Publications: Prof Peter McCormick

Hu X, Lin C, Xu Q, Zhou X, Zeng P, McCormick PJ, Jiang H, Li J et al. ( 2022 ) . Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor . Viruses vol. 14 , ( 9 )

Li J, Lin C, Zhou X, Zhong F, Zeng P, McCormick PJ, Jiang H, Zhang J ( 2022 ) . Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814 . Journal of Molecular Biology vol. 434 , ( 16 )

Aslanoglou D, Bertera S, Friggeri L, Sánchez-Soto M, Lee J, Xue X, Logan RW, Lane JR et al. ( 2022 ) . Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine . iScience . vol. 25 ,

Farooq Z, Howell LA, McCormick PJ ( 2022 ) . Probing GPCR Dimerization Using Peptides . Frontiers in Endocrinology vol. 13 ,

Li J, Lin C, Zhou X, Zhong F, Zeng P, Yang Y, Zhang Y, Yu B et al. ( 2022 ) . Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332 . Journal of Virology vol. 96 , ( 8 )

Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H et al. ( 2022 ) . Cryo-EM structure of mouse TRPML2 in lipid nanodiscs . Journal of Biological Chemistry vol. 298 , ( 2 )

Gazzi T, Brennecke B, Atz K, Korn C, Sykes D, Forn-Cuni G, Pfaff P, Sarott RC et al. ( 2022 ) . Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe . Chemical Science

Chalhoub G, McCormick PJ ( 2022 ) . Palmitoylation and G-protein coupled receptors . vol. 193 , ( 1 ) 195 - 211 .

Zhang Y, Gao H, Hu X, Wang Q, Zhong F, Zhou X, Lin C, Yang Y et al. ( 2022 ) . Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus . Journal of Virology vol. 96 , ( 1 )

Ciancetta A, Gill AK, Ding T, Karlov DS, Chalhoub G, McCormick PJ, Tikhonova IG ( 2021 ) . Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction . ACS Central Science vol. 7 , ( 11 ) 1847 - 1862 .

Andrews A, Cottrell E, Maharaj A, Ladha T, Williams J, Metherell LA, McCormick PJ, Storr HL ( 2021 ) . Novel dominant negative GH receptor variants provide important insights into GH receptor physiology . Endocrine Abstracts .

Begalli F, Komagata T, Suleyman O, Magid K, Rice T, Collier D, Dorward N, Grieve J et al. ( 2021 ) . Cabergoline treatment in human primary non-functioning pituitary adenomas . Endocrine Abstracts .

Joseph MD, Bort ET, Grose RP, McCormick PJ, Simoncelli S ( 2021 ) . Quantitative super‐resolution imaging for the analysis of GPCR oligomerization . Biomolecules vol. 11 , ( 10 )

Costas-Insua C, Moreno E, Maroto IB, Ruiz-Calvo A, Bajo-Grañeras R, Martín-Gutiérrez D, Diez-Alarcia R, Teresa Vilaró M et al. ( 2021 ) . Identification of bip as a cb1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain . Journal of Neuroscience vol. 41 , ( 38 ) 7924 - 7941 .

Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V et al. ( 2021 ) . Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling . Science vol. 372 , ( 6544 ) 808 - 814 .

Li J, Zhou X, Zhang Y, Zhong F, Lin C, McCormick PJ, Jiang F, Luo J et al. ( 2021 ) . Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode . Science Bulletin vol. 66 , ( 7 ) 661 - 663 .

Carreira EM, Grether U, Sarott RC, Westphal MV, Pfaff P, Korn C, Sykes DA, Gazzi T et al. ( 2020 ) . Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells . Journal of the American Chemical Society vol. 142 , ( 40 ) 16953 - 16964 .

Zhou X, Zhong F, Lin C, Hu X, Zhang Y, Xiong B, Yin X, Fu J et al. ( 2020 ) . Structure of SARS-CoV-2 main protease in the apo state . Science in China Series C: Life Sciences

Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA et al. ( 2020 ) . Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease . eLife vol. 9 , 1 - 31 .

Contino M, McCormick PJ ( 2020 ) . Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain . Frontiers in Pharmacology vol. 11 ,

Lewis R, Li J, McCormick PJ, L-H Huang C, Jeevaratnam K ( 2020 ) . Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review . IJC Heart and Vasculature vol. 26 ,

Botta J, Appelhans J, McCormick PJ ( 2020 ) . Continuing challenges in targeting oligomeric GPCR-based drugs . vol. 169 , 213 - 245 .

Bridge T, Shaikh SA, Thomas P, Botta J, McCormick PJ, Sachdeva A ( 2019 ) . Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody–Antigen Binding on Live Cells . Angewandte Chemie - International Edition vol. 58 , ( 50 ) 17986 - 17993 .

Bridge T, Shaikh SA, Thomas P, Botta J, McCormick PJ, Sachdeva A ( 2019 ) . Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells . Angewandte Chemie vol. 131 , ( 50 ) 18154 - 18161 .

Botta J, Bibic L, Killoran P, McCormick PJ, Howell LA ( 2019 ) . Design and development of stapled transmembrane peptides that disrupt the activity of G-protein coupled receptor oligomers . J Biol Chem

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L et al. ( 2019 ) . Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 9 ) 3863 - 3872 .

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L et al. ( 2019 ) . Erratum: Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (3863–3872) DOI: 10.1073/pnas.1815034116) . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 13 )

Aringhieri S, Carli M, Kolachalam S, Verdesca V, Cini E, Rossi M, McCormick PJ, Corsini GU et al. ( 2018 ) . Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences . Pharmacology and Therapeutics vol. 192 , 20 - 41 .

Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A et al. ( 2018 ) . Cross-communication between G<inf>i</inf> and G<inf>s</inf> in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain . BMC Biology vol. 16 , ( 1 )

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI et al. ( 2017 ) . A Positive Allosteric Modulator of the Serotonin 5-HT<inf>2C</inf> Receptor for Obesity . Journal of Medicinal Chemistry vol. 60 , ( 23 ) 9575 - 9584 .

Sauvageau E, McCormick PJ, Lefrancois S ( 2017 ) . In vivo monitoring of the recruitment and activation of AP-1 by Arf1 . Scientific Reports vol. 7 , ( 1 )

Fahradpour M, Keov P, Tognola C, Perez-Santamarina E, McCormick PJ, Ghassempour A, Gruber CW ( 2017 ) . Cyclotides isolated from an ipecac root extract antagonize the corticotropin releasing factor type 1 receptor . Frontiers in Pharmacology vol. 8 , ( SEP )

Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI et al. ( 2017 ) . Heteroreceptor Complexes Formed by Dopamine D<inf>1</inf>, Histamine H<inf>3</inf>, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease . Molecular Neurobiology vol. 54 , ( 6 ) 4537 - 4550 .

Botta J, Cordomi A, Bondar A, Lazar J, Pardo L, McCormick PJ ( 2017 ) . PROBING THE MOLECULAR MECHANISM BEHIND THE COGNITIVE IMPAIRMENT INDUCED BY THC . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 121 , 11 - 12 .

González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, De La Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J et al. ( 2017 ) . A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding . Scientific Reports vol. 7 ,

HOWELL LA, Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Resel E, Puente N et al. ( 2017 ) . Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum . Neuropsychopharmacology (Nature)

McCormick PJ, Botta J ( 2017 ) . Heteromers form novel signaling complexes . Receptors , vol. 33 ,

Hoffmann HM, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick PJ, Ortiz J, Vignes M ( 2017 ) . Long-lasting impairment of mGluR<inf>5</inf>-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration . International Journal of Neuropsychopharmacology vol. 20 , ( 1 ) 72 - 82 .

Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M et al. ( 2016 ) . The insulin-like growth factor I receptor regulates glucose transport by astrocytes . GLIA vol. 64 , ( 11 ) 1962 - 1971 .

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ et al. ( 2016 ) . Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure . Journal of Medicinal Chemistry vol. 59 , ( 15 ) 7152 - 7166 .

Navarro G, Aguinaga D, Angelats E, Medrano M, Moreno E, Mallol J, Cortés A, Canela EI et al. ( 2016 ) . A significant role of the truncated ghrelin receptor GHS-R1b in ghrelin-induced signaling in neurons . Journal of Biological Chemistry vol. 291 , ( 25 ) 13048 - 13062 .

Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A et al. ( 2016 ) . Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G<inf>i</inf> and G<inf>s</inf> . BMC Biology vol. 14 , ( 1 )

Scarselli M, Annibale P, McCormick PJ, Kolachalam S, Aringhieri S, Radenovic A, Corsini GU, Maggio R ( 2016 ) . Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: Methods, dynamics and biological function . FEBS Journal vol. 283 , ( 7 ) 1197 - 1217 .

Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM et al. ( 2016 ) . Adenosine deaminase regulates T<inf>reg</inf> expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1 . Journal of Leukocyte Biology vol. 99 , ( 2 ) 349 - 359 .

Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT et al. ( 2015 ) . Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling . PLoS Genetics vol. 11 , ( 8 )

Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S et al. ( 2015 ) . Role of cannabinoid receptor CB<inf>2</inf> in HER2 pro-oncogenic signaling in breast cancer . Journal of the National Cancer Institute vol. 107 , ( 6 )

Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS et al. ( 2015 ) . Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine . Journal of Neuroscience vol. 35 , ( 17 ) 6639 - 6653 .

Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, De La Torre R, Gasperini P, Navarro G et al. ( 2015 ) . Cognitive impairment induced by delta9- tetrahydrocannabinol occurs through heteromers between cannabinoid CB<inf>1</inf> and serotonin 5-HT<inf>2A</inf> receptors . PLoS Biology vol. 13 , ( 7 )

Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V et al. ( 2014 ) . Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers . Chemistry and Biology vol. 21 , ( 11 ) 1546 - 1556 .

Guitart X, Navarro G, Moreno E, Yano H, Cai NS, Sánchez-Soto M, Kumar-Barodia S, Naidu YT et al. ( 2014 ) . Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: The dopamine D<inf>1</inf>-D<inf>3</inf>receptor heterotetramer . Molecular Pharmacology vol. 86 , ( 4 ) 417 - 429 .

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR et al. ( 2014 ) . Targeting CB<inf>2</inf>-GPR55 receptor heteromers modulates cancer cell signaling . Journal of Biological Chemistry vol. 289 , ( 32 ) 21960 - 21972 .

Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ et al. ( 2014 ) . Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas . PLoS ONE vol. 9 , ( 7 )

Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE et al. ( 2014 ) . L-DOPA-treatment in primates disrupts the expression of A<inf>2A</inf> adenosine-CB<inf>1</inf> cannabinoid-D<inf>2</inf> dopamine receptor heteromers in the caudate nucleus . Neuropharmacology vol. 79 , 90 - 100 .

Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M et al. ( 2014 ) . Cocaine disrupts histamine H<inf>3</inf> receptor modulation of dopamine D<inf>1</inf> receptor signaling: σ<inf>1</inf>-D<inf>1</inf>-H<inf>3</inf> receptor complexes as key targets for reducing cocaine's effects . Journal of Neuroscience vol. 34 , ( 10 ) 3545 - 3558 .

Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G et al. ( 2014 ) . L-DOPA disrupts adenosine A<inf>2A</inf>-cannabinoid CB<inf>1</inf>-dopamine D<inf>2</inf> receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies . Experimental Neurology vol. 253 , 180 - 191 .

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C et al. ( 2013 ) . A<inf>1</inf>R-A<inf>2A</inf>R heteromers coupled to G<inf>s</inf> and G<inf>i/0</inf> proteins modulate GABA transport into astrocytes . Purinergic Signalling vol. 9 , ( 3 ) 433 - 449 .

Gracia E, Moreno E, Cortés A, Lluís C, Mallol J, McCormick PJ, Canela EI, Casadó V ( 2013 ) . Homodimerization of adenosine A<inf>1</inf> receptors in brain cortex explains the biphasic effects of caffeine . Neuropharmacology vol. 71 , 56 - 69 .

Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A et al. ( 2013 ) . Cocaine Inhibits Dopamine D<inf>2</inf> Receptor Signaling via Sigma-1-D<inf>2</inf> Receptor Heteromers . PLoS ONE vol. 8 , ( 4 )

Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI et al. ( 2013 ) . The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors . FASEB Journal vol. 27 , ( 3 ) 1048 - 1061 .

Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ ( 2013 ) . Challenges in the development of heteromer-GPCR-based drugs . Progress in Molecular Biology and Translational Science , vol. 117 ,

Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ ( 2013 ) . Challenges in the development of heteromer-GPCR-based drugs . vol. 117 ,

Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI et al. ( 2013 ) . Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology . Methods in Molecular Biology vol. 964 , 95 - 105 .

Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T et al. ( 2012 ) . Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals . PLoS ONE vol. 7 , ( 12 )

Luquin N, Sierra S, Rico AJ, Gómez-Bautista V, Roda E, Conte-Perales L, Franco R, McCormick P et al. ( 2012 ) . Unmasking adenosine 2A receptors (A<inf>2A</inf>Rs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB) . Neurobiology of Disease vol. 47 , ( 3 ) 347 - 357 .

Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL et al. ( 2012 ) . Cannabinoid receptors CB <inf>1</inf> and CB <inf>2</inf> form functional heteromers in brain . Journal of Biological Chemistry vol. 287 , ( 25 ) 20851 - 20865 .

González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J et al. ( 2012 ) . Dopamine D <inf>4</inf> receptor, but not the ADHD-associated D <inf>4.7</inf> variant, forms functional heteromers with the dopamine D <inf>2S</inf> receptor in the brain . Molecular Psychiatry vol. 17 , ( 6 ) 650 - 662 .

Navarro G, Hradsky J, Lluís C, Casadó V, McCormick PJ, Kreutz MR, Mikhaylova M ( 2012 ) . NCS-1 associates with adenosine A <inf>2A</inf> receptors and modulates receptor function . Frontiers in Molecular Neuroscience ( APRIL )

Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R et al. ( 2012 ) . Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through notch-dependent signaling . Cancer Research vol. 72 , ( 5 ) 1157 - 1169 .

González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V et al. ( 2012 ) . Circadian-related heteromerization of adrenergic and dopamine d<inf>4</inf> receptors modulates melatonin synthesis and release in the pineal gland . PLoS Biology vol. 10 , ( 6 )

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C et al. ( 2011 ) . Modulation of GABA transport by adenosine A <inf>1</inf>R-A <inf>2A</inf>R heteromers, which are coupled to both G <inf>s</inf>- and G <inf>i/o</inf>-Proteins . Journal of Neuroscience vol. 31 , ( 44 ) 15629 - 15639 .

Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y et al. ( 2011 ) . Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca ²⁺ sensor calneurons requires the TRC40/Asna1 protein chaperone . Journal of Biological Chemistry vol. 286 , ( 42 ) 36762 - 36776 .

Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI et al. ( 2011 ) . Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus . Journal of Neuroscience vol. 31 , ( 20 ) 7412 - 7423 .

Vendrell M, Molero A, González S, Pérez-Capote K, Lluis C, McCormick PJ, Franco R, Cortés A et al. ( 2011 ) . Biotin ergopeptide probes for dopamine receptors . Journal of Medicinal Chemistry vol. 54 , ( 4 ) 1080 - 1090 .

Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M et al. ( 2011 ) . Dopamine D<inf>1</inf>-histamine H<inf>3</inf> receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway . Journal of Biological Chemistry vol. 286 , ( 7 ) 5846 - 5854 .

Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortésa A, Casadó V et al. ( 2010 ) . Direct involvement of σ-1 receptors in the dopamine D<inf>1</inf> receptor-mediated effects of cocaine . Proceedings of the National Academy of Sciences of the United States of America vol. 107 , ( 43 ) 18676 - 18681 .

De La Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick PJ, Segarra M, Stone J et al. ( 2010 ) . The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 . Blood vol. 115 , ( 19 ) 3970 - 3979 .

McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G ( 2009 ) . Impaired recruitment of GrK6 and β-arrestin2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor . PLoS ONE vol. 4 , ( 12 )

McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G, Lefrancois S ( 2008 ) . Palmitoylation controls recycling in lysosomal sorting and trafficking . Traffic vol. 9 , ( 11 ) 1984 - 1997 .

Segarra M, Williams CK, De La Luz Sierra M, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P et al. ( 2008 ) . DII4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth . Blood vol. 112 , ( 5 ) 1904 - 1911 .

Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB ( 2008 ) . CD1a and MHC class I follow a similar endocytic recycling pathway . Traffic vol. 9 , ( 9 ) 1446 - 1457 .

Lefrançois S, McCormick PJ ( 2007 ) . The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes . Traffic vol. 8 , ( 10 ) 1440 - 1451 .

Sierra MDLL, Gasperini P, McCormick PJ, Zhu J, Tosato G ( 2007 ) . Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells . Blood vol. 110 , ( 7 ) 2276 - 2285 .

Saurí A, McCormick PJ, Johnson AE, Mingarro I ( 2007 ) . Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration . Journal of Molecular Biology vol. 366 , ( 2 ) 366 - 374 .

Salvucci O, Sierra MDLL, Martina JA, McCormick PJ, Tosato G ( 2006 ) . EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling . Blood vol. 108 , ( 9 ) 2914 - 2922 .

McCormick PJ, Martina JA, Bonifacino JS ( 2005 ) . Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments . Proceedings of the National Academy of Sciences of the United States of America vol. 102 , ( 22 ) 7910 - 7915 .

Woolhead CA, McCormick PJ, Johnson AE ( 2004 ) . Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins . Cell vol. 116 , ( 5 ) 725 - 736 .

McCormick PJ, Miao Y, Shao Y, Lin J, Johnson AE ( 2003 ) . Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins . Molecular Cell vol. 12 , ( 2 ) 329 - 341 .