Publications: Dr Paul Pfeffer

Patel P, Rupani H, Pfeffer P, Mansur A, Lipworth J, Lupton C, Watt M, Clewes C et al. ( 2024 ) . M20 Effectiveness of tezepelumab in patients with difficult-to-treat severe asthma: early insights from the tezepelumab patient access programme . Conference: ‘Through the Looking Glass’ – Airway disease therapies in the real worlda281.2 - a2a282 .

Jackson D, Burhan H, Pfeffer P, Clifton I, Faruqi S, Nanzer A, Dhariwal J, Morris T et al. ( 2024 ) . P20 Effectiveness of benralizumab in patients with severe asthma previously treated with mepolizumab in the United Kingdom; a BPAP study post-hoc analysis . Conference: ‘George’s Marvellous Medicine’ – Biologics, biologics, biologicsa119.2 - a1a120 .

Holmes L, Redmond C, Pfeffer P, Heaney L, Brown T, Busby J, Chaudhuri R, Jackson D et al. ( 2024 ) . S118 Young-adults (16–25) with severe asthma have worse outcomes when compared to other age-groups in the UK Severe asthma registry . Conference: ‘Brave New World’ – Asthma in the new eraa82.2 - a8a83 .

Le TT, Price DB, Erhard C, Cook B, Quinton A, Katial R, Christoff GC, Perez-de-Llano L et al. ( 2024 ) . Disease Burden and Access to Biologic Therapy in Patients with Severe Asthma, 2017–2022: An Analysis of the International Severe Asthma Registry . Journal of Asthma and Allergy vol. 17 , 1055 - 1069 .

Perez-de-Llano L, Scelo G, Tran TN, Le TT, Fagerås M, Cosio BG, Peters M, Pfeffer PE et al. ( 2024 ) . Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults . American Journal of Respiratory and Critical Care Medicine vol. 210 , ( 7 ) 869 - 880 .

Jackson DJ, Wechsler ME, Jackson DJ, Bernstein D, Korn S, Pfeffer PE, Chen R, Saito J et al. ( 2024 ) . Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype . N Engl J Med

Hajmohammadi H, Pfeffer P, Mudway I, Griffiths C . Understanding the Relationship Between Short-term Air Pollution Exposure and Asthma Exacerbations: East London Cohort Study . Proceedings of the World Congress on New Technologies . Conference: Proceedings of the 10th World Congress on New Technologies

Taquet M, Skorniewska Z, De Deyn T, Hampshire A, Trender WR, Hellyer PJ, Chalmers JD, Ho L-P et al. ( 2024 ) . Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK . The Lancet Psychiatry vol. 11 , ( 9 ) 696 - 708 .

Jackson DJ, Burhan H, Rupani H, Pfeffer PE, Clifton IJ, Faruqi S, Dhariwal J, Patel P et al. ( 2024 ) . Overcoming Barriers to Remission in Severe Eosinophilic Asthma: Two‐Year Real‐World Data With Benralizumab . Clinical & Experimental Allergy vol. 54 , ( 10 ) 734 - 746 .

Busby J, Menon S, Martin N, Lipworth J, Zhang R, Burhan H, Brown T, Chaudhuri R et al. ( 2024 ) . Clinical and Economic Burden of Severe Asthma With Low Blood Eosinophil Counts . The Journal of Allergy and Clinical Immunology In Practice vol. 12 , ( 10 ) 2785 - 2797 .

Denton E, Hew M, Peters MJ, Upham JW, Bulathsinhala L, Tran TN, Martin N, Bergeron C et al. ( 2024 ) . Real‐world biologics response and super‐response in the International Severe Asthma Registry cohort . Allergy vol. 79 , ( 10 ) 2700 - 2716 .

Pfeffer PE, Brown T, Chaudhuri R, Faruqi S, Gore R, Heaney LG, Mansur AH, Pantin T et al. ( 2024 ) . Impact of comorbidities on EQ-5D quality-of-life index in severe asthma . Journal of Allergy and Clinical Immunology Global vol. 3 , ( 3 )

Scelo G, Tran TN, Le TT, Fagerås M, Dorscheid D, Busby J, Al-Ahmad M, Al-Lehebi R et al. ( 2024 ) . Exploring Definitions and Predictors of Response to Biologics for Severe Asthma . The Journal of Allergy and Clinical Immunology In Practice vol. 12 , ( 9 ) 2347 - 2361 .

Chen W, Price D, Yadav CP, Beasley RW, Janson C, Lee TY, Koh Siyue M, Wang E et al. ( 2024 ) . Development and Validation of an Individualised Risk Prediction Model for Exacerbations in Patients With Severe Asthma in Real-world Settings . Conference: C102. CLINICAL AND TRANSLATIONAL ADVANCES IN ASTHMAa6700 - a6700 .

Yadav CP, Lee TY, Price DB, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ et al. ( 2024 ) . International Variation in Exacerbation Rates in Patients With Severe Asthma . Conference: D22. ADVANCES IN HEALTH SERVICES RESEARCH IN ASTHMAa7021 - a7021 .

Yadav CP, Chakraborty A, Price D, Beasley R, Sadatsafavi M, Janson C, Siyue MK, Wang E et al. ( 2024 ) . Unveiling the Real-World Causal Interaction of Essential Risk Factors in Severe Asthma Exacerbation: A Bayesian Network Analysis . Conference: C94. ASTHMA QUALITY IMPROVEMENT, HEALTH SERVICES RESEARCH, AND DISPARITIESa6605 - a6605 .

Porsbjerg CM, Townend J, Bergeron C, Christoff GC, Katsoulotos GP, Larenas-Linnemann D, Tran TN, Al-Lehebi R et al. ( 2024 ) . Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma . Frontiers in Immunology vol. 15 ,

Elneima O, Hurst JR, Echevarria C, Quint JK, Walker S, Siddiqui S, Novotny P, Pfeffer PE et al. ( 2024 ) . Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID . ERJ Open Research vol. 10 , ( 4 ) 00982 - 02023 .

Lee TY, Price D, Yadav CP, Roy R, Lim LHM, Wang E, Wechsler ME, Jackson DJ et al. ( 2024 ) . International Variation in Severe Exacerbation Rates in Patients With Severe Asthma . CHEST Journal vol. 166 , ( 1 ) 28 - 38 .

Wechsler ME, Scelo G, Larenas-Linnemann DES, Torres-Duque CA, Maspero J, Tran TN, Murray RB, Martin N et al. ( 2024 ) . Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma . American Journal of Respiratory and Critical Care Medicine vol. 209 , ( 3 ) 262 - 272 .

Chen W, Tran TN, Sadatsafavi M, Murray RB, Boon Wong NC, Ali N, Ariti C, Bulathsinhala L et al. ( 2024 ) . Reply to “Exploring the long-term effects of biologic initiation in severe asthma: Insights from the International Severe Asthma Registry” . The Journal of Allergy and Clinical Immunology In Practice vol. 12 , ( 2 ) 536 - 539 .

Lord JM, Veenith T, Sullivan J, Sharma-Oates A, Richter AG, Greening NJ, McAuley HJC, Evans RA et al. ( 2024 ) . Accelerated immune ageing is associated with COVID-19 disease severity . Immunity & Ageing vol. 21 , ( 1 )

Neunie OAM, Rabbani W, Baker D, Chambers ES, Pfeffer PE, Kang AS ( 2024 ) . Immunogenicity of biologics used in the treatment of asthma . Human Antibodies vol. 32 , ( 3 ) 121 - 128 .

Perez-de-Llano L, Scelo G, Canonica GW, Chen W, Henley W, Larenas-Linnemann D, Peters MJ, Pfeffer PE et al. ( 2023 ) . Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma . Annals of Allergy Asthma & Immunology vol. 132 , ( 5 ) 610 - 622.e7 .

Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho L-P, Marks M, Poinasamy K et al. ( 2023 ) . Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study . International Journal of Epidemiology vol. 53 , ( 1 )

Loewenthal L, Busby J, McDowell R, Brown T, Burhan H, Chaudhuri R, Dennison P, Dodd JW et al. ( 2023 ) . Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care . Thorax vol. 79 , ( 5 ) 403 - 411 .

McDowell R, Heaney L, Brown T, Bunting B, Burhan H, Chaudhuri R, Dennison P, Faruqi S et al. ( 2023 ) . An examination of factorial invariance of the Asthma Control Questionnaire among adults with severe asthma . PLOS ONE vol. 18 , ( 12 )

Busby J, McDowell PJ, Pfeffer PE, Mansur AH, Heaney LG ( 2023 ) . Ethnic variation in asthma phenotypic presentation and outcomes: a cross-sectional analysis of the UK Biobank . Thorax vol. 79 , ( 2 ) 186 - 190 .

Jackson D, Burhan H, Pfeffer P, Clifton I, Faruqi S, Nanzer A, Dhariwal J, Morris T et al. ( 2023 ) . M25 Reductions in healthcare resource utilisation (HCRU) over 2 years of benralizumab treatment in patients with severe eosinophilic asthma; analysis from the BPAP study . Conference: ‘Against all odds’ – Fight for the future of asthmaa275 - a275 .

Jackson D, Burhan H, Pfeffer P, Clifton I, Faruqi S, Nanzer A, Dhariwal J, Morris T et al. ( 2023 ) . P130 Clinical effectiveness over 2 years of benralizumab treatment in patients with severe eosinophilic asthma and concomitant nasal polyposis; analysis from the BPAP study . Conference: ‘The way you make me feel’ – Beyond the basics in asthmaa185.1 - a1a185 .

Vivaldi G, Pfeffer P, Talaei M, Basera J, Shaheen S, Martineau A ( 2023 ) . S18 Long-term symptom profiles after COVID-19 vs other acute respiratory infections: a population-based observational study . Conference: ‘Shake it off’ – Recovery from COVID-19a17 - a18 .

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2023 ) . Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet Diabetes & Endocrinology vol. 11 , ( 12 ) 905 - 914 .

Brightling CE, Evans RA, Singapuri A, Smith N, Wain LV, Brightling CE, Evans RA, Wain LV et al. ( 2023 ) . Long COVID research: an update from the PHOSP-COVID Scientific Summit . The Lancet Respiratory Medicine vol. 11 , ( 11 ) e93 - e94 .

Vivaldi G, Pfeffer P, Talaei M, Basera TJ, Shaheen S, Martineau A ( 2023 ) . Long-term symptom profiles after COVID-19 versus other acute respiratory infections: an analysis of data from the COVIDENCE UK study . EClinicalMedicine

Brightling CE, Evans RA, Wain LV, Chalmers JD, Harris VC, Ho LP, Horsley A, Marks M et al. ( 2023 ) . Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study . The Lancet Respiratory Medicine vol. 11 , ( 11 ) 1003 - 1019 .

Pfeffer PE, Rupani H, De Simoni A ( 2023 ) . Bringing the treatable traits approach to primary care asthma management . Frontiers in Allergy vol. 4 ,

Scelo G, Torres-Duque CA, Maspero J, Tran TN, Murray R, Martin N, Menzies-Gow AN, Hew M et al. ( 2023 ) . Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry . Annals of Allergy Asthma & Immunology vol. 132 , ( 1 ) 42 - 53 .

Byrne C, Pfeffer PE, De Simoni A ( 2023 ) . Experiences of Diagnosis, Symptoms and Use of Reliever Inhalers in Patients with Asthma and Concurrent Inducible Laryngeal Obstruction (ILO) or Breathing Pattern Disorder (BPD): qualitative analysis of a UK asthma online community . JMIR

Skene I, Kinley E, Pike K, Griffiths C, Pfeffer P, Steed L ( 2023 ) . Understanding interventions delivered in the emergency department targeting improved asthma outcomes beyond the emergency department: an integrative review . BMJ Open vol. 13 , ( 8 )

Chen W, Tran TN, Sadatsafavi M, Murray R, Wong NCB, Ali N, Ariti C, Bulathsinhala L et al. ( 2023 ) . Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry . The Journal of Allergy and Clinical Immunology In Practice vol. 11 , ( 9 ) 2732 - 2747 .

Walker S, Goodfellow H, Pookarnjanamorakot P, Murray E, Bindman J, Blandford A, Bradbury K, Cooper B et al. ( 2023 ) . Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study . BMJ Open vol. 13 , ( 6 )

Esposito I, Kontra I, Giacomassi C, Manou-Stathopoulou S, Brown J, Stratton R, Verykokou G, Buccafusca R et al. ( 2023 ) . Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma . Frontiers in Immunology vol. 14 ,

Scelo G, Porsbjerg C, Murray R, Tran TN, Martin N, Al-Ahmad M, Al-Lehebi RO, Bergeron C et al. ( 2023 ) . Association Between T2-related Comorbidities and Effectiveness of Biologics in Adult Patients From the International Severe Asthma Registry . Conference: C31. BIOLOGICS WANT TO RULE THE (ASTHMA) WORLDa4764 - a4764 .

Denton E, Hew M, Murray R, Bulathsinhala L, Trung TN, Martin N, Al-Ahmad M, Altraja A et al. ( 2023 ) . Biologic Responders and Super-responders in the International Severe Asthma Registry . Conference: C31. BIOLOGICS WANT TO RULE THE (ASTHMA) WORLDa4753 - a4753 .

Schleich F, Lougheed MD, Matucci A, Rodriguez Hermosa JL, Pfeffer P, Verghis RM, Jakes RW, Alfonso-Cristancho R et al. ( 2023 ) . Mepolizumab Reduces Clinically Significant Exacerbations in Patients With Severe Asthma Prior to and During the COVID-19 Pandemic: Results From the Real-world REALITI-A Study . Conference: D21. TRANSLATIONAL COVID-19 STUDIESa6298 - a6298 .

Zheng B, Vivaldi G, Daines L, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A et al. ( 2023 ) . Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls . The Lancet Regional Health - Europe vol. 29 ,

Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE et al. ( 2023 ) . Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study . The Lancet Respiratory Medicine vol. 11 , ( 8 ) 673 - 684 .

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2023 ) . Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 401 , ( 10387 ) 1499 - 1507 .

Pfeffer PE, Ali N, Murray R, Ulrik C, Tran TN, Maspero J, Peters M, Christoff GC et al. ( 2023 ) . Comparative effectiveness of anti‐IL5 and anti‐IgE biologic classes in patients with severe asthma eligible for both . Allergy vol. 78 , ( 7 ) 1934 - 1948 .

Louis R, Harrison TW, Chanez P, Menzella F, Philteos G, Cosio BG, Lugogo NL, de Luiz G et al. ( 2023 ) . Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy . The Journal of Allergy and Clinical Immunology In Practice vol. 11 , ( 6 ) 1759 - 1770.e7 .

Pfeffer P, Hajmohammadi H, Cole J, Griffiths C, Hull S, De Simoni A ( 2023 ) . Characteristics of asthma patients overprescribed short-acting beta-agonist (SABA) reliever inhalers stratified by blood eosinophil count in North East London – a cross-sectional observational study . BJGP Open vol. 7 , ( 2 )

McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL et al. ( 2023 ) . Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study . EClinicalMedicine vol. 57 ,

Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K et al. ( 2023 ) . International consensus statement on allergy and rhinology: Allergic rhinitis – 2023 . International Forum of Allergy & Rhinology vol. 13 , ( 4 ) 293 - 859 .

Hakim A, Ricketts W, Pfeffer P, Ashworth R ( 2023 ) . Integration of respiratory physiology and clinical reasoning in the early years of a medical curriculum: engaging with students in a large classroom setting . Advances in Physiology Education vol. 47 , ( 2 ) 237 - 242 .

Daines L, Zheng B, Elneima O, Harrison E, Lone NI, Hurst JR, Brown JS, Sapey E et al. ( 2022 ) . Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19 . ERJ Open Research vol. 9 , ( 1 ) 00274 - 02022 .

Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D et al. ( 2022 ) . SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination . EBioMedicine vol. 87 ,

Price D, Burkill S, Wang E, E. Wechsler M, Denton E, N.Tran T, Martin N, Katial R et al. ( 2022 ) . Biomarker-defined clusters by level of Type 2 inflammatory involvement in severe asthma . Conference: 05.01 - Airway pharmacology and treatment

Loewenthal L, Busby J, Mcdowell R, Brown T, Burhan H, Chaudhuri R, Dennison P, Dodd J et al. ( 2022 ) . Characterising the impact of sex on severe asthma (SA) in the UK Severe Asthma Registry (UKSAR) . Conference: 05.02 - Monitoring airway disease

Chen W, N Tran T, Sadatsafavi M, Garcia Gil E, Alacqua M, Menzies Gow A, G Heaney L, E.Pfeffer P et al. ( 2022 ) . Effectiveness of initiating biologics in severe asthma patients with high steroid exposure . Conference: 05.01 - Airway pharmacology and treatment

Burkill S, M. Porsbjerg C, Bourdin A, N Tran T, Martin N, Katial R, Barker P, E Wechsler M et al. ( 2022 ) . Real-life biomarker response to anti-IL5 and anti-IgE therapies in severe asthma patients . Conference: 05.01 - Airway pharmacology and treatment

Tydeman F, Pfeffer PE, Vivaldi G, Holt H, Talaei M, Jolliffe D, Davies G, Lyons RA et al. ( 2022 ) . Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK) . Thorax vol. 78 , ( 8 ) 752 - 759 .

Jackson D, Burhan H, Menzies-Gow A, Rupani H, Pfeffer P, Clifton I, Faruqi S, Nanzer A et al. ( 2022 ) . P11 Characteristics and long-term real-world outcomes of severe asthma patients treated with benralizumab in the United Kingdom; the BPAP study . Conference: Deciphering ‘The Da Vinci Code’ – Biomarkers in airways diseasea86 - a87 .

Holmes J, Dennison P, Jackson D, D’Ancona G, Mansur A, Patel P, Pfeffer P, Chen C et al. ( 2022 ) . P147 Use of a connected inhaler system in the pre-biologic assessment of patients with severe asthma . Conference: ‘The Force Awakens’ – The asthma patient experiencea161 - a162 .

Nanzer A, Burhan H, Menzies-Gow A, Rupani H, Pfeffer P, Clifton I, Faruqi S, Dhariwal J et al. ( 2022 ) . P207 The influence of obesity on the clinical outcome of benralizumab treatment in severe eosinophilic asthma a subgroup analysis from the BPAP study . Conference: ‘Into the Woods’ – Managing co-morbidities in airways diseasea192 - a193 .

Tydeman F, Martineau A, Pfeffer P ( 2022 ) . P80 Rebound in asthma exacerbations following relaxation of COVID-19 restrictions . Conference: ‘Contagion’ – The impact of COVID-19a124 - a125 .

Mansur A, Gonem S, Brown T, Burhan H, Chaudhuri R, Dodd J, Pantin T, Gore R et al. ( 2022 ) . S78 Biologic therapy practices in severe asthma; outcomes from the UK severe asthma registry and survey of specialist opinion . Conference: ‘The World is Not Enough’ – The epidemiological picture in airways diseasea49.1 - a4a49 .

Zheng B, Daines L, Han Q, Hurst JR, Pfeffer P, Shankar-Hari M, Elneima O, Walker S et al. ( 2022 ) . Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis . European Respiratory Review vol. 31 , ( 166 )

Chen W, Sadatsafavi M, Tran TN, Murray RB, Wong CBN, Ali N, Ariti C, Gil EG et al. ( 2022 ) . Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy . Journal of Asthma and Allergy vol. 15 , 1491 - 1510 .

Holt H, Relton C, Talaei M, Symons J, Davies MR, Jolliffe DA, Vivaldi G, Tydeman F et al. ( 2022 ) . Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK) . International Journal of Epidemiology vol. 52 , ( 1 ) e46 - e56 .

Mansur AH, Gonem S, Brown T, Burhan H, Chaudhuri R, Dodd JW, Pantin T, Gore R et al. ( 2022 ) . Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion . Clinical & Experimental Allergy vol. 53 , ( 2 ) 173 - 185 .

Jolliffe DA, Holt H, Greenig M, Talaei M, Perdek N, Pfeffer P, Vivaldi G, Maltby S et al. ( 2022 ) . Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: Phase 3 randomised controlled trial (CORONAVIT) . The BMJ

Hylton H, Long A, Francis C, Taylor RR, Ricketts WM, Singh R, Pfeffer PE ( 2022 ) . Real-world use of the Breathing Pattern Assessment Tool in assessment of breathlessness post-COVID-19 . Clinical Medicine vol. 22 , ( 4 ) 376 - 379 .

Hajmohammadi H, Pfeffer P, De Simoni A, Cole JN, Griffiths CJ, Hull SA, Heydecker B ( 2022 ) . Association between short-term NO x exposure and asthma exacerbations in East London: A time series regression model . Urban Climate vol. 44 ,

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2022 ) . Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis . The Lancet vol. 400 , ( 10349 ) 359 - 368 .

Redmond C, Heaney LG, Chaudhuri R, Jackson DJ, Menzies-Gow A, Pfeffer P, Busby J ( 2022 ) . Benefits of specialist severe asthma management: demographic and geographic disparities . European Respiratory Journal vol. 60 , ( 6 )

De Simoni A, Hajmohammadi H, Pfeffer P, Cole J, Griffiths C, Hull SA ( 2022 ) . Reducing SABA overprescribing in asthma: lessons from a Quality Improvement prescribing project in East London . British Journal of General Practice vol. 72 , ( 722 )

Scelo G, Porsbjerg CM, Carter V, Ariti C, Lyu J, Eleangovan N, Tran TN, Barker P et al. ( 2022 ) . Prevalence of Comorbidities in Adults with Severe Asthma: Results from the International Severe Asthma Registry (ISAR) . Conference: A34. TOPICS IN HEALTH SERVICES RESEARCH AND SELF-MANAGEMENT FOR PATIENTS WITH OBSTRUCTIVE LUNG DISEASEa1306 - a1306 .

Evans RA, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M et al. ( 2022 ) . Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study . The Lancet Respiratory Medicine vol. 10 , ( 8 ) 761 - 775 .

Busby J, Heaney LG, Pfeffer PE, Registry SA ( 2022 ) . Reply to “Ethnicity-based differences in asthma diagnostic thresholds” . The Journal of Allergy and Clinical Immunology In Practice vol. 10 , ( 4 ) 1124 - 1125 .

Jackson DJ, Burhan H, Menzies-Gow A, Pfeffer P, Nanzer A, Garcia Gil E, Morris T, Tran TN et al. ( 2022 ) . Benralizumab Effectiveness in Severe Asthma Is Independent of Previous Biologic Use . The Journal of Allergy and Clinical Immunology In Practice vol. 10 , ( 6 ) 1534 - 1544.e4 .

Daines L, Zheng B, Pfeffer P, Hurst JR, Sheikh A ( 2022 ) . A clinical review of long-COVID with a focus on the respiratory system . Current Opinion in Pulmonary Medicine vol. 28 , ( 3 ) 174 - 179 .

Murray E, Goodfellow H, Bindman J, Blandford A, Bradbury K, Chaudhry T, Fernandez-Reyes D, Gomes M et al. ( 2022 ) . Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living With COVID-19 Recovery): protocol for a mixed-methods study . BMJ Open vol. 12 , ( 2 )

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10325 ) 665 - 676 .

Singer A, Pfeffer P ( 2022 ) . Current Management of Asthma . Encyclopedia of Respiratory Medicine , Elsevier

Evans RA, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M et al. ( 2021 ) . Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study .

Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young K, Davies M et al. ( 2021 ) . Risk Factors for Developing COVID-19: A Population-Based Longitudinal Study (COVIDENCE UK) . Thorax

Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young KS, Davies MR et al. ( 2021 ) . Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) . Thorax vol. 77 , ( 9 ) 900 - 912 .

Smith S, Gillespie L, Heaney L, Brightling C, Mcconnachie A, Siddiqui S, Mistry V, Brown V et al. ( 2021 ) . Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design . Conference: Monitoring airway disease

Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH et al. ( 2021 ) . The impact of ethnicity on disease presentation and control in severe asthma . Conference: Epidemiology

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10320 ) 143 - 151 .

Holmes J, Dennison P, Jackson D, D’Ancona G, Mansur A, Menzies-Gow A, Patel P, Pfeffer P et al. ( 2021 ) . S88 Use of a connected inhaler system in the pre-biologic assessment of patients with severe asthma . Thorax . Conference: Biologics for asthma vol. 76 , a57 - a58 .

Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH et al. ( 2021 ) . Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care . The Journal of Allergy and Clinical Immunology In Practice vol. 10 , ( 2 ) 495 - 505.e2 .

Evans RA, McAuley HJC, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB et al. ( 2021 ) . Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study . The Lancet Respiratory Medicine vol. 9 , ( 11 ) 1275 - 1287 .

Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S et al. ( 2021 ) . The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease . The Lancet Respiratory Medicine vol. 9 , ( 12 ) 1467 - 1478 .

Chen Y-H, Cheadle CE, Rice LV, Pfeffer PE, Dimeloe S, Gupta A, Bush A, Gooptu B et al. ( 2021 ) . The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease . Frontiers in Nutrition vol. 8 ,

Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB, Panel TD, Mansur A et al. ( 2021 ) . Defining a Severe Asthma Super-Responder: Findings from a Delphi Process . The Journal of Allergy and Clinical Immunology In Practice vol. 9 , ( 11 ) 3997 - 4004 .

Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al. ( 2021 ) . Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19 . Circulation ResearchE54 - E71 .

Taylor RR, Trivedi B, Patel N, Singh R, Ricketts WM, Elliott K, Yarwood M, White V et al. ( 2021 ) . Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 21 , ( 4 )

Bullen G, Galson JD, Hall G, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Bentley EM et al. ( 2021 ) . Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses . Frontiers in Immunology vol. 12 ,

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial . The Lancet vol. 397 , ( 10289 ) 2049 - 2059 .

Jackson DJ, Burhan H, Menzies-Gow A, Pfeffer PE, Nanzer A, Garcia Gil E, Morris T, Tran TN et al. ( 2021 ) . Clinical Effectiveness of Benralizumab Is Independent of Baseline FeNO in Severe Eosinophilic Asthma: A Retrospective Real-World Observation Study in Five UK Severe Asthma Centers . Conference: TP6. TP006 CLINICAL STUDIES OF ALLERGIC AIRWAY DISEASES, LUPUS, AND EOSINOPHILIC DISEASESa1360 - a1360 .

Zenner D ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . International Journal of Tuberculosis and Lung Disease

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10285 ) 1637 - 1645 .

Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG et al. ( 2021 ) . Eosinophilic and Noneosinophilic Asthma An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort . CHEST Journal vol. 160 , ( 3 ) 814 - 830 .

Skene IP, Pfeffer PE ( 2021 ) . Improved asthma control during the COVID-19 pandemic: are there lessons to be learnt? . Thorax vol. 76 , ( 9 ) 852 - 853 .

Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A ( 2021 ) . Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study . American Journal of Respiratory and Critical Care Medicine vol. 203 , ( 7 ) 871 - 881 .

Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young K, Davies M et al. ( 2021 ) . Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) . MedRvx

Group P-CC, Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O et al. ( 2021 ) . Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study .

Abaleke E, Abbas M, Abbasi S, Abbott A, Abdelaziz A, Abdelbadiee S, Abdelfattah M, Abdul B et al. ( 2021 ) . Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10274 ) 605 - 612 .

Hylton H, Pfeffer P, Robson C, Goodfellow H, Murray E, Ricketts W ( 2021 ) . L10 Rapid design and implementation of a personalised holistic post-COVID recovery and rehab App . Thorax . Conference: COVID-19: impact on respiratory health vol. 76 , a236 - a236 .

Taylor R, Singh R, Quantrill S, Beverly A, Shaw H, Hylton H, Francis C, McGuckin R et al. ( 2021 ) . P172 Early clinical experience of a large hospital trust virtual Covid-19 follow up clinic . Thorax . Conference: The clinical experiences of post-COVID-19 recovery vol. 76 , a182 - a183 .

Smith S, Busby J, Heaney L, Pfeffer P, Jackson D, Yang J, Fowler S, Menzies-Gow A et al. ( 2021 ) . S25 The impact of COVID-19 on the UK severe asthma population . Thorax . Conference: New insights in asthma care vol. 76 , a18 - a18 .

Yang F, Busby J, Heaney LG, Menzies-Gow A, Pfeffer PE, Jackson DJ, Mansur AH, Siddiqui S et al. ( 2021 ) . Factors Associated with Frequent Exacerbations in the UK Severe Asthma Registry . The Journal of Allergy and Clinical Immunology In Practice vol. 9 , ( 7 ) 2691 - 2701.e1 .

Bullen G, Galson JD, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Hall G, Bentley EM et al. ( 2020 ) . Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence .

Singer A, Ali FR, Quantrill S, North N, Stevens M, Lambourne J, Grigoriadou S, Pfeffer PE ( 2020 ) . Utility of Immunology, Microbiology and Helminth Investigations in Clinical Assessment of Severe Asthma . Journal of Asthma1 - 12 .

Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG, Lugogo NL, Mohan A et al. ( 2020 ) . Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial . The Lancet Respiratory Medicine vol. 9 , ( 3 ) 260 - 274 .

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,

Jackson DJ, Busby J, Pfeffer PE, Menzies-Gow A, Brown T, Gore R, Doherty M, Mansur AH et al. ( 2020 ) . Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era . Thorax vol. 76 , ( 3 ) 220 - 227 .

Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R et al. ( 2020 ) . Potential Severe Asthma Hidden in UK Primary Care . The Journal of Allergy and Clinical Immunology In Practice vol. 9 , ( 4 ) 1612 - 1623.e9 .

Smith SJ, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Yang F, Fowler SJ, Menzies-Gow A et al. ( 2020 ) . The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown? . ERJ Open Research vol. 7 , ( 1 ) 00768 - 02020 .

Yang J, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqui S et al. ( 2020 ) . Effect of maintenance oral corticosteroids on risk factors for frequent exacerbations in a severe adult asthma population . Conference: Monitoring airway disease

Pfeffer PE, Mudway IS, Grigg J ( 2020 ) . Air Pollution and Asthma Mechanisms of Harm and Considerations for Clinical Interventions . CHEST Journal vol. 159 , ( 4 ) 1346 - 1355 .

Group RC, Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M et al. ( 2020 ) . Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 . New England Journal of Medicine vol. 383 , ( 21 ) 2030 - 2040 .

Busby J, Khoo E, Pfeffer PE, Mansur AH, Heaney LG ( 2020 ) . The effects of oral corticosteroids on lung function, type-2 biomarkers and patient-reported outcomes in stable asthma: A systematic review and meta-analysis . Respiratory Medicine vol. 173 ,

FitzGerald JM, Tran TN, Alacqua M, Altraja A, Backer V, Bjermer L, Bjornsdottir U, Bourdin A et al. ( 2020 ) . International severe asthma registry (ISAR): protocol for a global registry . BMC Medical Research Methodology vol. 20 , ( 1 )

Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W et al. ( 2020 ) . Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease . American journal of respiratory and critical care medicine vol. 202 , ( 3 ) 371 - 382 .

Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C et al. ( 2020 ) . Dexamethasone in Hospitalized Patients with Covid-19 . New England Journal of Medicine vol. 384 , ( 8 ) 693 - 704 .

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures .

Jackson D, Busby J, Heaney LG, Menzies-Gow A, Pfeffer P, Perez-de-Llano L, Cosio BG, Al-Ahmad M et al. ( 2020 ) . A Global Survey of Blood Eosinophil Distribution in Severe Asthma Patients: Data from the International Severe Asthma Registry (ISAR) . Conference: C21. ADVANCES IN ADULT AND PEDIATRIC ASTHMA PHENOTYPING AND ENDOTYPINGa4522 - a4522 .

Perez-de-Llano L, Tran TN, Al-ahmad M, Alacqua M, Bulathsinhala L, Busby J, Canonica GW, Carter V et al. ( 2020 ) . Characterization of Eosinophilic and Non-Eosinophilic Severe Asthma Phenotypes and Proportion of Patients with These Phenotypes in the International Severe Asthma Registry (ISAR) . Conference: C21. ADVANCES IN ADULT AND PEDIATRIC ASTHMA PHENOTYPING AND ENDOTYPINGa4525 - a4525 .

Jackson D, Dube S, Morris T, Hassan B, Pfeffer PE ( 2020 ) . Improvement of Clinical Outcomes in Severe Eosinophilic Asthma Patients Treated with Benralizumab in Real-World Clinical Practice in England: XALOC Study Programme . Conference: B32. ASTHMA OUTCOMESa3028 - a3028 .

Nixon R, Despiney R, Pfeffer P ( 2020 ) . Case of paradoxical adverse response to mepolizumab with mepolizumab-induced alopecia in severe eosinophilic asthma . BMJ Case Reports vol. 13 , ( 2 )

Glencross DA, Ho T-R, Camiña N, Hawrylowicz CM, Pfeffer PE ( 2020 ) . Air pollution and its effects on the immune system . Free Radical Biology and Medicine vol. 151 , 56 - 68 .

Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC, Menzies-Gow AN, Busby J, Jackson DJ et al. ( 2019 ) . Characterization of Severe Asthma Worldwide Data From the International Severe Asthma Registry . CHEST Journal vol. 157 , ( 4 ) 790 - 804 .

Ricketts W, Pfeffer P, Ashworth R, Hakim A, Hakim A ( 2019 ) . Audience response systems may help build confidence and competence in diagnosing and managing asthma . Conference: Medical education, web and internet

Wechsler M, Wang E, Canonica G, Heffler E, Jones R, Busby J, Heaney L, Pfeffer P et al. ( 2019 ) . Epidemiology of lung function in a global severe asthma population . Conference: Monitoring airway disease

Busby J, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Heaney LG, Chaudhuri R, Pfeffer PE ( 2019 ) . Late Breaking Abstract - Characteristics of Patients Diagnosed with Severe Asthma at UK Specialist Centres: Variation by Ethnicity . Conference: Monitoring airway disease

Busby J, Pfeffer PE, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Chaudhuri R, Heaney LG ( 2019 ) . Late Breaking Abstract - Characteristics of T2-biomarker low severe asthma patients in the UK Severe Asthma Registry (UKSAR) . Conference: Epidemiology

Heatley H, Bulathsinhala L, Carter V, Chaudhry I, Hosseini N, Murray R, Bosnic-Anticevich S, Heaney L et al. ( 2019 ) . Protocol to identify potential severe asthma in UK primary care . Conference: Monitoring airway disease

Busby J, Pfeffer P, Jackson D, Mansur A, Menzies-Gow A, Siddiqui S, Chaudhuri R, Patel M et al. ( 2019 ) . P14 Characteristics of T2-biomarker low severe asthma patients in the UK severe asthma registry . Thorax . Conference: Asthma: endotypes/biomarkers vol. 74 ,

Menzies-Gow A, Busby J, Jackson D, Mansur A, Siddiqui S, Chaudhuri R, Pfeffer P, Patel M et al. ( 2019 ) . P146 Characteristics of patients in the UK severe asthma registry . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,

Busby J, Jackson D, Mansur A, Menzies-Gow A, Heaney L, Chaudhuri R, Pfeffer P ( 2019 ) . P152 Characteristics of patients in the UK severe asthma registry: variation by ethnicity . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,

Hylton H, Long A, Quantrill S, Ali, Pfeffer P ( 2019 ) . P155 Prevalence of urinary incontinence within a difficult asthma population . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,

Hylton H, Long A, Quantrill S, Ali, Pfeffer P ( 2019 ) . P156 Use of the breathing pattern assessment tool within the difficult asthma service . Thorax . Conference: Targeted assessment of asthma vol. 74 ,

Yang J, Busby J, Heaney L, Pfeffer P, Jackson D, Mansur A, Menzies-Gow A, Siddiqui S et al. ( 2019 ) . S33 Risk factors for frequent exacerbations in a real-life adult population with severe refractory asthma . Thorax . Conference: Acute asthma: lessons from the frontline vol. 74 ,

van Bragt JJMH, Adcock IM, Bel EHD, Braunstahl G-J, Brinke AT, Busby J, Canonica GW, Cao H et al. ( 2019 ) . Characteristics and treatment regimens across ERS SHARP severe asthma registries . European Respiratory Journal vol. 55 , ( 1 )

Hawrylowicz C, Hornsby E, Cheadle C, Pfeffer P, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA et al. ( 2019 ) . Vitamin D in pregnancy and offspring immunology . Bone Abstracts

Agrawal SG, Pfeffer PE, White PL ( 2019 ) . 13th Annual Fungal Update Conference . Medical Mycology vol. 57 , ( Supplement_3 ) s257 - s258 .

Price DB, Wang E, Busby J, Heaney LG, Pfeffer P, Jackson DJ, Menzies-Gow A, Sirena C et al. ( 2019 ) . Cross-Country Comparison of Demographic and Clinical Characteristics of Patients Managed in Severe Asthma Services Across UK, USA, Australia, South Korea, and Italy . Conference: C44. ASTHMA EPIDEMIOLOGYa4899 - a4899 .

Mann EH, Gabryšová L, Pfeffer PE, O’Garra A, Hawrylowicz CM ( 2019 ) . High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype . The Journal of Immunology vol. 202 , ( 3 )

Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF et al. ( 2019 ) . Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10 . The Journal of Steroid Biochemistry and Molecular Biology vol. 189 , 1 - 9 .

Broadbent C, Pfeffer P, Steed L, Walker S ( 2018 ) . Patient-reported side effects of oral corticosteroids . Conference: Medical education, web and internet

Pfeffer PE, Lu H, Mann EH, Chen Y-H, Ho T-R, Cousins DJ, Corrigan C, Kelly FJ et al. ( 2018 ) . Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter . PLoS One vol. 13 , ( 8 ) e0200040 - e0200040 .

Pfeffer PE, Donaldson GC, Mackay AJ, Wedzicha JA ( 2018 ) . Increased COPD Exacerbations of Likely Viral Etiology Follow Elevated Ambient NOx . Am J Respir Crit Care Med

Pfeffer PE, Mudway IS ( 2018 ) . The Impact of Real-World Particulate Matter Air Pollution on the Airways of Susceptible Individuals . American Journal of Respiratory and Critical Care Medicine vol. 198 , ( 11 ) 1362 - 1363 .

PETERSEN SE, AUNG N, FUNG K, ZEMRAK F, PAIVA J, Thomson R, SANGHVI M, LEE A et al. ( 2018 ) . Variation in lung function and alterations in cardiac structure and function - analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy . PLOS ONE vol. 13 , ( 3 )

Pfeffer PE ( 2018 ) . Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma? . Expert Review of Clinical Immunology vol. 14 , ( 4 ) 241 - 243 .

Donaldson GC, Pfeffer PE, Mackay AJ, Wedzicha JA ( 2018 ) . Ambient Particulate Matter and Oxides of Nitrogen Are Associated with an Increased Incidence of COPD Exacerbations with Symptoms of Infective Etiology . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 197 ,

Mann EH, Pfeffer PE, Hawrylowicz CM ( 2018 ) . Chapter 104 Vitamin D and Adaptive Immunology in Health and Disease . Vitamin D , Elsevier

Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM ( 2017 ) . Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids . Clinical & Experimental Allergy vol. 48 , ( 1 ) 13 - 22 .

Pfeffer PE, Ho TR, Mann EH, Kelly FJ, Sehlstedt M, Pourazar J, Dove RE, Sandstrom T et al. ( 2017 ) . Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes . Immunology vol. 153 , ( 4 ) 502 - 512 .

Singer A, Barrett J, Ali F, Lambourne J, Pfeffer P ( 2017 ) . P20 Latent helminth disease as a cause of eosinophilia in respiratory patients . Thorax . Conference: Asthma: airways and antibodies vol. 72 ,

Pfeffer PE, Hawrylowicz CM ( 2017 ) . Vitamin D in Asthma Mechanisms of Action and Considerations for Clinical Trials . CHEST Journal vol. 153 , ( 5 ) 1229 - 1239 .

Kumar A, Bicer EM, Pfeffer P, Monopoli MP, Dawson KA, Eriksson J, Edwards K, Lynham S et al. ( 2017 ) . Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans . Nanomedicine Nanotechnology Biology and Medicine vol. 13 , ( 8 ) 2517 - 2521 .

Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ et al. ( 2017 ) . Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial . Journal of Allergy and Clinical Immunology vol. 141 , ( 1 ) 269 - 278.e1 .

Pfeffer PE, Hopkins S, Cropley I, Lowe DM, Lipman M ( 2017 ) . An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation . Respiratory Research vol. 18 , ( 1 )

Mann EH, Ho T-R, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM ( 2017 ) . Vitamin D Counteracts an IL-23–Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter . American Journal of Respiratory Cell and Molecular Biology vol. 57 , ( 3 ) 355 - 366 .

Pfeffer PE, Corrigan CJ ( 2017 ) . An Imbalance between Proteases and Endogenous Protease Inhibitors in Eosinophilic Airway Disease . American Journal of Respiratory and Critical Care Medicine vol. 195 , ( 6 ) 707 - 708 .

Mann EH, Pfeffer PE, Hawrylowicz CM ( 2017 ) . Vitamin D and Adaptive Immunology in Health and Disease . Vitamin D: Health, Disease and Therapeutics, Fourth Edition: Volume 2 , vol. 2 ,

Ho T, Camina N, Pfeffer P, Mann E, Mudway I, Hawrylowicz C ( 2016 ) . P121 Urban fine and coarse mode particulate matter differentially alter the maturation of monocyte-derived dendritic cells . Thorax vol. 71 , ( Suppl 3 )

Pfeffer P, Burman M, Milton V, Naidu V, Vaghela D, Kunst H ( 2016 ) . Eosinophilia and predominant Th2 immune responses are rarely evident in disseminated tuberculosis . Conference: 10.2 Tuberculosis

Matthews NC, Pfeffer PE, Mann EH, Kelly FJ, Corrigan CJ, Hawrylowicz CM, Lee TH ( 2016 ) . Urban Particulate Matter–Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells . American Journal of Respiratory Cell and Molecular Biology vol. 54 , ( 2 ) 250 - 262 .

Kumar A, Bicer EM, Morgan AB, Pfeffer PE, Monopoli M, Dawson KA, Eriksson J, Edwards K et al. ( 2016 ) . Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid . Nanomedicine Nanotechnology Biology and Medicine vol. 12 , ( 4 ) 1033 - 1043 .

Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al. ( 2015 ) . Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol . Journal of Allergy and Clinical Immunology vol. 136 , ( 3 ) 628 - 637.e4 .

Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen Y-H, Rice L, Hawrylowicz CM ( 2014 ) . Vitamin D Influences Asthmatic Pathology through Its Action on Diverse Immunological Pathways . Annals of the American Thoracic Society vol. 11 , ( Supplement 5 ) s314 - s321 .

Pfeffer PE, Chen Y-H, Woszczek G, Matthews NC, Chevretton E, Gupta A, Saglani S, Bush A et al. ( 2014 ) . Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33 . Journal of Allergy and Clinical Immunology vol. 135 , ( 3 ) 824 - 827.e3 .

Ho T, Pfeffer P, Mann E, Kelly F, Matthews N, Hawrylowicz C ( 2014 ) . S48 Air Pollution Particulate Matter Promotes Dc Maturation And Enhances Their Stimulation Of Cd8 Lymphocyte Responses . Thorax vol. 69 , ( Suppl 2 ) a27 - a28 .

Pfeffer P, Kelly F, Hawrylowicz C ( 2014 ) . T2 Vitamin D Enhances Bronchial Epithelial Cell Antioxidant Responses And Reduces Their Pro-inflammatory Cytokine Response To Stimulation By Urban Particulate Matter . Thorax vol. 69 , ( Suppl 2 ) a1 - a1 .

Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM ( 2014 ) . Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma . Annals of the New York Academy of Sciences vol. 1317 , ( 1 ) 57 - 69 .

Matthews NC, Faith A, Pfeffer P, Lu H, Kelly FJ, Hawrylowicz CM, Lee TH ( 2014 ) . Urban Particulate Matter Suppresses Priming of T Helper Type 1 Cells by Granulocyte/Macrophage Colony–Stimulating Factor–Activated Human Dendritic Cells . American Journal of Respiratory Cell and Molecular Biology vol. 50 , ( 2 )

Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM ( 2014 ) . Calcitriol restores glucocorticoid responsiveness in steroid resistant asthmatics through reduction of IL-17A . IMMUNOLOGY . vol. 143 , 50 - 50 .

Tribuddharat S, Suwannasaen D, Sathitkarnmanee T, Ngamsangsirisup K, Hawrylowicz C, Pfeffer P, Hurst CP, Silarat S et al. ( 2014 ) . Prognostic scoring models can be surrogates of plasma cytokine levels and predict a prolonged intensive care unit stay in cardiac surgery . Experimental and Clinical Cardiology vol. 20 , ( 7 ) 329 - 357 .

Pfeffer P, Kelly F, Hawrylowicz C ( 2013 ) . Vitamin D treatment reduces inflammatory cytokine secretion by pollution-stimulated bronchial epithelial cells . The Lancet vol. 381 ,

Pfeffer PE, Hawrylowicz CM ( 2012 ) . Vitamin D and lung disease . Thorax vol. 67 , ( 11 )

José RJ, Pfeffer PE, McDonald I, Shaw S, Padate B, McNamara C, Kibbler C, Agarwal B ( 2012 ) . Outcomes and patterns of infections in patients with underlying haematological malignancies admitted to intensive care . British Journal of Anaesthesia vol. 109 , ( 2 ) 291 - 292 .

( 2012 ) . The spleen, bone marrow and blood . Sarcoidosis , Taylor & Francis

Pfeffer PE, Nazareth D, Main N, Hardoon S, Choudhury AB ( 2011 ) . Are weekend handovers of adequate quality for the on-call general medical team? . Clinical Medicine vol. 11 , ( 6 ) 536 - 540 .

José R, McDonald I, Pfeffer P, Shaw S, Agarwal B ( 2011 ) . Outcome of haematology patients admitted to intensive care in a tertiary centre: primary haematological diagnosis, recent chemotherapy and bone marrow transplantation are not associated with outcome . Critical Care vol. 15 , ( Suppl 1 )

José R, McDonald I, Pfeffer P, Shaw S, Kibbler C, Agarwal B ( 2011 ) . Patterns of infection and impact on outcome in haematology patients admitted to intensive care . Critical Care vol. 15 , ( Suppl 1 )

Pfeffer PE, Sen A, Das S, Sheaff M, Sivaramakrishnan A, Simcock DE, Turner B ( 2010 ) . Eosinophilia, meningitis and pulmonary nodules in a young woman . Thorax vol. 65 , ( 12 )

Pfeffer PE, Sebire N, Lindsay I, McIndoe A, Lim A, Seckl M ( 2007 ) . Fertility-sparing partial hysterectomy for placental-site trophoblastic tumour . The Lancet Oncology vol. 8 , ( 8 ) 744 - 746 .

Pfeffer PE, Pfeffer JM, Hodson ME ( 2003 ) . The psychosocial and psychiatric side of cystic fibrosis in adolescents and adults . Journal of Cystic Fibrosis vol. 2 , ( 2 ) 61 - 68 .