Publications: Mr William Young
Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al.
(
2024
)
.
Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal
.
European Heart Journal
vol.
45
,
(
Supplement_1
)
Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al.
(
2024
)
.
The genetic architecture of exercise-induced ventricular ectopy
.
European Heart Journal
vol.
45
,
(
Supplement_1
)
Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al.
(
2024
)
.
Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
.
Journal of the American Heart Association
vol.
13
,
(
17
)
Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al.
(
2024
)
.
Fine mapping of candidate effector genes for heart rate
.
Human Genetics
vol.
143
,
(
9-10
)
1207
-
1221
.
Ramírez J, Young WJ, van Duijvenboden S, Munroe PB
(
2024
)
.
PO-01-089 PREDICTION OF ATRIAL AND VENTRICULAR ARRHYTHMIAS USING MULTIPLE CARDIOVASCULAR RISK FACTOR POLYGENIC RISK SCORES
.
Heart Rhythm
vol.
21
,
(
5
)
Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al.
(
2024
)
.
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
.
Nature Genetics
vol.
56
,
(
5
)
778
-
791
.
Hughes G, Young WJ, Bern H, Crook A, Lambiase PD, Goodall RL, Nunn AJ, Meredith SK
(
2024
)
.
T-wave morphology abnormalities in the STREAM stage 1 trial
.
Expert Opinion on Drug Safety
vol.
23
,
(
4
)
469
-
476
.
Young WJ, Maung S, Ahmet S, Kirkby C, Ives C, Schilling RJ, Lowe M, Lambiase PD
(
2024
)
.
The frequency of gene variant reclassification and its impact on clinical management in the inherited arrhythmia clinic
.
Heart Rhythm
vol.
21
,
(
6
)
903
-
910
.
Lambiase PD, Young WJ
(
2024
)
.
Genomic basis of heart rate and rhythm generation
.
Genomic and Molecular Cardiovascular Medicine: a Volume in Genomic and Precision Medicine in Clinical Practice
,
Ramírez J, Miguel A, van Duijvenboden S, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB et al.
(
2023
)
.
A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2023 Computing in Cardiology Conference (CinC)
vol.
50
,
1
-
4
.
Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe PB, Lambiase PD
(
2023
)
.
Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2023 Computing in Cardiology Conference (CinC)
vol.
50
,
1
-
4
.
Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD
(
2023
)
.
Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease
.
European Heart Journal
vol.
44
,
(
Supplement_2
)
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al.
(
2023
)
.
Long-term association of ultra-short heart rate variability with cardiovascular events
.
Scientific Reports
vol.
13
,
(
1
)
van Duijvenboden S, Ramírez J, Young WJ, Olczak KJ, Ahmed F, Alhammadi MJAY, Pressure ICOB, Bell CG et al.
(
2023
)
.
Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension
.
American Journal of Human Genetics
vol.
110
,
(
10
)
1718
-
1734
.
Young WJ, Vyas S, Wragg A, Sporton S, Rosengarten J, Schilling RJ, Ang R
(
2023
)
.
Right coronary artery compromise following radiofrequency catheter ablation for supraventricular tachycardia: cases reports
.
European Heart Journal - Case Reports
vol.
7
,
(
9
)
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al.
(
2023
)
.
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
.
Nature Communications
vol.
14
,
(
1
)
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD
(
2023
)
.
Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events
.
European Heart Journal - Digital Health
vol.
4
,
(
2
)
112
-
118
.
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al.
(
2022
)
.
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
.
Nature Communications
vol.
13
,
(
1
)
Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P
(
2022
)
.
Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors
.
Atherosclerosis
vol.
355
,
3
-
4
.
Carrington M, Creta A, Young WJ, Carrington M, Henriques J, Teixeira R, Gonçalves L, Lambiase PD et al.
(
2022
)
.
Defining electrocardiographic criteria to differentiate non‐type 1 Brugada ECG variants from normal incomplete RBBB patterns in the young SCD‐SOS cohort
.
Journal of Cardiovascular Electrophysiology
vol.
33
,
(
9
)
2083
-
2091
.
Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
(
2022
)
.
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors
.
Circulation Genomic and Precision Medicine
vol.
15
,
(
5
)
e003441
-
e003441
.
Maung S, Young W, Ives C, Kirkby C, Schilling R, Lowe M, Lambiase P
(
2022
)
.
84 Variants of uncertain significance: a real-world experience of reclassification from the inherited arrhythmia clinic
.
Conference:
Cardiac rhythm managementa62
-
a62
.
Naderi H, Ramírez J, Van Duijvenboden S, Aung N, Fung K, Young W, Petersen S, Munroe P
(
2022
)
.
PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK
.
Journal of Hypertension
.
vol.
40
,
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
(
2022
)
.
Prediction of coronary artery disease: Do risk factor genetic risk scores add value?
.
EUROPEAN JOURNAL OF HUMAN GENETICS
.
vol.
30
,
188
-
189
.
Young WJ, Munroe PB, Tereshchenko L
(
2022
)
.
Trans-ancestry GWAS of 118,780 individuals reveals biological mechanisms underlying the spatial QRS-T angle, a marker of arrhythmogenesis
.
EUROPEAN JOURNAL OF HUMAN GENETICS
.
vol.
30
,
599
-
599
.
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW
(
2021
)
.
B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL
.
Heart Rhythm
vol.
18
,
(
8
)
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW
(
2021
)
.
B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL
.
Heart Rhythm
vol.
18
,
(
8
)
van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB
(
2021
)
.
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
.
Human Molecular Genetics
vol.
30
,
(
24
)
2513
-
2523
.
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A
(
2021
)
.
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
.
JRSM Cardiovascular Disease
vol.
10
,
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al.
(
2021
)
.
BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study
.
Heart
.
Conference:
Basic science
vol.
107
,
a159
-
a160
.
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al.
(
2021
)
.
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization
.
Circulation Genomic and Precision Medicine
vol.
14
,
(
3
)
Chasapi A, Mbonye KA, Bajomo O, Young WJ, Primus C, Ambekar S, Wong K, Uppal R et al.
(
2021
)
.
Clinical and echocardiographic predictors of decompensation in acute severe aortic regurgitation due to infective endocarditis
.
Echocardiography
vol.
38
,
(
4
)
590
-
595
.
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
(
2021
)
.
Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors
.
GENETIC EPIDEMIOLOGY
.
vol.
45
,
783
-
783
.
Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M
(
2020
)
.
Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2020 Computing in Cardiology Conference (CinC)
vol.
00
,
1
-
4
.
van Duijvenboden S, Ramírez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M
(
2020
)
.
Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2020 Computing in Cardiology Conference (CinC)
vol.
00
,
1
-
4
.
Aung N, Young WJ, van Duijvenboden S, Ramírez J, Petersen SE, Munroe PB
(
2020
)
.
Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2020 Computing in Cardiology Conference (CinC)
vol.
00
,
1
-
4
.
Young WJ, Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M
(
2020
)
.
Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
.
2016 Computing in Cardiology Conference (CinC)
.
Conference:
2020 Computing in Cardiology Conference (CinC)
vol.
00
,
1
-
4
.
Young WJ, Hoare D, Bvekerwa I, Primus C, Wani RS, Das S, Wong K, Uppal R et al.
(
2020
)
.
Association of Vegetation Size With Valve Destruction, Embolism and Mortality
.
Heart Lung and Circulation
vol.
30
,
(
6
)
854
-
860
.
Carrington M, Creta A, Young W, Pais J, Rocha AR, Santos AR, Melo J, Henriques J et al.
(
2020
)
.
Non Type-1 Brugada pattern, diagnostic yield of 5 ECG criteria in a young adult cohort
.
European Heart Journal
vol.
41
,
(
Supplement_2
)
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M
(
2020
)
.
A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
.
Biomedical Signal Processing and Control
vol.
64
,
Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M
(
2020
)
.
Interaction between ECG and Genetic Markers of Coronary Artery Disease
.
Computing in Cardiology
.
Conference:
CinC 2020
from:
13/09/2020
to:
16/09/2020
,
vol.
2020-September
,
Hoare D, Bhattacharyya S, Lloyd G, Young WJ, Woldman S
(
2020
)
.
11 Impact of transthoracic versus transoesophageal echocardiography measurement of vegetation length in infective endocarditis on indications for surgery
.
Conference:
ACHD/Valve Disease/Pericardial Disease/Cardiomyopathya9.1
-
a9a9
.
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD
(
2020
)
.
Genetic Basis and Prognostic Value of Exercise QT Dynamics
.
Circulation Genomic and Precision Medicine
vol.
13
,
(
4
)
e002774
-
e002774
.
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A
(
2020
)
.
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
.
American Journal of Human Genetics
vol.
106
,
(
6
)
764
-
778
.
Noordam R, Young WJ, Munroe PB
(
2019
)
.
Electrolytes and electrophysiology: What's next?
.
Aging
vol.
11
,
(
18
)
7329
-
7330
.
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al.
(
2019
)
.
Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
.
Journal of the American College of Cardiology
vol.
73
,
(
24
)
3118
-
3131
.
Lambiase PD, Young WJ
(
2018
)
.
Sudden cardiac death risk prediction - As easy as ECG?
.
International Journal of Cardiology
vol.
276
,
152
-
153
.
Young WJ, Jeffery DA, Hua A, Primus C, Wani RS, Das S, Wong K, Uppal R et al.
(
2018
)
.
Echocardiography in Patients With Infective Endocarditis and the Impact of Diagnostic Delays on Clinical Outcomes
.
The American Journal of Cardiology
vol.
122
,
(
4
)
650
-
655
.
Javaid MR, Baca G, Dyall L, Maka R, Dillaway J, Chineah M, Young W, Akhtar J
(
2017
)
.
13 Keeping up the beat: a quality improvement project on heart failure monitoring & management
.
Heart
vol.
103
,
(
Suppl 5
)
Young W, Ibrahim M, Gall N
(
2015
)
.
66 The Management of Syncope on the Acute Medical Take. An Experience at a District General Hospital
.
Heart
.
vol.
101
,
Young W, Bhichhyan R, Kabir A, Hussain W
(
2014
)
.
ST-elevation myocardial infarction secondary to coronary artery spasm provoked by food
.
BMJ Case Reports
vol.
2014
,