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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Peter Thorpe

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Klemm C, Ólafsson G, Wood HR, Mellor C, Zabet NR, Thorpe PH ( 2024 ) . Proteome-wide forced interactions reveal a functional map of cell-cycle phospho-regulation in S. cerevisiae . Nucleus vol. 15 , ( 1 )
Peripolli S, Meneguello L, Perrod C, Singh T, Patel H, Rahman ST, Kiso K, Thorpe P et al. ( 2024 ) . Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner . Nature Communications vol. 15 , ( 1 ) 1579 - 1579 .
Mishra PK, Ali N, Au W, Boeckmann L, Takahashi Y, Castineira P, Bloom K, Thorpe P et al. ( 2023 ) . Constitutive methylation of budding yeast CENP-A contributes to chromosomal instability . Molecular Biology of the Cell . Conference: Molecular Biology of the Cell vol. 34 , 964 - 964 .
Mishra PK, Au W-C, Castineira PG, Ali N, Stanton J, Boeckmann L, Takahashi Y, Costanzo M et al. ( 2023 ) . Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability . Molecular Biology of the Cell vol. 34 , ( 10 ) ar99 - ar99 .
Thorpe PH, Marrero VA, Savitzky MH, Sunjevaric I, Freeman TC, Rothstein R ( 2023 ) . Cells Expressing Murine RAD52 Splice Variants Favor Sister Chromatid Repair . Molecular and Cellular Biology vol. 26 , ( 10 ) 3752 - 3763 .
Nitika, Zheng B, Ruan L, Kline JT, Omkar S, Sikora J, Texeira Torres M, Wang Y et al. ( 2022 ) . Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications . PLoS Biology vol. 20 , ( 10 ) e3001839 - e3001839 .
Klemm C, Howell RSM, Thorpe PH ( 2022 ) . ScreenGarden: a shinyR application for fast and easy analysis of plate-based high-throughput screens . BMC Bioinformatics vol. 23 , ( 1 ) 60 - 60 .
Klemm C, Wood H, Thomas GH, Ólafsson G, Torres MT, Thorpe PH ( 2021 ) . Forced association of SARS-CoV-2 proteins with the yeast proteome perturb vesicle trafficking . Microbial Cell vol. 8 , ( 12 ) 280 - 280 .
Mishra PK, Wood H, Stanton J, Au W-C, Eisenstatt JR, Boeckmann L, Sclafani RA, Weinreich M et al. ( 2021 ) . Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast . Molecular Biology of the Cell vol. 32 , ( 21 ) ar15 - ar15 .
Klemm C, Thorpe PH, Ólafsson G ( 2020 ) . Cell-cycle phospho-regulation of the kinetochore . Current Genetics vol. 67 , ( 2 ) 177 - 193 .
Howell RSM, Klemm C, Thorpe PH, Csikász-Nagy A ( 2020 ) . Unifying the mechanism of mitotic exit control in a spatiotemporal logical model . PLOS Biology vol. 18 , ( 11 )
Herrero E, Stinus S, Bellows E, Berry LK, Wood H, Thorpe PH ( 2020 ) . Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression . Genetics vol. 216 , ( 3 ) 701 - 716 .
Ólafsson G, Thorpe PH ( 2020 ) . Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA . PLOS Genetics vol. 16 , ( 8 )
Berry LK, Thomas GH, Thorpe PH ( 2020 ) . CATS: Cas9-assisted tag switching. A high-throughput method for exchanging genomic peptide tags in yeast . BMC Genomics vol. 21 , ( 1 )
Garcia E, Guo W, Kumar S, Görlitz F, Sparks H, Alexandrov Y, Munro I, Kelly DJ et al. ( 2020 ) . FLIM, FRET and high content analysis . Progress in Biomedical Optics and Imaging - Proceedings of SPIE . Conference: SPIE BiOS vol. 11244 ,
Howell RSM, Csikász-Nagy A, Thorpe PH ( 2019 ) . Synthetic Physical Interactions with the Yeast Centrosome . G3 (Bethesda) vol. 9 , ( 7 ) 2183 - 2194 .
Howell RSM, Csikász-Nagy A, Thorpe PH ( 2019 ) . Synthetic Physical Interactions with the Yeast Centrosome . G3 (Bethesda) vol. 9 , ( 7 ) 2183 - 2194 .
Mishra PK, Olafsson G, Boeckmann L, Westlake TJ, Jowhar ZM, Dittman LE, Baker RE, D'Amours D et al. ( 2019 ) . Cell cycle dependent association of polo kinase Cdc5 with CENP-A contributes to faithful chromosome segregation in budding yeast . Mol Biol CellmbcE18090584 - mbcE18090584 .
Guo W, Kumar S, Görlitz F, Garcia E, Alexandrov Y, Munro I, Kelly DJ, Warren S et al. ( 2019 ) . Automated Fluorescence Lifetime Imaging High-Content Analysis of Förster Resonance Energy Transfer between Endogenously Labeled Kinetochore Proteins in Live Budding Yeast Cells . SLAS Technol vol. 24 , ( 3 ) 308 - 320 .
Thorpe PH, Porteous DJ ( 2018 ) . Rapid Quantitation of Gene Therapy Specific CFTR Expression Using the Amplification Refractory Mutation System . BioTechniques vol. 27 , ( 1 ) 122 - 127 .
Ólafsson G, Thorpe PH ( 2017 ) . Rewiring the Budding Yeast Proteome using Synthetic Physical Interactions . Genome Instability , vol. 1672 , Springer Nature
Ledesma-Fernández E, Thorpe PH, de Bruin RAM ( 2016 ) . Bringing Functional Genomics into Focus . Cell Systems vol. 3 , ( 3 ) 214 - 216 .
Olafsson G, Thorpe PH ( 2016 ) . Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions . G3-GENES GENOMES GENETICS vol. 6 , ( 8 ) 2531 - 2542 .
Berry LK, Ólafsson G, Ledesma-Fernández E, Thorpe PH ( 2016 ) . Synthetic protein interactions reveal a functional map of the cell . eLife vol. 5 ,
Herrero E, Thorpe PH ( 2016 ) . Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2 . PLOS Genetics vol. 12 , ( 2 )
Ólafsson G, Thorpe PH ( 2015 ) . Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 33 ) 10413 - 10418 .
Ledesma-Fernández E, Thorpe PH ( 2015 ) . Fluorescent foci quantitation for high-throughput analysis . Journal of Biological Methods vol. 2 , ( 2 )
Thorpe PH, Rothstein R ( 2012 ) . Visualizing global effects of the DNA damage response . Nature Cell Biology vol. 14 , ( 9 ) 900 - 901 .
Thorpe PH, Dittmar JC, Rothstein R ( 2012 ) . ScreenTroll: a searchable database to compare genome-wide yeast screens . Database vol. 2012 ,
Thorpe PH, Alvaro D, Lisby M, Rothstein R ( 2011 ) . Bringing Rad52 foci into focus . Journal of Cell Biology vol. 194 , ( 5 ) 665 - 667 .
Thorpe PH, Bruno J, Rothstein R ( 2009 ) . Kinetochore asymmetry defines a single yeast lineage . Proceedings of the National Academy of Sciences of the United States of America vol. 106 , ( 16 ) 6673 - 6678 .
Thorpe PH, Bruno J, Rothstein R ( 2008 ) . Modeling Stem Cell Asymmetry in Yeast . Cold Spring Harbor Symposia on Quantitative Biology vol. 73 , ( 0 ) 81 - 88 .
Thorpe PH, González-Barrera S, Rothstein R ( 2007 ) . More is not always better: the genetic constraints of polyploidy . Trends in Genetics vol. 23 , ( 6 ) 263 - 266 .
Cagney G, Alvaro D, Reid RJ, Thorpe PH, Rothstein R, Krogan NJ ( 2006 ) . Functional genomics of the yeast DNA-damage response . Genome Biology vol. 7 , ( 9 )
Simpson A, King J, Thorpe P, McLachlan G, Sallenave J-M ( 2004 ) . Towards Gene Therapy for Inflammatory and Infective Pulmonary Diseases . Current Genomics vol. 5 , ( 4 ) 365 - 383 .
Thorpe P, Stevenson BJ, Porteous DJ ( 2002 ) . Optimising gene repair strategies in cell culture . Gene Therapy vol. 9 , ( 11 ) 700 - 702 .
Thorpe PH, Stevenson BJ, Porteous DJ ( 2002 ) . Functional correction of episomal mutations withshort DNA fragments and RNA–DNA oligonucleotides . The Journal of Gene Medicine vol. 4 , ( 2 ) 195 - 204 .
Thorpe PH, Ternent D, Murray NE ( 1997 ) . The specificity of StySKI, a type I restriction enzyme, implies a structure with rotational symmetry . Nucleic Acids Research vol. 25 , ( 9 ) 1694 - 1700 .
Dryden DTF, Cooper LP, Thorpe PH, Byron O ( 1997 ) . The in Vitro Assembly of the EcoKI Type I DNA Restriction/Modification Enzyme and Its in Vivo Implications † . Biochemistry vol. 36 , ( 5 ) 1065 - 1076 .
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