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Research

Publications: Dr James Ruffle

Nelson APK, Gray RJ, Ruffle JK, Watkins HC, Herron D, Sorros N, Mikhailov D, Cardoso MJ et al. ( 2022 ) . Deep forecasting of translational impact in medical research . Patterns vol. 3 , ( 5 )
Rajiah R, Henderson M, Aziz Q, Yiannakou Y, Ruffle J ( 2021 ) . Network modelling in chronic constipation . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,
Rajiah R, Takahashi K, Aziz Q, Ruffle J ( 2021 ) . Transcutaneous vagal nerve stimulation as a potential treatment in functional gastrointestinal disorders: A meta-analysis of neuroimaging evidence . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,
Ruffle JK, Hyare H, Howard MA, Farmer AD, Apkarian AV, Williams SCR, Aziz Q, Nachev P ( 2021 ) . The autonomic brain: multi-dimensional generative hierarchical modelling of the autonomic connectome . Cortex
Lim EA, Gnanadurai R, Ruffle JK, Lee H, Miller RF, Hyare H ( 2021 ) . Neuroimaging of CNS infection in haematological malignancy: important signs and common diagnostic pitfalls . Clinical Radiology vol. 76 , ( 6 ) 470.e1 - 470.e12 .
Ruffle J, Tinkler L, Emmett C, Ford A, Nachev P, Aziz Q, Farmer A, Yiannakou Y ( 2021 ) . P342 Constipation-predominant irritable bowel syndrome and functional constipation are not discrete disorders: a machine learning approach . Conference: Postersa218 - a218 .
Ruffle JK, Tinkler L, Emmett C, Ford AC, Nachev P, Aziz Q, Farmer AD, Yiannakou Y ( 2021 ) . Constipation Predominant Irritable Bowel Syndrome and Functional Constipation Are Not Discrete Disorders: A Machine Learning Approach . American Journal of Gastroenterology vol. 116 , ( 1 ) 142 - 151 .
Colecchia F, Ruffle JK, Pombo GC, Gray R, Hyare H, Nachev P ( 2020 ) . Knowledge-driven deep neural network models for brain tumour segmentation . Journal of Physics: Conference Series . vol. 1662 ,
Albu-Soda A, Aziz Q, FARMER A ( 2020 ) . Transcutaneous vagus nerve stimulation prevents the development of, and reverses, established oesophageal pain hypersensitivity . Alimentary Pharmacology and Therapeutics
Kanber B, Ruffle J, Cardoso J, Ourselin S, Ciccarelli O ( 2020 ) . Neurosense: deep sensing of full or near-full coverage head/brain scans in human magnetic resonance imaging . Neuroinformatics vol. 18 , ( 2 ) 333 - 336 .
Farmer AD, Wood E, Ruffle JK ( 2020 ) . An approach to the care of patients with irritable bowel syndrome . CMAJ vol. 192 , ( 11 ) E275 - E282 .
Ruffle JK, Farmer AD, Aziz Q ( 2020 ) . Chapter 33 Artificial intelligence in gastroenterology . Precision Medicine for Investigators, Practitioners and Providers ,
Farmer AD, Ruffle JK ( 2019 ) . Irritable bowel syndrome . Medicine (United Kingdom) vol. 47 , ( 6 ) 350 - 353 .
Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y ( 2019 ) . OWE-14 Symptom burden in chronic constipation is predicted by sensory domains, not stool frequency . Gut . Conference: Neurogastroenterology vol. 68 ,
Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y ( 2019 ) . PWE-097 Machine learning can accurately classify chronic constipation patients by symptom burden using pain measures alone . Gut . Conference: Posters vol. 68 ,
Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . MACHINE LEARNING WITH PAIN MEASURES ALONE CAN ACCURATELY CLASSIFY CHRONIC CONSTIPATION PATIENTS TO HIGH OR LOW TOTAL SYMPTOM BURDEN . GASTROENTEROLOGY . vol. 156 , S590 - S591 .
Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . SENSORY DOMAINS, NOT STOOL FREQUENCY, PREDICT A HIGHER SYMPTOM BURDEN AND A REDUCTION IN QUALITY OF LIFE IN CHRONIC CONSTIPATION . GASTROENTEROLOGY . vol. 156 , S590 - S590 .
Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al. ( 2019 ) . Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning . Journal of Physiology vol. 597 , ( 6 ) 1517 - 1529 .
Farmer AD, Ruffle JK, Hobson AR ( 2019 ) . Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation . Neurogastroenterology and Motility vol. 31 , ( 2 )
Ruffle JK, Farmer AD, Aziz Q ( 2019 ) . Artificial intelligence in gastroenterology . Precision Medicine for Investigators, Practitioners and Providers ,
Farmer AD, Ruffle JK, Barber M ( 2018 ) . Moving Neurogastroenterology and Motility into the social media age . Neurogastroenterology and Motility vol. 30 , ( 11 )
Ruffle JK, FARMER A, AZIZ Q ( 2018 ) . Artificial Intelligence Assisted Gastroenterology – Promises and Pitfalls . American Journal of Gastroenterology
Albusoda A, Ruffle JK, Friis KA, Gysan MR, Drewes AM, Aziz Q, Farmer AD ( 2018 ) . Systematic review with meta-analysis: conditioned pain modulation in patients with the irritable bowel syndrome . Alimentary Pharmacology and Therapeutics vol. 48 , ( 8 ) 797 - 806 .
Ruffle JK, AZIZ Q ( 2018 ) . Abdominal pain presenting as a tight squeeze on a Tchaikovsky score . Gastroenterology
Ruffle JK, AZIZ Q, FARMER A, COEN S, Giampietro V, Williams SCR ( 2018 ) . Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain . Scientific Reports vol. 8 , Article 13410 ,
Ruffle J, Patel A, Giampietro V, Aziz Q, Farmer A ( 2018 ) . A thalamic-cingulate-caudate functional network identifies nausea severity and predicts susceptibility using machine learning . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,
Keszthelyi D, Aziz Q, Ruffle JK, O'Daly O, Sanders D, Krause K, Williams SCR, Howard MA ( 2018 ) . Delineation between different components of chronic pain using dimension reduction – an ASL fMRI study in hand osteoarthritis . European Journal of Pain (United Kingdom) vol. 22 , ( 7 ) 1245 - 1254 .
Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A ( 2018 ) . Nausea susceptibility is associated with subcortical brain morphology . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,
Farmer A, Ruffle J, Holt CB ( 2018 ) . Real world experience of naloxegol in treating opioid induced constipation . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,
Albusoda A, Friss K, Gysan M, Ruffle J, Aziz Q, Farmer A ( 2018 ) . OWE-026 Conditioned pain modulation in functional gastrointestinal disorders: systematic review & meta-analysis . Conference: Neurogastroenterology & motilitya207 - a207 .
Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A ( 2018 ) . PWE-144 Susceptibility to nausea is concurrently associated with subcortical morphology and autonomic tone . Gut . Conference: Neurogastroenterology & motility vol. 67 ,
Ruffle J, Coen S, Giampietro V, Williams S, Aziz Q, Farmer A ( 2018 ) . PWE-146 Pain endophenotypes display complex subcortical brain morphological differences influenced by autonomic neurophysiology or personality traits . Gut . Conference: Neurogastroenterology & motility vol. 67 ,
Ruffle JK, Aziz Q, Farmer AD ( 2018 ) . Pronociceptive effects mediated by adenosinergic A2A activity at the nucleus accumbens, but what about the autonomic nervous system? Letter to Editor . Pain vol. 159 , ( 5 )
Ruffle JK, Coen SJ, Giampietro V, Williams SC, Aziz Q, Farmer AD ( 2018 ) . VISCERAL PAIN ENDOPHENOTYPES ASSOCIATE TO INTRICATE SUBCORTICAL BRAIN MORPHOLOGICAL DIFFERENCES CONTINGENT ON DIFFERING AUTONOMIC PHYSIOLOGY OR PERSONALITY . GASTROENTEROLOGY . vol. 154 , S155 - S156 .
Farmer AD, Ruffle JK, Aziz Q ( 2018 ) . Brain Processing of Gastrointestinal Sensory Signaling . Physiology of the Gastrointestinal Tract: Sixth Edition , vol. 1-2 ,
Farmer AD, Ruffle JK, Aziz Q ( 2018 ) . Chapter 16 Brain Processing of Gastrointestinal Sensory Signaling . Physiology of the Gastrointestinal Tract ,
Ruffle J, Farmer A, Aziz Q ( 2017 ) . Morphology of Subcortical Brain Nuclei Is Associated With Autonomic Function in Healthy Humans . Human Brain Mapping
Mudawi T, Mahto A, Ruffle JK, Bubbear J ( 2017 ) . 23. Multi-site avascular necrosis of idiopathic aetiology . Rheumatology Advances in Practice vol. 1 , ( suppl_1 )
Ruffle JK, Aziz Q, Farmer AD ( 2017 ) . Neuroimaging of vagal nerve stimulation: Are we missing a trick? . Pain vol. 158 , ( 10 ) 2053 - 2055 .
Ruffle J, Coen S, Giampietro V, Williams S, Farmer A, Aziz Q ( 2017 ) . OC-054 Pain endophenotypes can be accurately predicted by whole brain connectivity during painful oesophageal stimulation . Gut . vol. 66 ,
Ruffle J, Coen S, Giampietro V, Williams S, Farmer A, Aziz Q ( 2017 ) . PTH-117 Subcortical brain morphology differences in gastrointestinal disorders may be confounded by baseine autonomic function . Gut . vol. 66 ,
Ruffle JK, Frokjaer JB, Farmer AD ( 2017 ) . Neuroimaging of v1isceral pain . Neuroimaging of Pain ,
Albusoda A, Ruffle J, Drewes A, Farmer A, Aziz Q ( 2017 ) . Autonomic modulation via slow deep breathing and attention . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 47 , 123 - 123 .
Albusoda A, Ruffle JK, Drewes A, Farmer AD, Aziz Q ( 2017 ) . 367 Effect of Slow Deep Breathing and Attention on the Autonomic Nervous System . Gastroenterology . vol. 152 , s88 - s89 .
Ruffle JK, Coen SJ, Giampietro V, Williams SC, Farmer AD, Aziz Q ( 2017 ) . Tu1621 Brain Morphological Differences in Gastrointestinal Disorders May Be in Part Due to Alteration in Resting Autonomic Function . Gastroenterology . vol. 152 , s918 - s919 .
Farmer AD, Ruffle JK, Aziz Q ( 2017 ) . The role of esophageal hypersensitivity in functional esophageal disorders . Journal of Clinical Gastroenterology vol. 51 , ( 2 ) 91 - 99 .
Hoff DAL, Brock C, Farmer AD, Dickman R, Ruffle JK, Shaker A, Drewes AM ( 2016 ) . Pharmacological and other treatment modalities for esophageal pain . Annals of the New York Academy of Sciences vol. 1380 , ( 1 ) 58 - 66 .
Ruffle JK, Shah M, Monro J, Julu POO ( 2015 ) . Pattern Of Dysautonomia In Patients With Functional Gastrointestinal Disorders . Autonomic Neuroscience vol. 192 ,
Ruffle JK, Bajgoric S, Samra K, Chandrapalan S, Aziz Q, Farmer AD ( 2015 ) . Cannabinoid hyperemesis syndrome: An important differential diagnosis of persistent unexplained vomiting . European Journal of Gastroenterology and Hepatology vol. 27 , ( 12 ) 1403 - 1408 .
Ruffle JK, Farmer AD, Kano M, Giampietro V, Aziz Q, Coen SJ ( 2014 ) . The influence of extraversion on brain activity at baseline and during the experience and expectation of visceral pain . PERSONALITY AND INDIVIDUAL DIFFERENCES vol. 74 , 248 - 253 .
Ruffle JK ( 2014 ) . Molecular neurobiology of addiction: What's all the (Δ)FosB about? . American Journal of Drug and Alcohol Abuse vol. 40 , ( 6 ) 428 - 437 .
Ruffle J, Coen S, Farmer A, Kano M, Giampietro V, Williams S, Aziz Q ( 2014 ) . OC-066 Influence Of Extraversion On Brain Activity At Baseline, Pain Anticipation And Visceral Pain Processing . Gut vol. 63 Suppl 1 , A32 - A33 .
Ruffle JK, Coen SJ, Farmer AD, Kano M, Gampietro V, Williams S, Aziz Q ( 2014 ) . Influence of Extraversion on Brain Activity During Rest, Pain Anticipation and Visceral Pain Processing . GASTROENTEROLOGY . vol. 146 , S847 - S847 .
Ruffle JK, Coen SJ, Farmer AD, Kano M, Gampietro V, Williams S, Aziz Q ( 2014 ) . Tu1803 Influence of Extraversion on Brain Activity During Rest, Pain Anticipation and Visceral Pain Processing . Gastroenterology vol. 146 , ( 5 ) s - 847 .