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Research

Publications: Dr Paul Pfeffer

Zheng B, Daines L, Han Q, Hurst JR, Pfeffer P, Shankar-Hari M, Elneima O, Walker S et al. ( 2022 ) . Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis . European Respiratory Review vol. 31 , ( 166 )
Tydeman F, Pfeffer PE, Vivaldi G, Holt H, Talaei M, Jolliffe D, Davies G, Lyons RA et al. ( 2022 ) . Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK) . Thorax
Price D, pfeffer P, Ali N, Murray R, Ulrik C, Tran T, Maspero J, Peters M et al. ( 2022 ) . Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in severe asthma patients eligible for both .
Holt H, Relton C, Talaei M, Symons J, Davies MR, Jolliffe DA, Vivaldi G, Tydeman F et al. ( 2022 ) . Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK) . Int J Epidemiol
Jolliffe DA, Holt H, Greenig M, Talaei M, Perdek N, Pfeffer P, Vivaldi G, Maltby S et al. ( 2022 ) . Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: Phase 3 randomised controlled trial (CORONAVIT) . The BMJ
Tydeman F, Pfeffer P, Vivaldi G, Holt H, Talaei M, Jolliffe D, Davies G, Lyons R et al. ( 2022 ) . Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK) .
De Simoni A, Hajmohammadi H, Cole J, Griffiths C, Hull SA, Pfeffer P ( 2022 ) . Reducing short-acting beta-agonist overprescribing in asthma: lessons from a quality-improvement prescribing project in East London . British Journal of General Practice vol. 72 , ( 722 ) E619 - E626 .
Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young KS, Davies MR et al. ( 2022 ) . Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) . Thorax vol. 77 , ( 9 ) 900 - 912 .
Evans RA, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M et al. ( 2022 ) . Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study . The Lancet Respiratory Medicine vol. 10 , ( 8 ) 761 - 775 .
Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2022 ) . Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis . The Lancet vol. 400 , ( 10349 ) 359 - 368 .
Hajmohammadi H, Pfeffer P, De Simoni A, Cole JN, Griffiths CJ, Hull SA, Heydecker B ( 2022 ) . Association between short-term NO<inf>x</inf> exposure and asthma exacerbations in East London: A time series regression model . Urban Climate vol. 44 ,
Redmond C, Heaney LG, Chaudhuri R, Jackson DJ, Menzies-Gow A, Pfeffer P, Busby J, UK Severe Asthma Registry ( 2022 ) . Benefits of specialist severe asthma management: demographic and geographic disparities . Eur Respir J
Hylton H, Long A, Francis C, Taylor RR, Ricketts WM, Singh R, Pfeffer PE ( 2022 ) . Real-world use of the Breathing Pattern Assessment Tool in assessment of breathlessness post-COVID-19 . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 22 , ( 4 )
Holt H, Relton C, Talaei M, Symons J, Davies M, Jolliffe D, Vivaldi G, Tydeman F et al. ( 2022 ) . Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK) .
Jackson DJ, Burhan H, Menzies-Gow A, Pfeffer P, Nanzer A, Garcia Gil E, Morris T, Tran TN et al. ( 2022 ) . Benralizumab Effectiveness in Severe Asthma Is Independent of Previous Biologic Use . Journal of Allergy and Clinical Immunology: In Practice vol. 10 , ( 6 ) 1534 - 1544.e4 .
Scelo G, Porsbjerg CM, Carter V, Ariti C, Lyu J, Eleangovan N, Tran TN, Barker P et al. ( 2022 ) . Prevalence of Comorbidities in Adults with Severe Asthma: Results from the International Severe Asthma Registry (ISAR) . Conference: A34. TOPICS IN HEALTH SERVICES RESEARCH AND SELF-MANAGEMENT FOR PATIENTS WITH OBSTRUCTIVE LUNG DISEASEa1306 - a1306 .
Daines L, Zheng B, Pfeffer P, Hurst JR, Sheikh A ( 2022 ) . A clinical review of long-COVID with a focus on the respiratory system . Current opinion in pulmonary medicine vol. 28 , ( 3 ) 174 - 179 .
Busby J, Heaney LG, Pfeffer PE ( 2022 ) . Reply to “Ethnicity-based differences in asthma diagnostic thresholds” . Journal of Allergy and Clinical Immunology: In Practice vol. 10 , ( 4 ) 1124 - 1125 .
Jolliffe D, Holt H, Greenig M, Talaei M, Perdek N, Pfeffer P, Vivaldi G, Maltby S et al. ( 2022 ) . Vitamin D Supplements for Prevention of COVID-19 or other Acute Respiratory Infections: a Phase 3 Randomised Controlled Trial (CORONAVIT) .
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10325 ) 665 - 676 .
Murray E, Goodfellow H, Bindman J, Blandford A, Bradbury K, Chaudhry T, Fernandez-Reyes D, Gomes M et al. ( 2022 ) . Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living With COVID-19 Recovery): protocol for a mixed-methods study . BMJ Open vol. 12 , ( 2 )
Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH et al. ( 2022 ) . Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care . Journal of Allergy and Clinical Immunology: In Practice vol. 10 , ( 2 ) 495 - 505.e2 .
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2022 ) . Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 399 , ( 10320 ) 143 - 151 .
Mansur AH, Gonem S, Brown T, Burhan H, Chaudhuri R, Dodd JW, Pantin T, Gore R et al. ( 2022 ) . Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion . Clinical and Experimental Allergy
Chen W, Sadatsafavi M, Tran TN, Murray RB, Wong CBN, Ali N, Ariti C, Gil EG et al. ( 2022 ) . Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy . Journal of Asthma and Allergy vol. 15 , 1491 - 1510 .
Singer A, Pfeffer P ( 2022 ) . Current Management of Asthma . Encyclopedia of Respiratory Medicine ,
( 2021 ) . Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study .
Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S et al. ( 2021 ) . The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease . The Lancet Respiratory Medicine vol. 9 , ( 12 ) 1467 - 1478 .
Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young K, Davies M et al. ( 2021 ) . Risk Factors for Developing COVID-19: A Population-Based Longitudinal Study (COVIDENCE UK) . Thorax
Holmes J, Dennison P, Jackson D, D’Ancona G, Mansur A, Menzies-Gow A, Patel P, Pfeffer P et al. ( 2021 ) . S88 Use of a connected inhaler system in the pre-biologic assessment of patients with severe asthma . Thorax . Conference: Biologics for asthma vol. 76 , a57 - a58 .
Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB, Mansur A, Detoraki A et al. ( 2021 ) . Defining a Severe Asthma Super-Responder: Findings from a Delphi Process . Journal of Allergy and Clinical Immunology: In Practice vol. 9 , ( 11 ) 3997 - 4004 .
Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB et al. ( 2021 ) . Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study . The Lancet Respiratory Medicine vol. 9 , ( 11 ) 1275 - 1287 .
Smith S, Gillespie L, Heaney L, Brightling C, Mcconnachie A, Siddiqui S, Mistry V, Brown V et al. ( 2021 ) . Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design . Conference: Monitoring airway disease
Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH et al. ( 2021 ) . The impact of ethnicity on disease presentation and control in severe asthma . Conference: Epidemiology
Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG et al. ( 2021 ) . Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort . Chest vol. 160 , ( 3 ) 814 - 830 .
Skene IP, Pfeffer PE ( 2021 ) . Improved asthma control during the COVID-19 pandemic: Are there lessons to be learnt? . Thorax vol. 76 , ( 9 ) 852 - 853 .
Chen YH, Cheadle CE, Rice LV, Pfeffer PE, Dimeloe S, Gupta A, Bush A, Gooptu B et al. ( 2021 ) . The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease . Frontiers in Nutrition vol. 8 ,
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al. ( 2021 ) . Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19 . Circulation ResearchE54 - E71 .
Yang F, Busby J, Heaney LG, Menzies-Gow A, Pfeffer PE, Jackson DJ, Mansur AH, Siddiqui S et al. ( 2021 ) . Factors Associated with Frequent Exacerbations in the UK Severe Asthma Registry . Journal of Allergy and Clinical Immunology: In Practice vol. 9 , ( 7 ) 2691 - 2701.e1 .
Taylor RR, Trivedi B, Patel N, Singh R, Ricketts WM, Elliott K, Yarwood M, White V et al. ( 2021 ) . Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 21 , ( 4 )
Bullen G, Galson JD, Hall G, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Bentley EM et al. ( 2021 ) . Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses . Frontiers in Immunology vol. 12 ,
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial . The Lancet vol. 397 , ( 10289 ) 2049 - 2059 .
Jackson DJ, Burhan H, Menzies-Gow A, Pfeffer PE, Nanzer A, Garcia Gil E, Morris T, Tran TN et al. ( 2021 ) . Clinical Effectiveness of Benralizumab Is Independent of Baseline FeNO in Severe Eosinophilic Asthma: A Retrospective Real-World Observation Study in Five UK Severe Asthma Centers . Conference: TP6. TP006 CLINICAL STUDIES OF ALLERGIC AIRWAY DISEASES, LUPUS, AND EOSINOPHILIC DISEASESa1360 - a1360 .
Zenner D ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . International Journal of Tuberculosis and Lung Disease
Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N et al. ( 2021 ) . Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10285 ) 1637 - 1645 .
Pfeffer PE, Mudway IS, Grigg J ( 2021 ) . Air Pollution and Asthma: Mechanisms of Harm and Considerations for Clinical Interventions . Chest vol. 159 , ( 4 ) 1346 - 1355 .
Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A, Oral Corticosteroids Tapering Delphi Expert Panel ( 2021 ) . Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study . Am J Respir Crit Care Med vol. 203 , ( 7 ) 871 - 881 .
Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R et al. ( 2021 ) . Potential Severe Asthma Hidden in UK Primary Care . Journal of Allergy and Clinical Immunology: In Practice vol. 9 , ( 4 ) 1612 - 1623.e9 .
Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young K, Davies M et al. ( 2021 ) . Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) .
PHOSP-COVID Collaborative Group, Evans RA, McAuley H, Harrison E, Shikotra A, Singapuri A, Sereno M, Elneima O et al. ( 2021 ) . Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study .
Jackson DJ, Busby J, Pfeffer PE, Menzies-Gow A, Brown T, Gore R, Doherty M, Mansur AH et al. ( 2021 ) . Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era . Thorax vol. 76 , ( 3 ) 220 - 227 .
Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG, Lugogo NL, Mohan A et al. ( 2021 ) . Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial . The Lancet Respiratory Medicine vol. 9 , ( 3 ) 260 - 274 .
RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N et al. ( 2021 ) . Dexamethasone in Hospitalized Patients with Covid-19 . N Engl J Med vol. 384 , ( 8 ) 693 - 704 .
Abaleke E, Abbas M, Abbasi S, Abbott A, Abdelaziz A, Abdelbadiee S, Abdelfattah M, Abdul B et al. ( 2021 ) . Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 397 , ( 10274 ) 605 - 612 .
Hylton H, Pfeffer P, Robson C, Goodfellow H, Murray E, Ricketts W ( 2021 ) . L10 Rapid design and implementation of a personalised holistic post-COVID recovery and rehab App . Thorax . Conference: COVID-19: impact on respiratory health vol. 76 , a236 - a236 .
Taylor R, Singh R, Quantrill S, Beverly A, Shaw H, Hylton H, Francis C, McGuckin R et al. ( 2021 ) . P172 Early clinical experience of a large hospital trust virtual Covid-19 follow up clinic . Thorax . Conference: The clinical experiences of post-COVID-19 recovery vol. 76 , a182 - a183 .
Smith S, Busby J, Heaney L, Pfeffer P, Jackson D, Yang J, Fowler S, Menzies-Gow A et al. ( 2021 ) . S25 The impact of COVID-19 on the UK severe asthma population . Thorax . Conference: New insights in asthma care vol. 76 , a18 - a18 .
Smith SJ, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Yang F, Fowler SJ, Menzies-Gow A et al. ( 2021 ) . The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown? . ERJ Open Res vol. 7 , ( 1 )
Bullen G, Galson J, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Hall G, Bentley E et al. ( 2020 ) . Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence .
Singer A, Ali FR, Quantrill S, North N, Stevens M, Lambourne J, Grigoriadou S, Pfeffer PE ( 2020 ) . Utility of Immunology, Microbiology and Helminth Investigations in Clinical Assessment of Severe Asthma . Journal of Asthma1 - 12 .
Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,
RECOVERY Collaborative Group, Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M et al. ( 2020 ) . Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 . N Engl J Med vol. 383 , ( 21 ) 2030 - 2040 .
Busby J, Khoo E, Pfeffer PE, Mansur AH, Heaney LG ( 2020 ) . The effects of oral corticosteroids on lung function, type-2 biomarkers and patient-reported outcomes in stable asthma: A systematic review and meta-analysis . Respiratory Medicine vol. 173 ,
Yang J, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqui S et al. ( 2020 ) . Effect of maintenance oral corticosteroids on risk factors for frequent exacerbations in a severe adult asthma population . Conference: Monitoring airway disease
Fitzgerald JM, Tran TN, Alacqua M, Altraja A, Backer V, Bjermer L, Bjornsdottir U, Bourdin A et al. ( 2020 ) . International severe asthma registry (ISAR): Protocol for a global registry . BMC Medical Research Methodology vol. 20 , ( 1 )
Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W et al. ( 2020 ) . Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease . American journal of respiratory and critical care medicine vol. 202 , ( 3 ) 371 - 382 .
Galson J, Schaetzle S, Bashford-Rogers R, Raybould M, Kovaltsuk A, Kilpatrick G, Minter R, Finch D et al. ( 2020 ) . Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures .
Jackson D, Busby J, Heaney LG, Menzies-Gow A, Pfeffer P, Perez-de-Llano L, Cosio BG, Al-Ahmad M et al. ( 2020 ) . A Global Survey of Blood Eosinophil Distribution in Severe Asthma Patients: Data from the International Severe Asthma Registry (ISAR) . Conference: C21. ADVANCES IN ADULT AND PEDIATRIC ASTHMA PHENOTYPING AND ENDOTYPINGa4522 - a4522 .
Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE ( 2020 ) . Air pollution and its effects on the immune system . Free Radical Biology and Medicine vol. 151 , 56 - 68 .
Perez-de-Llano L, Tran TN, Al-ahmad M, Alacqua M, Bulathsinhala L, Busby J, Canonica GW, Carter V et al. ( 2020 ) . Characterization of Eosinophilic and Non-Eosinophilic Severe Asthma Phenotypes and Proportion of Patients with These Phenotypes in the International Severe Asthma Registry (ISAR) . Conference: C21. ADVANCES IN ADULT AND PEDIATRIC ASTHMA PHENOTYPING AND ENDOTYPINGa4525 - a4525 .
Jackson D, Dube S, Morris T, Hassan B, Pfeffer PE ( 2020 ) . Improvement of Clinical Outcomes in Severe Eosinophilic Asthma Patients Treated with Benralizumab in Real-World Clinical Practice in England: XALOC Study Programme . Conference: B32. ASTHMA OUTCOMESa3028 - a3028 .
Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC, Menzies-Gow AN, Busby J, Jackson DJ et al. ( 2020 ) . Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry . Chest vol. 157 , ( 4 ) 790 - 804 .
Nixon R, Despiney R, Pfeffer P ( 2020 ) . Case of paradoxical adverse response to mepolizumab with mepolizumab-induced alopecia in severe eosinophilic asthma . BMJ Case Reports vol. 13 , ( 2 )
van Bragt JJMH, Adcock IM, Bel EHD, Braunstahl GJ, ten Brinke A, Busby J, Canonica GW, Cao H et al. ( 2020 ) . Characteristics and treatment regimens across ERS SHARP severe asthma registries . European Respiratory Journal vol. 55 , ( 1 )
Busby J, Pfeffer P, Jackson D, Mansur A, Menzies-Gow A, Siddiqui S, Chaudhuri R, Patel M et al. ( 2019 ) . P14 Characteristics of T2-biomarker low severe asthma patients in the UK severe asthma registry . Thorax . Conference: Asthma: endotypes/biomarkers vol. 74 ,
Menzies-Gow A, Busby J, Jackson D, Mansur A, Siddiqui S, Chaudhuri R, Pfeffer P, Patel M et al. ( 2019 ) . P146 Characteristics of patients in the UK severe asthma registry . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,
Busby J, Jackson D, Mansur A, Menzies-Gow A, Heaney L, Chaudhuri R, Pfeffer P ( 2019 ) . P152 Characteristics of patients in the UK severe asthma registry: variation by ethnicity . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,
Hylton H, Long A, Quantrill S, Ali F, Pfeffer P ( 2019 ) . P155 Prevalence of urinary incontinence within a difficult asthma population . Thorax . Conference: Asthma epidemiology: understanding the problem vol. 74 ,
Hylton H, Long A, Quantrill S, Ali F, Pfeffer P ( 2019 ) . P156 Use of the breathing pattern assessment tool within the difficult asthma service . Thorax . Conference: Targeted assessment of asthma vol. 74 ,
Yang J, Busby J, Heaney L, Pfeffer P, Jackson D, Mansur A, Menzies-Gow A, Siddiqui S et al. ( 2019 ) . S33 Risk factors for frequent exacerbations in a real-life adult population with severe refractory asthma . Thorax . Conference: Acute asthma: lessons from the frontline vol. 74 ,
Wechsler M, Wang E, Canonica G, Heffler E, Jones R, Busby J, Heaney L, Pfeffer P et al. ( 2019 ) . Epidemiology of lung function in a global severe asthma population . Conference: Monitoring airway disease
Busby J, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Heaney LG, Chaudhuri R, Pfeffer PE ( 2019 ) . Late Breaking Abstract - Characteristics of Patients Diagnosed with Severe Asthma at UK Specialist Centres: Variation by Ethnicity . Conference: Monitoring airway disease
Busby J, Pfeffer PE, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Chaudhuri R, Heaney LG ( 2019 ) . Late Breaking Abstract - Characteristics of T2-biomarker low severe asthma patients in the UK Severe Asthma Registry (UKSAR) . Conference: Epidemiology
Heatley H, Bulathsinhala L, Carter V, Chaudhry I, Hosseini N, Murray R, Bosnic-Anticevich S, Heaney L et al. ( 2019 ) . Protocol to identify potential severe asthma in UK primary care . Conference: Monitoring airway disease
Hawrylowicz C, Hornsby E, Cheadle C, Pfeffer P, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA et al. ( 2019 ) . Vitamin D in pregnancy and offspring immunology . Bone Abstracts
Agrawal SG, Pfeffer PE, Lewis White P ( 2019 ) . 13th Annual Fungal Update Conference . Medical Mycology vol. 57 , S257 - S258 .
Price DB, Wang E, Busby J, Heaney LG, Pfeffer P, Jackson DJ, Menzies-Gow A, Sirena C et al. ( 2019 ) . Cross-Country Comparison of Demographic and Clinical Characteristics of Patients Managed in Severe Asthma Services Across UK, USA, Australia, South Korea, and Italy . Conference: C44. ASTHMA EPIDEMIOLOGYa4899 - a4899 .
Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF et al. ( 2019 ) . Vitamin D (1,25(OH) <inf>2</inf> D3) induces α-1-antitrypsin synthesis by CD4 <sup>+</sup> T cells, which is required for 1,25(OH) <inf>2</inf> D3-driven IL-10 . Journal of Steroid Biochemistry and Molecular Biology vol. 189 , 1 - 9 .
Mann EH, Gabryšová L, Pfeffer PE, O’Garra A, Hawrylowicz CM ( 2019 ) . High-dose IL-2 skews a glucocorticoid-driven IL-17 <sup>+</sup> IL-10 <sup>+</sup> memory CD4 <sup>+</sup> T cell response towards a single IL-10–producing phenotype . Journal of Immunology vol. 202 , ( 3 ) 684 - 693 .
Pfeffer PE, Mudway IS ( 2018 ) . The impact of real-world particulate matter air pollution on the airways of susceptible individuals . American Journal of Respiratory and Critical Care Medicine vol. 198 , ( 11 ) 1362 - 1363 .
Broadbent C, Pfeffer P, Steed L, Walker S ( 2018 ) . Patient-reported side effects of oral corticosteroids . Conference: Medical education, web and internet
Pfeffer PE, Lu H, Mann EH, Chen Y-H, Ho T-R, Cousins DJ, Corrigan C, Kelly FJ et al. ( 2018 ) . Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter . PLoS One vol. 13 , ( 8 ) e0200040 - e0200040 .
Pfeffer PE, Donaldson GC, Mackay AJ, Wedzicha JA ( 2018 ) . Increased COPD Exacerbations of Likely Viral Etiology Follow Elevated Ambient NOx . Am J Respir Crit Care Med
Pfeffer PE, Hawrylowicz CM ( 2018 ) . Vitamin D in Asthma: Mechanisms of Action and Considerations for Clinical Trials . Chest vol. 153 , ( 5 ) 1229 - 1239 .
Pfeffer PE ( 2018 ) . Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma? . Expert Review of Clinical Immunology vol. 14 , ( 4 ) 241 - 243 .
Pfeffer PE, Ho TR, Mann EH, Kelly FJ, Sehlstedt M, Pourazar J, Dove RE, Sandstrom T et al. ( 2018 ) . Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes . Immunology vol. 153 , ( 4 ) 502 - 512 .
PETERSEN SE, AUNG N, FUNG K, ZEMRAK F, PAIVA J, Thomson R, SANGHVI M, LEE A et al. ( 2018 ) . Variation in lung function and alterations in cardiac structure and function - analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy . PLOS ONE vol. 13 , ( 3 )
Donaldson GC, Pfeffer PE, Mackay AJ, Wedzicha JA ( 2018 ) . Ambient Particulate Matter and Oxides of Nitrogen Are Associated with an Increased Incidence of COPD Exacerbations with Symptoms of Infective Etiology . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 197 ,
Mann EH, Pfeffer PE, Hawrylowicz CM ( 2018 ) . Chapter 104 Vitamin D and Adaptive Immunology in Health and Disease . Vitamin D ,
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM ( 2018 ) . Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids . Clinical and Experimental Allergy vol. 48 , ( 1 ) 13 - 22 .
Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ et al. ( 2018 ) . Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial . Journal of Allergy and Clinical Immunology vol. 141 , ( 1 ) 269 - 278.e1 .
Mann EH, Pfeffer PE, Hawrylowicz CM ( 2017 ) . Vitamin D and Adaptive Immunology in Health and Disease . Vitamin D: Fourth Edition , vol. 2 ,
Singer A, Barrett J, Ali F, Lambourne J, Pfeffer P ( 2017 ) . P20 Latent helminth disease as a cause of eosinophilia in respiratory patients . Thorax . Conference: Asthma: airways and antibodies vol. 72 ,
Kumar A, Bicer EM, Pfeffer P, Monopoli MP, Dawson KA, Eriksson J, Edwards K, Lynham S et al. ( 2017 ) . Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans . Nanomedicine: Nanotechnology, Biology, and Medicine vol. 13 , ( 8 ) 2517 - 2521 .
Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM ( 2017 ) . Vitamin D counteracts an IL-23-dependent IL-17A1IFN-g1 response driven by urban particulate matter . American Journal of Respiratory Cell and Molecular Biology vol. 57 , ( 3 ) 355 - 366 .
Pfeffer PE, Hopkins S, Cropley I, Lowe DM, Lipman M ( 2017 ) . An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation . Respiratory Research vol. 18 , ( 1 )
Pfeffer PE, Corrigan CJ ( 2017 ) . An imbalance between proteases and endogenous protease inhibitors in eosinophilic airway disease . American Journal of Respiratory and Critical Care Medicine vol. 195 , ( 6 ) 707 - 708 .
Ho T, Camina N, Pfeffer P, Mann E, Mudway I, Hawrylowicz C ( 2016 ) . P121 Urban fine and coarse mode particulate matter differentially alter the maturation of monocyte-derived dendritic cells . Thorax vol. 71 , ( Suppl 3 )
Pfeffer P, Burman M, Milton V, Naidu V, Vaghela D, Kunst H ( 2016 ) . Eosinophilia and predominant Th2 immune responses are rarely evident in disseminated tuberculosis . Conference: 10.2 Tuberculosis
Kumar A, Bicer EM, Morgan AB, Pfeffer PE, Monopoli M, Dawson KA, Eriksson J, Edwards K et al. ( 2016 ) . Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid . Nanomedicine: Nanotechnology, Biology, and Medicine vol. 12 , ( 4 ) 1033 - 1043 .
Matthews NC, Pfeffer PE, Mann EH, Kelly FJ, Corrigan CJ, Hawrylowicz CM, Lee TH ( 2016 ) . Urban particulate matter-activated human dendritic cells induce the expansion of potent inflammatory Th1, Th2, and Th17 effector cells . American Journal of Respiratory Cell and Molecular Biology vol. 54 , ( 2 ) 250 - 262 .
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al. ( 2015 ) . Distinct endotypes of steroid-resistant asthma characterized by IL-17A<sup>high</sup> and IFN-γ<sup>high</sup> immunophenotypes: Potential benefits of calcitriol . Journal of Allergy and Clinical Immunology vol. 136 , ( 3 ) 628 - 637.e4 .
Pfeffer PE, Chen YH, Woszczek G, Matthews NC, Chevretton E, Gupta A, Saglani S, Bush A et al. ( 2015 ) . Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33 . Journal of Allergy and Clinical Immunology vol. 135 , ( 3 ) 824 - 827.e3 .
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM ( 2014 ) . Calcitriol restores glucocorticoid responsiveness in steroid resistant asthmatics through reduction of IL-17A . IMMUNOLOGY . vol. 143 , 50 - 50 .
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, Hawrylowicz CM ( 2014 ) . Vitamin D influences asthmatic pathology through its action on diverse immunological pathways . Annals of the American Thoracic Society vol. 11 , S314 - S321 .
Ho T, Pfeffer P, Mann E, Kelly F, Matthews N, Hawrylowicz C ( 2014 ) . S48 Air Pollution Particulate Matter Promotes Dc Maturation And Enhances Their Stimulation Of Cd8 Lymphocyte Responses . Thorax vol. 69 , ( Suppl 2 ) a27 - a28 .
Pfeffer P, Kelly F, Hawrylowicz C ( 2014 ) . T2 Vitamin D Enhances Bronchial Epithelial Cell Antioxidant Responses And Reduces Their Pro-inflammatory Cytokine Response To Stimulation By Urban Particulate Matter . Thorax vol. 69 , ( Suppl 2 ) a1 - a1 .
Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM ( 2014 ) . Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma . Annals of the New York Academy of Sciences vol. 1317 , ( 1 ) 57 - 69 .
Tribuddharat S, Suwannasaen D, Sathitkarnmanee T, Ngamsangsirisup K, Hawrylowicz C, Pfeffer P, Hurst CP, Silarat S et al. ( 2014 ) . Prognostic scoring models can be surrogates of plasma cytokine levels and predict a prolonged intensive care unit stay in cardiac surgery . Experimental and Clinical Cardiology vol. 20 , ( 7 ) 329 - 357 .
Matthews NC, Faith A, Pfeffer P, Lu H, Kelly FJ, Hawrylowicz CM, Lee TH ( 2014 ) . Urban particulate matter suppresses priming of T helper type 1 cells by granulocyte/macrophage colony-stimulating factor-activated human dendritic cells . American journal of respiratory cell and molecular biology vol. 50 , ( 2 ) 281 - 291 .
Pfeffer P, Kelly F, Hawrylowicz C ( 2013 ) . Vitamin D treatment reduces inflammatory cytokine secretion by pollution-stimulated bronchial epithelial cells . The Lancet vol. 381 ,
José RJ, Pfeffer PE, McDonald I, Shaw S, Padate B, McNamara C, Kibbler C, Agarwal B ( 2012 ) . Outcomes and patterns of infections in patients with underlying haematological malignancies admitted to intensive care . British Journal of Anaesthesia vol. 109 , ( 2 ) 291 - 292 .
Pfeffer PE, Pfeffer JM ( 2012 ) . Psychiatric aspects . Sarcoidosis ,
Pfeffer PE, Hawrylowicz CM ( 2012 ) . Vitamin D and lung disease . Thorax vol. 67 , ( 11 ) 1018 - 1020 .
Pfeffer PE, Nazareth D, Main N, Hardoon S, Choudhury AB ( 2011 ) . Are weekend handovers of adequate quality for the on-call general medical team? . Clinical Medicine, Journal of the Royal College of Physicians of London vol. 11 , ( 6 ) 536 - 540 .
José R, McDonald I, Pfeffer P, Shaw S, Agarwal B ( 2011 ) . Outcome of haematology patients admitted to intensive care in a tertiary centre: primary haematological diagnosis, recent chemotherapy and bone marrow transplantation are not associated with outcome . Critical care (London, England) vol. 15 , ( Suppl 1 ) P497 - P497 .
José R, McDonald I, Pfeffer P, Shaw S, Kibbler C, Agarwal B ( 2011 ) . Patterns of infection and impact on outcome in haematology patients admitted to intensive care . Critical care (London, England) vol. 15 , ( Suppl 1 ) P496 - P496 .
Pfeffer PE, Sen A, Das S, Sheaff M, Sivaramakrishnan A, Simcock DE, Turner B ( 2010 ) . Eosinophilia, meningitis and pulmonary nodules in a young woman . Thorax vol. 65 , ( 12 ) 1066 - 1067 .
Pfeffer PE, Sebire N, Lindsay I, McIndoe A, Lim A, Seckl M ( 2007 ) . Fertility-sparing partial hysterectomy for placental-site trophoblastic tumour . Lancet Oncology vol. 8 , ( 8 ) 744 - 746 .
Pfeffer PE, Pfeffer JM, Hodson ME ( 2003 ) . The psychosocial and psychiatric side of cystic fibrosis in adolescents and adults . Journal of Cystic Fibrosis vol. 2 , ( 2 ) 61 - 68 .