Publications: Dr Liliane Fossati-Jimack

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .

Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al. ( 2024 ) . Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes . Arthritis Research & Therapy vol. 26 , ( 1 )

Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al. ( 2024 ) . OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Conference: Scientific Abstracts12 - 12 .

Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al. ( 2024 ) . OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS . Conference: Scientific Abstracts13.1 - 1313 .

Surace A, Overend L, Sciacca E, Fossati-Jimack L, Jaworska E, Pontarini E, Bashford-Rogers RJM, Pitzalis C et al. ( 2024 ) . OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA . Conference: Scientific Abstracts13.2 - 1314 .

Iaquinta FS, Sciacca E, Abatecola F, Fossati-Jimack L, Pitzalis C, Rivellese F ( 2024 ) . POS0351 A POST-HOC ANALYSIS OF THE BIOPSY-DRIVEN, MULTICENTRE, RANDOMISED R4RA CLINICAL TRIAL REVEALS AN INNATE IMMUNE SIGNATURE IN MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS PATIENTS WITH A LYMPHO-MYELOID PATHOTYPE . Conference: Scientific Abstracts302.2 - 30303 .

Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E et al. ( 2024 ) . Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response . Journal of Clinical Investigation vol. 134 , ( 12 )

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis & Rheumatology vol. 76 , ( 5 ) 763 - 776 .

Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F, Pitzalis C ( 2023 ) . Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features . Osteoarthritis and Cartilage vol. 32 , ( 2 ) 166 - 176 .

Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C et al. ( 2023 ) . AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD . 1212.2 - 121213 .

Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 ,

Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al. ( 2022 ) . Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT . Efficacy and Mechanism Evaluation vol. 9 , ( 7 ) 1 - 58 .

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 52.2 - 5253 .

Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299.2 - 29300 .

Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 470.1 - 47470 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .

Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,

Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .

Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F et al. ( 2021 ) . Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis . Frontiers in Immunology vol. 12 ,

Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .

Jackson WD, Gulino A, Fossati-Jimack L, Seoane RC, Tian K, Best K, Köhl J, Belmonte B et al. ( 2020 ) . C3 Drives Inflammatory Skin Carcinogenesis Independently of C5 . Journal of Investigative Dermatology vol. 141 , ( Immunobiology 209 7 2004 Nov ) 404 - 414.e6 .

Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .

Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .

Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M, Mavilio D ( 2018 ) . NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation . Journal of Leukocyte Biology vol. 105 , ( 3 ) 589 - 602 .

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 1 ) 53 - 60 .

Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 )

Shikh ME, Sayed RE, Fossati-Jimack L, Pitzalis C ( 2018 ) . O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis . Annals of the Rheumatic Diseases . Conference: Oral presentations vol. 77 ,

Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M, Pickering MC ( 2016 ) . Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy . Kidney International vol. 89 , ( 4 ) 823 - 832 .

Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC et al. ( 2015 ) . Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes . Cell Reports vol. 12 , ( 11 ) 1802 - 1815 .

Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G et al. ( 2014 ) . Intranasal peptide‐induced tolerance and linked suppression: consequences of complement deficiency . Immunology vol. 144 , ( 1 ) 149 - 157 .

Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L et al. ( 2014 ) . Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum . Particle and Fibre Toxicology vol. 11 , ( 1 )

Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T et al. ( 2014 ) . IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut . Journal of Autoimmunity vol. 50 , ( 100 ) 107 - 122 .

Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G et al. ( 2014 ) . Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages . Nature Communications vol. 5 , ( 1 )

Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto M ( 2014 ) . C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 4 ) 1503 - 1508 .

Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT et al. ( 2013 ) . Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells . PLOS ONE vol. 8 , ( 2 )

Lewis MJ, Malik TH, Fossati‐Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M ( 2012 ) . Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia . Arthritis & Rheumatism vol. 64 , ( 8 ) 2707 - 2718 .

Huang FP, Sattler S, Ling GS, Xu D, Hussaart L, Romaine A, Zhao HZ, Fossati-Jimack LM et al. ( 2012 ) . An essential protective role of IL-10-producing regulatory B cells against IL-33-mediated mucosal inflammation . IMMUNOLOGY . vol. 137 , 77 - 77 .

Tarzi RM, Sharp PEH, McDaid JP, Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT, Warrens AN ( 2011 ) . Mice with defective Fas ligand are protected from crescentic glomerulonephritis . Kidney International vol. 81 , ( 2 ) 170 - 178 .

Botto, Lewis, Malik, Fossati-Jimack, Carassiti, Cook, Haskard ( 2011 ) . A novel mouse model of systemic lupus erythematosus (SLE) and atherosclerosis: Distinct roles of complement in the kidney and atherosclerotic plaques . Molecular Immunology . vol. 48 ,

McDonald JU, Cortini A, Rosas M, Fossati‐Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K et al. ( 2011 ) . In vivo functional analysis and genetic modification of in vitro‐derived mouse neutrophils . The FASEB Journal vol. 25 , ( 6 ) 1972 - 1982 .

Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA et al. ( 2010 ) . Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3 . The Journal of Immunology vol. 184 , ( 11 ) 6256 - 6265 .

Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A, Izui S ( 2010 ) . Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation . Journal of Autoimmunity vol. 34 , ( 4 ) 349 - 355 .

Izui S, Ibnou-Zekri N, Fossati-jimack L, Iwamoto M ( 2009 ) . Lessons from BXSB and Related Mouse Models . International Reviews of Immunology vol. 19 , ( 4-5 ) 447 - 472 .

Izui S, Merino R, Fossati L, Iwamoto M ( 2009 ) . The Role of the Yaa Gene in Lupus Syndrome . International Reviews of Immunology vol. 11 , ( 3 ) 211 - 230 .

Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2009 ) . COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND GLOMERULONEPHRITIS IN SLE . RHEUMATOLOGY . vol. 48 , I15 - I16 .

Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT, Botto M ( 2008 ) . A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice . Genes & Immunity vol. 10 , ( 1 ) 47 - 55 .

Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S et al. ( 2008 ) . Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis . The Journal of Immunology vol. 181 , ( 4 ) 2846 - 2854 .

Fossati L, Merino J, Izui S ( 2008 ) . CD4+ T cells play a major role for IgM and IgG anti-DNA production in mice infected with Plasmodium yoelii . Clinical & Experimental Immunology vol. 79 , ( 2 ) 291 - 296 .

Fossati‐Jimack L, Cortes‐Hernandez J, Norsworthy PJ, Cook HT, Walport MJ, Botto M ( 2008 ) . Regulation of B cell tolerance by 129‐derived chromosome 1 loci in C57BL/6 mice . Arthritis & Rheumatism vol. 58 , ( 7 ) 2131 - 2141 .

Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M ( 2008 ) . Lupus phenotype accelerates atherosclerosis in a novel mouse model of SLE . RHEUMATOLOGY . vol. 47 , II97 - II98 .

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT, Botto M ( 2007 ) . C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice . Molecular Immunology vol. 45 , ( 3 ) 787 - 795 .

Baudino L, Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ, Izui S ( 2007 ) . IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation . Blood vol. 109 , ( 12 ) 5355 - 5362 .

Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT, Botto M ( 2007 ) . Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice . The Journal of Immunology vol. 178 , ( 4 ) 2352 - 2360 .

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy P, Cook HT, Botto M ( 2007 ) . C1q can alter the levels of IgM autoantibody production in anti-DNA transgenic models . Molecular Immunology . vol. 44 ,

IZUI S, IWAMOTO M, FOSSATI U, MERINO R, TAKAHASHI S, IBNOU‐ZEKRI N ( 2006 ) . The Yaa Gene Model of Systemic Lupus Erythematosus . Immunological Reviews vol. 144 , ( 1 ) 137 - 156 .

Kikuchi S, Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL, Izui S ( 2006 ) . Contribution of NZB Autoimmunity 2 to Y-Linked Autoimmune Acceleration-Induced Monocytosis in Association with Murine Systemic Lupus . The Journal of Immunology vol. 176 , ( 5 ) 3240 - 3247 .

Carlucci F, Cortes-Hernandez J, Fossati-Jimack LM, Bygrave AE, Cook TH, Vyse TJ, Botto M ( 2006 ) . Genetic contribution of 129 chromosome 1 intervals to autoimmunity in C57BL/6 mice . RHEUMATOLOGY . vol. 45 , I4 - I4 .

Reininger L, Shibata T, Schurmans S, Merino R, Fossati L, Lacour M, Izui S ( 2005 ) . Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice . European Journal of Immunology vol. 20 , ( 11 ) 2405 - 2410 .

Fossati L, Merino R, Iwamoto M, Lemoine R, Izui S ( 2005 ) . Lack of association of Vβ8+ T cells with lupus‐like syndrome in MRL‐lpr/lpr mice . European Journal of Immunology vol. 24 , ( 7 ) 1717 - 1720 .

Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA, Izui S ( 2005 ) . The Yaa gene‐mediated acceleration of murine lupus: Yaa− T cells from non‐autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo . European Journal of Immunology vol. 25 , ( 12 ) 3412 - 3417 .

Merino R, Fossati L, Lacour M, Lemoine R, Higaki M, Izui S ( 2005 ) . H‐2‐linked control of the Yaa gene‐induced acceleration of lupus‐like autoimmune disease in BXSB mice . European Journal of Immunology vol. 22 , ( 2 ) 295 - 299 .

Fossati L, Iwamoto M, Merino R, Izui S ( 2005 ) . Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens . European Journal of Immunology vol. 25 , ( 1 ) 166 - 173 .

Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT, Botto M ( 2005 ) . The Role of Complement in Cryoglobulin-Induced Immune Complex Glomerulonephritis . The Journal of Immunology vol. 175 , ( 10 ) 6909 - 6914 .

Amano H, Amano E, Santiago‐Raber M, Moll T, Martinez‐Soria E, Fossati‐Jimack L, Iwamoto M, Rozzo SJ et al. ( 2005 ) . Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus . Arthritis & Rheumatism vol. 52 , ( 9 ) 2790 - 2798 .

Tas SW, Quartier P, Botto M, Fossati-Jimack L ( 2005 ) . Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells . Annals of the Rheumatic Diseases vol. 65 , ( 2 )

Kikuchi S, Amano H, Amano E, Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL et al. ( 2005 ) . Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice . Blood vol. 106 , ( 4 ) 1323 - 1329 .

Kikuchi S, Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C et al. ( 2005 ) . Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis . The Journal of Immunology vol. 174 , ( 2 ) 1111 - 1117 .

Cortes‐Hernandez J, Fossati‐Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT, Botto M ( 2004 ) . Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice . European Journal of Immunology vol. 34 , ( 12 ) 3713 - 3722 .

Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR et al. ( 2004 ) . Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease . The Journal of Immunology vol. 173 , ( 7 ) 4277 - 4285 .

Trendelenburg M, Manderson AP, Fossati‐Jimack L, Walport MJ, Botto M ( 2004 ) . Monocytosis and accelerated activation of lymphocytes in C1q‐deficient autoimmune‐prone mice . Immunology vol. 113 , ( 1 ) 80 - 88 .

LEE NJ, RIGBY RJ, GILL H, BOYLE JJ, FOSSATI-JIMACK L, MORLEY BJ, VYSE TJ ( 2004 ) . Multiple loci are linked with anti-red blood cell antibody production in NZB mice−comparison with other phenotypes implies complex modes of action . Clinical & Experimental Immunology vol. 138 , ( 1 ) 39 - 46 .

Kuroki A, Moll T, López‐Hoyos M, Fossati‐Jimack L, Ibnou‐Zekri N, Kikuchi S, Merino J, Merino R et al. ( 2004 ) . Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production . European Journal of Immunology vol. 34 , ( 4 ) 1077 - 1084 .

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ et al. ( 2004 ) . Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis . The Journal of Immunology vol. 172 , ( 6 ) 3406 - 3414 .

Lajaunias F, Ida A, Kikuchi S, Fossati‐Jimack L, Martinez‐Soria E, Moll T, Law C, Izui S ( 2003 ) . Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus . Arthritis & Rheumatism vol. 48 , ( 6 ) 1612 - 1621 .

Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ, Cook HT ( 2002 ) . Nephrotoxic nephritis is mediated by Fcγ receptors on circulating leukocytes and not intrinsic renal cells . Kidney International vol. 62 , ( 6 ) 2087 - 2096 .

CORTES-HERNANDEZ J, FOSSATI-JIMACK L, CARUGATI A, POTTER PK, WALPORT MJ, COOK HT, BOTTO M ( 2002 ) . Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms . Clinical & Experimental Immunology vol. 130 , ( 3 ) 459 - 466 .

Kikuchi S, Pastore Y, Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S et al. ( 2002 ) . A Transgenic Mouse Model of Autoimmune Glomerulonephritis and Necrotizing Arteritis Associated with Cryoglobulinemia . The Journal of Immunology vol. 169 , ( 8 ) 4644 - 4650 .

Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Pastore Y, Fossati-Jimack L, Reininger L et al. ( 2002 ) . Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor . Blood vol. 99 , ( 8 ) 2922 - 2928 .

da Silveira SA, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ et al. ( 2002 ) . Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody . Journal of Experimental Medicine vol. 195 , ( 6 ) 665 - 672 .

Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M, Walport MJ ( 2002 ) . C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression . The Journal of Immunology vol. 168 , ( 5 ) 2538 - 2543 .

Fossati-Jimack L, da Silveira SA, Moll T, Kina T, Kuypers FA, Oldenborg P-A, Reininger L, Izui S ( 2002 ) . Selective Increase of Autoimmune Epitope Expression on Aged Erythrocytes in Mice: Implications in Anti-erythrocyte Autoimmune Responses . Journal of Autoimmunity vol. 18 , ( 1 ) 17 - 25 .

Izui S, Fossati-Jimack L, Azeredo da Silveira S, Moll T ( 2001 ) . Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia . Seminars in Immunopathology vol. 23 , ( 4 ) 433 - 445 .

Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M, Fossati-Jimack L et al. ( 2001 ) . Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins . Blood vol. 97 , ( 11 ) 3537 - 3543 .

Chicheportiche Y, Fossati-Jimack L, Moll S, Ibnou-Zekri N, Izui S ( 2000 ) . Down-Regulated Expression of TWEAK mRNA in Acute and Chronic Inflammatory Pathologies . Biochemical and Biophysical Research Communications vol. 279 , ( 1 ) 162 - 165 .

Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FMA, Gessner JE et al. ( 2000 ) . Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III . Journal of Experimental Medicine vol. 191 , ( 8 ) 1293 - 1302 .

Hügin AW, Fossati-Jimack L, Izui S ( 2000 ) . The Autoimmune Accelerating Yaa Mutation Does Not Accelerate Murine AIDS . Cellular Immunology vol. 200 , ( 2 ) 76 - 80 .

Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch JV, Honjo T, Izui S ( 1999 ) . High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia . Journal of Experimental Medicine vol. 190 , ( 11 ) 1689 - 1696 .

Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ, Izui S ( 1997 ) . Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice . Proceedings of the National Academy of Sciences of the United States of America vol. 94 , ( 26 ) 14654 - 14659 .

Santiago M-L, Fossati L, Jacquet C, Müller W, Izui S, Reininger L ( 1997 ) . Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome . Journal of Experimental Medicine vol. 185 , ( 1 ) 65 - 70 .

Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S ( 1996 ) . Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice . Journal of Clinical Investigation vol. 97 , ( 7 ) 1597 - 1604 .

Moll S, Menoud P-A, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli J-D, Sappino A-P et al. ( 1995 ) . Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis . Kidney International vol. 48 , ( 5 ) 1459 - 1468 .

Merino R, Fossati L, to MI, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J et al. ( 1995 ) . Effect of Long-Term Anti-CD4 or Anti-CD8 Treatment on the Development oflprCD4−CD8−Double Negative T Cells and of the Autoimmune Syndrome in MRL-lpr/lprMice . Journal of Autoimmunity vol. 8 , ( 1 ) 33 - 45 .

Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD, Vassalli P ( 1994 ) . A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice . Diabetologia vol. 37 , ( 12 ) 1277 - 1279 .

Izui S, Merino R, Iwamoto M, Fossati L ( 1994 ) . Mechanisms of genetic control of murine systemic lupus erythematosus . Seminars in Immunopathology vol. 16 , ( 2-3 ) 133 - 152 .

IZUI S, BERNEY T, SHIBATA T, FULPIUS T, FOSSATI L, MERINO R ( 1994 ) . Molecular and Cellular Basis for Pathogenicity of Autoantibodies . The Tohoku Journal of Experimental Medicine vol. 173 , ( 1 )

Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K et al. ( 1993 ) . Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain . Journal of Experimental Medicine vol. 178 , ( 4 ) 1189 - 1197 .

Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry J-P, Nose M, Spach C, Motta R et al. ( 1993 ) . An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome . International Immunology vol. 5 , ( 5 ) 525 - 532 .

Merino R, Fossati L, Izui S ( 1992 ) . The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus . Seminars in Immunopathology vol. 14 , ( 2 ) 141 - 157 .

Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC, Izui S ( 1992 ) . Effect of Cyclosporin A and Zidovudine on Immune Abnormalities Observed in the Murine Acquired Immunodeficiency Syndrome . The Journal of Infectious Diseases vol. 166 , ( 2 ) 285 - 290 .

Merino R, Fossati L, Lacour M, Izui S ( 1991 ) . Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice . Journal of Experimental Medicine vol. 174 , ( 5 ) 1023 - 1029 .