
)
.
Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors
.
Physical Chemistry Chemical Physics
vol.
17
,
(
28
)
18393
-
18402
.
da Conceicao Pereira G, Krams R
(
2015
)
.
182 Flow Characteristics Enhanced by the Compliant Arteries and their effects in Vulnerable Plaque Formation
.
Heart
.
vol.
101
,
Kis Z, Pereira HSA, Homma T, Pedrigi RM, Krams R
(
2015
)
.
Mammalian synthetic biology: Emerging medical applications
.
Journal of the Royal Society Interface
vol.
12
,
(
106
)
Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M et al.
(
2015
)
.
INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA
.
Journal of the American College of Cardiology
.
vol.
65
,
Villanueva ME, Pereira HSA, Rajyaguru J, Krams R, Chachuat B
(
2015
)
.
Bifurcation and stability analysis of nonlinear dynamic systems using complete search
.
Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting
.
vol.
2
,
627
-
628
.
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ, Weinberg PD
(
2014
)
.
Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model
.
PLoS ONE
vol.
9
,
(
12
)
Towhidi L, Maimari N, Kis Z, Khodadadi D, Krams R
(
2014
)
.
A novel high-throughput platform for siRNA transfection of primary mammalian cells
.
Atherosclerosis
vol.
237
,
(
2
)
Maimari N, Towhidi L, Oh D, Broda K, Russo A, Krams R
(
2014
)
.
A novel integrated platform for gene network inference and validation: beyond the dream consortium
.
Atherosclerosis
vol.
237
,
(
2
)
Pereira G, Krams R
(
2014
)
.
Forecasting vulnerable plaque response to aemorheological flow
.
Atherosclerosis
vol.
237
,
(
2
)
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W, Krams R
(
2014
)
.
Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis
.
Atherosclerosis
vol.
237
,
(
2
)
Maimari N, Broda K, Kakas A, Russo A, Krams R
(
2014
)
.
Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks
.
Atherosclerosis
vol.
237
,
(
2
)
Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG et al.
(
2014
)
.
Transcriptome analysis of local shear dependent gene expression in endothelial cells during thin-cap fibroatheroma(TCFA) development
.
Atherosclerosis
.
vol.
237
,
Maimari N, Broda K, Kakas A, Krams R, Russo A
(
2014
)
.
Symbolic Representation and Inference of Regulatory Network Structures
.
Logical Modeling of Biological Systems
,
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al.
(
2014
)
.
In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106
.
Mol Imaging
vol.
13
,
(
6
)
Cuhlmann S, Gsell W, Van Der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al.
(
2014
)
.
In vivo mapping of vascular inflammation using the translocator protein tracer <sup>18</sup>F-FEDAA1106
.
Molecular Imaging
vol.
13
,
(
6
)
Kwak BR, Bäck M, Bochaton-Piallat ML, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P et al.
(
2014
)
.
Biomechanical factors in atherosclerosis: Mechanisms and clinical implications
.
European Heart Journal
vol.
35
,
(
43
)
3013
-
3020
.
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P et al.
(
2014
)
.
Erratum: Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: Influence of intraluminal flow (Journal of the Royal Society Interface (2013) 10, (20130578) DOI: 10.1098/rsif.2013.0578)
.
Journal of the Royal Society Interface
vol.
11
,
(
92
)
Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R, Weinberg PD
(
2014
)
.
Elevated arterial wall permeability may cause vulnerable plaque formation in mice
.
Atherosclerosis
.
vol.
232
,
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A, Krams R
(
2014
)
.
An In situ electroporation and flow device for mechanotransduction studies
.
Microarrays: Principles, Applications and Technologies
,
Pereira G, Krams R, van Wachem B
(
2014
)
.
Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis
.
Biophysical Journal
.
vol.
106
,
Pedrigi RM, De Silva R, Bovens SM, Mehta VV, Petretto E, Krams R
(
2014
)
.
Thin-cap fibroatheroma rupture is associated with a fine interplay of shear and wall stress
.
Arteriosclerosis, Thrombosis, and Vascular Biology
vol.
34
,
(
10
)
2224
-
2231
.
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G et al.
(
2013
)
.
Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: Influence of intraluminal flow
.
Journal of the Royal Society Interface
vol.
10
,
(
89
)
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S et al.
(
2013
)
.
Stabilization of atherosclerotic plaques: An update
.
European Heart Journal
vol.
34
,
(
42
)
3251
-
3258
.
Maimari N, Turliuc CR, Broda K, Kakas A, Krams R, Russo A
(
2013
)
.
ARNI: Abductive inference of complex regulatory network structures
.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
.
vol.
8130 LNBI
,
235
-
237
.
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C
(
2013
)
.
M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
.
European Heart Journal
vol.
34
,
(
suppl_1
)
p2398
-
p2398
.
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al.
(
2013
)
.
Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
.
European Heart Journal
vol.
34
,
(
suppl_1
)
p582
-
p582
.
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C
(
2013
)
.
M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
.
EUROPEAN HEART JOURNAL
.
vol.
34
,
443
-
443
.
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V et al.
(
2013
)
.
Method for percutaneously introducing, and removing, anatomical stenosis of predetermined severity in vivo: The "stenotic stent"
.
Journal of Cardiovascular Translational Research
vol.
6
,
(
4
)
640
-
648
.
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al.
(
2013
)
.
Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
.
EUROPEAN HEART JOURNAL
.
vol.
34
,
110
-
110
.
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L, Krams R
(
2013
)
.
Systems biology of the functional and dysfunctional endothelium
.
Cardiovascular Research
vol.
99
,
(
2
)
334
-
341
.
Seneviratne A, Cole J, Goddard M, Udalova I, Krams R, Monaco C
(
2013
)
.
181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
.
Heart
.
vol.
99
,
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R et al.
(
2013
)
.
Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE-/- mice
.
Atherosclerosis
vol.
227
,
(
2
)
236
-
243
.
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB, Rainger GE
(
2013
)
.
The role of platelet-endothelial cell adhesion molecule-1 in atheroma formation varies depending on the site-specific hemodynamic environment
.
Arteriosclerosis, Thrombosis, and Vascular Biology
vol.
33
,
(
4
)
694
-
701
.
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J et al.
(
2013
)
.
Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice
.
Arteriosclerosis, Thrombosis, and Vascular Biology
vol.
33
,
(
2
)
354
-
361
.
Da Silva RF, Gambillara V, Krams R, Stergiopulos N
(
2012
)
.
Modulation of arginases by different patterns of shear stress: New signaling pathway in atherogenesis?
.
Computer Methods in Biomechanics and Biomedical Engineering
vol.
10
,
(
SUPPL. 1
)
77
-
78
.
Falck-Hansen MA, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C
(
2012
)
.
Macrophage activation during chronic inflammation in atherosclerosis
.
Atherosclerosis
.
vol.
225
,
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Krams R, Monaco C
(
2012
)
.
Macrophage polarisation in shear stress modulated atherosclerotic plaque vulnerability
.
Atherosclerosis
.
vol.
225
,
Foin N, Sen S, Petraco R, Torii R, Nijjer S, Xu YX, Mehta V, Mayet J et al.
(
2012
)
.
TCT-231 Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis
.
Journal of the American College of Cardiology
.
vol.
60
,
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC et al.
(
2012
)
.
Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
.
Journal of Molecular and Cellular Cardiology
vol.
53
,
(
2
)
299
-
309
.
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E et al.
(
2012
)
.
Systems and synthetic biology of the vessel wall
.
FEBS Letters
vol.
586
,
(
15
)
2164
-
2170
.
Van Bochove GS, Sanders HMHF, De Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ, Nicolay K
(
2012
)
.
Molecular MR imaging of collagen in mouse atherosclerosis by using paramagnetic CNA35 micelles
.
European Journal of Inorganic Chemistry
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Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN, Serruys PW
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Helical velocity patterns in a human coronary artery: a three-dimensional computational fluid dynamic reconstruction showing the relation with local wall thickness
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Circulation
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Ca<sup>2+</sup> sensitization and diastolic function of normal and stunned porcine myocardium
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Oomen JA, Trines SAIP, Vermeulen WB, Krams R, Schuurbiers JCH, Vletter WB, Roelandt JRTC, Slager CJ
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Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging
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Computers in Cardiology
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Trines SA, Van der Moer J, Krams R, Slager CJ, Van Meegen JR, Verdouw PD
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External work recruitment can be restored in stunned myocardium without increasing oxygen consumption using EMD 57033, a calcium sensitizer
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CIRCULATION
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Wentzel JJ, Kloet J, Krams R, Serruys PW, Slager CJ
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The relationship between neo intimal thickness and shear stress after wallstent implantation in human coronary arteries at 6 months follow up
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CIRCULATION
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Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, Van Der Steen AFW, Lancee CT, Slager CJ
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Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
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Ultrasound in Medicine and Biology
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Osterop AP, Kofflard MJ, Sandkuijl LA, ten Cate FJ, Krams R, Schalekamp MA, Danser AH
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AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy
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Stager CJ, Wentzel JJ, Schuurbiers JC, Oomen JA, Krams R, Achterberg H, Kloet J, deFeyter PJ
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True 3-D reconstruction of coronary arteries in patients shows accurate correspondence between x-ray and IVUS derived dimensions
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CIRCULATION
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van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT, Bom N
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Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
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European Journal of Ultrasound
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Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Ten Cate FJ, Serruys PW
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Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation
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Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH, Danser AHJ
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AT<inf>1</inf> receptor A/C<sup>1166</sup> polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy
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Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B et al.
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Shear stress in atherosclerosis, and vascular remodelling
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Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams ROB
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Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
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Wentzel JJ, Krams R, van der Steen AFW, Li W, Cespedes EI, Bom N, Slager CJ
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Disturbance of 3D velocity profiles induced by an IVUS catheter: Evaluation with computational fluid dynamics
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Computers in Cardiology
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Krams R, Wentzel JJ, Oomen J, Schuurbier J, Vinke R, Slager CJ
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Evidence for a pivotal role of shear stress on the endothelium in human atherosclerosis
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Endothelium: Journal of Endothelial Cell Research
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5
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Fan DS, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams R
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deZeeuw S, Soei L, vanMeegen JR, Trines SA, Krams R, Duncker DJ, Verdouw PD
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Recovery of systolic function of stunned myocardium by the Ca2+-sensitizer EMD 57033 is not accompanied by impairment of diastolic function
.
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Wentzel JJ, Krams R, vanBeusekom HMN, Whelan DM, vanderGeissen WJ, Krabbendam SC, Andhyiswara I, Tjien ATJ et al.
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Stent implantation causes alterations in 3D-geometry and 3D-shear stress distribution at the endothelium of coronary arteries
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Van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B et al.
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Cardiac depression after experimental air embolism in pigs: Role of addition of a surface-active agent
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Van Der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC, Bom N
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Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
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Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, De Feyter PJ, Serruys PW, Slager CJ
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Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo: Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics
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True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data
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Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient
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Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
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Soei LK, Krams R, Duncker DJ, Verdouw PD
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The ca<sup>2+</sup> sensmser emd 60263 only impairs diastolic function of stunned myocardium at high doses in anesthetized swine
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FASEB Journal
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Bezstarosti K, Soei LK, Krams R, Ten Cate FJ, Verdouw PD, Lamers JMJ
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The effect of a thiadiazinone derived Ca<sup>2+</sup> sensitizer on the responsiveness of Mg<sup>2+</sup>-ATPase to Ca<sup>2+</sup> in myofibrils isolated from stunned and nonstunned porcine and human myocardium
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Biochemical Pharmacology
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Rijsterborgh H, Van Der Steen AFW, Krams R, Mastik F, Lancée CT, Verdouw PD, Roelandt JRTC, Bom N
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The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study
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Laban M, Oomen JA, Slager CJ, Wentzel JJ, Krams R, Schuurbiers JCH, den Boer A, von Birgelen C et al.
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ANGUS: a new approach to three-dimensional reconstruction of coronary vessels by combined use of angiography and intravascular ultrasound
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Computers in Cardiology
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325
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VONBIRGELEN C, KRAMS R, GIL R, TENGATE FJ, DIMARIO C
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HOW SHOULD WE EVALUATE THE VASODILATORY CAPACITY OF CORONARY RESISTANCE VESSELS IN PATIENTS WITH ASYMMETRIC HYPERTROPHIC CARDIOMYOPATHY
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VONBIRGELEN C, KRAMS R, DIMARIO C, GIL R, KOFFLARD M, TENCATE FJ, REIMERS B, SLAGER CJ et al.
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SYSTEMATIC STUDY OF FLOW VELOCITY PROFILES IN EPICARDIAL CORONARY-ARTERIES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUBAORTIC OUTFLOW GRADIENT
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CIRCULATION
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1995
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734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS
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Journal of the American College of Cardiology
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Wilson RA, di Mario C, Krams R, Soei LK, Wenguang L, Laird AC, The SHK, Gussenhoven E et al.
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In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia
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Di Mario C, Gil R, Krams R, De Feyter PJ, Serruys W
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New invasive techniques of assessment of the physiological significance of coronary stenoses in humans
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European Heart Journal
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KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ, VERDOUW PD
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1994
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LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP
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Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD
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Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
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FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD
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1994
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REVERSAL OF INCREASED LOAD-DEPENDENCY OF EFFICIENCY OF ENERGY-CONVERSION IN STUNNED MYOCARDIUM BY INCREASING THE CA2+ SENSITIVITY
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CIRCULATION
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FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD
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VARIABILITY IN OXYGEN-CONSUMPTION MEASUREMENTS DURING MYOCARDIAL STUNNING CAN BE EXPLAINED BY A PRONOUNCED AFTERLOAD DEPENDENCY OF SEGMENT LENGTH SHORTENING, EXTERNAL WORK AND MECHANICAL EFFICIENCY
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Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E, Verdouw PD
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On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers
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Ann N Y Acad Sci
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Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R, Verdouw PD
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Increasing the Ca<sup>++</sup> sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium
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Applied Cardiopulmonary Pathophysiology
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Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD
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Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
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American Journal of Physiology - Heart and Circulatory Physiology
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Loe Kie Soei, Sassen LMA, Dong Sheng Fan, Van Veen T, Krams R, Verdouw PD
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Myofibrillar Ca<sup>2+</sup> sensitization predominantly enhances function and mechanical efficiency of stunned myocardium
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FAN D, KIE SOEI L, SASSEN LMA, KRAMS R, HENDRIK E, VERDOUW PD
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On the Reversal of Myocardial Stunning: A Role for Ca<sup>2+</sup>‐Sensitizers
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Annals of the New York Academy of Sciences
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Di Mario C, Krams R, Gil R, Serruys PW
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Slope of the instantaneous hyperemic diastolic coronary flow velocity- pressure relation: A new index for assessment of the physiological significance of coronary stenosis in humans
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Circulation
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The instantaneous hyperemic pressure-flow relationship in conscious humans
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Progress in quantitative coronary arteriography
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KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA, VERDOUW PD
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1993
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END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION
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AMERICAN JOURNAL OF PHYSIOLOGY
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Krams R, Soei LK, McFalls EO, Winkler Prins EA, Sassen LM, Verdouw PD
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End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
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Bruining N, Krams R, Passchier H, Meij S, de Feijter P, Keane D
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Modular hard and software system for the analysis of cardiac signals: application to real time pressure-volume loops
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Computers in Cardiology
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Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ, Verdouw PD
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Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia
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Cardiovascular Drugs and Therapy
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7
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DIMARIO C, KRAMS R, BALK A, VERDOUW PD, ROELANDT J
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1993
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CAN THE ZERO-FLOW PRESSURE BE EXTRAPOLATED FROM THE FLOW VELOCITY-PRESSURE RELATION DURING LONG DIASTOLIC PAUSES IN HUMANS
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McFalls EO, Duncker DJ, Sassen LMA, Krams R, Man in't Veld AJ, Ruffolo RR, Verdouw PD
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Altered coronary flow reserve in the hypertrophied heart: Implications for therapy
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Journal of Human Hypertension
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Krams R, Duncker DJ, Mcfalls EO, Hogendoorn A, Verdouw PD
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Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium
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American Journal of Physiology - Heart and Circulatory Physiology
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265
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De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M, Verdouw PD
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High-energy phosphates and their catabolites
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Ischemia-reperfusion in cardiac surgery
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L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs
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Journal of Cardiovascular Pharmacology
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MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A, VERDOUW PD
(
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RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM
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Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD
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L-propionylcarnitine and myocardial performance in stunned porcine myocardium
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Molecular and Cellular Biochemistry
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MCFALLS EO, KRAMS R, DUNCKER DJ, SASSEN LMA, HOOGENDOORN A, VERDOUW PD
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1992
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RECRUITMENT OF REGIONAL EXTERNAL WORK AND OXYGEN-CONSUMPTION IN STUNNED PORCINE MYOCARDIUM
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DUNCKER DJ, MCFALLS EO, KRAMS R, VERDOUW PD
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PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM
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Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A, Kie Soei L
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1992
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Amiodarone increases ATP and decreases NaK ATPase activity and protein content of cultured rat heart myocytes
.
Journal of Molecular and Cellular Cardiology
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24
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Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A, Soei LK
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Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium
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Journal of Molecular and Cellular Cardiology
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24
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Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD
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L-propionylcarnitine and myocardial performance in stunned porcine myocardium
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Lipid Metabolism in the Healthy and Disease Heart
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Duncker DJ, McFalls EO, Krams R, Verdouw PD
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Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
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American Journal of Physiology - Heart and Circulatory Physiology
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McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A, Verdouw PD
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American Journal of Physiology - Heart and Circulatory Physiology
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McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD
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Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
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Krams R, Duncker DJ, McFalls EO, Verdouw PD
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Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia
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Journal of Molecular and Cellular Cardiology
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23
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Krams R, Duncker DJ, McFalls EO, Verdouw PD
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Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion
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Journal of Molecular and Cellular Cardiology
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Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD, Roelandt J
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)
.
Does intravenous milrinone have a direct effect on diastolic function?
.
Am Heart J
vol.
121
,
(
6 Pt 2
)
1951
-
1955
.
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD, Roelandt J
(
1991
)
.
Does intravenous milrinone have a direct effect on diastolic function?
.
American Heart Journal
.
vol.
121
,
1951
-
1955
.
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD
(
1991
)
.
Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
.
Cardiovascular Research
vol.
25
,
(
8
)
659
-
665
.
KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW, ROELANDT J
(
1991
)
.
THE EFFECT OF MILRINONE ON DIASTOLIC FUNCTION - DIRECT OR INDIRECT EFFECT
.
ACUTE THERAPY OF HEART FAILURE
.
vol.
2
,
35
-
42
.
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R, YIN FCP
(
1990
)
.
EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM
.
AMERICAN JOURNAL OF PHYSIOLOGY
vol.
259
,
(
6
)
H1869
-
H1880
.
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FC
(
1990
)
.
Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
.
Am J Physiol
vol.
259
,
(
6 Pt 2
)
H1869
-
H1880
.
WESTERHOF N, SIPKEMA P, KRAMS R
(
1990
)
.
MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY
.
AMERICAN JOURNAL OF PHYSIOLOGY
vol.
259
,
(
6
)
H1936
-
H1937
.
Westerhof N, Sipkema P, Krams R
(
1990
)
.
Myocardial modulation of coronary circulation Reply)
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
259
,
(
6 28-6
)
KRAMS R, SIPKEMA P, WESTERHOF N
(
1990
)
.
CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
.
AMERICAN JOURNAL OF PHYSIOLOGY
vol.
258
,
(
6
)
H1889
-
H1898
.
Krams R, Sipkema P, Westerhof N
(
1990
)
.
Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
.
Am J Physiol
vol.
258
,
(
6 Pt 2
)
H1889
-
H1898
.
Krams R, Sipkema P, Westerhof N
(
1990
)
.
Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
258
,
(
6 27-6
)
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FCP
(
1990
)
.
Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
259
,
(
6 28-6
)
Krams R, Sipkema P, Zegers J, Westerhof N
(
1989
)
.
Contractility is the main determinant of coronary systolic flow impediment
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
257
,
(
6
)
Krams R, Sipkema P, Zegers J, Westerhof N
(
1989
)
.
Contractility is the main determinant of coronary systolic flow impediment
.
Am J Physiol
vol.
257
,
(
6 Pt 2
)
H1936
-
H1944
.
Krams R, Sipkema P, Westerhof N
(
1989
)
.
Varying elastance concept may explain coronary systolic flow impediment
.
Am J Physiol
vol.
257
,
(
5 Pt 2
)
H1471
-
H1479
.
Krams R, van Haelst ACTA, Sipkema P, Westerhof N
(
1989
)
.
Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance?
.
Basic Research in Cardiology
vol.
84
,
(
2
)
149
-
159
.
Krams R, Sipkema P, Westerhof N
(
1989
)
.
Varying elastance concept may explain coronary systolic flow impediment
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
257
,
(
5
)
Van Dijk LC, Krams R, Sipkema P, Westerhof N
(
1988
)
.
Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
.
Am J Physiol
vol.
255
,
(
3 Pt 2
)
H476
-
H482
.
YIN F, SIPKEMA P, KRAMS R, STRUMPF R, RESAR J
(
1988
)
.
EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM
.
FASEB JOURNAL
.
vol.
2
,
A302
-
A302
.
SIPKEMA P, KRAMS R, WESTERHOF N
(
1988
)
.
SYSTOLIC CORONARY FLOW IMPEDIMENT EXPLAINED ON BASIS OF THE TIME-VARYING ELASTANCE CONCEPT
.
FASEB JOURNAL
.
vol.
2
,
A929
-
A929
.
Van Dijk LC, Krams R, Sipkema P, Westerhof N
(
1988
)
.
Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
255
,
(
3
)
Westerhof N, Krams R
(
1986
)
.
Comments on "Pressure and tone dependence of coronary diastolic input impedance and capacitance"
.
American Journal of Physiology
vol.
250
,
(
2
)
h330
-
h331
.
Westerhof N, Krams R
(
1986
)
.
Comments on "Pressure and tone dependence of coronary diastolic input impedance and capacitance"
.
Am J Physiol
vol.
250
,
(
2 Pt 2
)
H330
-
H331
.
Westerhof N, Krams R, Canty JM
(
1986
)
.
Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'
.
American Journal of Physiology - Heart and Circulatory Physiology
vol.
250
,
(
2 (19/2)
)
KRAMS R, SIPKEMA P, WESTERHOF N
(
1985
)
.
DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT
.
JOURNAL OF PHYSIOLOGY-LONDON
.
vol.
366
,
P42
-
P42
.
Sipkema P, Burattini R, van Haelst ACTA, Krams R, Westerhof N
(
1984
)
.
EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW
.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
.
Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P et al.
(
1984
)
.
"Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog"
.
Circulation research
vol.
54
,
(
3
)
Westerhof N, Krams R, Van Haelst ACTA, Sipkema P
(
1984
)
.
Can left ventricular pressure explain coronary flow impediment?
.
Federation Proceedings
.
vol.
43
,
BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P, WESTERHOF N
(
1982
)
.
THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS
.
CIRCULATION RESEARCH
vol.
51
,
(
6
)
822
-
822
.