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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Mr William Young

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Burns R, Young WJ, Aung N, Lopes LR, Elliott PM, Syrris P, Barriales-Villa R, Sohrabi C et al. ( 2024 ) . Genetic basis of right and left ventricular heart shape . Nature Communications vol. 15 , ( 1 )
Shah R, Kirkby C, Ives C, Lowe M, Munroe PB, Lambiase PD, Young WJ ( 2024 ) . Can variants of genes associated with familial heart block predict conduction disease in the general population? A UK Biobank study . European Heart Journal vol. 45 , ( Supplement_1 )
Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al. ( 2024 ) . Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal . European Heart Journal vol. 45 , ( Supplement_1 )
Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al. ( 2024 ) . The genetic architecture of exercise-induced ventricular ectopy . European Heart Journal vol. 45 , ( Supplement_1 )
Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 )
Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .
Ramírez J, Young WJ, van Duijvenboden S, Munroe PB ( 2024 ) . PO-01-089 PREDICTION OF ATRIAL AND VENTRICULAR ARRHYTHMIAS USING MULTIPLE CARDIOVASCULAR RISK FACTOR POLYGENIC RISK SCORES . Heart Rhythm vol. 21 , ( 5 )
Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al. ( 2024 ) . Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits . Nature Genetics vol. 56 , ( 5 ) 778 - 791 .
Hughes G, Young WJ, Bern H, Crook A, Lambiase PD, Goodall RL, Nunn AJ, Meredith SK ( 2024 ) . T-wave morphology abnormalities in the STREAM stage 1 trial . Expert Opinion on Drug Safety vol. 23 , ( 4 ) 469 - 476 .
Young WJ, Maung S, Ahmet S, Kirkby C, Ives C, Schilling RJ, Lowe M, Lambiase PD ( 2024 ) . The frequency of gene variant reclassification and its impact on clinical management in the inherited arrhythmia clinic . Heart Rhythm vol. 21 , ( 6 ) 903 - 910 .
Lambiase PD, Young WJ ( 2024 ) . Genomic basis of heart rate and rhythm generation . Genomic and Molecular Cardiovascular Medicine: a Volume in Genomic and Precision Medicine in Clinical Practice ,
Ramírez J, Miguel A, van Duijvenboden S, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB et al. ( 2023 ) . A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .
Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .
Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease . European Heart Journal vol. 44 , ( Supplement_2 )
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of ultra-short heart rate variability with cardiovascular events . Scientific Reports vol. 13 , ( 1 )
van Duijvenboden S, Ramírez J, Young WJ, Olczak KJ, Ahmed F, Alhammadi MJAY, Pressure ICOB, Bell CG et al. ( 2023 ) . Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension . American Journal of Human Genetics vol. 110 , ( 10 ) 1718 - 1734 .
Young WJ, Vyas S, Wragg A, Sporton S, Rosengarten J, Schilling RJ, Ang R ( 2023 ) . Right coronary artery compromise following radiofrequency catheter ablation for supraventricular tachycardia: cases reports . European Heart Journal - Case Reports vol. 7 , ( 9 )
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 )
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events . European Heart Journal - Digital Health vol. 4 , ( 2 ) 112 - 118 .
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )
Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .
Carrington M, Creta A, Young WJ, Carrington M, Henriques J, Teixeira R, Gonçalves L, Lambiase PD et al. ( 2022 ) . Defining electrocardiographic criteria to differentiate non‐type 1 Brugada ECG variants from normal incomplete RBBB patterns in the young SCD‐SOS cohort . Journal of Cardiovascular Electrophysiology vol. 33 , ( 9 ) 2083 - 2091 .
Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation Genomic and Precision Medicine vol. 15 , ( 5 ) e003441 - e003441 .
Maung S, Young W, Ives C, Kirkby C, Schilling R, Lowe M, Lambiase P ( 2022 ) . 84 Variants of uncertain significance: a real-world experience of reclassification from the inherited arrhythmia clinic . Conference: Cardiac rhythm managementa62 - a62 .
Naderi H, Ramírez J, Van Duijvenboden S, Aung N, Fung K, Young W, Petersen S, Munroe P ( 2022 ) . PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK . Journal of Hypertension . vol. 40 ,
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of coronary artery disease: Do risk factor genetic risk scores add value? . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 188 - 189 .
Young WJ, Munroe PB, Tereshchenko L ( 2022 ) . Trans-ancestry GWAS of 118,780 individuals reveals biological mechanisms underlying the spatial QRS-T angle, a marker of arrhythmogenesis . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 599 - 599 .
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )
van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovascular Disease vol. 10 ,
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization . Circulation Genomic and Precision Medicine vol. 14 , ( 3 )
Chasapi A, Mbonye KA, Bajomo O, Young WJ, Primus C, Ambekar S, Wong K, Uppal R et al. ( 2021 ) . Clinical and echocardiographic predictors of decompensation in acute severe aortic regurgitation due to infective endocarditis . Echocardiography vol. 38 , ( 4 ) 590 - 595 .
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .
Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .
van Duijvenboden S, Ramírez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .
Aung N, Young WJ, van Duijvenboden S, Ramírez J, Petersen SE, Munroe PB ( 2020 ) . Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .
Young WJ, Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .
Young WJ, Hoare D, Bvekerwa I, Primus C, Wani RS, Das S, Wong K, Uppal R et al. ( 2020 ) . Association of Vegetation Size With Valve Destruction, Embolism and Mortality . Heart Lung and Circulation vol. 30 , ( 6 ) 854 - 860 .
Carrington M, Creta A, Young W, Pais J, Rocha AR, Santos AR, Melo J, Henriques J et al. ( 2020 ) . Non Type-1 Brugada pattern, diagnostic yield of 5 ECG criteria in a young adult cohort . European Heart Journal vol. 41 , ( Supplement_2 )
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 ,
Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Interaction between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology . Conference: CinC 2020 from: 13/09/2020 to: 16/09/2020 , vol. 2020-September ,
Hoare D, Bhattacharyya S, Lloyd G, Young WJ, Woldman S ( 2020 ) . 11 Impact of transthoracic versus transoesophageal echocardiography measurement of vegetation length in infective endocarditis on indications for surgery . Conference: ACHD/Valve Disease/Pericardial Disease/Cardiomyopathya9.1 - a9a9 .
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation Genomic and Precision Medicine vol. 13 , ( 4 ) e002774 - e002774 .
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .
Noordam R, Young WJ, Munroe PB ( 2019 ) . Electrolytes and electrophysiology: What's next? . Aging vol. 11 , ( 18 ) 7329 - 7330 .
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .
Lambiase PD, Young WJ ( 2018 ) . Sudden cardiac death risk prediction - As easy as ECG? . International Journal of Cardiology vol. 276 , 152 - 153 .
Young WJ, Jeffery DA, Hua A, Primus C, Wani RS, Das S, Wong K, Uppal R et al. ( 2018 ) . Echocardiography in Patients With Infective Endocarditis and the Impact of Diagnostic Delays on Clinical Outcomes . The American Journal of Cardiology vol. 122 , ( 4 ) 650 - 655 .
Javaid MR, Baca G, Dyall L, Maka R, Dillaway J, Chineah M, Young W, Akhtar J ( 2017 ) . 13 Keeping up the beat: a quality improvement project on heart failure monitoring & management . Heart vol. 103 , ( Suppl 5 )
Young W, Ibrahim M, Gall N ( 2015 ) . 66 The Management of Syncope on the Acute Medical Take. An Experience at a District General Hospital . Heart . vol. 101 ,
Young W, Bhichhyan R, Kabir A, Hussain W ( 2014 ) . ST-elevation myocardial infarction secondary to coronary artery spasm provoked by food . BMJ Case Reports vol. 2014 ,
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