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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Mr Findlay Bewicke-Copley

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Boot J, Nelmes E, Bewicke-Copley F, Paleja K, Davenport E, Henderson R, Hann W, Zhang X-Y et al. ( 2024 ) . Delays to Diagnosis of Peripheral T-Cell Lymphoma and Clinical Utility of Molecular Profiling: A UK Multicentre Real-World Study . Blood vol. 144 , ( Supplement 1 )
Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al. ( 2024 ) . CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma . British Journal of Haematology vol. 205 , ( 5 ) 1804 - 1809 .
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .
Xu D, Bewicke-Copley F, Close K, Okosun J, Gale RP, Apperley J, Weinstock DM, Wendel H-G et al. ( 2024 ) . Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma . Blood Cancer Journal vol. 14 , ( 1 )
Coulter EM, Bewicke-Copley F, Mossner M, Graham TA, Fitzgibbon J, Okosun J ( 2024 ) . Defining an Optimized Workflow for Enriching and Analyzing Residual Tumor Populations Using Intracellular Markers . Journal of Molecular Diagnostics vol. 26 , ( 4 ) 245 - 256 .
Zheng J, Bewicke-Copley F, Vermeulen C, Casado P, Kaya F, Demeulemeester J, Guscott M, Krizsán S et al. ( 2023 ) . Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML . Blood vol. 142 , ( Supplement 1 )
Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al. ( 2023 ) . The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients . Blood vol. 142 , ( Supplement 1 )
Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al. ( 2023 ) . LB1663 A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis . Journal of Investigative Dermatology vol. 143 , ( 9 )
Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R et al. ( 2023 ) . Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis . Journal of the American Academy of Dermatology vol. 89 , ( 6 ) 1159 - 1166 .
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S et al. ( 2023 ) . Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma . Blood Advances vol. 7 , ( 5 ) 845 - 855 .
Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al. ( 2023 ) . Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes . Signal Transduction and Targeted Therapy vol. 8 , ( 1 )
Berastegui N, Ainciburu M, Romero JP, Garcia-Olloqui P, Alfonso-Pierola A, Philippe C, Vilas-Zornoza A, San Martin-Uriz P et al. ( 2022 ) . The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes . Nature Communications vol. 13 , ( 1 )
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al. ( 2022 ) . Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML . Blood vol. 140 , ( Supplement 1 ) 1030 - 1032 .
Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .
Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al. ( 2022 ) . Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment . British Journal of Haematology vol. 199 , ( 5 ) 754 - 764 .
Grey W, Rio-Machin A, Casado P, Grönroos E, Ali S, Miettinen JJ, Bewicke-Copley F, Parsons A et al. ( 2022 ) . CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia . Science Translational Medicine vol. 14 , ( 650 ) eabn3248 - eabn3248 .
Grey W, Rio‐Machin A, Casado‐Izquierdo P, Gronroos E, Ali S, Miettinen J, Bewicke‐Copley F, Parsons A et al. ( 2022 ) . P405: INHIBITION OF CKS1‐DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIETIC STEM CELLS . HemaSphere vol. 6 , 305 - 306 .
Armes H, Rio-Machin A, Krizsán S, Bödör C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al. ( 2022 ) . Acquired somatic variants in inherited myeloid malignancies . Leukemia vol. 36 , ( 5 ) 1377 - 1381 .
Armes H, Rio-Machin A, Krizsan S, Bodor C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al. ( 2022 ) . Acquired somatic variants in inherited myeloid malignancies . LEUKEMIA vol. 36 , ( 5 ) 1377 - 1381 .
Walne AJ, Vulliamy T, Bewicke-Copley F, Wang J, Alnajar J, Bridger MG, Ma B, Tummala H et al. ( 2021 ) . Genome-wide whole-blood transcriptome profiling across inherited bone marrow failure subtypes . Blood Advances vol. 5 , ( 23 ) 5360 - 5371 .
Maybury BD, Bewicke-Copley F, Johnson P, Fitzgibbon J, Calado DP ( 2021 ) . Characterising Tumour and Microenvironmental Responses to R-CHOP in Immunocompetent Mouse Models of DLBCL . Blood vol. 138 , ( Supplement 1 )
Close K, Armes H, Kumar E, Bewicke-Copley F, Cribbs A, Dunford J, Philpott M, Oppermann U et al. ( 2021 ) . The Paradoxical Efficacy of KDM6 Inhibition in Germinal Centre B-Cell Lymphomas . Blood vol. 138 , ( Supplement 1 )
Anene CA, Khan F, Bewicke-Copley F, Maniati E, Wang J ( 2021 ) . ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles . Patterns vol. 2 , ( 6 ) Article 100270 , 100270 - 100270 .
Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al. ( 2021 ) . KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas . Blood vol. 138 , ( 5 ) 370 - 381 .
Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al. ( 2021 ) . The Genomic Landscape of Actinic Keratosis . Journal of Investigative Dermatology vol. 141 , ( 7 ) 1664 - 1674.e7 .
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .
Uyulur F, Bewicke-Copley F, Anene CA, Schlesner M, Project IM-S, Siebert R, Okosun J, Fitzgibbon J et al. ( 2020 ) . Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma . Blood vol. 136 , ( Supplement 1 ) 26 - 27 .
Dokal I, Tummala H, Vulliamy T, Walne A ( 2020 ) . A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure . Proceedings of the National Academy of Sciences of USA Article 32636268 ,
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al. ( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) 318 - 321 .
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al. ( 2020 ) . The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants . Nature Communications vol. 11 , ( 1 )
Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel . Blood vol. 134 , ( Supplement_1 )
Bewicke-Copley F, Kumar EA, Palladino G, Korfi K, Wang J ( 2019 ) . Applications and analysis of targeted genomic sequencing in cancer studies . Computational and Structural Biotechnology Journal vol. 17 , 1348 - 1359 .
Kumar E, Korfi K, Bewicke‐Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al. ( 2019 ) . PF513 MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA . HemaSphere vol. 3 , ( S1 )
Korfi K, Araf S, Bewicke‐Copley F, Kumar E, Cummin T, Ashton‐Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA . Hematological Oncology vol. 37 , ( S2 ) 142 - 143 .
Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al. ( 2019 ) . MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA . HemaSphere vol. 3 ,
Bewicke‐Copley F, Mulcahy LA, Jacobs LA, Samuel P, Akbar N, Pink RC, Carter DRF ( 2017 ) . Extracellular vesicles released following heat stress induce bystander effect in unstressed populations . Journal of Extracellular Vesicles vol. 6 , ( 1 )
Bewicke-Copley F, Samuel P, Carter DR ( 2015 ) . RNAi2015 - Ten years of RNAi Oxford . Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research vol. 11 , 515 - 518 .
Jacobs LA, Bewicke-Copley F, Poolman MG, Pink RC, Mulcahy LA, Baker I, Beaman E-M, Brooks T et al. ( 2013 ) . Meta-Analysis Using a Novel Database, miRStress, Reveals miRNAs That Are Frequently Associated with the Radiation and Hypoxia Stress-Responses . PLOS ONE vol. 8 , ( 11 )
Hickman R, Hill C, Penfold CA, Breeze E, Bowden L, Moore JD, Zhang P, Jackson A et al. ( 2013 ) . A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves . The Plant Journal vol. 75 , ( 1 ) 26 - 39 .
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