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Research

Publications: Dr Diego Villar Lozano

Roller M, Stamper E, Villar D, Izuogu O, Martin F, Redmond AM, Ramachanderan R, Harewood L et al. ( 2021 ) . LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions . Genome Biology vol. 22 , ( 1 )
Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 ) 200088 - 200088 .
Roller M, Stamper E, Villar D, Izuogu O, Martin F, Redmond A, Ramachanderan R, Harewood L et al. ( 2020 ) . LINE elements are a reservoir of regulatory potential in mammalian genomes .
Berthelot C, Villar D, Odom DT, Flicek P ( 2019 ) . The gene expression consequences of mammalian regulatory evolution . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 767 - 767 .
Berthelot C, Villar D, Horvath JE, Odom DT, Flicek P ( 2018 ) . Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression . Nat Ecol Evol vol. 2 , Article 1 , 152 - 163 .
Berthelot C, Villar D, Horvath J, Odom D, Flicek P ( 2017 ) . Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression .
Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi OW, DeYoung J, Eskin E et al. ( 2017 ) . Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate . Nat Genet vol. 49 , Article 12 , 1714 - 1721 .
Jasinska A, Zelaya I, Service S, Peterson C, Cantor R, Choi O-W, DeYoung J, Eskin E et al. ( 2016 ) . Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate .
Naranjo JR, Zhang H, Villar D, Gonzalez P, Dopazo XM, Moron-Oset J, Higueras E, Oliveros JC et al. ( 2016 ) . Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease . J Clin Invest vol. 126 , Article 2 , 627 - 38 .
Rudolph KL, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT ( 2016 ) . Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States . PLoS Genet vol. 12 , Article 5 , e1006024 - e1006024 .
Rensch T, Villar D, Horvath J, Odom DT, Flicek P ( 2016 ) . Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data . Genome Biol vol. 17 , Article 1 , 139 - 139 .
Villar D, Odom DT ( 2016 ) . Unwinding Limb Development . Cell vol. 167 , Article 3 , 598 - 600 .
Villar D, Berthelot C, Aldridge S, Rayner TF, Lukk M, Pignatelli M, Park TJ, Deaville R et al. ( 2015 ) . Enhancer evolution across 20 mammalian species . Cell vol. 160 , Article 3 , 554 - 66 .
Villar D, Odom DT ( 2015 ) . When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say? . Dev Cell vol. 35 , Article 1 , 3 - 4 .
Villar D, Flicek P, Odom DT ( 2014 ) . Evolution of transcription factor binding in metazoans - mechanisms and functional implications . Nat Rev Genet vol. 15 , Article 4 , 221 - 33 .
Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodriguez-Lara MI, Lopez-Jimenez L, Lopez-Rodriguez M, Peralta-Leal A et al. ( 2014 ) . Interaction between PARP-1 and HIF-2alpha in the hypoxic response . Oncogene vol. 33 , Article 7 , 891 - 8 .
Tiana M, Villar D, Perez-Guijarro E, Gomez-Maldonado L, Molto E, Fernandez-Minan A, Gomez-Skarmeta JL, Montoliu L et al. ( 2012 ) . A role for insulator elements in the regulation of gene expression response to hypoxia . Nucleic Acids Res vol. 40 , Article 5 , 1916 - 27 .
Villar D, Ortiz-Barahona A, Gomez-Maldonado L, Pescador N, Sanchez-Cabo F, Hackl H, Rodriguez BA, Trajanoski Z et al. ( 2012 ) . Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions . PLoS One vol. 7 , Article 9 , e45708 - e45708 .
Villar D, Odom DT ( 2012 ) . Generalizing complexity: a fruitful partnership of functional genomics and systems biology . Genome Med vol. 4 , Article 2 , 11 - 11 .
Rivas M, Villar D, Gonzalez P, Dopazo XM, Mellstrom B, Naranjo JR ( 2011 ) . Building the DREAM interactome . Sci China Life Sci vol. 54 , Article 8 , 786 - 92 .
Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L ( 2010 ) . Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction . Nucleic Acids Res vol. 38 , Article 7 , 2332 - 45 .
Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordonez A, Cuevas Y et al. ( 2010 ) . Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 . PLoS One vol. 5 , Article 3 , e9644 - e9644 .
Villar D, Vara-Vega A, Landazuri MO, Del Peso L ( 2007 ) . Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains . Biochem J vol. 408 , Article 2 , 231 - 40 .
Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landazuri MO, Del Peso L ( 2005 ) . Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene . Biochem J vol. 390 , Article Pt 1 , 189 - 97 .